Editorial
Attack of the COVIDians - Editorial
K Paul Stoller*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-125
Review Article
Christina Rahm*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-126
Case Study
Possible Integrative Approaches to Fibromyalgia, Anxiety, and Depression
Christina Rahm*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-127
Case Study
Fibromyalgia, Anxiety, and Depression and Related Disorders - White Paper
Christina Rahm*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-128
Case Study
Case Study: Chronic Obstructive Pulmonary Disease (COPD)
Christina Rahm*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-129
Case Study
Case Study and Protocol for Natural Ingredients used to Support Breast Cancer Patients
Christina Rahm*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-130
Case Study
Case Study concerning Ulcerative Colitis with Literature Review
Christina Rahm*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-131
Comprehensive Review
The Science Behind Taking the Right Green Supplements
Christina Rahm*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-132
Comprehensive Review
Detoxing & Remediating Land, Air, and Water & Implications on Human and Animal Health
Christina Rahm*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-133
Comprehensive Review
Possible Integrative Approaches to Treatments of Colon Cancer
Christina Rahm*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-134
Short Communication
Literature Review on Chronic Fatigue Syndrome
Christina Rahm*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-135
Short Communication
Blood Analysis Utilizing Natural Supplements to Assist People with Health and Wellness
Christina Rahm*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-136
Review Article
Combating Malnutrition among Vulnerable Groups (Goal 2)
Vijaya Khader*
Published : August 16, 2024
DOI : 10.56831/PSSRP-04-137
Change in the lifestyle leads to several types of diseases in which knee OA is leading amongst all. According to global burden of disease published in the year 2000 shows that some specific jobs and occupations which involve physical labor have increased risk to develop OA of knee. Especially the jobs such as farmers, dock workers, mine workers etc. which require heavy weight lifting, squatting and kneeling have high chances to develop knee OA. In 2005, a study named ‘A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis’ shows that females are more prone to knee OA than men. Whereas a study in England, UK shows that reduced BMD and use of oral contraceptive pills may be associated with knee OA. A study conducted in the university of Boston, USA in the year 2010 showed that increase in the age leads to biological changes which reduces joint capabilities to cope with adversity such as oxidative damage, poor proprioception, muscle weakness and thinning of cartilage. Weakness of quadriceps muscle also leads to structural damage to the joint along with painful knee OA shown in the study ‘Is Quadriceps Muscle Weakness a Risk Factor for Incident or Progressive Knee Osteoarthritis?’ in the year 2011.
A study named ‘Lifestyle changes in the management of osteoarthritis’ in the year 2001 reveals that exercise regimes for OA knee consists of both aerobic exercises and strengthening exercises with resistance of quadriceps muscles which helps to improve physical functioning along with pain reduction in the patients. The main aim is to increase balance, ROM, aerobic capacity and strength. A study conducted in 2010 showed that continuous sitting for two hours increases the risk of knee OA.
Lifestyle modification helps to delay or prevent the onset of OA and also prevents many musculoskeletal disabilities. Exercises and weight reduction management are the two lifestyle changes for the management of OA. Several clinical trials support that knee strengthening and aerobic exercises delays disability and reduce pain. Along with this treatment, comorbidities like hypertension and depression also increase the risk of OA knee. So, therefore identifying the risk factors and uplifting the lifestyle could delay the onset of knee OA.
Lifestyle refers to the characteristics of residents living in a region. It comprises day to day behavior and functioning of an individual’s physical activity, diet and occupation. It is a way practiced by groups, nations and people living in specific culture, geographical, political and religion. Quality of life and individual health are both associated with lifestyle. Alcohol consumption, drug abuse, malnutrition, stress and unhealthy diet depicts unhealthy lifestyle, which causes cardio-vascular diseases, hypertension, skeletal problems, metabolic diseases and overweight in the people. According to WHO, musculoskeletal condition is the major cause of disability and morbidity in 2017. Global Burden of Disease (GBD) has declared musculoskeletal conditions are having the highest contribution in global disability. Under musculoskeletal conditions Osteoarthritis (OA), back pain, neck pain, fracture and rheumatoid arthritis are the commonly prevailing disabling conditions. Out of which OA is the 10th most disabling condition in the developing world. Osteoarthritis refers to degenerative joint disease. In OA there is progressive destruction of articular cartilage, osteophyte formation and inflammation of synovium. It affects mainly the weight bearing joints of the body i.e., hip and knee. As per WHO, 9.6% and 18.0% of men and women respectively aged above 60 years are suffering from symptomatic arthritis. Out of which 80% of the population is suffering with OA along with restricted Range of Motion (ROM) and 25% of them cannot do majority of activities. Among all the population who complain of knee pain 80% of them shows knee OA. Globally, it is considered to be the 4th and 8th significant cause of infirmity in men and women respectively.
Keywords: telerehabilitation; rehabilitation; neck pain; shoulder pain; frozen shoulder; shoulder impingement; rotator cuff tear; fracture; chronic neck pain
Telerehabilitation is a way of providing physiotherapy in remote mode with increased satisfaction and success rates. Physiotherapy plays a major role in rehabilitation of such conditions by proper assessment and early intervention leading to a better quality of life for the patient. Neck and shoulder pain are quite increasing in number because of many reasons like poor posture, trauma, poor lifestyle, post-surgery complications. 13 articles were included in the scoping review related to rehabilitation of neck and shoulder related conditions respectively. After reviewing various related articles, it was concluded that better results were found in terms of decrease in pain, disability and improvement in terms of range of motion (ROM), posture, endurance, quality of life and patient satisfaction. Patients described better sense of security and adherence in telerehabilitation as compared to the conventional treatment provided.
Keywords: Artificial- intelligence; Sustainable Peace and Development; Human Rights-Legal personality- Health care- Insurance liability
Artificial Intellects or robots are becoming all-pervasive in the present modern society. Artificially Intelligence Technology has brought incredible change in the day to day lives of people around world. Large number of populations are familiar with AI technology like “chat-bots” and usage of “virtual personal assistants” like Apple’s Siri, Amazon’s Alexa; ok, Google and Microsoft’s Cortana. Where the whole world is relying on this AI technology in this context the present paper explores the impact of AI on Education, Amicable Conflict resolution, Economic stability, health sector, industry, Human rights protection, Fair and Speedy Justice - access to justice system. Recognition and protection of Human Rights are major elements for maintaining “sustainable peace and development” (UNSDG) of the society. Artificial Intelligence (AI) has huge impact on the improvement of health care systems apart from economic status of individuals, inequality in the communities as well as states and help to meet the United Nations’ Sustainable Development Goals. India’s policy think tank, the NITI Aayog paper on National Strategy on Artificial Intelligence is focused on leveraging AI for inclusive growth in line with the Government policy of Sabka Saath Sabka Vikas.
Keywords: Subclavian artery occlusion; upper extremity thrombosis; primary care
Subclavian artery thrombosis is a rare cause of upper limb ischemia resulting from occlusion of the upper extremity blood supply. The exact incidence or prevalence of subclavian steal syndrome is unknown, most literature reports the prevalence of SSS as between 0.6% to 6.4% [9]. Symptomatic presentation is quite rare and a high suspicion of index is required for its diagnosis in primary care setting. It is imperative to diagnose the condition early in order to avoid the complications. Possible catastrophic clinical consequences necessitate prompt rectification of the underlying disease and risk factors. Treatment modalities are often selected depending on the severity of clinical presentation, while modification of secondary risk factors in primary care is often sufficient among the asymptomatic patients. We report a case of a 70 years old female patient in primary care who presented with decreased appetite, intermittent diarrhea and 3 kg weight loss over 3 months and on physical exam discrepancy of blood pressure measurements was found in both arms. She was advised CT-angiogram which showed Subclavian artery thrombosis.
Keyword: Hand fractures; K-wire; JESS
Background: The fracture of the hand results in significant disability and leads to long term negative functional sequelae including loss of ability to work and live at pre injury level. Most of these fractures can be treated conservatively. However, conservative treatment has poor outcome in unstable, intra-articular and compound fractures, making operative means a necessity for such cases. Materials and Methods: A prospective randomized control study was undertaken in our institute consisting of 100 cases of intra-articular and juxta-articular fractures of the small long bones of the hand who were treated with either simple K-wiring versus K-wiring with external fixation over a period of 12 months from January till December 2020. The cases were evaluated for functional outcome at the end of 12 months of follow up. Results: 100 cases with 129 fractures of the metacarpals and phalanges of hand were randomized and treated with either K-wires or Joshi’s External Stabilisation System (JESS) fixator. The mean age of the cases was 31-40 years with male predominance. Motor vehicle accidents were the commonest cause of trauma. The operative time for JESS fixation was longer than K-wiring alone, which was statistically significant. Functional outcome was assessed based on Modified Mayo Wrist Score and ASSH-TAF scores. At the end of 12 months, JESS fixation had statistically and functionally better results. Discussion: The authors advocate the early management of hand fractures with JESS Fixation compared to K-wiring alone. The outcomes were also dependent on the age, gender and compliance of the patients.
Keywords: Shirahshula; Jaladhara; Shirodhara; Aswagandha; Anxiety; Stress; Depression; Primary headache
Shirodhara is a popular traditional Panchakarma treatment for balancing the Doshas and for improving the function of the brain, there by relieving headache and stress. Shirodhara induces a state of peaceful awareness that results in a dynamic psycho-somatic balance. The present study was conducted on 40 cases of primary headache. The treatment was continued for 15 days with the objective to evaluate clinically the efficacy of Jaladhara and Jaladhara with some herbal medicines in the management of Headache. These patients were divided into two groups of 20 patients each. It was observed that the patients of group B treated with Ashwagandha extract (500 mg OD) and Shirodhara with water showed significant improvement, whereas the group A treated with only Shirodhara with water also showed similar improvement.
.
Gout, a common type of crystal arthropathy, predominantly present with episodic, acute, asymmetric, lower limb predominant arthritis, often starts from the first meta-tarso-phalangeal joint. But polyarticular symmetric hand joint involvement is also commonly found in clinical practice, predominantly in chronic untreated or inadequately treated cases. Here we present clinical images of two gout patients’ hands with deforming inflammatory polyarthritis of hand joints, multiple subcutaneous tophi, with few shows chalky like discharge and superficial ulceration. Both patients were old male with chronic disease courses and inadequately treated. Early diagnosis with adequate treatment, lifestyle modification can prevent this debilitating condition and patients suffering..
References
Joint function losses that occur as a result of injury, healing and scarring of the cartilage tissue are varied. In this study, the contralateral joints of rabbits with complete cartilage loss were defined as the control group. Self-healing of similar cartilage losses and popular surgical methods were compared, and the results were examined histopathologically. As a result, it was determined that while autogenous full-thickness osteochondral cartilage transfer resulted in the best cartilage healing, the healed cartilage tissue without any intervention was superior to methods such as drilling and carbon fiber. We concluded that cartilage tissue must be “no men land” if lower than full thickness cartilage lesions. Cartilage must be protected any surgical impact instead of main mechanical articular problems must be focused.
Keywords: Cartilage Defects; Mosaicplasty; Cartilage debridement
References
Coronary heart disease (CHD) is a multifactorial disease resulting due to accumulation of atheromatous plaques within the walls of the coronary arteries that supply the myocardium (the muscle of the heart) with oxygen and nutrients. The aim of the present study is to investigate association of epidemiological and clinical risk factors in the development of disease in CHD patients and their first degree relatives (FDRS) in comparison with controls. The aetiology of CHD is multifactorial. It is the result of interaction between genetic, lifestyle and environmental factors. Monitoring the epidemiology and clinical risk factors of CHD is an important component in the pathogenesis of CHD.
In the peripheral nervous system, the mechanism ends up being very effective. The injury process triggers changes in the cellular phenotypes of Schwann cells (SC), axonal immaturation and activation of genes to stimulate neuronal survival and neurite growth, in addition to the influx of calcium responsible for stimulating neuroregeneration. The inflammatory process contributes to the secretion of SCs growth factors in addition to stimulating their mitosis to enhance the effect. Inflammation also promotes the elimination of myelin molecules and residues that are neuro-inhibitory and impede axonal regeneration. The SCs also have particularities for successful neuroregeneration. By losing axonal contact, they manage to remain active without the need for contact with the axons with an autocrine survival system. In case of extensive injuries and many local cell losses due to the injury mechanism, nearby veins have precursor cells for new ones to appear in the area and favor neuroregeneration. The SCs also participate in the elimination of myelin residues, being stimulated by the remnants of myelin residues degenerated in the environment after injury, together with the inflammatory response mediated by cytokines, chemokines, interleukins/interferons and necrosis factors, events that can be found during the Wallerian degeneration process. A series of responses and molecular interactions are reported in the literature and cannot be addressed in this opinion article due to its length [1-3, 6, 25-30]. However, it is important to highlight the possibility that many peripheral diseases without a specific etiology may have their origin through the activation of neuroregeneration mechanisms, culminating in changes in the central nervous system, in other words, a central pathological mechanism secondary to a peripheral process. The considerations will be carried out in the next topic. We must always think of all possible ways for the evolution of scientific knowledge to reach extraordinary levels.
Considerations On the Topic
Due to the findings of the previous studies mentioned, we can consider the possibility of creating new terms for the subject of neuroplasticity. The change in central neuronal circuits after injury to the peripheral nervous system, as well as the onset of neuropathic pain and other clinical conditions mentioned, we can postulate that peripheral neuroplasticity can be both maladaptive and compensatory, triggering central changes that may lead to sequelae neurology for patients. For example, the development of trigeminal nerve neuralgia without previous damage, which can be explained by micro-stimuli that occur over time until the neuroplasticity process starts, either by genetic, inflammatory or cellular/molecular stimuli that modify the central neuronal circuits favoring the onset of pain. It is also possible to postulate that the mechanism of neuroplasticity and neuroregeneration does not occur in the central nervous system precisely to avoid more serious neurological complications/sequelae than the already installed lesion itself, with individuals who had this characteristic being eliminated by natural selection, or that we are still in an evolutionary process of the species so that these two mechanisms occur properly in the post-injury nervous system without harming the patient, this characteristic being positively selected in individuals.
References
The mechanism of neuroplasticity begins in human intrauterine life and extends until the end of it. This phenomenon is complex, involving many intracellular pathways and has a compensatory and maladaptive outcome. When comparing central and peripheral neuroplasticity, it is possible to identify a difference between both. The peripheral neuroplasticity phenomenon ends up culminating in a successful neuroregeneration process, with pro-regeneration stimuli, while in the central nervous system, the phenomenon ends up being inhibited by neuro-inhibitory stimuli, interrupting the mechanism. Strategies for central neuroplasticity have been developed and are still being developed so that the mechanism is successful and culminates in a functional recovery due to some central nervous system injury. Analyzing both mechanisms, it can be deduced that neuroplasticity is something essentially beneficial that will provide a regeneration of the nervous tissue allowing a functional recovery. However, we must consider its complications that can be observed in the central nervous system after neuroplasticity provides tissue regeneration in the peripheral nervous system. Through this, we can infer some theories on the subject that will be shown at the end of this opinion article.
Understanding Neuroplasticity and The Types That Can Be Evidenced and Stated
First, we must understand the concepts inherent to neuroplasticity and neuroregeneration, as well as their definitions. Neuroplasticity is related to the property of the nervous system to change its function and structure in order to remodel itself to the conditions that are imposed on it, whether physiological or pathological, and can promote functional recovery in a short or medium period of time. Neuroregeneration consists of the ability to generate new neurons, that is, to promote neurogenesis, establishing new connections and promoting long-term functional recovery. Therefore, the process of neuroregeneration must be linked to neurogenesis due to the mechanism of neuronal proliferation [2-6, 17, 18, 34].
Although body tissues have a certain ability to regenerate and restore their previously established functionality, in the nervous system, especially in the central one, this does not occur adequately. Neurons have a finite number of multiplier cycles, which are more exuberant in intrauterine life and in children/young people and less expressive in adults and the elderly, but they can still be found in different regions of the brain, such as the dentate gyrus of the hippocampus. The cell division cycle can be found in two distinct moments, the first one being symmetrical and later, asymmetrical. Symmetric division is when the precursor cell gives rise to two other precursor cells, and so on. This phase is fast and quickly becomes asymmetrical, where the precursor daughter cell continues cycling and the precursor mother cell interrupts the cycle, becoming a young neuron that will go through a process of morphofunctional differentiation in the region where it is found to become in a mature neuron [2, 3, 6, 21, 25]. Axonal development can be evidenced by the expression of a wide range of genes, such as Kruppel-like factor 7 (KLF7) and Sox11, as well as activation of the Rapamycin (mTOR) pathway, which will trigger a series of intracellular signals [2, 3, 6, 22, 24].
Neuroplasticity can be identified at various stages of human development. In the embryonic and postnatal period we have ontogenetic plasticity, an interaction between the genome and the environment capable of promoting an important variety in the human species. Then we have the critical period, when the nervous system is most susceptible to the environment, such as the development of vision in children. Related to the critical period, we can observe the presence of the imprinting mechanism, which can be called the short critical period evidenced by the ethologist Konrad Lorenz when being recognized as a mother by geese chicks, that is, just the gaze mechanism, made the recognition circuit stabilized instantly, without the need for time. An example of a critical period in humans can be seen in the speech development process, which can last until adolescence. In addition to these, neuroplasticity can be didactically divided into three large groups, called: Morphological Neuroplasticity, Functional Neuroplasticity and Synaptic Plasticity. However, success for a successful neuroplasticity that will provide a new connection is directly dependent on three steps and which area of the nervous system was injured. The first step is the distance between the stump proximal and distal to the lesion, the smaller the distance, the greater the success of the mechanism. The second stage is due to synaptic modulations, which can be called metaplasticity, which can be intense or weak and will depend on the stimulus that will be applied. The third step is related to excitatory or inhibitory signals from interneuronal GABAergic circuits that can promote changes in different neuronal firings [1-5].
Studies were published with the aim of highlighting the types of neuroplasticity, explaining its adaptation and development. In the morphological neuroplasticity, dysgenesis of the corpus callosum was evidenced, resulting from a weak molecular stimulation towards the axonal fibers, which culminates in a malformation of the corpus callosum. Another example would be amblyopia after visual deprivation, resulting in a change in the pattern of ocular dominance [4, 5, 7-11]. Synaptic plasticity was reported as responsible for promoting communication and the flow of information in neuronal circuits, with the phenomena of Long-Term Potential (LTP) and Long-Term Depression (LDP) being described and having strong relationships with cyclooxygenase-2 (COX -2) and the p38 MAP kinase (p38 MAPK) [2-5, 11, 19].
However, functional neuroplasticity is what we can use to formulate some theories and thoughts. Within this group, we can highlight the most macroscopically palatable subtypes. It has been demonstrated through experimental studies that functional neuroplasticity can exhibit clinical conditions found in patients. Focal dystonia was evidenced in young patients when compared to more adult patients, where they exhibited cortical increase in the area of representation of the hands. The tactile pattern in blind patients was also different depending on age, whose tactile information ended up being processed in the visual cortex. At this moment, we can observe a maladaptive character of the functional neuroplasticity evidenced by the clinical condition of focal dystonia and confirmed by the phantom limb syndrome of the Ramachandran study, while the processing of tactile information in the visual cortex shows a compensatory character of the functional neuroplasticity. Maladaptive neuroplasticity can be defined as the appearance of symptoms after their appearance, while compensatory neuroplasticity ends up causing the relief of symptoms after their installation in the nervous system [2-4, 7-11, 17, 18].
What Differes the Central Nervous System from the Peripheral in regard to Neuroplasticity and Neuroregeneration?
After understanding the concepts of neuroplasticity and its differentiation from neuroregeneration, it is noteworthy that these two buttons have different behaviors depending on the region of the nervous system, with a higher success rate in the peripheral nervous system (PNS) and a lower one central nervous system (CNS) [2-4, 6, 20-22]. Such behaviors are due to a series of intracellular and molecular signals, reactions triggered by the local inflammatory response, ionic response, physical barriers and genetic response that make the process unfeasible in the CNS and viable in the PNS. However, complications can be evidenced in the CNS and PNS after the onset of neuroplasticity resulting from damage to both systems. In spinal cord trauma, dysfunctions were evidenced after alteration of neuronal circuits, such as autonomic dysreflexia, diaphragmatic dysfunction after degeneration of the frenetic nerve, among others. In the peripheral nervous system, however, it is possible to identify the formation of aberrant circuits, neuropathic pain, allodynia and the phenomenon of preferential motor reinnervation (PMR), in addition to the lack of myelin differentiation that ends up harming the process of peripheral neuroplasticity [1, 4, 6, 22, 28, 34-51].
The neuroregeneration mechanism needs three pillars for the phenomenon to be successful. The first pillar is the genetic response triggered after neuronal injury, which may have a neuro-inhibitory or neuro-stimulatory character. The second pillar is the inflammatory response triggered after the initial injury. The third pillar is the molecular and cellular interactions for the adjustment of neuroregeneration. These three pillars work synchronously and together, providing neuro-inhibition and neurostimulation. In the central nervous system, the mechanism is, in a way, inhibitory and neuroplasticity can have a maladaptive character, while in the peripheral nervous system the phenomenon is stimulatory with a high success rate, however, it can have a maladaptive character in the central nervous system. secondary to peripheral nervous system injury, as previously reported [1-6, 20-22, 28, 50, 51].
In central nervous system injuries, mainly related to mechanical trauma after spinal cord injury, the primary injury is the initial stimulus to trigger the neuroplasticity process in order to repair the injured circuit. However, the mechanism does not work properly. After the primary lesion, there is the appearance of a secondary lesion characterized by an inflammatory and cellular response, in addition to the activation of ion channels and gene expression. The ionic reaction triggered by increased cellular calcium influx increases reactive oxygen species and glutamate species triggering damage to genetic material, proteins and phospholipids, culminating in neurological dysfunction. The ionic response of calcium is responsible for the activation of genes associated with regeneration, however there is a stimulation of Phosphatase Tensin Homolog (PTEN) and Suppressor of Cytokine Signaling 3 (SOCS3) proteins that trigger inhibition of the neuroregeneration process by interfering in signaling pathways Janus Kinase/Signal Transducer and Transcription Activator 3 (JAK/STAT3) and Mammalian Target of Rapamycin Complex 1 (mTORC1). Deficient gene expression may be responsible for not adequately influencing neurogeneration, angiogenesis and cell adhesion/differentiation after vascular disruption and apoptosis after injury, such as the dysregulation of circRNAs. Hub genes, may have a neurotoxic character depending on oxidative stress and ischemia as reported for DNA DamageInducible Transcript 4 (DDIT4), or are responsible for the formation of gliosis through the RhoA pathway by stimulation of Transcription Activator-3 (STAT3), described for the Erzin gene (ERZ). Other physical barriers include the formation of cystic cavities and maturation of the glial scar [1-5, 45, 49, 52-57, 61]. The molecular response also has a great influence on inhibiting the reconstitution of circuits. Lipid peroxidation of oligodendrocytes is responsible for the release of neuro-inhibitory molecules. These cells do not support a long time away from the axons, suffering rapid degeneration, releasing such molecules. In addition, microglia have a lower phagocytic power compared to macrophages, contributing to the formation of gliosis. Chondroitin Sulfate Proteoglycan (CSPG) and Keratan Sulfate Proteoglycan (KSPG) molecules have been reported to inhibit the neuroregeneration process. Acrolein has been reported to cause neuropathic hyperreflexia, in addition to causing mitochondrial damage and triggering apoptosis. The Nogo family (NI250), mainly NogoA, are reported as the main family of neuro-inhibitory stimuli and are capable of interacting with several receptors, such as NgR1 and p75, inhibiting remyelination by activating the RhoA pathway. Myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp) are also responsible for inhibiting remyelination through the same signaling pathway as NogoA. Versican (GSPG2) also prevents neuroregeneration by interactions between inflammatory leukocytes and inflammatory cells, favoring the recruitment of chemokines. Other molecules are also responsible for inhibiting neuroregeneration such as Ephrins (B3), semaphorins (4D and 3A) and NI-35 [1, 3-5, 47, 49, 54, 58-61].
References
Arteriosclerosis often does not cause symptoms until the lumen of the affected artery is critically narrowed or is totally blocked. The symptoms of arteriosclerosis are highly variable and can range from no symptoms (in the early stage of the disease) to heart attack or stroke (when the lumen of the artery is critically blocked). Sudden cardiac death can also be the first symptom of coronary heart disease. As a plaque grows along the lining of an artery, it produces a rough area in the artery's normally smooth surface. This rough area can cause a blood clot to form inside the artery, which can totally block blood flow. As a result, the organ supplied by the blocked artery starves for blood and oxygen. The organ's cells may either die or suffer severe damage. Atherosclerosis can narrow the major arteries that supply blood to the legs, especially the femoral and popliteal arteries. These two arteries are affected in 80% to 90% of people with this problem. The reduced blood flow to the legs may result in a crampy leg pain during exercise called intermittent claudication. If blood flow is compromised severely, parts of the leg may become pale or cyanotic (turn blue), feel cold to the touch and eventually develop gangrene. There are various drugs which reduces plasma lipids but with potential side effects. Herbal medication like Green Cardamom has potential to lower bad cholesterol, i.e. LDL-cholesterol and raise good cholesterol, i.e. HDL-cholesterol. In this work we compared hypolipidemic effects of Niacin with Cardamom. Seventy five hyperlipidemic patients were selected for research work. They were divided in three groups. Group-I was on placebo, group-II was given 1.5 grams Niacin, and group-III was advised to use powdered Cardamom thrice daily for the period of two months. Their lipid profile was measured at start of research and then on day-60. After two months therapy group-II reduced total cholesterol 30.8 mg/dl and LDL cholesterol 12.1 mg/dl and increased HDL cholesterol 5.6 mg/dl. In group-III Cardamom decreased total cholesterol 7.2 mg/dl and LDL cholesterol 8.8 mg/dl. HDL cholesterol in this group increased 4.9 mg/dl. When results were compiled and analyzed biostatistically, these changes were significant. We conclude from the research work that Niacin has more effects on total cholesterol but effects of both drugs on LDL cholesterol reduction was almost same.
References
The article considers the integration of modular solutions of therapeutic landscapes and interactive public spaces with a high degree of digitalization into the infrastructure of the city and special-purpose facilities, medical complexes and institutions. The article examines the role of the therapeutic function of therapeutic landscapes using a modular approach as a response to the challenges of time. It is important to combine growing technological capabilities with landscaping components. It is in this synthesis that the author sees the future development of the urban environment and the landscape of medical facilities.
Keyword: pattern; urban morphology; integrity; development; BIM for landscape; unique design; simulation algorithm; identity; utilities; technologies; innovations; design of alternatives; construction; competitive ability; potential; innovative development; municipal economy; community economy; urban semiotics; residential yards and gardens; county level; digital public spaces; neurorehabilitation; formation of man of today; scenario approach
It has revealed that autonomic innervation represents 85-90% of innervation faced to sympathetic one. The mastery of the unmyelinated C fibers than faster conductors Aδ fibers, gives the eye more sensitivity as only hyperosmolarity or heat. In dry eye disease, even the inability of tear production, the stimulation of receptor neuro-activator as nicotinic acetylcholine receptor, or treatment via nasal route, alleviated this infirmity. In other hand, tear film homeostasis could be repaired via stimulation of parasympathetic fibers of trigeminal nerve.
The surface of eye and lacrimal glands are exposed to air infection, and viruses of hand contact, which increase the risk of infection that land first the tear film. The resilience of tear film protect corneal and conjunctival epithelium, but its lipophilicity increases possibility of viruses to access the ocular surface. The prevalence of vision impairment has taken various origins like exaggeration of electronic surfaces use, some kinds to environment toxicity, chronic diseases and after surgical neuropathies as it could take birth even earlier as preterm birth. As high levels of glucose induced neurotoxicity, glia cells intervenes via glutamate, chemokines and pro-inflammatory cytokines, the retina of diabetic retinopathy is a thickening in retina, and cornea is useful for identifying neuropathy, as shown a deficiency in number of nerve’s fibers. About 57% of people with Down syndrome have visual problems, and analyzing visual acuity considered as the basis of an eye exam. Age-related macular degeneration, glaucoma, uncorrected refractive error, cataract, and diabetic retinopathy are the most abundant eye diseases.
Many studies interested in developing eye drops holding drugs with high solubility in water and high retention on ocular surface, to repair the defects of corneal epithelium; and to prevent surgery laser usually used in high intraocular pressure and ocular pain. In other hand, while treating glaucoma, the drug subsistence remain a discomfort matter for the patients, as it guarantee only a short term eye protection; eye lenses have been proposed due their longer protection referring to higher rates of drug absorption they offered and their substitution into a drug source for the eye’s anterior chamber and the corneal layer.
Between embarrassing health’s conditions of both males and females, males are prone to retinal detachment, and females are subject to inflammation. Dry eye disease is marked with high levels of inflammatory mediators IL-1β, IL-6, IL-10, IFN-γ, TNF-α and ‘matrix metalloproteinase’ MMP-9 mRNA expression in tears. During pregnancy, it has noticed that disorders of ocular as inflammatory demyelination and autoimmune disease provoking disorders of intraocular pressure, and falling blood pressure in cornea. While, thyroid eye disease begins with an inflammation until the fibrotic phase, this autoimmune perturbation when involved the extraocular muscles induce strabismus, the steady progress of the surgery of the horizontal strabismus, estimated with the motor and sensory success accomplished with adjustable suture. The surgery of strabismus with thyroid eye disease expected as successful with eye movements and senses.
Patients practically undergo magnetic resonance imaging (MRI) and computed tomography (CT), to disclose neuro-ophthalmological and orbital conditions of the eye, via assessing orbital mass/malformation, abscess or thyroid eye disease, or identify white matter lesions inducing neuromyelitis optica spectrum disorder. Thyroid hormones as exerted a crucial role on neuro-sensorial development of the eye, the volume of the eye measured via a morphometric and stereological studies of the retina myelination and glial development of the optic nerve, remain crucial in eye diseases diagnosis. Strabismus identified using multiple technics as synaptophore, alternate cover-uncover test with or without prism, and the Krimsky test. Keratoconus, diagnosed by corneal tomography, this disease could aggravated with collagen or genetic alterations.
Recently, doctors’ decision between pharmacological treatments and surgeries became obvious, and its success or failure are prejudged. Strabismus required a surgical intervention, but amblyopia could been corrected pharmacologically. In appropriate cases to surgery, the blind painful and neoplasms, the eye removal is lifesaving, but in other cases as glaucoma, trauma and inflammation surgery remain just a failure of treatment [1]. In some cases, like the pathology of acute angle-closure glaucoma, the doctors should immediately intervene to prevent vision loss and ophthalmology consultations to avoid post-operative complications. During surgery, the vital signs are mainly important to ensure the smooth completion of the operation like blood pressure, pulse rate and respiratory rate. For completing their job, the doctors would better prescribe a convenient treatment after surgery, as wound healing became a main step in surgical; a pH value close to 7, and Polyethylene glyco-lysozyme considered as a tissue adhesive after corneal surgeries with assured biosafety proven by absence of cytotoxic effects on epithelial cells, neither conjunctival epithelial cells.
Interested in the movement of the eye from a departure point to another one, and as the arrangement of the eye identified with three fixations, spatial location, assessment of the saccade, and its landing point. One arrangement succeed in estimation of a shorter saccade amplitudes, and doctors keep as well the gaze necessary in the surgical interface. Recently, the importance of eye tracking use in surgical research has emphasized, spread among surgeons and used as an inspector of surgeon’s cognition, attention and the most abundant use while using laparoscope and the ability of Eye-tracking technology (ET) to precise the appropriate zoom according to the distance between the surgical monitor and the pupil. A study about eye-gaze data indicated the ability of an algorithm with a minimum of information sources and maximum of fault tolerance, to ameliorate the conditions of surgical activities and enrich their methods, while using instruments for tracking signals, which assure the best surgical condition [2]. ET reduces errors in real time of examinations and surgical operations, in a jumbled environment, and supervising key elements utilization accurately as well, during clinical anatomy. ET work as a vigil supervisor while monitoring surgical interfaces, laparoscopic zoom, validity of content, vigilance, fatigue and individual vigilance alike the vigilance of the whole team, and steering them with a feedback. ET technologies adding a mark of specification, limitations confronted by glasses to avoid data loss and algorithms used for assessment of gaze metrics [3]. To resume teams of medical and biological research have been debt to the equipment, and technologies performing their methods of work.
Stress and anxiety of the surgery room, and careless of nurses in some countries, as the eye surgery could been realized with mere local anesthesia, whence the consciousness of the patient aggravated the sensation of fear. In order to earn the trust of patients, doctors work always harder to ameliorate the conditions and performance of their work. Trying to guarantee a safe hospital departure, doctors have developed a new method more secure for eye surgery before healing. To avoid long-term hospital stays and ensure eye protection in case the patient leave the hospital just after the surgery, the orbital rims of the eye have been sutured with a plastic eye shield, which accelerate the healing of operated open globe. Surgeons, to ensure a permanent healing of the injured globe fixed with the plastic eye shield during surgery, which offer extended protection even the patient careless of his health. To sum, fixation of a plastic eye shield during surgery relieves the doctor's conscience.
Surgical teams confirmed that a surgical simulator is required for the performance of residents’ training, the generalization of surgical training of all residents will assure enhancement of competencies between residents, whilst, residents found difficulties in achieving within a time frame the residency program, which lead to a heaped surgical training in the last year. Such problems could only been solved with prolongation of the residency training, and providing simulator early in training to prevent a training end with least operations, which ensure professional teams in eye surgery with minimum errors.
Performance of daily life routines remain the key way to prevent ocular diseases as the healthy nutrition, and exerting sport preserving a healthy lifestyle, which lead to preclude vision deficiency, and constitute a main key to prevent inflammation.
References
Eye innervation analysis, has showed the multiplicity of nerves and the diversity of their particularities. The optic nerve “second cranial nerve” innervated retina, the sensory cells. The third cranial nerve; the oculomotor nerve play a major role in extrinsic motility of eyeball, while the pathetic nerve responsible for the extrinsic motility of the eye. Lacrimal nerve innervated cornea, it emerged from Willis ophthalmic nerve that constitutes a branch of trigeminal nerve. Retina and cornea deemed fundamental when studying eye surgery and the complexity of their innervations with multiple nerves from different sources makes the eye surgery more complex. It is evident that, eye diseases in case of neurodegenerative diseases exhibited a large spectrum of symptoms, as Apraxia of eyelid opening, increased blink rate, decreased spontaneous blink, decrease in corneal sensitivity and deposition of phosphorylated a-synuclein in retinal ganglion cells.
References
The subiculum is still an understudied part of hippocampal pharmacy. According to histological terminology, the following layers are distinguished in the subiculum: molecular, pyramidal, multiform, perforating tract, tray, commissure of the arch, layers of dorsal and ventral fibers. In the presubiculum there are molecular, outer and inner small pyramidal, reticular, pyramidal and multiform layers. Parasubiculum contains molecular, pyramidal and multiform layers. II, the main layer, is formed by the perikarya of large pyramidal neurons. The dentate gyrus (parahippocampus) in the anterior part of the brain is located under the hippocampus proper, and in the posterior part it is medial to it. It consists of three layers. There are 9 types of neurons in these layers. The data presented in the article can serve as a fundamental basis for further study of the parts of the rat brain in normal and pathological conditions with further extrapolation of the obtained data to humans.
Keywords: subiculum; presubiculum; parasubiculum; dentate gyrus; hippocampus
References
The aim of the present study was to examine the relationships between the Yo-Yo intermittent recovery test level 2 (YYIR2) performance and match-running performance across playing positions in elite youth soccer players. Participants were 129 players (age = 17.0 ± 0.8 years) from 11 professional soccer academy teams. A Global Positioning System was employed to analyze 26, 11-a-side matches for: total distance covered; distance covered high-intensity running (HIR, 3.6 to 4.4 m·s-1), very high-intensity running (VHIR, 4.5 to 5.3 m·s-1), sprinting (> 5.3 m·s-1) and very high-intensity activity (VHIA, calculated as VHIR plus sprinting); distance covered by high power (HP, 20-35 W·kg-1), elevated power (EP, 35-55 W·kg-1), maximal power (MaxP, > 55 W·kg-1) and MP≥35 (calculated as EP plus MaxP); and number of accelerations (> 2 m·s-2) and decelerations (< 2 m·s-2). The YYIR2 test was conducted within three weeks of the matches. When all players were included, the YYIR2 distance was positively associated with all match-running performance variables (r = 0.36-0.47, all P < 0.01). When each playing position was analyzed separately, the YYIR2 distance was significantly related to: total distance in central defenders (CD) (r = 0.47, P < 0.05); VHIA in all playing positions except CD (r = 0.49-0.69, all P < 0.05); MP≥35 distance in all playing positions (r = 0.52-0.82, all P < 0.05); and number of accelerations and decelerations in defenders (r = 0.53-0.83, all P < 0.05). These findings suggest that the YYIR2 is a valid test for the assessment of match-related physical fitness in elite youth soccer players regardless of playing position. However, the relationships between the YYIR2 and match running performance variables are playing position-dependent except for when the metabolic power approach (MP≥35) is employed.
Keywords: Association football; endurance fitness; field test; match analysis; young players
References
In recent years, significant advances in molecular biology has facilitated emerging knowledge pertaining to genetics in sport science research. Specific regions of DNA are known to influence genetic polymorphism(s) and partly explain individual variations in response to exercise stimuli and diet. Following exhaustive exercise, certain genetic variations or polymorphisms have been associated with muscle damage indices and may influence muscular recovery. The purpose of this narrative review is to outline the transcription factors of co-activators of associated polymorphisms that appear to play a role in muscle recovery. We also highlight the potential interaction of gene expression and the impact of macronutrients. Several genes (ACE, ACTN3, CCL 2 (C> T), COL5A1, CKM (A> G) have been implicated in various aspects of skeletal muscle remodeling. Individuals with specific genotypes experience changes in muscle damage and recovery rates following exercise. The contribution of heritability to a specific phenotype is likely dependent and the modality, intensity, and duration of exercise. Future research is warranted to explore multigenetic characteristics to provide a deeper molecular understanding of recovery, adaptation and nutritional modulation that may allow the identification of individuals with a greater genetic predisposition, or with a greater risk of developing muscle injuries.
Keywords: Genetic; Athletes; Sports Performance; Nutrients
Whiplash-associated disorders (WAD) occur when shifting and movement of energy, during a crash or collision, from acceleration-deceleration mechanism is transferred to the neck region. WAD is characterized by excessive extension-flexion movements, and/or excessive side bending of the head and neck, beyond the normal and regular range of motion.
Motor vehicle collisions remain the majority of trauma responsible for WAD, nevertheless, other causes include contact sports injuries, falls, physical and domestic abuse, and other types of traumas.
Clinical features and presentations are variable. In general, these includes neck pain, decreased range of motion at cervical spine, spasms, and tightness, headaches, arm(s) numbness or achiness, and other symptoms and signs depending on the extent of the insult. These range from fractures, joint dislocations, ligament tears, and even traumatic brain injuries/post-concussional syndrome, with its subsequent clinical sequalae.
The trauma associated with WAD outcome can result in acute and chronic pain syndromes, functionality limitations and restrictions, psychological and psychosocial ramifications, financial crisis, unemployment, and in cases, even prolonged disability. This causes a significant economic burden on country.
This review manuscript will review the latest in WAD approaches for interventional procedures. We base our review on relevant databases such as PubMed, Ovid-Medline, Embase, Web of Science, NIH website, Google Scholar, and the Cochrane Library. No Institutional Review Board permission was obtained since this manuscript does not directly involve animals or humans.
Keywords: Whiplash; whiplash-associated disorder; neck pain; chronic neck pain; motor vehicle collision; chronic pain syndrome; chronic pain; neck trauma
What I want to transmit today in this article is that Western medicine is seeing the human being only in parts, and not in its entirety, because it still does not consider the energy part, and only the materialized part of the energy, which are the visible parts that we can see by the naked eye [4, 5].
Therefore, when a patient is brought into the or for any surgical procedure, I often find that "I could still be treated medically instead of being rushed into the or for surgery”.
In various articles I write, I always demonstrate the differences in point of view of Western medicine with traditional Chinese medicine, through the figure of the tree. In this tree, I explain that Western medicine is represented through the part of the tree that is above the earth, which we usually can see with the naked eye. This part is composed of the branches of the tree, which represent the different specialties of Western medicine, and the leaves that come out of each branch, represent each disease treated by each medical specialty [6, 7].
All surgical pathologies that Western medicine is treating are at the “leaf” level of the tree, for example, when a patient has an esophagogastric hernia, Western medicine treats it by performing surgery to contain the contents in the stomach by making a ring so that reflux does not occur [8].
However, if we analyze the figure of the tree, according to traditional Chinese medicine, all the symptoms that appear at the leaf level in the different medical specialties, are caused by alterations in the energy present in the “root” of the tree, which Western medicine still does not recognize its existence and therefore does not study and does not treat [6, 9].
Just today I saw a woman aged around 62 who said she had undergone surgery on her knee and had her meniscus removed, because of she was suffering a lot of knee pain. In these cases, traditional Chinese medicine understands that the cause of knee pain is at the “root” of the tree, which are the energy deficiencies of the Kidney and Liver as I am showing in the article written by myself titled (2020) Why Patients with Knee Pain Still Have Symptoms Despite the Use of Anti-inflammatory Medications [10, 11].
That is why I am saying that patients who are taken for surgery have not yet completed their clinical treatment, where they could still have a cure. Nowadays, we see many cases being taken, and they could still do a clinical treatment and solve the case. The example I can give is surgeries to correct hiatus hernia, where it is known that reflux occurs due to lack of energy in the fifth chakra or the Spleen-pancreas energy (that is responsible for the function of the stomach, breast, spleen, pancreas, thyroid), and when the patient replaces this energy (of the Spleen) and of the whole system that is also without energy (such as the energy of the Lungs, Kidney, Liver, Heart), the patient improves from reflux without having to undergo surgery, which is not entirely innocuous, as I reported in the article written by myself (2021) titled How Can We Treat Gastroesophageal Reflux Without Doing Surgery? In this article, I am demonstrating a patient with hiatal hernia who was submitted to hernia correction using surgery. In the surgery there was an intestinal perforation, leading to septicemia, kidney failure, and vision loss. The patient has been more than 8 years after surgery and she is still dealing with the serious complications caused by this surgery [8].
Patients with any kind of abdominal pain have in common, energy deficiency inside the five internal massive organs causing the formation of internal Fire, that it is the cause of abdominal pain, in the energy level, as I am showing in the article written by myself (2022) titled Energy Alterations in Patients with Abdominal Pain [12].
Even in patients with a brain tumor, there is a chance of avoiding surgery when the doctor pays attention to treating the “root” of the tree and not just the symptoms, which are the tumor itself. I say this because the son of a patient had a brain tumor and blurred vision. As I know that the majority of the world's population is without energy in the five massive internal organs (Liver, Heart, Spleen, Lung, Kidney), I sent the medicines by a friend ( the patient lives in London) so that it would fill the energy of these organs and what happened to this patient was that he improved with the use of highly diluted medications (according to the theory written by me ( 2020), titled Constitutional Homeopathy of the Five Elements Based on Traditional Chinese Medicine and also medications made based on crystals). In this theory, I am using Phosphorus to treat Liver, Sulphur to treat Heart, Calcarea Carbonica to treat Spleen, Silicea to treat Lung, Natrum muriaticum to treat Kidney [5, 13, 14].
Even patients with hemorrhoids can be treated clinically without the need for surgery, as they all have in common the lack of energy in the five massive internal organs (Liver, Heart, Spleen, Lungs, and Kidney), and thus, by treating the “root” of the problem and associating some techniques of traditional Chinese medicine, patients improve immediately after the auriculotherapy session without the need for surgery. Usually when the patient with hemorrhoids who was submitted to surgery, they need to stay at home for about two weeks and with a lot of pain in the postoperative period, and cannot work during this period, as I am talking about in the article written by myself (2020) titled Chakras Energy Alterations in Patients with Hemorrhoids and How to Treat it without Surgery [15].
I am saying this because all surgical procedures today are considered high risk, because even if the patients' exams are normal, what is altered in all patients today (even in newborn children), are in the energy level, characterized as this lack of energy in the five massive internal organs (Liver, Heart, Spleen, Lungs, and Kidney), leading to a state of immunodepression, as I am showing in the article written by myself (2022) titled Are Patients Without Surgical Risks Really Without Surgical Risk? in the second article also written by myself (2021) title Are We Vaccinating Immunocompetent or Immunocompromised People for COVID 19? [16-17].
All these energy alterations inside the human body are due to the lack of energy caused by chronic exposure to electromagnetic radiation, due to the modernization of telecommunication globally, and for this reason, all surgical patients are at high risk for complications in the operative period or in the postoperative period, as the anesthetic drugs normally used are all highly concentrates medications. According to the Arndt-Schultz law, created in 1888 by two German researchers, the use of any highly concentrated medication can cause a drop in vital energy and this effect can cause stagnation of Blood inside the blood vessels or other complications such as thrombosis, myocardial infarction, strokes or even death of this patient [16, 18-20].
To minimize all these complications when using highly concentrated medications in all these energy-deficient patients, all patients who went for a surgical procedure should first be submitted to the treatment of the lack of energy of the five massive internal organs, using highly diluted medications according to the theory Constitutional Homeopathy of the Five Elements Based on Traditional Chinese Medicine using Phosphorus to treat the Liver, Sulphur to treat the Heart, Calcarea Carbonica to treat Spleen, Silicea to treat the Lungs and Natrum muriaticum to treat the Kidney, thus maintaining the energy to keep the Blood circulation normally, without causing so much energy drop, when being undergoing an anesthetic procedure [13, 16].
The world population is not the same as in the past, as I am showing in the article written by myself (2021) titled Is the Population in the World the Same as in the Past? So, the clinical measurements used in the diagnosis and treatment of all these patients needs to be careful because of this drop of energy, depending on the type of medication we need to use in the surgical procedure, causing complications or even death of all these patients, independently on the type of diagnosis or the age group, as I am showing in the article also written by myself (2021) titled Energy Alterations and Chakras’ Energy Deficiencies and Propensity to SARS-CoV-2 Infection [21, 22].
References
I am writing this article today because in my daily clinical practice, I come across patients who are often submitted to surgical procedures without being properly treated clinically and this I want to be discussing with you in this article.
Western medicine, since the implementation of the Flexner report in 1910, has been considered “scientific”, only what can be seen or can be demonstrated through laboratory and/or radiological exams, and everything that cannot be seen with the naked eye, was considered “unscientific” by the medical community and this happens even today [1].
However, in the face of so many changes on our planet, I live in Brazil, a country that considers acupuncture and homeopathy as medical specialties, which have been recognized by the Federal Council of Medicine since 1980 and 1995 respectively [2].
I feel privileged to live in my country Brazil because I know that in many countries such as the United States, acupuncture and homeopathy are still not considered medical specialties, and in the US, acupuncture treatment is allowed to be made by medical doctors but also by nurses, nutritionists, psychologists, etc [3].
Davy’s lectures were charismatic and explosive (sometimes literally, see the recreation of his exploding volcano demonstration here). And they were often poetic. Now, as the first edition of the Collected Letters of Humphry Davy is set to be published, it is perhaps time to take another look at one of Britain’s most renowned scientists.
It has been almost six decades since CP Snow famously argued that there were “two cultures” of the arts and sciences. He thought that an unbridgeable chasm divided those who worked in these fields, that they had become so specialised they no longer had the language to talk to each other. Whether you think that this was true then or is true now, Davy – as a poet and a chemist – shows that any such chasm can be bridged.
The Royal Institution, Davy studies became an axis indispensable for the study of the literary romantic generation in the United Kingdom, celebrated worldwide, though certainly not always because of its connection to the scientific profession.
In this way, we elucidate how the possibility of these studies, together with the critical biographical account of Davy's literature, expand the theses on the stereotype of the narrative genre science, poetic production, and scientific nationalism.
Humphry Davy was a pioneer in his professional area for sedimenting this permeability between genres but also for consolidating the profession of the experimental scientist, whose objective became the controlled investigation, under an institutional direction, of the available paradigms and your progress. At least for the public sphere, therefore, Davy had a contribution unique historical context, which involves enlightenment, in the face of an enlightened and moderately prosperous, of a scientific vocation related to the visible progress of technoscience. Likewise, the glorification of this professional function, in view of its persona public, contributed to the ideals of the modern scientist, a possible statement in the face of his original popularity and relationship with the public.
Sir Humphry Davy fascinated rapturous crowds when he delivered his lectures in chemistry to the Royal Institution in London. In the late 1700s and early 1800s and in sumptuous surroundings, Davy would demonstrate – with whizzes and bangs – the latest chemical discoveries. His audiences were not just made up of fellow scientists but also poets and genteel ladies of the fashionable West End.
His experiments with nitrous oxide, or laughing gas, and his invention of the miner’s safety lamp went down in history – but perhaps his greatest legacy is what he did for science communication and breaking down the barriers between the sciences and the arts.
References
Systemic mastocytosis is a heterogeneous disorder characteristically demonstrating mast cells with aberrant cytology and immuno-phenotype accumulated within diverse organs. The condition exhibits an anomalous pattern of neoplastic evolution.
World Health Organization (WHO) classification 2008 denominates distinct categories of mastocytosis as
References
Background: The knowledge of mothers on immunization as a public health intervention that has greatly reduced mortality and morbidity globally is very vital as they play a great role in child care. Their ability to have the right knowledge will enhance their practice and attitude towards immunization. This study assessed the knowledge, attitude and practice of mothers on immunization and the impact of sociodemographic characteristics of children undergoing immunization. Objective: The aim of the study is to access the knowledge, attitude and practice (KAP) of mothers on immunization in Akure Ondo State, South West Nigeria. Method: A descriptive study was conducted on mothers of children born between 26th September 2011 to 26th September 2012. A household multi-stage sampling 48-item questionnaire study design was modified, adopted and administered. Consents of respondents were sought before the administration of questionnaires. IBM SPSS Statistics version 27.0.1.0 was used in analyzing the data. Results: The study showed that majority of respondent (89.6%) had an overall good knowledge while 5.2% each had fair and poor knowledge. But less than 60% and 3% reported for vaccination at the stipulated time and had negative attitude towards immunization respectively. Factors that affect the knowledge of mothers on immunization from the study are educational status, marital status, religion, geopolitical zone and her and/or the father of the child been immunized as children. Conclusion: This study revealed that respondents had high knowledge on immunization, however it doesn’t translate practice since some mothers did not complete their immunization schedule. There is a need for health promotion and education to sensitize mothers on the importance, objectives and benefits of immunization.
Keywords: Knowledge; attitude; practices; mothers; immunization
Clinical Case
25-year-old male patient, one-pack-per-week smoker, with no other relevant history. He seeks medical advice for a 1-week left otodynia, associated with scanty yellowish otorrhea in addition to a rapidly growing left temporozygomatic swelling. No antibiotic treatment.
Good condition on physical examination. Apyretic. Left ear: external auditory canal with mucopurulent secretions; dull, congestive tympanic membrane, without luminous shine and with punctiform attic perforation through which little purulent material comes out; no fetidness; no skin flakes. Myringosclerosis plaque (Fig. 3). Instrumental acoumetry with 256 Hz tuning fork; Weber lateralized to the left ear. Bilateral positive Rinne.
Diffuse left temporozygomatic swelling (Fig. 1-2) measuring approximately 8 x 4 cm (A-P) and (L). Its upper limit occupies the entire left supra-auricular region, reaching the tail of the eyebrow and ipsilateral malar region; modified root of the Helix, facial asymmetry and effacement of the retroauricular sulcus, displacement of auricular pavilion. Soft and depressible. Mastoid with mild erythema.
Tomography
Total occupation of mastoid cells on the left, bone erosion with soft tissue involvement. Collection at the level of temporal, zygomatic and left parietal bones. Septations. It measures 80 x 33 x 91 mm L, T and AP (Fig. 4-5). The laboratory study revealed a leukocytosis of 17,000 with neutrophilia (80%). Elevation of C-reactive protein 20 mg/dl, Hemoglobin 12.1 g/dl, Hematocrit 35.8%. Hospitalized patient with medical-surgical treatment. Puncture aspiration (Fig. 6) and surgical drainage. Ampicillin-Sulbactam 3 g every 6 hours, Ketoprofen 100 mg every 8 hours and Hydrocortisone 100 mg every 12 hours were administered. Due to the lack of an emergency block, mastoidectomy was not performed. The infectious process eroded the bone cortex of the temporal bone, dispersing pus between the cortex and the periosteum in the temporozygomatic region (Fig. 5). The causative germ was not isolated; empirical antibiotic therapy was sufficient. Chronic cholesteatomatous otitis media was ruled out; in its evolution, the eardrum was found to be normal with good shine and no collection in the tympanic box. Normal hearing. Control tomography with clear attic (Fig. 7).
We present a case of acute otitis media complicated by zygomatic-malar abscess in a 25-year-old patient with no previous medical/otorhinolaryngological history, who comes to consultation due to large left temporozygomatic swelling. Its atypical clinical presentation and the applied medical-surgical procedures are reported.
Keywords: Complicated otitis media; zygomatic abscess; temporozygomatic swelling; subperiosteal abscess
References
Knowledge networks and organizational collaboration reflect a culture of success, transformational leadership and a climate of relationships around which relationships of trust, support, innovation and goals are generated. These are bi-directional and horizontal organizations with equity and solidarity. The objective of the present study is to establish the correlations between the factors, a non-experimental, transversal and exploratory study was carried out with a selection of 300 administrative staff, students and teachers from a public university in central Mexico. to structural model. The results show that there is a dependence relationship between goal climate and collaboration. Based on these findings, research lines related to trust as a determinant of knowledge networks and organizational collaboration are noted.
Keywords: Culture; institutionalism; leadership; network; collaboration
References
Background: Electrical medical devices have become a crucial part of modern healthcare, aiding in diagnosis, treatment, and monitoring of various medical conditions. However, the exposure of the human body to electrical currents produced by these devices can cause adverse effects, ranging from mild tingling sensations to severe injuries, and even death.
Aim and objective: This systematic review aims to investigate the effect of exposure to electrical current produced by medical equipment on the human body.
Material and Method: The review included studies which investigated the effects of exposure to electric current in healthcare workers, patients, and the general public. The search was conducted using the following keywords: “medical equipment”, “electrical current”, “exposure”, “health hazards”, and “assessment”. The studies were identified through searches of electronic databases, including PubMed, Embase, and Scopus, using a predefined search strategy. After screening 1240 studies, 43 studies were included in the review. The studies evaluated a range of medical equipment, including electrosurgical devices, defibrillators, electrocardiographs, and magnetic resonance imaging machines.
Result and Discussion: The results of this systematic review indicate that exposure to electrical current produced by medical equipment can lead to a range of adverse effects. These effects include burns, tissue damage, nerve damage, cardiac arrhythmias, and even death. The severity of the effects was found to depend on the duration and intensity of the electrical current, the pathway of the current through the body, the electrical resistance of the body tissues, and the individual’s health status. Furthermore, the review identified several risk factors associated with electrical injuries, such as the presence of moisture or conductive materials on the skin, the use of metallic implants, and the proximity of the equipment to vital organs. The review also revealed that various safety measures, including proper equipment insulation, grounding, and the use of safety protocols, can minimize the risk of electrical injuries associated with medical equipment.
Conclusion: The study found that exposure to electric current can cause a range of health effects, including burns, cardiac arrhythmias, nerve damage, and even death. The review also found that the level of risk associated with exposure to electric current varies depending on the type of equipment and the individual’s susceptibility. Exposure to electrical current produced by medical equipment can have significant adverse effects on the human body. Therefore, healthcare providers and medical personnel must be aware of the risks associated with electrical medical devices and implement appropriate safety measures to prevent such injuries. Healthcare workers and patients with pre-existing medical conditions may be at higher risk of adverse health effects. Overall, the review highlights the need for improved safety measures and training programs to reduce the risk of exposure to electric current in healthcare settings. Further research is needed to better understand the mechanisms of injury and to develop more effective prevention strategies.
References
Parasitic migration into the bile ducts is less common. Few cases of parasitic cholitis were reported despite Madagascar being a parasitic endemic country. Our goal is to report the case and stimulate the search for Gilbert's disease in free bilirubin cholitis. A 24-year-old Malagasy woman is hospitalized for febrile jaundice. She is not obese and had no history of vesicular lithiasis. The interrogation reveals the absence of deworming for several years. The clinical examination showed pain on palpation of the right hypochondrium. An abdominal ultrasound showed an intravesicular rail image and extrahepatic bile duct dilation. Biology revealed an elevation of alkaline phosphatase and gamma GT associated with an elevation of predominantly free total bilirubin. There was no anemia or eosinophilia. Blood culture series had come back negative as well as viral serologies (hepatitis A, B, C and HIV). The hemolysis balance was negative. Microscopic examination of the stool for KAOP showed the presence of numerous roundworm eggs. The diagnosis of parasitic cholitis is made associated with Gilbert's disease. The clinico-biological evolution is favorable after deworming associated with antibiotic therapy. A control abdominal CT scan was normal after a one-month setback.
Keywords: jaundice; bilirubin; abdominal ultrasound; Madagascar; parasitosis
Telemedicine is now widely used in surgery from performing operations to teaching and can be divided into three main components; telesurgery, tele-mentoring and teleconsultation. Developments across these fields have led to remarkable achievements such as intercontinental telesurgery and tele-mentoring [3].
Due to the limitation of special regions and unbalanced development of medical technology, many patients lost the best opportunity for operation. The idea of telesurgery robot was proposed for the first time to quickly and safely treat trauma patients in the rear hospital in the wartime. With the development of medical and remote communication technology, the demand of telesurgery has increased. Laparoscopic and endoscopic technology changed the previous operation mode that operated under direct vision. By presenting the operation vision through video images, tele-present surgery came into reality, and it was early used for remote surgery guidance and education of complex operation and emergency trauma cases [4].
Patients far away from hospital, can consult with their doctors easily with teleconsultation and can reduce the number of hospital visits. Patients can have teleconsultation for follow-up.
During the covid error, surgeons need to take care of surgical patients, and operate on covid-positive patients. Surgeons also take care of covid-positive non-surgical patients as the medical staffs are not enough to take care of the rising number of patients. Health-care personnel have to attend patients both personally and on-line. Many patients consult with medical professionals via tele-consultation, video-calling by using viber, messenger, etc...
Doctors with busy schedule can have multidisciplinary meeting via online. Doctors perform continue medical educations in the form of webinars.
Surgeons can also use video-calling to discuss about the patients during ward-round and also during operation. Surgeons from different places can collaborate without long travel.
Surgeons can perform surgery and broadcast so that doctors from remote areas can view the live surgery on-line and can do questions and answers in real time.
Senior surgeons can supervise the operations of juniors by video-call. Seniors can see both the intraoperative findings and the skills and handicrafts of juniors. Seniors can also do the tele-mentoring.
There are many advances and benefits, due to improvement of communication media.
The biggest challenge of telepresence system at present is not to compromise the optimal balance of remote operation process due to excessive occupancy of available bandwidth when meeting the quality requirement of real-time medical image and video [4].
Telesurgery benefits not only the developed countries but also the low and middle-income countries by facilitating in the areas of patient consultation, pre-operative preparation, operation and follow-up. It also aids in training of juniors, supervision of juniors, mentoring the juniors and collaboration between doctors. Doctors should make the best use of telesurgery to get quality care in medical practice.
References
Telesurgery uses wireless networking and robotic technology to allow surgeons to operate on patients who are distantly located. This technology not only benefits today’s shortage of surgeons, but it also eliminates geographical barriers that prevent timely and high-quality surgical intervention, financial burden, complications, and often risky long-distance travel [1].
Benefits of remote robot-assisted surgery are multiple. Geographic constraints will no longer determine the type of treatment the patient receives because of lack of surgical expertise. Ideally, any patient can receive the form of treatment more appropriate for his or her condition or more advantageous, such as new minimally invasive techniques. This may have an even more profound impact on developing countries, where healthcare is often provided by volunteers who do not necessarily have expertise in all fields of medicine and surgery [2].
References
Human life is not only a matter of biology and biochemistry, it is also a cybernetic-information and bioelectronic construct that affects health, disease and human behavior. In this new bioelectronic paradigm, human cognition begins to emerge in the aspect of quantum processes taking place in an integrated circuit. In bioelectronic terms, an organism is understood as an integrated system made of biological piezoelectrics, pyroelectrics, ferroelectrics and semiconductors, filled with bioplasma and managed by quantum processes electronically using biocomputers.
The human biological system, apart from the biochemical way, uses the transfer of information by means of electromagnetic, acoustic, soliton waves, electric, electromagnetic, torsion (spin) fields and bioplasma. In stem cells, quantum processes play a significant role, it depends on them human psychophysical development. In the Universe, the primordial information "ingeneza" works, which is encoded in atoms. Each DNA atom is encoded with specific genetic information. Ingeneza programs are quantized and create all stages of development, cell, organism, biosphere and cosmos. Water molecules are carriers of information.
Keywords: stem cells; autism; quantum processes
References
The objective of this paper was to specify a model for the study of intellectual capital formation. A documentary, retrospective and exploratory study was carried out with a selection of sources indexed to international repositories, considering the period from 2019 to 2022, as well as the search by keywords. The axes, themes, dimensions and categories of discussion were established in the research agenda, suggesting the extension of work towards other scenarios such as training and training.
Keywords: Institutionalism; agenda; entrepreneurship; talents; formation
References
Virtual simulation experiment teaching can make up for the shortcomings of traditional physical experiments, but most of the current simulation software is two-dimensional, and the teaching effect is limited. This article uses Three.js3D technology, taking the "Saxon Bowl Sinking Experiment" as an example, and breaks through the plane constraints by constructing a three-dimensional model to achieve a three-dimensional, online, cross platform, real-time and interactive virtual simulation system. The system performs three-dimensional modeling of experimental equipment and processes, achieves three-dimensional simulation, and designs four types of experiments for users to explore the relationship between variables. Supported by virtual teachers, the system fully simulates the interactive scene between teachers and students offline. Video and voice add role switching, greatly increasing interest and observability. The application practice shows that the system can greatly improve the teaching effect during COVID-19 pandemic.
Keywords: Physical experiments; Stereoscopic simulation; 3D modelling; three.js; saxon bowl
.
I had the great fortune to study and work closely with outstanding Russian physicists Alexander Mikhailovich Prokhorov and Nikolai Gennadievich Basov. I have never ceased to be amazed at the manifestations of their genius, each time discovering new facets of the teachers' many talents.
What is the first thing that comes to mind when they are no longer with us for more than 20 years and the acute emotions of parting have long since subsided? An incredibly developed sense of intuition, an amazingly quick ability to find the right solutions, a keen sense of the new, fundamentally important for the leap into the future, humanity. But a sense of the cutting edge of science, of the trends of its development, were perhaps central to the character of these phenomenal scientists. My task in this article is to add my colors to complement the images of these great scientists and citizens of Russia - Alexander Mikhailovich Prokhorov and Nikolai Gennadievich Basov [1, 2].
Nowadays Simulation Training technology has developed much and I can help in designing cost effective "Simulation Training Centre." Simulation has many advantages, for it results in highly trained medical graduates who are less likely to make life-threatening or costly medical errors. Some of the advantages of simulation are listed in Employing medical simulation techniques can help move medical training from the old “See One, Do One, Teach One” method into a “See One, Practice Many, Do One” model of success. Virtual simulation can be used for clinical judgement training to students. Simulation-based teaching has proved to reduce risks to both patients and learners. It has also proved to be effective in both undergraduate and post graduate education as well as faculty development. Simulation can be used in the primary health care setting to improve confidence in performing life-saving skills, clinical skills, communication skills, and the quality of care for patients with chronic diseases such as diabetes mellitus and bronchial asthma. Such simulators as part task trainers, computer-based systems, virtual reality and the haptic system, simulated patients, simulated environment, and integrated simulators have been also used effectively to assess and evaluate clinical skills. Virtual simulation for Nursing provides students with a realistic, true-to-life clinical experience. The immersive virtual scenarios allow students to engage with 3D patients, testing their ability to recognize and analyse cues through unfolding visual and audio responses and by experiencing lifelike reactions. Students decide what actions to take for Nursing with the system adapting to student-driven decisions so they can see immediate cause and effect, strengthening their clinical judgment skills.
There has been changes from time to time in medical education teaching methodology. Both Clinical Theory and Clinical Rotations is a must for learning students so that they can practice without compromising patient safety. Most of the medical institutions do not have simulation technology. Simulation teaching can be of two types one for teaching Communication, hands on skills and the other is to make clinical judgement. Simulation approach has to be customized as per project or training objectives. In developed medical institutions around the globe the healthcare providers candidates have to complete clinical rotations and simulation learning as well. How many Nursing colleges and medical colleges does have simulation curriculum? For example, In Paramedicine the paramedic licensing exam includes an integrated out-of-hospital simulation scenario where a candidate is required to effectively manage a simulated patient for 15 to 20 minutes. After initial licensing recurring competency assessments are often conducted through simulation activities. These assessments are meant to capture continued competence of providers. Drawing a quality standard on EMS simulation activities is vital since simulation-based assessments are utilized for determining provider competence and workforce readiness. Shortcutting this level of quality can negatively impact providers and ultimately patient safety.
During emergencies, being READY is critical and can save lives. “IMMAST” Institute of Medical and Minimal Access Surgery Training (Mumbai, India) is providing simulation training on surgeries and allied health sectors. It is the only center of its kind in India that offers hands-on training on close to life models, using in-vivo and ex-vivo animal tissue, which perfectly mimic a live patient, in a re-created OT setting with top-of-the-line equipment. The hand-picked faculty at IMMAST enjoys national and international recognition in their respective surgical disciplines, and are bound by their passion for teaching. The center offers a plethora of surgical and medical education courses, spanning 16 surgical super-specialties, with hands-on practice, live transmissions, didactic lectures, and operative videos constituting basic as well as advanced levels of training." Sandor Medicaids Pvt Ltd (India, SARRC Countries) is committed to providing durable, affordable and comprehensive training Manikins and Turnkey Projects for Medical Intuitions that help our Physicians, Nurses and Paramedics to provide worldclass care. Pirogov Anatomy has introduced 3D virtual anatomy with case study for medical students and allied health sciences which is very important for any medical students to make clinical judgement. NMC policy in India makes mandatory that each medical institutions must have 3D anatomy dissection table in every medical college. The decision makers of Medical Institutions and Nursing Institutions need to understand that this is the time not to waste anymore. This is the time to get the resources for better training of Physicians, Nurses and Paramedics for the country. Then only we can hope for better care and patient safety.
Simulation can be used to resemble existing curricular material. The simulated scenarios are realistic enough to engage the students emotionally, thus providing a unique learning experience, where the high-fidelity simulator “patient” actually talks, breathes, blinks, and moves like a real patient. Simulation can be adapted to accommodate the need of various medical specialties such as anesthesia, emergency medicine and trauma, intensive care medicine, obstetrics, pediatrics, neurology and radiology as well as for the use of other professionals such as nurses, paramedics, and respiratory therapists. There are different simulations products available. An ideal simulation training center must have "Physical Simulators" and "Virtual Simulator”. Simulation laboratories are quite costly. A single high-fidelity physical simulator with its monitoring system and other necessary equipment may cost up to $200 000. Virtual Simulators can be cost effective as per training requirements. In addition, synthetic body fluids, replacement skins, bandages, syringes and other supplies are necessary to simulate the experience of treating real patients in a real hospital. The ability to practice without risk must be weighed against the cost of this new technology.
Geriatric care has to be popularized
Life in geriatric care institutions and services is not very popular in India. This is not encouraged for a variety of reasons. Lack of social and family support is also a factor. The community needs to understand the need for care for the elderly. The rates of dependence on geriatric centers are increasing in India. The situation may arise where the children are abroad and the parents are at home. When relying on nursing homes, we need to think about whether our parents will get better care like home. Otherwise the situation of our parents will be miserable. Facilities and quality of care and maintenance should be ensured.
Good service and quality care are the focus of aging care. Elderly routines, diets, current health status and previous knowledge, functional capacity, strengths and weaknesses are allessential for the smooth functioning of rehabilitation. Adverse conditions are such as sudden depression, uncontrolled functioning of the internal organs, ulcers, weight loss, etc. This will reduce the risk of future complications. The family should be informed at regular intervals about the care and if there are any significant problems. The Resident Assessment Form is an effective tool for valuing things in geriatric care centers.
Serve the elderly
Policies are currently formulated by the National Policy of Older Persons and the National Program for the Elderly. However, there are no specific restrictions or guidelines for institutional managers on what to do in geriatric care facilities. This needs to be changed. However, the Standard Wise International India Association, a subsidiary of Standard Wise International, has launched a new initiative to evaluate and recognize geriatric care centers in India. This will lead to a broader vision of the elderly living in the country and new policy formulations. Special training Gerontology education and the number of people in need of long-term care are very limited in the country. Errors occur in areas where the elderly are cared for due to lack of education. We need to be trained to care for each other as we care for our parents. Once we all have to be there in any of the old age home because our culture is in a ongoing process of change. If there are hundred people in an old age home, instead of looking at a hundred people as one, they should take care of the needs of each one. Education is essential for this. Before ending I am just visualizing the concept of family it will be extolled in the pages of the history books from where the new generation will read and learn. We just try to foresee a better society then our vision will be clear and precise.
The challenge facing the whole world, especially developing countries like India, foraging and their protection. According to the United Nations, the number of people over the age of 60 in the world is growing exponentially. Lack of knowledge and experience in geriatric care has affected our country. The number of elderly parents who are left alone without adequate care or support is increasing day by day. In the struggle to survive, the protection of parents becomes a burden to the new generation, or there are those who see it that way. Despite the rise of modern technology, the elderly are not getting much benefit. Social services have to be developed for the mental, physical and social health and wellbeing of the elderly, and innovative care styles. Awareness is also essential for a healthy life. When I started my social work studies, I was so much getting touch with one of my geriatric service center that really helped me to ponder once how can I help the aged people those who are rejected from the family. What I tried to say is that we can’t change this transforming world but we can save our aged people. Recently I heard there is a heavy scope in geriatric service from one of my friend that really helps me to rethink or run through my vision in geriatric advancements required in modern society.
References
Most adolescents are sexually active, but the age at which they start having sexual intercourse varies between regions, and within a country. This study aims to assess the sexual behaviours and its consequences among unmarried adolescents in two secondary schools in Bonaberi-Ndobo, Douala, Cameroon. A cross-sectional study was carried out from January to February 2023 among 134 unmarried adolescents. The study population included all unmarried adolescent at St. BC and N.M.C who gave their consent and where able to take part in this study. Data was collected with the used of structured questionnaires and inputted in Microsoft excel and analysed using SPSS version 23. With a 5% confidential interval. Among the 134 study participants who responded to the questionnaire, majority 110(82.1%) were female. 68(50.7%) were aged between 12 to 17 years. All the study participants (100%) had knowledge on sexual behaviours, and the main source of information was from school (57.4%). 56.7% (78) reported that they have had sexual intercourse before and majority of them declared that they preferred vaginal sex (42.5%). 66.4% (89) did not use condom during sexual intercourse and about 19.4% have more than one sexual partners. 16.4% have once contracted a sexually transmitted infection, 9% have had an unintended pregnancy and 4.2% have repeated a class. All the study participants had knowledge on sexual behaviours. More than half of the study population have had sexual intercourse at least once and without the use of condoms. A non-negligible proportion of the adolescents had multiple sexual partners. Sexually transmitted infections and unintended pregnancies and school dropout were the main consequences of sexual behaviours as reported in this study.
Keywords: Sexual behaviour; consequences; adolescents; secondary schools
Findings and analysis
Majority of the respondents are from the age of 40-45. This is a newly invented information by this research because the most of the middle aged women are affected psychos somatic disorder in the ages of 40-45. The reason is that the stated age is the initial stage of occurrence of the psycho somatic symptoms. There will not be any chances of misinterpreting on the basis of aging difficulties.
The second major finding which is obtained in the type of the family, the type of nuclear and joint family is significant factors while dealing with psychosomatic disorder in middle aged women. The social interaction and family sharing are the important role in reducing the levels of stress in middle aged women because after 40 ages they will be more vulnerable to stress and social isolation within the family.
The third aspect must be taken into account is that the marital status of the respondent. The majority of the respondents are married women because comparatively the married women are undergoing various stresses and worse life situations than unmarried women. It depends on the stress level through which each woman is facing in their day to day life.
Another important thing is regarding the symptoms which are mostly affected with middle aged women. The back pain and joint pains are the initial symptoms in the psychosomatic disorder. The reason why is that pain is attributed to get relief from the stressful situations. The age will be negatively conceptualized by the middle aged women since they all have children those who are trying to settle themselves.
There is another most visible symptom is that low energy and trouble in sleeping. The fact is that both of these symptoms are quite similar in its effect. Initially it will be started with sleeping disturbance which will direct to energy loss in day time. If the brain is not able to manage with stress then automatically brain shuts down the activity so mind and its function will be collapsed which will be affected the sleeping stimulation in human body.
The anxiety and depression are the major cause of the psycho somatic disorder in middle aged women. The research mainly focused on the ratio of anxiety and depression which causes the possibility of the psycho somatic disorder. The important thing is that most of the respondents are affected with mixed anxiety and depression which gives high possibility of psycho somatic disorder especially in middle aged women due to the hormonal changes and menopause circle.
As per the collected data 78% of respondents are having drastic improvements by the help of medication. The changes which is visible in the hospital where researcher has taken for the study, it is a categorical result of effectiveness of medication for the respondents.
The family care and support are low approximately 70% of the respondent. The low family support and care for the women will be loosening their emotional well being from the family itself. The stress which comes from the family itself because the majority of them is married and house wives, the stress in the family easily affects the women those who are mid life. So if there is stress factors in the family there will be chances likely to affect middle aged women with psycho somatic disorder.
Interventions
The therapies and counseling can change their thoughts and consciousness in a better way. The majority of the respondents are benefited by the counseling and therapies in the hospital. If the therapies and counseling should be taken as a serious part in their life then which will be useful so here in the hospital this will be ensured in a right way. There are drastic improvements in patients for middle aged women those who come with psycho somatic disorder which will help to refresh and purify their distress into positive way.
The last major finding is an unresolved question whether the psychiatric medicine is having any side effects or not. Here researcher has no valid answer to question because there may be chances of side effect but not that much dangerous thing. Another typical situation of self treatment of the respondents will cause serious psychiatric issues in the future life.
Rising suggestions
Barriers to middle-aged women?s mental health fell into two main themes including increased life concerns and physical and psychological tensions. The two sub-categories of the first theme included having mental concerns and increased burden of roles. The second main theme also consisted of two categories including perceived undesirable physical changes and perceived undesirable psychological changes. So here researcher would like to write aside some suggestion to the respondents and the people those are in the psycho somatic condition.
To the middle aged women
To the Family
Conclusion
Menopause and the postmenopausal period are very important landmarks in a woman?s life since she will spend more than a third of her life during these periods without significant endogenous estrogen production. Menopause is a physiological process, which takes place universally in all women who reach midlife. Midlife is a period of transition for both men and women. It brings about changes in women and it has an implication on women?s health. Menopause may be viewed as a transition of women from middle age to old age. Menopause is not just cessation of menstruation it is depletion of ovarian follicles leading to decrease in ovarian hormones. Natural menopause occurs after 40 years of age and has no underlying pathologic cause. Menopause is considered premature or late when it occurs before 40 years and after 55 years, respectively. The commonest age range is at which women experience menopause after 40 to 50 years. Though menopause is a normal physiological phenomenon, but women at menopausal and postmenopausal age get a variety of symptoms like irritability, lethargy, depression, forgetfulness, weight gain, insomnia, joint and muscle pain and constipation. The most of the psychosomatic symptoms are similar as the menopausal period of the women. Another important thing is that unbalanced stress level of the women which are contributing to psycho somatic condition.
The study findings revealed that majority of the postmenopausal women had one or more of the psychosomatic problems with the most common being fatigue, muscle and joint pain, irritability, anxiety and depression. Women experience such problems due to reduction of the ovarian function. Thus, women need to recognize these symptoms early and seek timely medical care. It is the dilemma that every middle aged women are vulnerable to psycho somatic disorder. After the completion of the research I would say “NO” because when over stress and menopausal difficulties are come together where there is a high possibility of psychosomatic disorder. The environment of the middle aged women has a vital role of leading a mentally free and happy life with family.
As the result of entire study on psycho somatic disorder in middle aged women come to a one word of conclusion is that menopausal period of women should be treated well and supported physically and mentally by the family members and it is the social concern to women because being a mother is the most challenging and most rewarding position so respect women when they come in the midlife through which we will love our mother then we all become the most beautiful person in the world.
Reference
This article is a sum up of my research paper entitled “A Study on Psycho Somatic Disorder in Middle Aged Women: Symptoms, Causes and Interventions”. What is psychosomatic disorder which is not common because most of the middle aged women considered as if something related to age but it?s not that Psychosomatic disorder is a psychological condition that leads to physical symptoms, often without any medical explanation. It can affect almost any part of the body. People with the disorder tend to seek frequent medical attention, becoming frustrated with no diagnosis. Behavioral therapy and stress reduction may help.
The analysis of data of my study reveals the certain significant aspects while turned as the major findings of the study. This study consists of all the major findings that were derived during the analysis of data collected. It is an indented version of data under analysis. Here, each aspect has been treated partially and only the relevant and significant findings have been emphasized. The details of the findings are given below.
The psychosomatic disorder in middle aged women and its symptoms, cause and interventions was the subject of the research was done in various psychiatric hospitals in Karnataka state India. The respondents were from the respective hospitals so the major findings will be the approximated value of the respondents from Karnataka and the border places of Kerala.
References
Molecular markers have over the years permitted the rapid identification, phylogenetic classification and antimicrobial resistance profile of microbial taxa as compared to the traditional culture method. Through molecular analysis of 16S rRNA gene, this study investigated the molecular and genetic differences that exist between E. coli isolated from local scavenging chicken in relation to their pathogenicity and antimicrobial resistance. Our analysis revealed that E. coli samples from the two different housing systems showed significant genetic diversity and we postulated that this is attributable to the pressure created by vaccines and antimicrobial drugs. The different genetic patterns corresponded to different antimicrobial susceptibility patterns and prevalence of virulence genes. Thus, the 16SrRNA gene can also be used as a molecular marker to indicate the antimicrobial resistance and pathogenicity of chicken.
Keywords: Pathogenecity; 16SrRNA; free-ranged chicken
References
Elites from around the globe have been obsessed with population control as far back as recorded history. It has always been about keeping “them” in power with a small group of servants and a manageable slave class. Surprising it was a faction within the United States that assumed the mantle of this death cult, and had the means to carry off genocidal plans. There are many variations on a theme of population control, but the latest one involves encouraging children as young as two years of age to cut off their ability to reproduce under the guise of gender diversity. It is a corporate driven phenomena and in hindsight it will be seen as one of the causes of a failed nation.
Keywords: Gender dysphoria; population control; trans-gender; Gender Identity Disorder; New World Order; Pandemic treaty; birth control; human chorionic gonadotropin; Drag Queen Story Hour
References
Introduction: Cervical epidural steroid injections (CESI) have been frequently used since long time for diagnosis and treatment cervical radiculopathies. cervical epidural corticosteroid injection helps in reducing swelling and inflammation of the compressed nerves, hence improving pain for several days to months or longer which leads to help delaying or avoiding the need for surgery.
In this retrospective observational study, we aim to compare clinical efficacy of Dexamethasone vs Triamcinolone in the management of chronic neck, shoulder and arm pain due to herniated intervertebral disc in the cervical region.
Methodology: a retrospective observational study of 1 year follow up was performed in 100 patients of either sex complaining of chronic neck pain with signs of cervical radiculopathy. Patients were divided into 2 groups of 50 each. Those in Group A received Injection Dexamethasone sodium phosphate 12mg and in Group B received Injection Triamcinolone acetonide 40mg in the cervical epidural space under fluoroscopy guidance. All the patients were monitored before the procedure and post-procedure for 4 h following epidural injection and subsequently followed by at the 10 days, 1 month, 3 months, 6 months, 8 months, 10 months and 1 year on telephonic conversation. The primary outcome was to measure the intensity of pain using Visual Analog score (VAS) score of 0-10.
Result: The mean VAS score in both the group A and B pre-procedure was 8.6 and 8.78 respectively and Mean VAS scores were significantly improved to 2.16 and 1.90 respectively post-procedure during 1 year follow up with p value of 0.76. hence from mentioned quantitative data it can be stated that there is no statistically significant difference in the efficacy of both the drugs used in cervical epidural injection.
Conclusion: Based on the results, this retrospective study strengthens the existing evidence that dexamethasone can produce equivalent pain relief to triamcinolone for the treatment of cervical radiculopathy. Though the need for more research studies to prove that Dexamethasone can be used an effective alternative to Triamcinolone continues.
References
Adrenocortical carcinoma is an exceptionally discerned, malignant, endocrine, epithelial tumour emerging from adrenal cortical cells. The heterogeneous neoplasm may be engendered due to overexpression of IGF2 and is associated with significant mortality. Majority of neoplasms appear as sporadic lesions although may demonstrate diverse syndromic settings. Prognostic outcomes are contingent to age of incriminated subject, clinical representation, tumour stage, precise histological variant and molecular or genomic characteristics of the neoplasm.
Additionally designated as adrenal cortical carcinoma (ACC), conventional subtype of adrenocortical carcinoma, adrenal cortical adenocarcinoma or malignant adrenal cortical tumour, the neoplasm configures around ~6.8% of primary adrenal neoplasms. Median age of disease occurrence is ~55 years although no age of disease emergence is exempt. A bimodal distribution of disease is encountered with peak occurrence within first decade and fifth decade. Caucasians are commonly implicated. A female preponderance is observed with male to female proportion of 1:1.5 - 2.5. Adrenocortical carcinoma is predominantly sporadic although ~10% instances arise within syndromic settings (1,2).
References
Physical pain in children has been identified by multiple evidences of research as a source of discomfort among children that can even limit their reception of other medical treatment. In this study, effort is made to highlight the role of physiotherapy in psychological pain management in children and how it helps in improving pain management for better treatment and rehabilitation.
The current study examined evidences of literature from over 30 authoritative sources made up mostly of authoritative journals in the medical field of physiotherapy with specific focus on paediatric physiotherapy. The research sought to extract evidence of the different needs of children when it comes to pain management and how physiotherapy practice can be effectively deployed in the management of pain among children both from a psychological and physical point of view.
The findings of the research highlighted the important role that physiotherapy with specific focus on psychological capabilities of physiotherapist to identify pain in children and effectively manage it. This was noted to assist children in their rehabilitation process post injury including but not limited to the positive uptake of other treatment such as surgery.
Keywords: physiotherapy; psychology; paediatric physiotherapy
References
Examined and treated 1246 patients with complicated diabetic foot syndrome (DFS) for the period from 2010 to 2015 (326 patients - a comparison group, 888- main groups - representative) and of 32 patients in the Development of Sepsis. Found that in patients with pyonecrotic processes of DFS in which surgery is performed in an ambulatory, ABT can be administered in the tablet forms. Patients of groups II-III the one should remember that in the presence of sensitivity to multiple antimicrobials, use sequence - from the weaker to the stronger, and at the risk of MRSA – linezolid, daptomycin. With the development of sepsis - drugs of choice are fluoroquinolones of III - IV generation, carbapenems, and the presence of MRSA – linezolid, daptomycin or vancomycin. Suggested tactics of ABT contributed to the reduction of length of hospitalization, with an average of (31,4±1,8) to (19,4±2,3) patient days (t=3,32; P<0,05), and the reduction of postoperative mortality from 7,5 to 3,8% (x2=6,74; P<0,05).
Keywords: diabetic foot syndrome; sepsis; antibiotic therapy
References
This is the era of Artificial Intelligence, where AI models are growing fast for making critical decisions for several predictive models. Here AI is giving solution to the medical practices for diagnosis as well as prognosis with its increasing intelligence to simplify the ambiguity and complexity in data to carry out clinical decisions. Several research studies have truly demanded the need of AI-based systems and how to enhancing their capabilities to help medical practitioners. However, instead of giving highest effort for making most accurate AI based models, still now assessing the magnitude and impact of human trust on AI technology demands substantial attention. In the last decade many AI based CAD models were developed which hardly could persuade the experienced medical practitioners to accept the machine-specified decisions. In this research work, it was attempted to interpret and explain a supervised AI model built using XGBoost on Lung cancer detection by using XAI (Explainable AI) tools - two post-hoc methods (LIME and SHAP) and one ante-hoc method, to provide satisfactory explanations to medical practitioners, thereby minimize the AI risk factor in implementation of the model and reinforce the trust to the medical experts and patients in accepting such model. In this paper, the results of all three XAI tools were illustrated using heatmaps to select important input bi- omarkers that contributed more in detection of the benign or malignancy state of the pulmonary nodules. Finally the supervised AI model was rebuilt using only those important input features and it was found out that the metrics like specificity, precision, the AUC of the newer model under the ROC curve were giving better result in prediction of lung cancer nodule state. It is a study to explore how XAI tools highlight the contributions of input features in an AI model and how that AI model’s performance can be fine-tuned based on the outputs of XAI mechanism.
Keywords: AI; LIME; Pulmonary nodules; SHAP; XAI; XGBoost
References
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease, especially in elderly individuals and those with comorbidities. The predominant clinical manifestation of COVID-19 is respiratory dysfunction, while neurological presentations are increasingly being recognized. SARS-CoV-2 invades host cells primarily via attachment of the spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor expressed on cell membranes. Patients with Alzheimer’s disease (AD) are more susceptible to SARS-CoV-2 infection and prone to severe clinical outcomes. Recent studies have revealed some common risk factors for AD and COVID-19. An understanding of the association between COVID-19 and AD and the potential related mechanisms may lead to the development of novel approaches to treating both diseases. It is important to understand the mechanisms by which SARS-CoV-2 invades the central nervous system (CNS) and the associations and potential shared factors between COVID-19 and AD.
Keywords: COVID-19; Alzheimer’s disease; correlation; mechanism of action
References
Renal cell carcinoma (RCC) is the most common malignant tumor of the kidney, presentation as spontaneous rupture and hemorrhage is rare, it presents as acute abdominal pain and is diagnosed with a computed tomography scan (CT), which is the most common modality used for diagnosis, a variety of causes have been described such as neoplasm, vascular abnormalities, and renal parenchymal diseases, RCC was reported in up to 26% of causative etiology. A rare case with spontaneous rupture of renal cell carcinoma in 40 years old male patient, presented with left flank pain for 3 weeks with massive retroperitoneal hemorrhage, patient was resuscitated and a left nephrectomy was done.
When KPI is being applied to healthcare organizations, it measures the degree of how much improvement in the outcome of healthcare providers. We all know that what gets measured gets improved. Healthcare leaders should establish a system of quality and performance metrics to control and improve overall healthcare quality; poor quality not only adversely affects patient outcomes, but also affect budget and profits.
For improving healthcare services, indicators should cover healthcare service capability to achieve organization goals and resources with special standards covering patient safety, risk management, and integrated health services, which makes it important to comply with standards and correct performance safely and at an acceptable cost by society, so that it leads to continuous improvement of healthcare outcomes and conformity with the expectations.
We can define healthcare operational excellence as building sustainable competitive standards through operation management, to improve the quality of patient healthcare at different health departments from primary care to intensive care, rehabilitation care and home care. Competitive, visionary healthcare leaders and policy planners are required to transform the daily health dynamics into sustainable, well-established services.
An excellence model in Saudi Arabia has been started for few years now. Due to the importance of sustaining quality and organizational excellence, the role of the government sector is being supported by different governmental and private organizations.
Reference
Key Performance Indicators (KPI) are measures that organizations use to determine and track their progress to meet its strategic goals. KPIs provide a measurement tool at all departmental levels and are considered as a scale by which organizations can keep score and the success of their outcome. KPI implementation reinforces the organization’s mission, vision, strategic planning and timeline of professional performance.
In response to the competitive healthcare environment, organizations are continuously searching for practical standard tools and methods to improve their performance outcome. Not only shows improvements made over time within the organization departments, but it also measures performance by comparing results against other similar organizations.
Contemporary research in arts therapies [1] brings evidence that integrating arts practice with neuroscientific discoveries are effective methods to support mental and physical health. Biological and ecological sciences join human health issues. Alltogether scientists and artists foster « one health » philosophical and epistemological concepts.
The human society faces a critical period of multiple challenges with traumatic consequences for many populations. Arts and arts therapies offer a powerful lever for emotional regulation, thus being at the core of care, healing and well-being. As we are writing these lines, the 2023 International Conference of the European Federation of Art Therapy [2] « Growing*Together », held on 15-17 June in Riga, just closed and the conference « Arts for the Well-Being of All : New Horizons for Research » is going on at the Edge Hill University’s Research Centre for Arts and Well-Being, 20-21 June 2023, in collaboration with WHO and NHS. The time has come for effective integrative reflexion and action in health research, policies and practice, based on the fondamental creativity of the human being as part of the living and non-living world.
References
Sensitive, vulnerable and so fragile, humans are constantly seeking for apraisal and well-being. Ancient traditions all arround the planet teach us how our senses, emotions and thinking contribute to foster the individual and community esthetic sensibility in collaborative ways of belonging, attachement, security.
Contemporary medical practice integrates some of the arts therapies’ methods – music in anesthesia and surgery, palliative care or rehabilitation, visual arts in chronic diseases such as cancer, diabetis, sclerosis…, dance and drama in education and social work. The mental health area uses expressive and creative techniques as powerful complementary treatments. Sensible arts experiences help healing. We need arts as a regulator of our body-mind fonctioning, thus preventing destabilization, unbalance and illness.
References
Microspheres are tiny sphere-shaped particles with sizes under 200 nm. The analysis focuses on the microspheres of its qualities, forms, preparation, outcomes, and application of process variables. This article discusses a cutting-edge drug delivery technology.
It overcame a number of issues with other dosing forms. The various kinds of microspheres are employed in a variety of ways to increase therapeutic efficacy and bioavailability. Investigations are being done into how process factors affect drug release, drug trapping, and particle size. Microspheres are typically free-flowing powders made of synthetic polymers that are naturally biodegradable. A medication is located in the centre of a microsphere, where it is protected by a unique polymeric membrane.
keywords: Microspheres; Drug Delivery; Particle Size; Controlled Release
References
Modern lifestyle has increased the risk of various physical and psychological health problems. The unhealthy lifestyle of people in the modern world has exposed them to various illnesses, disabilities and even deaths. The various metabolic diseases that are a result of these modern lifestyles are obesity, hypertension, cancer, cardiovascular problems, diabetes and other health problems. A proper discussion of the impact of the various aspects of the modern lifestyle on our health has been done in the below article. It has been found that millions of deaths across the globe are occurring due to the choices of the modern lifestyle. Hence, it is only important to make appropriate changes to the modern lifestyle to reduce the negative impact on health. Regular exercise, a balanced diet and improved sleep patterns are some of the effective steps that can be taken to improve health outcomes.
Keywords: Lifestyle; health; diseases; sleep; diet; smoking
References
The aim of this study is to investigate the matching between emergency department and discharge diagnosis as well as how investigations affect accurately of emergency department diagnosis. One of the primary consequences of inconsistent diagnosis is the prolongation of hospital stays. The process of diagnosis entails identifying the illness that is the source of a patient's symptoms and warning signs. Investigations, the physical examination, and the history all play a significant role in making a successful initial diagnosis. The study was conducted retrospectively over a seven-month period in 2019 including four in-patient specialties: orthopedics, surgery, and medicine. All patients that entered the emergency room during the study period. The diagnostic accuracy was shown to be considerably higher in the younger age group when the adult patients were divided into groups by age (19-62 years versus 65 years or above, p value less than 0.001). 74% of diagnoses at admission completely or partially matched diagnoses at discharge. Traumatized cases and young people had significantly superior diagnosis accuracy, according to data. Improvements in ED diagnostic definitely needed, particularly for nontrauma situations, young patients, and the elderly. Patient history and clinical examination are the two tools that one may use to increase the accuracy of an ED diagnosis. Diagnoses such as chest illness, hip fracture, and injuries to the finger, leg, or foot were considered partial matches. Simple tests available in the ER were frequently ineffective at improving diagnostic accuracy.
Keywords: Emergency diagnosis; Traumatized cases; ER; investigations
Introduction
Electronic Medical Records (EMRs) have become widely adopted across healthcare systems in both the United States and Latin America. These digital repositories contain comprehensive patient data, including medical history, diagnoses, laboratory results, medication records, and demographic information. Extracting this vast amount of data and integrating it with advanced technologies such as neural networks presents an opportunity to derive actionable insights for improving prognostic care.
Scope of Extracting Vital Patient Informatics
Improved Treatment Decision-Making
Extracting EMR data and feeding it into neural networks enables healthcare providers to analyze large datasets and identify patterns that may be crucial for accurate prognostic care. By utilizing machine learning algorithms, physicians can gain access to predictive models capable of assisting in treatment decisions, risk assessment, and prognosis evaluation.
These models can provide evidence-based recommendations tailored to individual patients, optimizing clinical outcomes.
Personalized Interventions
The extraction of EMR data allows for the identification of specific patient characteristics, such as genetic predispositions, lifestyle factors, and comorbidities. Neural networks can integrate these factors with clinical data to create personalized intervention strategies for disease management. This individualized approach enhances patient engagement, adherence to treatment plans, and overall therapeutic efficacy.
Enhanced Healthcare Outcomes
Utilizing EMR data with neural networks promotes population health management by analyzing large-scale patient data to identify disease patterns, risk factors, and potential outbreaks. By leveraging this information, healthcare systems can develop preventive strategies, optimize resource allocation, and improve patient outcomes on a broader scale.
Challenges and Considerations
Data Privacy and Security
When dealing with sensitive patient data, ensuring privacy and security is of utmost importance. Adequate measures must be implemented to protect patient information and comply with existing regulations and ethical guidelines.
Data Quality and Standardization
EMR data extraction relies on accurate and standardized data entry. Inconsistent or incomplete data may lead to biased results and inaccurate prognostic models. Efforts should be made to improve data quality and establish standardized protocols for data collection and storage.
Health Inequality and Accessibility
While extracting EMR data for neural networks shows promising potential, it is essential to consider health inequalities and accessibility issues prevalent in both the United States and Latin America.
Efforts should be made to bridge the digital divide and ensure equitable access to technology and healthcare services.
Conclusion
Extracting EMR data and leveraging neural networks hold significant potential for enhancing prognostic care in the United States and Latin America. By utilizing machine learning algorithms, healthcare providers can improve treatment decision-making, develop personalized interventions, and achieve enhanced healthcare outcomes. However, challenges such as data privacy, quality, and accessibility must be addressed to fully harness the potential benefits of this approach. Further research, collaboration, and investment are necessary to optimize the utilization of EMR data for neural networks in clinical care in both regions.
References
Electronic Medical Records (EMRs) hold a wealth of valuable patient information that, when properly extracted and analyzed, can significantly contribute to improving prognostic care for patients in both the United States and Latin America. This paper explores the potential of extracting EMR data and leveraging neural networks to enhance clinical care and support disease management in these regions. By examining the scope of extracting vital patient informatics, we highlight the benefits of utilizing EMR data to augment prognostic care, including improved treatment decision-making, personalized interventions, and enhanced healthcare outcomes.
The recommendation issued by the World Health Organization in 1981 and the resolutions regulating the subsequent merchandising code for breast milk substitutes aim at standardizing the rules for advertising and inappropriate promotion of these products, including: infant formula, baby bottles, pacifiers, and supplementary food products.
Despite the efforts to bring forward these regulations at national levels, it has been very difficult for most countries to create legal bodies enabling actions to be taken in defense of the rights of mothers, fathers, and families to access reliable information about infant nutrition. This information must be free from the influence of aggressive marketing campaigns and merchandising for these substitute products. These campaign strategies continue to influence the decisions on food and nutrition of babies, reducing or even causing an early halt of breastfeeding, which would otherwise widely benefit babies and their mothers’ health and nutrition in the short and long term.
Commercial influence in decisions about infants’ nutrition
In contrast to the aforementioned breastfeeding figures, the state of the baby formula industry shows its increasing profit worldwide. In 2019, this market achieved a total worldwide income of 70.6 billion USD.
The 2023 Lancet series on the topic of breastfeeding, describe the multilayered and highly effective strategies of baby formula manufacturers to address the parents, health professionals, and policymakers. These include:
Code dissemination and further action
After more than 40 years since the promulgation of the international code for commercialization of breast milk substitutes, the WHO with the support of civil societies like the IBFAN network (International baby food action network), held the first world congress on the code in Geneve in June 2023. They proposed several goals, such as: the creation of policies and strengthening mechanisms to coordinate and manage these policies. Thereof, countries would finally acknowledge the mandatory character of the code making it into legislation. Thereafter, it is possible to subdue the conflicts of interest created by the food industry within the health system through health professionals and the ongoing advertising broadcasted across mass media, social networks, and other communication platforms on the internet.
IBFAN is committed to continue supporting breastfeeding and overseeing the observance of the code as we continue to advocate for the unobstructed advancement of the implementation of the code. Likewise, we seek to promote public policies that favor breastfeeding. We overall seek to work in accordance with the conclusions and recommendations expressed by the countries participating in the Geneve forum which became a milestone in policymaking to support breastfeeding.
To conclude, the way to achieve dissemination and promotion of breastfeeding is still complex. Nevertheless, there are more foreseen actions and awareness by many to get the necessary support of governments, the civil society, and health professionals to gain the needed knowledge on this subject and its successful implementation in the public and private areas.
Similarly, we need to bear in mind that it is also relevant to address individuals, a key factor to foster breastfeeding aiming to overcome the fear and lack of confidence experienced by mothers in their own capacity to breastfeed. These limitations are induced by baby food campaigns that seem to take advantage from their doubts and also attempt to convince mothers of the impossibility to breastfeed bringing forth ideas like an alleged failure in milk production. Actually, such events are absolutely possible to reverse and many of them are merely untrue. These beliefs prevent achieving successful breastfeeding, and totally surmountable and essential to SAVING MORE BREASTFEEDING as well. Therefore, we will continue to support mothers and their babies in this life period of utmost importance for nutrition, both at public and individual levels.
“Less than half of the world’s infants and young children (aged 0–36 months) are breastfed as recommended; a third of all neonates received pre lacteal feeds during the first 3 days after birth and only one in two neonates are put to the breast within the first hour of life”.
These reduced figures in breastfeeding commonly respond to the extended promotion of infant formula and infant milk. There are many ways that advertisement for breast milk substitutes impact mothers’ choice to breastfeed their babies and to continue breastfeeding during the first two years of the child’s life.
Value intelligence is defined as; The ability to engage in a range of behaviors that call for the use of specific skills such as language and social skills, It possesses a set of characteristics that enable it to communicate and adapt to the values and attitudes of individuals from different cultures. Value intelligence is also defined as; The ability that allows individuals to understand and interact positively with a wide range of values, It can be said that value intelligence is the ability to find a new useful product, or to develop a valuable service for the value system in which the individual lives, and it includes a number of skills that enable its owner to solve problems facing him, in addition to being a biological possibility that interacts with environmental factors. Here it must be noted that value intelligence does not only mean cognitive understanding of value differences, but it includes several components: motivation, behavior, In addition to knowledge, therefore, we find that individuals who have value intelligence have effectiveness regarding new value situations related to value differences, and this is what is known as behavioral value intelligence. Which determines the totality of practices, actions and behaviors that the individual performs in relation to life situations, especially those related to the value side, and we also find those who enjoy intelligence and have the motivation and ability to interact with new value concepts. This is what is known as the value-motivational intelligence, which constitutes the main engine for the individual's practice of the intelligent side and uses it to identify the total value attitudes surrounding him and interacts with the incubating environment with all its cultural variables. They are also more capable of adapting and interacting with people of different cultures, and they have a desire to ask many questions, to be constantly exposed to new situations, and to feel pleasure when communicating with individuals from different cultures and to increase their value experiences. This is what is known as the value-cognitive intelligence that is based on the love of exploration, inquiring and diving into an ocean of questions that may not end at times, as they express depth in the levels of intelligence related to individuals within the framework of different cultural systems. Over the ages, human societies have been concerned with the development of their institutions in all economic, social and value fields, and the development of their intellectual and value skills, which has led to a kind of mixing of values. Educational institutions such as schools and universities are a meeting point for individuals from different backgrounds, especially since the educational institution as a whole is the first organizational entity in the educational process. It has occupied great interest in all countries of the world, especially as it is an effective tool that contributes to the progress and development of nations. Therefore, many countries have paid great attention to improving the level of universities by improving educational programs and their curricula, as well as paying attention to the academic aspect and faculty members, developing their personal experiences and knowledge in learning strategies in general, and drawing inspiration from renewable knowledge in particular. The success of the educational process in universities has been largely linked to the success of the faculty member, who is the leader in the educational process and is responsible for implementing the educational mission and educational policies within the walls of the educational institution. By making decisions and applying educational laws with the help of educational specialists, including administrators and educational leaders, and following up students in their academic achievement and urging them to be knowledgeable and knowledgeable and research in order to achieve educational goals with their correct goals, As well as his role in cooperating with his colleagues in exchanging educational experiences. The university environment may consist of diverse cultures and the culture of the majority prevails, which may affect the sub-cultures of students. Therefore, the faculty member’s possession of value intelligence is an effective factor in the success of the educational process, through his ability to Communication and adaptation with people from different cultures.
Today, the world is witnessing major changes in all areas of economic, social, political, intellectual and educational life, especially in the field of information and communication, which has facilitated friction between different cultures. Intelligence is an important factor in successfully dealing with modern developments brought about by globalization and the communications and information revolution, which in turn; It has multidimensional effects on the content of the value framework surrounding man. New mechanisms were developed for patterns of human behavioral interaction, as well as new perceptual values and judgments that shook the value legacies, which in turn embraced human thought, awareness and culture throughout contemporary history. The concept of intelligence is one of the most controversial concepts due to the multiplicity of its topics and definitions. This concept has been associated with the necessities of success in life, especially since individuals differ in the percentage of each type of these intelligences they have. One of the most important types of intelligences that scholars and researchers in management science and social psychology have paid attention to is value intelligence. Which appeared as an inevitable necessity as a result of the convergence of civilizations and the diversity of values that took many patterns in our societies as a result of the great technological development that we are witnessing in the current century. Culture is also the thread that connects a person to himself and others, and that the interactions and behavior of individuals involve, in essence, a cultural relationship. In light of the different cultures, we find that there are similarities and differences in light of these multiple cultures, which culture in turn works to create a suitable environment for living together in light of the diversity of values. Therefore, culture is responsible for shaping the value structure of each human society. It is what shapes the economy and determines the political system. It is also developed and has a dynamic interaction. Value intelligence refers to a group of abilities related to situations that are characterized by value diversity Value intelligence also comes as a form of intelligence that focuses on understanding, management, and behavior in situations characterized by value diversity There is no doubt that individuals from multiple environments and cultures differ in their intelligence, and they can develop types of these intelligences to an appropriate level through the availability of adequate support from the environment or culture in which they live.
References
Over the last couple of years, biotechnology has been giving many leads in different areas of production. In the pharmaceutical industry, it has led to many discoveries and innovations by birthing vaccines, killing microbes using antibiotics and developing many products of pharmaceutical importance. Having served and still serving as an alternative to the chemical approach of drug discovery and development in pharmacy, it is conspicuous that the application of biotechnology in the production and development of biopharmaceuticals could serve as a breakthrough in the development of novel pharmaceuticals. This paper aims to (i) identify and shed light on certain areas which are currently posing a threat to the development and use of biopharmaceuticals and those which may likely have a crippling effect on biopharmaceuticals in the future (ii) suggest and/or provide solutions to these problems, and (iii) identify promising areas for subsequent researches on the seemingly vast benefits of biotechnology in modern healthcare.
Keywords: Biopharmaceuticals; Biotechnology; Anti-drug Antibody; Healthcare
Practice patterns regarding glasses use vary among students for a variety of reasons. The level of awareness about the importance of eye health and the need for spectacles can significantly impact practice patterns. Lack of awareness about the potential impact of uncorrected refractive errors on academic performance and eye health can be a significant barrier to adopting spectacles. Wearing spectacles can sometimes be associated with a negative self-image or social stigma. Students, especially adolescents, may also fear being teased or bullied by their peers, leading to reluctance to wear spectacles. The cost of spectacles can be a significant factor affecting practice patterns among students in developing countries. Many families in these countries may require more financial resources, and purchasing spectacles for their children might be considered a lower priority than other essential needs such as food, housing, or education. A multi-pronged approach is necessary to address the challenges associated with attitudes and practice patterns toward wearing spectacles. Educational institutions, eye care professionals, parents, philanthropic organizations, and society should collaborate to create an environment that supports and encourages students to embrace spectacles for refractive error correction. School-wide initiatives, including awareness campaigns, regular vision screenings, and providing free spectacles, particularly for economically challenged students, can play a pivotal role in identifying students with refractive errors and promoting early intervention. Students' perspectives should be given high importance when designing refractive error programs. The low self-esteem and stigmas associated with spectacle use among students can be effectively addressed through health and education information, allowing students to use spectacles and improve their quality of life.
Correcting refractive errors in children poses many challenges when left undetected and untreated. Spectacles have long been a trusted instrument for correcting refractive problems for students in academics and daily activities. This fact is essential to comprehend students' attitudes toward wearing glasses and their practice patterns to overcome potential obstacles and encourage the widespread use of correct spectacles. Cultural norms, personal preferences, peer influence, self-perception, and individual experiences often influence attitudes toward spectacle use among students. Many students understand the advantages of wearing spectacles and have a positive attitude toward them. They recognize that spectacles can improve their eyesight, enhance academic achievement, and simplify daily tasks. However, some students may not prioritize their visual health or understand the value of wearing spectacles. They might be unaware of how visual impairment affects their ability to focus on class or their overall well-being. Unfortunately, stigmatizing refractive problems can occasionally lead to negative opinions about wearing spectacles. Students may be reluctant to take advantage of the corrective benefits of spectacles due to concerns about being seen as "unattractive," which can make them feel self-conscious. Females are more likely than boys to stigmatize wearing spectacles because they tend to believe that females who wear spectacles are not ideal marriage candidates. They may also feel that wearing glasses hinders their participation in extracurricular activities. Peer pressure and the desire to fit in can influence students' opinions about wearing spectacles. Some students may choose not to wear spectacles if doing so is stigmatized or considered uncool by their peers to avoid teasing or exclusion. On the other hand, positive peer experiences or role models who wear spectacles can influence children to accept vision correction.
References
Fixators are internal or external rigid equipment that acts as stabilizing frames to hold broken bones in their proper anatomical positions while they heal. The application of a fixator is a complex procedure that is done in the operating theatre by orthopaedic and trauma surgeons. Fixators may be temporary or permanent, however, they are often indicated in fractures. Fractures may simply be understood as a partial or complete break in the continuity of bones. They may be caused by trauma, fractures due to overuse, infections and diseases that weaken the bones. The latter is most common in children and physiologically in some women who have attained menopause. This paper however shades more lamplight on the use of fixators in the treatment of fractures that are non-traumatic in young adults. These fractures have a rather pathologic course in their aetiology.
Keywords: Pathologic Fractures; Internal; External; Fixators; young adults; adolescents; orthopaedics; bone cancer
Reference
Background: Prostate-specific antigen (PSA) testing has long been used as a screening tool for prostate cancer. However, it is not without its limitations. In some cases, men may receive a false-positive PSA result, which can lead to unnecessary anxiety and concerns about their risk of developing cancer.
Aim: This study aims to reveal and discuss the case of a patient with a false-positive PSA value of 100 ng/mL.
Discussion/Conclusion: Depending on PSA assays as an all-seeing eye in detecting and screening for Prostate Cancers (PCa), may not be completely reliable. Studies have found its sensitivity and specificity questionable. Although current studies have put the borderline values between 4ng/mL and 10ng/mL, many studies have found PCa biopsy-positive cases at values lower than 4ng/mL and negative cases at values greater than 10ng/mL. Nevertheless, the concept of overtreating and overdiagnosis was also touched on.
The Importance of Rational Antibiotic Use
Nosocomial and community-based ease of infection is a serious consideration in the postoperative management of patients in this region. Likewise, CS deliveries carry an increased risk of complications associated with infection compared to vaginal deliveries [2]. SSIs, endometritis, and urinary tract infections are common post-operative complications that can lead to increased morbidity, healthcare costs, and antibiotic resistance [3]. To mitigate these risks, the rational use of antibiotics is essential. Rational antibiotic use involves selecting the appropriate antibiotic, optimizing the dosage regimen, and considering factors such as the patient's health status, local resistance patterns, and cost-effectiveness [4].
Pattern of antibiotics prophylaxis
Currently, International guidelines provide recommendations for antibiotic prophylaxis in CS. These guidelines emphasize the importance of selecting antibiotics with appropriate spectra of activity against common pathogens, administering the antibiotics at the optimal time, and limiting the duration of prophylaxis. However, adherence to these guidelines can vary, and it is essential to evaluate the compliance with international guidelines in different healthcare settings [4].
This variation in compliance may result in varied patients’ outcome that may be positive or negative. In Nigeria, some hospitals in the federal capital give 2g single dose intravenous ceftriaxone or other potent cephalosporin intra-operatively as its sole prophylactic measure, without any other complications in the theatre, no further antibiotics are given. Whereas, while the intra-operative prophylactic ceftriaxone is given, routine intravenous antibiotics are continued for 24 hours post-operatively and then orals subsequently for 7-10 days, in Bauchi State, Nigeria. Sadly, at the moment, there are no comparative studies between these two states in Nigeria. However, a study conducted in Sudan at Elquatainah Teaching Hospital where similar practices as those of Abuja and Bauchi State were compared. Cost wise and pharmaceutically speaking, not prescribing post-CS antibiotics were found to reduce expenditure and general work load. But the medical repercussion was not examined in that study [5].
That notwithstanding, several studies have investigated the adherence to international guidelines for antibiotic prophylaxis in CS in various African countries. For example, a study conducted at Mulago National Referral Hospital in Uganda implemented a randomized clinical trial to assess the timing of antibiotic administration in CS. The study found that administering antibiotics before the skin incision significantly reduced the risk of postoperative infections. This research highlights the importance of following evidence-based guidelines to optimize patient outcomes [6].
Another study conducted in Lusaka, Zambia, examined the antibiotic prescribing patterns and prevalence of SSIs in CS deliveries. The study found that the most commonly prescribed antibiotics were the third-generation cephalosporin, ceftriaxone, and a triple combination therapy of benzylpenicillin, gentamicin, and metronidazole. The prevalence of SSIs was 6.0%, with factors such as the level of education, type of CS, and oral antibiotics post-CS influencing the risk of infection. These findings highlight the need for targeted interventions to improve antibiotic prescribing practices and reduce the prevalence of SSIs [7].
As regards targeted interventions, another study conducted at AL Ain Hospital in UAE amongst 807 women; found that there was a significantly low rate (1.4%) of SSI following CS. All women diagnosed with SSI had wound discharges within 30 days of the operation. More important, was the common denominator they identified amongst these women. That’s, they all had prolonged pregnancies. This was thus now tabled as a targeted risk for SSI after CS, and as thus subsequent patients fitting this profile ought to be on longer antibiotics regimens [8].
Implementing Guidelines for Rational Antibiotic Use
Like earlier mentioned, about the variation in approach in Abuja and Bauchi state in Nigeria, there are also intra-hospital variations in antibiotics utilization in CS. A study conducted at Elqutainah Teaching Hospital in Sudan implemented a hospital guideline for the rational use of prophylactic antibiotics in ECS. The intervention involved withdrawing metronidazole dosage forms from prophylactic antibiotics according to international guidelines. The study found that this intervention significantly reduced the overuse of antibiotics and medication costs while maintaining patient safety [5].
While this approach has been found to be effective in this hospital in Sudan, there are no searchable evidences for its implementation or trial in other areas in Sudan, north Africa or in the Africa region as a whole. Similar tales can be told about many other rational approaches. Also, the study also went on to show the vital role of clinical pharmacists in the development of rationale guidelines for antibiotics in obstetrics and gynaecological clinical practice, in this case, prevention of SSIs following CS.
Furthermore, when selecting antibiotics for prophylaxis in CS, several factors need to be considered. These factors include the local epidemiology of pathogens and their antibiotic resistance patterns, the patient's individual risk factors, the surgical procedure's specific characteristics, and the available resources and infrastructure. Adapting international guidelines to the local context is crucial to ensure the effective prevention of postoperative infections.
Understanding the local epidemiology of pathogens and their antibiotic resistance patterns is essential for selecting appropriate antibiotics. Studies have shown variations in pathogen profiles and resistance patterns across different African regions. For example, a study conducted in Nigeria found that Staphylococcus aureus and Escherichia coli were the most common pathogens isolated from SSIs in CS, with high rates of resistance to commonly used antibiotics. These findings emphasize the need for local surveillance and tailored antibiotic recommendations.
However, it is worth of note that individual patient risk factors, such as obesity, diabetes, and immunosuppression, should be considered when selecting antibiotics for prophylaxis. These risk factors can increase the likelihood of postoperative infections and may require broader-spectrum antibiotics or extended prophylaxis durations. Integrating patient-specific risk stratification into antibiotic prescribing practices can help optimize outcomes and reduce unnecessary antibiotic use.
Surgical Procedure Characteristics
The type of CS procedure, whether elective or emergency, can influence the choice and duration of antibiotic prophylaxis. Elective CS procedures are considered clean surgeries with lower infection risks, while emergency CS procedures carry a higher risk due to potential contamination. Tailoring the antibiotic prophylaxis regimen based on the specific surgical procedure characteristics can help ensure adequate coverage while minimizing unnecessary antibiotic exposure.
Resource Constraints and Infrastructure
Resource constraints and infrastructure limitations pose challenges to antibiotic selection and administration in many African healthcare settings. Limited access to certain antibiotics, inadequate laboratory facilities for culture and sensitivity testing, and suboptimal healthcare infrastructure can impact the choice and availability of antibiotics. It is crucial to consider these factors when implementing guidelines for rational antibiotic use and explore strategies for optimizing antibiotic stewardship in resource-limited settings.
Strategies for Optimizing Antibiotic Use
To promote rational antibiotic use after CS in Africa, several strategies can be implemented at various levels of healthcare delivery.
Education and Training
Education and training programs targeting healthcare professionals involved in CS deliveries can enhance their knowledge and awareness of rational antibiotic use. Providing evidence-based guidelines, conducting workshops, and promoting continuous medical education can help improve antibiotic prescribing practices and increase adherence to guidelines.
Antibiotic Stewardship Programs
Formulating antibiotic stewardship programs specific to CS deliveries can be an effective approach to optimize antibiotic use. These programs can involve multidisciplinary teams, including clinical pharmacists, infectious disease specialists, obstetricians, and microbiologists. The programs can focus on implementing guidelines, monitoring antibiotic prescribing patterns, providing feedback to healthcare providers, and promoting appropriate antibiotic use.
Surveillance and Monitoring Systems
Establishing surveillance and monitoring systems for SSIs and antibiotic resistance can provide valuable data for guiding antibiotic prescribing practices. These systems can help identify trends, detect outbreaks, and evaluate the effectiveness of interventions. Regular monitoring and feedback to healthcare providers can facilitate continuous improvement in rational antibiotic use.
Collaboration and Partnerships
Collaboration and partnerships between healthcare facilities, professional organizations, and policymakers are crucial for promoting rational antibiotic use. Sharing best practices, implementing standardized protocols, and advocating for policies that support evidence-based antibiotic prescribing can contribute to reducing the burden of SSIs and antibiotic resistance after CS.
Conclusion
The rational use of antibiotics after CS in Africa is essential to mitigate the risk of postoperative infections and combat antibiotic resistance. Adhering to international guidelines, considering local epidemiology and resistance patterns, individual patient risk factors, surgical procedure characteristics, and resource limitations are key factors in optimizing antibiotic use. Implementing strategies such as education and training, antibiotic stewardship programs, surveillance systems, and collaboration can contribute to improving antibiotic prescribing practices and ultimately improving patient outcomes. By prioritizing rational antibiotic use, Africa can address the unique challenges associated with CS deliveries and pave the way for sustainable healthcare practices.
Recommendations
References
The increasing global rates of caesarean section (CS) deliveries have raised concerns about the rational use of antibiotics to prevent post-operative infections. In Africa, CS is a common surgical procedure, accounting for a significant portion of the surgical workload [1]. This is even now more prevalent as CS has been seen as one of the most appropriate means for emergency deliveries in cases of obstetric emergencies presenting with hopes of fetal viability [1].
However, the appropriate use of antibiotics after CS is crucial to minimize the risk of surgical site infections (SSIs) and reduce the burden of antibiotic resistance. Nosocomial and community-based SSIs are a serious challenge in Africa too, in combination with a sad rise in antimicrobial resistance (AMR) [1]. So, a balance needs to be struck.
The aim of this short review is thus to explore the rational use of antibiotics after CS in Africa, taking into account the unique challenges and considerations in the region.
References
The pigs used in these experiments were raised from the initial five pigs reserved as breeding stock in January 1969 from stock at the Arlington Farm, UW. They were challenged with 3% Halothane in O2 and identified as MH susceptible whenever the rear legs became extended and appeared to be in rigor. The Halothane challenge was stopped and the animals spontaneously recovered and were raised for breeding stock. The two males and three females were raised in UW Swine Barn A under Leo’s supervision. Unfortunately, when they reached 225-240 lbs. in weight, they were hauled off to the UW slaughter house. Leo found them missing and called the slaughter house and recovered one male and two females that had not been slaughtered. We relocated the MH breeding stock to the UW Sheep Farm so there could not be any other possible confusion with other pigs in Swine Barn A. I moved the key MHS breeding animals to Sinclair Research Farm at MZZOU in 1973 when I relocated to MIZZOU for a new research position. Later in 1982, the entire stock of MHS susceptible breeding animals were moved to TTUHSC at El Paso, TX. They were housed on a pig farm near El Paso, TX.
One reason for little attention is that a clinician can not see the occlusion. If you can not see then you can not treat. Dentists use older techniques to mark the occlusal contact areas of the teeth however they rarely obtain a complete oral picture making it easy to neglect essential problems. Occlusion is also an essential element for implant longevity. If the “bite” isn’t even then the bone attached implant health is jeopardized. Closing the jaws in harmony is an essential element for a long term life because choice of food coupled with chewing efficiency controls what we purchase and ingest. Nutritional supplements such as powdered foods are used as a substitute to masticating actual fruits and vegetables. Basically a sound occlusion is essential to food selection and digestion. There are no substitutions to properly functioning dentitions. Our health depends on it.
Dental occlusion is a neglected factor in dentistry. Oftentimes it is spoken about yet it is not comprehensively addressed by the dental profession. Why is its practical application not addressed? The occlusion is the coming together of the upper and lower jaws in harmony.
References
Prediction of postoperative complications, which determine the result and consequences, is an important element in the choice of treatment tactics for acute peritonitis management what makes it possible to apply preventive measures. Many methods which are based on taking into account various indicators have been proposed for this. However, none of these methods have sufficient recognition. The most famous and recognized scales are PIPAS [1], WSES Sepsis Severity Score [2], Mannheim Peritonitis Index [3], Peritonitis Index Altona [4], Combined Peritonitis Score [5]. These scales assess only the degree of organ dysfunction, the severity of AP and the possibility of patient’s death. But these scales do not assess the risk of certain complications.
APACHE, SAPS, SOFA, etc. are suggested to be used to predict the effects of treatment. However, these scales are nonspecific, in addition, the scales predict only the possibility of death of patients [6-8].
Most prognostic scales determine the risk of complications only during or after surgery. This limits the possibility of justified prevention of complications already during preoperative preparation. Only separate scales make it possible to make predictions before the operation [9-10].
Many scales specific to certain causes of peritonitis have been proposed. These include Peritonitis Severity Score, Boey Score, Jabalpur Index, Hacettepe Score, PULP Score, etc. However, this does not solve the problem as a whole.
A large number of scales have been created for various types of comorbidities. But only some such scales are universal enough and easy to use.
So, the prognostic problem for acute peritonitis has not been solved. Therefore, the problem of developing an informative prognostic universal scale remains relevant.
References
Obesity is a global health challenge with few pharmacologic options. Whether adults with obesity can achieve weight loss with once weekly Semaglutide at a dose of 0.5-1.0 mg as an adjunct to lifestyle intervention has not been confirmed. Method: This is a clinical case report of a 29-year-old female, who tried weekly Semaglutide with lifestyle intervention. We conducted a baseline mental and physical health, and we did a biweekly follow up with her. This was over 6 months period starting from September 2022 until March 2023. Consent: Written informed consent has been obtained from the patient. Results: Our participant was able to lose 16.3 % of her body weight in 6 months, dropping her body weight from 74.3 kilograms to 61.2 kilograms, with a decrease in her body mass index from 29.3 to 23.9. With a significant improvement in mental and physical health, particularly, an improvement in her depression, generalized anxiety, and ADHD symptoms. Conclusion: In participants with overweight or obesity, 0.5-1.0 mg of Semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight.
Keywords: Obesity; Semaglutide; weight loss
References
Toxic megacolon is defined as an acute non-obstructive inflammatory condition with dilatation of the bowel causing septicemia and peritonitis. The cut off point for the bowel dilatation is taken as 6cm and above with loss of haustration on imaging. The exact cause of toxic megacolon is still debatable but several postulations have been laid down. The etiology of toxic megacolon can be divided into several factors such as inflammatory, autoimmune, tumors and others. Toxic megacolon carries a high morbidity and mortality with delayed interventions. The incidence increases with age with male preponderance.
References
Liver involvement in Hodgkin's lymphoma is common and is caused by hepatic infiltration, biliary obstruction by lymphoma, hepatitis, sepsis or complications of chemotherapeutic treatment. Jaundice caused by the vanishing bile duct syndrome related to Hodgkin's lymphoma is very rare. The mechanism is poorly understood but a paraneoplastic effect seems most likely as liver biopsy and imaging study the absence of lymphoma cells in liver. We describe a 13-year-old man with vanishing bile duct syndrome and Hodgkin's lymphoma who was treated successfully with chemotherapy. The markedly elevated serum Bilirubin levels completely normalized. Our case demonstrates that although dosing of chemotherapy in this situation can be very difficult, a good clinical outcome is possible, which makes the attempt at curative treatment worthwhile.
Keywords: Hodgkin’s lymphoma; jaundice; vanishing bile duct
References
Yoga is the science and art of living healthily. Yoga seeks inner perfection as it helps unite the body, mind, and spirit, creating amazing life harmony. Yoga can improve health and happiness in many ways. Yoga is one of many strategies to live a healthy and peaceful life, but it may be most effective when combined with a nutritious diet, regular exercise, and great relationships. This practice is suitable for many religions, races, and nationalities because it emphasises overall wellness in the individual and community.
Keywords: Yoga; healthy; body; mind; peaceful life
Journals are important for the development of surgery. Journals can help distribute the knowledge and information about the subject. Journals can act as a forum for exchanging scientific knowledge from various points of views. Journals are platforms for the papers regarding new developments in surgery. Journal reading clubs are essential part of surgical training.
In conclusions, surgeons must focus not only on patient care but also on training of new generations.
Surgery is an ever developing and changing subject. Minimal assess surgery and enhanced recovery after surgery are evolving very quickly.
Day by day, more techniques, more materials, new concepts, and updated guidelines are introduced.
For a surgeon, diagnosis, decision making, pre-operative optimization, intraoperative care, operation and post-operative care are all very important in the patients’ journey. Patient safety and rapid recovery are the goals of the surgical care.
For the patient safety, regular audits like mortality review, morbidity review, debriefing after patient care, training, etc. are all needed to improve.
Trainees need not only principles and practice of surgery, and surgical skills but also non-technical skills to develop efficiently. International collaboration and co-operation are essential for the development of the surgical care.
Continued medical education, mentoring, competency-based surgical training and non-technical skills for surgeons are being carried out in various forms.
Surgical teams must be more productive, organized and upgraded.
One of the predators, who actually was and may never have stopped being a Nazi is global financier and convicted felon George Soros [10]. His plan, which is shared by many in these elite circles, was to shut down every part of the economy in the first world, and de-industrialize the USA. The collapsing borders, super-inflation, total elimination of fossil fuels (unless it comes from perhaps British Petroleum or those in league with the globalists), and collapse of the world food supply (mass starvation). All this so a corporate UN coordinated world government can come in and act as saviors. It is a decarbonizing agenda, an anti-terraforming religion where carbon dioxide will be removed from the atmosphere in the name of being Green. Green was intended to be the new anti-human, anti-science religion used to isolate, control and eventually eliminate as much as 80% of the human population on the planet, for the carbon they really want to remove is us. If Green were really “Green” why are we outsourcing our energy needs to China where slaves are many and human rights are few. Those batteries for electric cars require cobalt mined by exploited African children. Who do you think are making all those Chinese solar panels (yes, they make most of them)? How about a million Uyghur Muslim slaves incarcerated because of their religion - at least until someone with money needs an organ that matches one of the slaves, be they Muslim or Fallon Gong practitioners. It’s called Green Washing or environmental virtue signaling.
By 2026, there will be more than three Chinese males for every female aged 15-29, thanks to their policy of sex-selective abortion. The Chinese gender gap is fueling the trafficking of poor women, who are being kidnapped or lured into China and forced to be prostitutes or slave-brides. This is an unspoken driver of Chinese policy.
A massive global death cult has been lurking for decades for the moment to strike. They actually believe(d) they could transcend carbon-based life and have their consciousness transferred to some silicon-based life-form. In the short term, their plan is to neutralize the USA with a civil war/economic collapse while China takes over the South China Sea including Taiwan.
Whether you personally believe in malevolence, Satan [11] or nasty inter-dimensionals is your choice, but the globalists believe in them and most have sold their proverbial souls [12] for something they already had and now they have created a covenant with the losing team. The weird thing is on some level they know it, but can’t stop themselves so they push forward with their deranged game plans to create a transhuman world where most humans have been eliminated and they want this all to happen by 2030 according to their own published agenda [13].
A world that will be free of poverty and hunger because we won’t be in it, but those who remain will own nothing, be happy and eat bugs - again, this plan has been cooking for the last century. The globalists’ desire to be top dogs on a prison planet is so intense their wish may actually be granted, but not on this Earth. That seems to be the way a benevolent universe works, you get what you want, eventually, but it may not be exactly how you planned it out. Be that as it may, there also seems to be a lot of malevolence tolerated at certain levels and layers of our reality undoubtedly to stir the evolutionary pot for the benefit of all. Nevertheless, what goes around comes around, so if true, you don’t trade your future for temporary misuse of power as seductive as it may be. It is a poor choice, but some insist on learning the hard way, yet even in their insanity, the lessons they offer benefit the whole.
Medical Tyranny and Soft Kill weapons
Fluoride seems to have been the first foray into medical tyranny to control populations. The historical use of fluoride for behavior control probably started in the Soviet gulags in the 1930’s but Nazi Germany was quick to apply same in their prison camps as the mineral makes humans apathetic and easy to dominate - stupid and docile. The propaganda campaign in the USA was so convincing that fluoride was essential for preventing tooth decay that anyone who questioned its use in the water supply, even though fluoride is more poisonous than lead, was considered a nut case. The book The Fluoride Deception is well researched and goes over this in detail [14].
The practice and paradigm of fluoridating municipal drinking water demonstrated that the public would accept drinking poison if the government insisted it was a public health measure being done for the benefit of citizen’s well-being - “Fur Ihre Sicherheit” - it’s for your safety a common Nazi reframe. This poison is still universally defended by the dentists who will willingly put the most poisonous non-radioactive element on the periodic table in your mouth, mercury amalgam fillings, and call it silver. The mercury is constantly leeching out and you breathe it in and swallow it too.
During WW II, the biowarfare activities of the Japanese were particularly atrocious. As many as 3000 allied troops lost their lives in places such as the infamous Unit 731 testing biologics and untold number of civilians when these agents were released in Asia. The USA covertly granted the scientists involved immunity not unlike Operation Paper Clip [15].
Blame it on the fluoridated water, but we have allowed ourselves to be experimented on far too easily and without holding anyone accountable. There is no freedom without accountability. In 1950, the U.S. Army sprayed the bacteria serratia marcescens in San Francisco from a boat(s) in the bay - Operation Sea Spray and continued till 1969. There was at least one documented death from the infections that followed.
Infantile paralysis or polio didn’t exist until the heavy use of various pesticides the most notable being DDT, which is required to weaken the immune system so a previously benign stomach virus could start causing paralysis. But the government had encouraged and required the liberal use of DDT, and it was used everywhere and on almost everything (still is in certain parts of the world). Nevertheless, a virus and only a virus would be blamed for what was actually an illness caused by a pesticide or else there would be great liability to both the government and industry. So fear of a virus was ginned up - sound familiar? The mass vaccination campaign (Polio) initially gave 98 million Americans a retrovirus infection, a simian virus (SV40), now known to be causally related to several types of cancer. Now it seems genetic sequences from SV40 are in the mRNA bioweapon for COVID.
Don’t misunderstand what is written here… an enterovirus causes the illness but it needs a toxic co-factor in most cases. If the truth of the toxic cause of polio was known, and the government held accountable for infecting millions with a cancer-causing retrovirus, we would not be where we are today. The first mass vaccination program for polio in the USA, now called the Cutter Incident, gave 200,000 children polio. To convince the public the polio vaccine program was working, the definition of polio was changed so that one had to be paralyzed for at least 60 days to be classified as polio - most cases resolved before 60 days and of course they knew that. It made the vaccine look very effective. Today, the definition of what is a vaccine has been redefined to accommodate a hard to sell, problematic gene-transfer therapy that makes the human body create a pathogenic protein (forever in some people), potentially sterilize [16] many recipients and inflame their hearts [17]. Make the human body produce a pathogenic spike protein - what could go wrong?
Oh, and the definition of “Gain-of-Function” was changed as well, so the reader can decide if that made Dr. Fauci look any more credible. Especially, when it was found he wanted EcoHealth Alliance to spray more virulent corona virus in Wuhan caves to infect the local population (the Pentagon refused to fund the project - maybe because it was an act of war?) [18].
Made in the USA
By masking biowarfare programs as public health measure producing vaccines these fools were able to get around restrictions. The Department of Defense (DoD)/DARPA admitted to operating 46 biolabs in Ukraine, for public health of course - but pay no attention to the fact we operate these labs all over the world…. “we are the good guys.” In 2012, DARPA developed their ADEPT:PROTECT project that would use gene-encoded vaccines to stop a pandemic (they would create?). There was no WARP speed program - they had already been working on this for ten years before Trump announced WARP speed. Moderna got its first contract in 2013, but it was the DoD that came up with the idea of mRNA vaccines - this whole thing has been a military operation from the get go. By 2015, the peer reviewed literature had articles announcing the enhanced CoV2 was ready to be used (on the human population). It was never a China-virus, the Wuhan lab was just enhancing what was created in the USA. With the first week thousands of pregnant women were taking this vaccine. Never have we given experimental vaccines to pregnant women and in the past medicine went out of its way to protect pregnant women from as much as possible and certainly not interventions that would upset their immune systems, but medicine was now neutered - only Pharmakeia existed and was in full control.
The polio outbreak showed that you could herd the sheep (humans in this case) into a slaughter house if there was an invisible enemy and a virus is perfect for that because one can use fear to get populations to turn to their government to protect them from this invisible enemy. If you have control of the media, you can also implement a divide & conquer strategy, so if you can turn men against women, blacks against whites, heterosexuals against the LGBQTs, established populations against imported immigrants by the millions - all of that causes people to turn to their governments for interventions. Do you think those funding Critical Race Theory to Drag Queen Story-Time want harmony? No, they want culture wars and civil wars.
In the USA, if one disagreed with the narrative the media, the Department of Justice or FBI would label that individual either a domestic terrorist or white supremacist/racist regardless of their skin color. It was part of the plan to blame the destruction of the USA on white supremacists, but ponder this one example - the City of Oakland California is deeply beset with crime and violence, but I would challenge you to find even one white supremist in Oakland. Those behind the tyrannical cult we have been subjected to are not super-intelligent, but few realize they get their power from public acquiescence whose perceptions they have to control. Yes, the cult has a lot of financial resources and many deluded minions who will blindly do their bidding, but they are weak - only the weak censor. The censorship was a desperate move to control perceptions. But the censorship surrounding COVID killed tens of thousands.
So, with a virus, you can stop people from gathering, organizing and if you can digitize a population, you can control who is talking to whom and where. If you can get people to school online or do their work online the government can listen to everything everyone is saying and writing and buying. The excuse is that it is Fur Ihre Sicherheit to protect against the invisible enemy. It also keeps people lonely, isolated, and depressed. People will buy into solutions before they know anything about the consequences of that solution, so you can mandate lockdowns without proper science supporting same, injections that have not been adequately tested, or vaccines that are known to cause harm for the greater good of someone’s bottom-line.
Infectious Disease Skullduggery
This is not a comprehensive tome of infectious disease skullduggery, but in 1955 it has been reported that the CIA conducted an open-air biological warfare experiment near Tampa, Florida and environs with the Pertussis bacteria. It was alleged that the nasty endeavor tripled the whooping cough infections in Florida to over one-thousand cases and caused whooping cough deaths in the state to increase 12-fold over the previous year [19].
In 1966, the U.S. Army released Bacillus globigii into the tunnels of the New York City Subway system, as part of a field experiment called A Study of the Vulnerability of Subway Passengers in New York City to Covert Attack with Biological Agents. The Chicago subway system was also subject to a similar experiment by the Army [20].
Bacillus globigii was used to simulate an attack with anthrax, but as it turned out, now we know this bacteria is a human pathogen [21].
The USA government conducted many radiation experiments on the unwary, MKULTRA drug experiments on the unknowing, torture experiments on the incarcerated, but again…this is not meant to be a comprehensive list. By the time U.S. President Eisenhower left office with his infamous speech beware the “military-industrial-complex” we were being lead into unending military conflicts, often initiated by false flag events such as the Gulf of Tonkin incident that was used to start the Vietnam war.
Men in Black
In the 1950s, the CIA had split into two factions. The western faction was almost exclusively in control of anything that had to do with ETs - I don’t mention this to be sensational. In the years that followed the military-industrial paradigm evolved and became inclusive of many multinational corporations, investment houses and banks, which benefited from this arrangement leading to where we have massive corporate interests, such as Black Rock/Vanguard, which span the globe and whose shareholder-ships are networked among a very small oligarch class.
While President Roosevelt avoided a coup, President John F Kennedy did not, and was assassinated (1963) in a coordinated plot managed by the CIA’s E. Howard Hunt. Lyndon B. Johnson was Vice-President and was fully aware of the planned elimination of JFK as was the infamous director of the FBI, J Edgar Hoover. Apparently, America decided to explore the dark side and so begin unending wars and skullduggery around the globe. But I doubt this could have been possible without the cooperation of the press in covering up the facts of the event. Why was Kennedy assassinated?
Kennedy wanted the USA back on the gold standard, he wanted the CIA dismantled, he never wanted the USA to get entangled in Viet Nam. Unbeknownst to Kennedy, the CIA had become far more than the “CIA” they were literally the Men in Black in matters extraterrestrial and if the CIA was threatened it also threatened the cover being used in such matters and the monopoly of information the CIA had on this information. Kennedy had a vision for the space program, but his vison was not shared by those using NASA as a front organization for their secret space program (they were back engineering crashed vehicles probably with the help of low-vibrational ETs, but that is speculation). Just days before his murder, Kennedy signed an agreement with Kurschev to cooperate on moon exploration and signed an executive order requesting the CIA share what they knew about UFO’s to make sure there were no accidents from confusing UFOs with an aggressive act by either side. The CIA had no intention of sharing anything with anyone and certainly wasn’t going to let the chief executive tell them what to do even if that meant making him “wet.”
Meanwhile, the secret biowarfare facility located on Plum Island off the coast of Connecticut was developing an enhanced version of the Borrelia bacteria (Lyme disease) under the directorship of former German SS-officer and microbiologist Eric Traub - Gain of Function research. This organism with increased virulence now infects 20% of the world’s population. Be that as it may, the virulence of the organism was not robust enough for the globalists.
The fall-guy set-up to take the blame for the JFK assassination was CIA asset Lee Harvey Oswald, who strangely enough was mixed up in a virus gain-of-function program for the purpose of developing a weapon that would kill Fidel Castro. Oswald knew too much and was expendable, so he was a convenient “patsy.” Mary Sherman, the scientist running the program, was murdered. It is still speculation whether there was a link to this apparent effort to create a deadly virus and the subsequent identification and possible enhancement of the HIV virus.
Maurice Hillerman, one of the world’s most prominent virologists of his time and a Vice President of Merck, was recorded boasting, “So we brought African Greens in and I didn't know we were importing the AIDS virus at the time.” Merck switched from Indian rhesus to green monkeys because the rhesus monkey were full of retroviruses including SV40. Was HIV just due to sloppy virology, or was HIV, once identified, manipulated and chosen as a bioweapon. A weapon that must have been a big disappointment as it took far too long to kill its victims. Intentional or not, in all likelihood it was introduced in the USA via the Hepatitis B vaccine trials that exclusively recruited gay men in New York, San Francisco and Los Angeles. The bottom-line is that vaccineologists in the 20th century were creating invasive medical interventions with no clue as to what they were doing and as a result murdered many. Or did they know what they were doing?
The situation in Africa is a little less clear, starting in 1957 [22], oral polio vaccines were administered by the Wistar Institute and given to “hundreds of thousands of Africans.” As with almost all vaccines there was no follow-up. The FDA has archived vaccines from that period and if they forensically looked at them to see if HIV was present, they have not told anyone. That would eliminate the conspiracy theories, but it would also implicate the whole vaccine program as a very problematic, unethical and sloppy endeavor to say the least.
Big Pharma, in the USA, was able to get unconditional liability protection from lawsuits related to adverse events from their vaccines in 1986. Safety was no longer their concern as the responsibility of vaccine safety was now the responsibility of the U.S. Government. So, there was an explosion of vaccines required for children, and a mysterious increase in sudden infant death syndrome, chronic health conditions and a formerly rare neurological disorder called autism. Autism is a post-vaccination encephalitis but the connection between vaccines, mercury, aluminum (found in ~ 80% of vaccines at toxic levels), acetaminophen and autism was deliberately covered up by agencies of the U.S. Government. When the CDC had the objective data the vaccines were connected to autism their response was to shred the data. A high-level whistleblower came forward and disclosed this but no one in government did anything - no hearings, no investigation - nothing. This was the subject of the documentary “Vaxxed.”
Big Pharma was already well on their way to capturing regulatory agencies and politicians. No one in the upper echelons of government would dare reveal what they knew, and they never did; however, that silence empowered the eugenics cult. The U.S. Government never met their obligations under the 1986 Vaccine Act and ignored all safety issues even as they pushed the mantra, “Safe & Effective” so that by the time CoV2 showed up the population was good and indoctrinated. Health & Human Services (HHS) already had decades of blowing off their responsibilities for vaccine safety and few seemed to care.
SARS -1, the predecessor to SARS-2 (CoV2) arrived on the scene in 2002, and in all likelihood was a test run. The reason one does not here about it anymore is that is has no natural host, and therefore not in circulation. If there is no natural host, then where did it come from? Is there wet market in the Wuhan virology lab? CoV2 was a made in the USA, but was sent to the Wuhan Virology Lab for enhancements that became illegal to do in the U.S.
There is strong circumstantial evidence that A/H1N1, the so-called novel Mexican Swine flu event of 2009 was neither Mexican nor novel, but a genetically engineered creation from the USA. The virus included genetic bits of North American human, avian and swine flus and Eurasian swine flu —the virus had not been detected in any pigs except those in a single herd in Canada [23]. A variant of A/H1N1 broke out in India in 2015, but has apparently not been a player since. No natural host.
Had there been a sincere and honest attempt to flesh out the origins of these viruses, again we would not be where we are today. While A/H1N1 was very infectious, the virus was no more problematic than the normal flu virus and has vanished. It may have just been a test run for a future release.
The destruction of the World Trade Center on 9/11, was another coup d’état this time by the NeoCon faction of the New World Order set. It greatly empowered them to have been able to get away with that event. Firing a missile into the Pentagon, but telling everyone it was a 757 jet, the overt demolishing of WTC 7 (no plane hit this building), and clear evidence WTC 1 & 2 were demolished. It was carried off by traitors within the USA in conjunction with several middle eastern countries. Much could be said here about the horrors unleashed post-coup d’état, but no one in officialdom would dare speak the obvious truths. It really set the stage for what would be coming soon enough. And what was that?… the continued NeoCon agenda to take over Eastern Europe (in violation of the agreement made with Gorbachev that there would be no expansion into Eastern Europe [by NATO] if the Warsaw Pact was dissolved).
The attempt to scare the world with the Zika virus was a really big flop. They would not make that mistake again. So quick to blame a relatively benign virus for the clusters of microcephaly in Brazil. However, too many found out fairly quickly that the pocket of mothers in Brazil who gave birth to children with microcephaly were vaccinated with DTP while pregnant and while drinking larvicide laden tap water at the same time. So, that attempt to scare the world had to be shut down immediately because a vaccine was clearly implicated. At the same time a sentinel paper was published - a retrospective look (using matched controls) at 30 years of DPT use in Africa showing in increased overall mortality 10-fold, so it was very important to shut down any interest in looking at the safety and efficacy of the DPT [24].
Which brings us to CoV2, and the announcement by Dr. Fauci in 2017, that a surprise outbreak was imminent. The plot was apparently hatched as far back as 1999, at the University of North Carolina. In the subsequent years numerous white papers, such as SARS 2025-2028, [25] the pandemic war games, such as Event 201, [26] which were priming both the media and the public. Finally, they would have the event that would allow them to bring in their great reset of the world economy and cull the population at the same time. Key players in multiple governments had already been compromised, regulatory agencies had been captured, and Big Pharma along with Big Tech were in total control of conventional media outlets.
Yet, CoV2 virus was not an infectious disease hellion. It took out the old and the infirm just like influenza does every year, so the hype had to go into overdrive, which the PCR tests accomplished cycled so high clean swabs would test positive. It was critical the number of deaths for CoV2 to be very high in order to generate the fear to justify what would come next. So, despite long standing rules for data collection and reporting, successfully used for years by all hospitals, medical examiners, coroners, and physicians, suddenly CDC changed the way they wanted deaths reported. Had they used the normal criteria the mortality figures would have had to be revised down 90%. The very people within government who might have sounded the alarm that we were being manipulated into a bio-security state based on false information were compromised as many of them would be able to earn millions of dollars from the licensing of the mRNA technology. It has been determined that almost half of all PCR results were false positives, which if nothing else calls into question the clinical trials used to validate the “vaccine.” [27] As an aside, we have never had a vaccine that makes the human body create a pathogen in a controlled way for an uncontrolled duration. The Spike protein is a significant pathogen - a loaded weapon if you will with no assurance it would control the outbreak.
What happened next was 50 countries panicked and were cajoled into signing secret agreements with Pfizer essentially putting them into receivership in exchange for the injections and monetary assistance from the World Bank and the International Monetary Fund [28]. An agreement to remain secret for 50 years. Any criticism of the injections or of Pfizer would be forbidden, Pfizer would not only direct the global response but also the response individual countries would have so a worldwide extermination system could be initiated. The Federal Drug Administration (FDA) now under operational control of the Department of Defense (DoD) even asked a federal court to allow them 55 years to hold onto the data they relied on to give Emergency Use Authorization for the Pfizer injection. There can only be one reason for this request, and that is the FDA/DoD didn’t want anyone to see that the Pfizer data showed that at best, one would have to inject 22,000 people to potentially prevent one death. No need to point out the Wuhan A strain was no longer in circulation. I am also sure they didn’t want anyone to see that there were more deaths in the injected group than in the control group.
The lack of early prevention and treatment protocols, and the persecution of anyone trying to treat COVID patients prior to hospitalization was not a form of treatment nihilism, it was a well-organized, well-funded conspiracy to make sure nothing would interfere with an injection rollout. Never have sick patients been turned away from hospitals and told to come back when their lips were blue.
All the big players were deeply, corruptly and maliciously in bed with Pharma, so would lose billions if it were found off-patent drugs could treat COVID. The FDA, under the direction of the Department of Defense (DoD), illegally exercised emergency use powers, and was a willing ally in the suppression of treatments known to be effective against the virus, such as something as benign as vitamin D. In some countries physicians were arrested for prescribing Ivermectin. Then injections were illegally marketed to children as well after the FDA advisory panelist said "We're never gonna learn about how safe the vaccine is until we start giving it," said panel member Dr. Eric Rubin. "That's just the way it goes." No Dr. Rubin… that is not the way it goes [29]. When you ignore safety, you tend to ignore whether the injection even works, and while the “science” is moving forward, unfortunately deluded technocrats were not [30]. The FDA stopped being a regulatory agency and became part of the other alphabet agencies to promote the “vaccine.” They saw their role was to get a needle in every arm, in everyone in every country - it was choreography to dance to the edicts of the DoD.
Pfizer now had the power to silence governments, maximize profits and power. Military bases, National Parks - just a few of the items signed over [31]. Big Tech and Pharma had bled out multiple governments to create this giant one world government monster with Pfizer calling the shots - literally. The human infestation would be eliminated with the silent, obedient consent of governments around the world.
Original Antigenic Sin
But there were problems. The injection was going to kill too many too fast (as intended) even though many of the injections were expired and ineffective (they were thawed for too long) and many blanks were shipped to many locations to mitigate the number of adverse events anticipated. Nevertheless, the body count increased as well hidden as those bodies may have been. They had to buffer the rollout of the injection because again it was supposed to have come on the scene after billions were already dead from CoV2 and few would be left to ask important questions.
One question was why give a non-sterilizing vaccine to everyone possible in the middle of a pandemic…all that would do is prolong the length of illness by pumping out a multitude of variants, which is exactly what took place. They were called variants because they had a different spike protein than the one the injection was having the human body manufacture, and so the efficacy of the injections started falling into the single digits [32]. This was all predicted well in advance, but the injections were rushed for socio-political reasons not medical/scientific reasons. Compare and contrast what took place in Gibraltar vs. Africa.
Africa, a heavy user of hydroxychloroquine (HCQ) - taken by millions - by the end 2021, the vaccination rates in 20 African countries wasn’t even close to coming out of the single digits.
Overall the African vaccination rate was around 6%, but for some reason the “experts” were mystified as to why there is so little COVID in Africa [33]. On the other hand, perhaps the most vaccinated country on the planet was Gibraltar where there is a 100%+ vaccination rate and yet cases of COVID were so high Christmas 2021, was canceled. Unintentionally, they proved boosters don’t work. In Singapore, with at 94% vaccination rate, cases and mortality spiked to record levels, and in Ireland, where 92% of the adult population is vaccinated, cases and mortality doubled [34]. England was the only country, worldwide, that seemed to keep accurate records of its deaths by vaccination status (at least for a while). The COVID vaccines used in England (mRNA & DNA vector vaccines Pfizer, Moderna, and Astrazenica) do not significantly reduce COVID mortality, but did result in greatly increased all-cause mortality [35]. Specifically in England, if you are under 60 and you get injected, you are twice as likely to die. As the months went by the mortality of the injected only increased.
The mortality from COVID in an African country, such as Zaire was 0.6 per 100,000. Almost no one received the injection. In the USA the mortality was 1000 per 100,000. There should be no need to read one more word if you understand the obvious implications of that last sentence. Even before President Trump announced he had taken HCQ, the drug was disappearing and countries were removing it from over-the-counter status and requiring prescriptions. Someone didn’t want HCQ to be around, and studies were being conducted with near lethal doses of HCQ in late-stage patients (no zinc, no azithromycin) - it was as if someone deliberately wanted to destroy any chance HCQ might have to help treat COVID patients. Then perhaps one of the most momentous medical frauds in history took place - both the New England Journal of Medicine and the Lancet simultaneously published completely fabricated, fictional articles that concluded HCQ was not efficacious. What someone(s) had the power to fund fraudulent studies, compromise the world’s top medical journals, and then get the Federal Drug Administration (FDA) to pull the emergency use authorization (EUA) for HCQ? Apparently, that was the FTX group. Even after the papers were retracted the FDA did not reinstate the EUA. This brings up the problem that there is no FDA - the DoD took over the FDA regarding all things COVID.
However, those who successfully destroyed the possibility of using HCQ for COVID weren’t done - they went after Ivermectin, but not with the same success. First and foremost, data from 19 countries that participated in the World Health Organization (WHO) sponsored African Programmed for Onchocerciasis Control (APOC), from 1995 until 2015, were compared with thirty-five (Non-APOC) - in other words, APOC countries are on Ivermectin. That may be why they had almost a 30% lower mortality from COVID than non-APOC countries [36]. But what took place in India was even better. Two provinces took opposite stands. Tamal Nadu followed WHO recommendations and had the same dismal stats that the USA had, but Uttar Pradesh supplied Ivermectin to its population and 97% of the cases were eliminated. Uttar Pradesh has 2/3rds the population of the USA.
Despite the data on Ivermectin, leaders from Australia to Austria actually believed the COVID injections worked and the unvaccinated were spreading CoV2 - they probably still believe it. Ignore the fact there are no unvaccinated in Gibraltar. Are these leaders psychotic or, following orders from the Fauci/Francis Collins/Gates/Bio-Pharmaceutical-Military complex? They wanted us to panic with each new variant, so they could continue to lock-down, take people to camps, and have the ability to inject humanity multiple times a year forever [37] …that was always the plan.
This was not the greatest public health disaster the USA had ever seen; this was done on purpose but when events deviated from what was projected the cabal scrambled to salvage the situation as best they could. So, insane medical rituals that had no foundation in science or medicine were pushed - the less than worthless cloth masks, the quarantining of health asymptomatic adults and children, the meaningless six feet social distancing (the pulled that out of their rear-ends).
Remember, those that expired were very old, fat and had multiple medical problems. There was never any credible reason to keep children from attending school and most lost two full years of education they will never be able to make up. Suicides increased, along with obesity and delays in treatment for medical problems that cost lives. The burden was on the poor who didn’t have jobs where they could work from home, while the elite rich got richer.
It doesn’t take a degree in immunology to understand that if you occupy the body’s immune system making a spike protein that is no longer connected to the circulating variant, not only is the vaccine worthless, it perniciously lowers one’s ability to deal with the actual viral infection one may get in the real world, because one’s immune system is busy making antibodies to something that is not present and may be oblivious to an actual virus invading the body. The CoV2 infection has a very low risk of myocarditis, but it is there. The injection had the body make massive amounts of spike protein, and the amounts the injection was having the body make caused significant myopericarditis. The FDA actually asked that prospective studies be done but they were never done by manufacturers. One such study has the actual risk is about 2.8% or about 3 people out of every 100. Conservative estimates have the risk at 1:<2000 (for context the Swine flu vaccine from the late ‘70’s was pulled when it was found the risk of a neurological disorder Guillain-Barre was 1:100,000).
The population continued to be told “Safe & Effective” and the usual “one in a million (side-effects).” There was 20 years of data showing corona viruses can cause heart disease, so one case of myocarditis should have shut the “vaccine” program down. But instead of pulling the vaccine the CDC went to work pushing the idea that the “vaccine” induced myocarditis was mild. It is just there is no such thing as mild myocarditis, in fact 20% of those that die within a day of receiving the “vaccine” have myocarditis [38]. There is only one solution…immediately end the worldwide vaccination program and try to help people repair their immune systems. But compromised, well-paid “experts” will never acknowledge this solution. There is just too much money to be made giving everyone more “vaccines.”
Then there is this insane group-think that needs to be overcome, because there are people in government, medicine and academia that have been so indoctrinated that if something is a vaccine it is safe & effective - end of story - they shut out objective reality at all costs. Even the government’s own VAERS vaccine adverse event reporting system produced a massive death safety signal. VAERS recognized for under reporting adverse events by 99-fold still produced a massive death safety signal, but between the corruption and group think it was ignored.
The response to this inconvenient data was to order people to get more and more worthless injections that would do nothing but cause side-effects. Yet the presence of so many un-injected showed how robust natural immunity is, still promoting natural immunity could put one on a terrorist watch list. They needed as many as possible to be injected as often as possible before the public became aware of the hidden sequalae of the injections. The control group had to be eliminated, or rounded up and terminated - at least that is what they wanted to happen.
Obviously, this story is not over. On their way out the globalists will do whatever they think they can get away with to undermine and collapse civilization, including more bioweapons, they know their future is bleak and would sooner take as many with them as possible. But all stories end sooner or later, and when the story of the New World Order ends, it will look nothing like what its proponents had in mind. So, fight for freedom of knowledge, and in place of deceit, intolerance and prejudice fight for the possibilities of understanding, truth and acceptance. For that is the reality humanity is moving towards no matter how hard those who dish out their cruelties try and stop this change. Change is inevitable - it is the only Universal constant.
Pharmakeia a false hope and deception of false peace, false healing, and a false future.
“The Armenian genocide was not a mistake; Holodomor was not a mistake; the Final Solution was not a mistake; the Killing Fields was not a mistake; the Great Leap Forward was not a mistake. Name your genocide it was not a mistake - that in includes the Great Democide of the 2020’s, to imply otherwise is to give “them” the out they are seeking.
“It was not botched; it was not bungled; it was not a blunder; it was not incompetence; it was not lack of knowledge; it was not spontaneous mass hysteria. The planning occurred in plain sight; the planning is still occurring in plain sight.
“The philanthropaths bought the science; the modelers projected the lies; testers concocted the crisis; the NGOs leased the academics; the scientists fabricated the findings; the mouth-pieces spewed the talking points; the organizations declared the emergency; the governments erected the walls; the departments rewrote the rules; the governors quashed the rights; the politicians passed the laws; the bankers installed the control grid; the stooges ordered the money; the DoD placed the orders; the corporations fulfilled their contracts; the regulators approved the solution; the laws shielded the contractors the agencies ignored the signals; the behemoths consolidated the media; the psychologists crafted the messaging; the propogandists chanted the slogans; the fact-chokers smeared the dissidents; the censors silenced the questioners; jack-boots stomped the dissenters; the tyrants summoned; the puppeteers jerked; the puppets danced; the colluders implemented; the doctors ordered; the hospitals administered; the menticide is scripted; the bamboozled leaded; the totalitarianized bullied; the COVIDians tattled; the parents surrendered; the good citizens believed and forgot.
“This was calculated; this was formulated; this was focused grouped; this was articulated; this was manufactured; this was falsified; this was coerced; this was invective; this was denied.
“We were terrorized; we were isolated; we were gas lite; we were dehumanized; we were wounded; we were killed. Don’t let them get away with it. Don’t let them get away with it. Don’t let them get away with it.”
---- by Margaret Anna Alice.
The world now knows, thanks to 46 Pages FOIA’ed emails between CDC managers, Dr. Fauci, Dr. Collins, and White House, NIH, HHS, that they all knew about vaccine-induced myocarditis and thrombotic thrombocytopenia in early 2021, despite that over 80% of the emails were redacted [1].
Every American citizen must be given access to this complete set of unredacted communications, and the guilty must be prosecuted in a special court arranged by the victims’ families.
We are still in the midst of the greatest worldwide psychological operation (Psy-Op) in the history of man. Not that long ago we were hunter-gatherers where family, purpose, cooperation and community where paramount to survival. We were never wired to withstand the level of psychological manipulation we have been experiencing the purpose of which was to invert reality so we could easily be led to slaughter. It has split our realities, and now we have two separate realities co-existing in the same space-time. The splitting of these two realities is inevitable, the only question is how will it happen.
It takes about 2 years, on average, for citizens in the United States of America (USA) to recognize they are being poisoned, for captured regulatory agencies to make some token inadequate attempt to fix the problem.
Now, who captured most of these agencies that are meant to regulate and protect… well, the obvious answer is Big Pharma - nothing new and no big surprise. Agencies developed mercantile relationships with the very companies they were supposed to be regulating - kind of an economic Stockholm Syndrome. Pharma cares about one thing - profits, and we have let this psychopathic entity run policy in multiple countries. Yet, does someone control Big Pharma like the military? Or is it Big Pharma that is in control of the military?
Maybe they just work hand and hand, because what we saw take place in the last few years is a Globalist military run operation where everyone seemed to be controlled by a central source… “Operation Lockstep?” if you will… even though the population was kept in the dark. After all, you just don’t announce there has been a Bio-Military coup of the US Government (along with many other countries) and expect the population will be ok with that. When it came to COVID, the FDA (Federal Drug Administration) was MIA, the Centers for Disease Control (CDC) was but rubberstamping because on a practical level there was no more CDC - they became the propaganda arm of Pharma prevaricating their dark little hearts out to the public. The FDA existed in name only when it came to COVID… it was all a military operation perhaps in cooperation with China’s 5th Column war to take down the USA. The CDC actually had the Public Relations firm for Pfizer/Moderna embed themselves inside the CDC. The CDC is a regulatory agency it is not supposed to be marketing the very things they are supposed to be regulating. But then they have been doing just that for all vaccines for decades and few complained. You never have the same entity in charge of promoting, distributing (that also owns patents) on vaccines also be in charge of safety - that is a recipe for disaster.
It was an out-in-the-open fact that the NIH was funding Gain-of-Function research at the Wuhan lab [2]. In 2015, a paper was published, A SARS -like cluster of circulation bat coronaviruses shows potential for human emergence. This study clearly states that the authors conducted Gain-of-Function research on bat coronaviruses in order to make them infectious to primary human airway epithelial cells. Ralph Baric (University North Carolina) and colleague, Zhengli-Li Shi were very much engineering the CoV2 virus in Wuhan to make sure that virus was highly infectious to humans. So, literally everything that came out of Fauci’s mouth and the rest of the government was gas-lighting.
Western Civilization, was targeted for destruction and subjected to an intense propaganda campaign to create a permanent global government, but beneath the Psy-Op a spiritual war. Not being tangential here, but one can’t ignore these Macro disease issues - the spiritual sickness component of all this and expect to understand the Micro disease issues, such as how does one deal with the myocarditis the bioweapon causes. Part of this spiritual war is to destroy the experiment called the USA - a Constitutional Republic where rights were given by God. That doesn’t work for the imperialistic New World Order group. The USA was always the thorn in their side and had to be destroyed and they got very far along in doing so, too far it seems. Gates and Zuckerberg have poured in millions upon millions into the public education system in the USA but students have only been getting dumber and dumber, so one has to assume all that money was not to improve education but destroy it. You don’t want your future slaves to be educated - indoctrinated absolutely - but not educated. The dumbing down of Americans was by design.
Nature, the creative spark of life, is an anathema to this group of misanthropes who pretend they care about the environment. We are just useless eaters and bottom-feeders to them to be exploited and killed, but humanity must know the enemy to end this. If we don’t’ face this head-on then Pharma will take over the world and will make sure, for example, you can’t travel if you are over 14 and not taking a statin drug.
It was easy to lose faith in humanity when it was so obvious millions were being encouraged to illegally come to the USA (weaponized immigration) and bring one of the bio-weapons being used to destroy us from the inside. Not CoV2 but Fentanyl. Because journalists (the legacy press), was captured and carried water for these enemies and traitors, the failsafe that would have prevented all this was removed. Without the media CoV2 would have just been another flu like illness that primarily affected the elderly and those with multiple co-morbidities. Remember how the flu completely disappeared in 2020? The media truly was the virus and also made sure you didn’t know the USA was being invaded as policy - globalist United Nations policy.
Yet, the flu never disappeared it was just called COVID to juice the numbers in a case-demic extraordinaire (PCR tests cycled so high clean swabs would be positive). We actually saw our hospitals become de facto euthanasia factories inappropriately putting patients on ventilators and pumping them full of the deadly drug Remdesivir (what nurses called “Run-Your-Death-is Near”). I always wondered if all the videos of dancing nurses was their way of telling the public that hospitals were not being overwhelmed with COVID patients. But there was no science supporting the use of Remdesivir and it was well known as a deadly drug that was killing Ebola victims in a drug trial and its use was halted. But the regulatory gatekeepers were all compromised, fired or had resigned in disgust. The hospitals received a 20% payment bonus if they used the drug. A $500,000 hospital bill would generate an extra $150,000 if Remdesivir was used. Putting a patient on a ventilator earned the hospital $40,000. A lot of money to help hospitals make choices about priorities (wink, wink).
Media organizations played a central role, especially Big Tech IT companies, in stifling anything that wasn’t the approved narrative. Mainstream scientists, many leading experts in their field, working in prestigious institutions, and some medical journal editors themselves were all silenced, while others were paid off. Where was all the billions coming from to create fabricated research critical of effective early interventions such as hydroxychloroquine (HCQ) and Ivermectin? How much did the New England Journal of Medicine and Lancet get from FTX (the criminal crypto group) to publish articles so obviously flawed they would have been the cause of expulsion from any academic center that still had any integrity. FTX was critical in funding the attacks on effective early interventions with the resultant loss of life.
FTX, backed by elite investors like BlackRock (Rockefeller Foundation) and Sequoia Capital, rapidly became one of the biggest crypto exchanges in the world… laundering and stealing investor funds to bankroll the Neo-Con proxy war in Ukraine, and the Democrat party to name two pet projects. Laundering money to the “right” people, Bankman-Fried had Wall Street and the media in his pocket while he practiced effective altruism (aka deceit that makes one look like a moral leader). But it was just another Ponzi scheme that was funding favorite New World Order players. It happened right out in the open. Bankman-Fried’s mother was apparently responsible for running major voter harvesting operations in the 2020 election, so the FTX group was a critical component of a fraudulent government and its fraudulent economy. Yet, maybe FTX’s implosion was all part of a bigger scam to allow a centrally controlled digital currency to come to the fore.
Wonder why it was so important to keep the conflict in Ukraine going with no efforts at peace negotiations? Yeah, it was a money laundering operation and they never wanted it to end even if the end was an all-out nuclear holocaust. Few knew Ukraine was the playground for the dark ones - the local population didn’t know any more than USA citizens knew their country is actually the headquarters of the dark ones and that our Constitutional Republic vanished years ago. Drug trafficking, sex trade, organ harvesting, etc. all taking place in Ukraine without any interference until the Russian invasion. Just an aside… don’t invest with anyone who looks and smells like they can’t afford a bar of soap.
Pandemic/Scamdemic
Decades of pandemic preparedness protocols were trashed so a psychotic, pip-squeak, criminal mastermind could enrich himself, and his loyal following (loyal because he controlled their NIH grants). It seems, based on the FOIA documents Fauci may have been telling the CIA what to do not the other way around. We were literally in the middle of a Godfather movie, but it wasn’t Don Corleone calling the shots but dog torturer, vivisectionist, Don “I am the Science.” There was some truth to that statement though, because this one man literally was the point man for distributing $10’s of billions of dollars to academic and research institutions throughout the world, so he had almost complete control of the “science.” This was a very dark, pernicious situation, for example, if a research team finds out that it is very dangerous to inject vaccines that contain aluminum (80% of vaccines contain aluminum) that research team will be defunded and journals will be told not to print their research papers.
Eighty-six percent of the world was shut down for an infection that had a 0.035% mortality from 0 to 59 years of age, 0.095% mortality for the post 60 set [3]. If you are younger than 20 the fatality rate was 0.0003%. Clearly, this is below fatality rates from the flu and yet this was the emergency that allowed them to bypass safety studies and force/coerce people to get an experimental injections that had never been used before and lie about what they would do. They even lied about saying the “vaccine” would prevent transmission and infection and of course was safe and effective as they say all vaccines are…safe and effective became an indoctrination mantra. Most vaccines do not have adequate safety studies despite what we have all been led to believe. This was not just regulatory maleficence - this was about trashing the U.S. Constitution and murdering as many as possible in the process.
The median/mean age of death from COVID holds steady at 82 years of age. Seventy percent of the mortality in the USA were in the elderly with six or more underlying medical conditions. If it were not going to be COVID it would have been something else as they were already beyond the average life expectancy. Over the last three years no healthy child in the USA died from a CoV2 infection… not a single healthy child.
Well, we weren’t supposed to be alive to discuss any of this, but the criminal “reset” plan failed out of the starting gate because CoV2 was supposed to have killed billions and the jab was supposed to finish off as many survivors as possible. Too many people were left alive asking inconvenient questions. One of the few true responsibilities of a government is to protect the integrity of the nation’s border, but the so-called “open border” was intended to bring in a replacement population, because the rest of us were supposed to be already dead or dying.
If you can’t define the enemy you can’t defeat your enemy
One of the things that makes fleshing out these events important is medicine as we have known it will not survive - the population is losing and will soon lose completely any trust in Public Health institutions and modern medicine in general, and that trust won’t be coming back any time soon nor should it. Evidence Based Medicine (EBM) was destroyed during the last few years and public health decisions were being made on plausibility, as in how much money is it plausible to make if we force deadly injections on the public that don’t even work and lock them down?
Modern medicine decided to follow a dark agenda and became a dark influence. While COVID may have been a Hail Mary for the dying paradigm of the Bio-Military-Pharmaceutical complex to maintain control it still caused a lot of death and suffering. They will try and regroup if we don’t all wake-up. I will assume that post financial collapse the money to fund many of these shenanigans just won’t be there to fuel the murder. The lockdown fetishism imposed on us was an import from China as part of their 5th column attack to destroy our economy, but it was also the agenda of the NWO/WEF set.
Human history has been replete with invasions, attacks, trade wars, etc. It seems like raging war on each other was chosen to be the primary operational paradigm on this planet. For the most part they were driven by the need to eat, have land to grow food, trade routes, etc. I am not assigning blame and after all it was the crucible of our modern civilization, which I have to say has not turned out so well. Today, war is machine - unending on anything and everything be it COVID, drugs, terrorism, Afghanistan - it doesn’t matter. The population is never told the real reasons for war, which is to wash money out of our hands and into the hands of this group of dark elites. So, war is never over, there is always another and it never stops.
Alexander the Great wanted to take over the world, but even he wouldn’t recognize modern war even though he was a one-man wrecking crew. Even the Roman Empire was less about cruelty, power and greed than what human kind now experiences. In the 1200s CE, the Mongol hoard pieced together the largest contagious empire the world had ever seen and unlike the plethora of wars that preceded it, this was being driven by power, cruelty, brutality without honor and greed. Energetically, Earth was being beset upon by a dark energy that was not home grown, it was only present because there were enough humans who held these negative traits for this energy to become interested in feeding off of them and the havoc they could reap. The generation of fear is key to its survival or presence on this planet - fear (the opposite of love) is the gasoline this dark force runs on.
What does any of this ancient esoterica have to do with what we are experiencing today where the USA government, the largest empire in modern times, has become vicious, incompetent, utterly corrupt and under the control of agendas pushed from elsewhere.
They know they are lying; we know they are lying; they know we know they are lying
The Southern border of the USA was in full operational control by traitors inside the USA and that control was to keep the boarder wide open and lie about it - it is a weaponized invasion. The American people didn’t understand their country had been taken over. Since it seems politicians lie and can’t stop themselves from lying, the public lost the ability to know big lies from small lies - call it some kind of desensitization but it produced an apathy that only empowered the cabal. Institutionalized lying is a major factor that enables LIERS-IN-CHIEF to carry out their illegal, immoral and criminal practices of institutionalized discrimination, retaliation, defamation, and intellectual harassment.
Deception is the modus operandi of the dark ones, which is why free speech had to be eliminated in their playbook. Puppets are never told the true reasons for doing what they are doing, only the upper tier of puppets are made privy to some of this information. For example, the CIA hitman who murdered Marylin Monroe was told she was sleeping with Castro and leaking to him things JFK had whispered to her under the sheets. Normand Hodges said he carried out 37 assassinations for the USA between 1959-1972.
Follow the Money
Jumping ahead in this story to address one of the top puppets, Peter Daszak, who is a perfect example of how this dark energy turns the like-minded into its puppets. Can you believe that a scientist funded by the U.S. government could possibly create a virus on purpose to release it and then hype up a resulting infectious disease crisis all for profit and power? Daszak’s Eco-Health Alliance was essentially a front group for a faction of the CIA.
“Daszak reiterated that, until an infectious disease crisis is very real, present, and at an emergency threshold, it is often largely ignored. To sustain the funding base beyond the crisis, he said, we need to increase public understanding of the need for MCMs (medical countermeasures) such as a pan-influenza or pan-coronavirus vaccine. A key driver is the media, and the economics follow the hype. We need to use that hype to our advantage to get to the real issues. Investors will respond if they see profit at the end of process, Daszak stated.”
The above paragraph is from page 73 of Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public and Private-Sector Partnerships - published by the National Academy of Sciences in 2016 [4].
How did we get here?
We know so little about the true history of mankind on this planet - the great civilizations that have waxed and waned long before recorded modern history [5]. Regardless of the time or place, oligarchs of the civilizations that we do know about have been obsessed with over-population going back to at least the days of Plato (Plato [De republica, V] and Aristotle [De republica, II, vi]). While, there are some areas on the planet that have too many humans in the same space or in the wrong place, over-population itself is a myth perpetuated to help the ruling class maintain control - it is about wealth transfer. Even though most of humanity is not aware of the full extent of what has been going on, open war has been declared by those who want to repress and command with the purpose of keeping the rest of us unconscious, keep us from being inquiring beings, keep us from knowing how strong the human spirit is or exploring what we are capable of becoming. This is the emotional grid they want to impose. They want to keep us small, controlled so they can feed off of our assets and energies. They are literally deranged fools whose minds have been warped by their greed and the covenant they have made with forces that have always lied to them and continue to lie to them. This struggle is not new and is addressed in fable and parable by many of the world’s ancient texts, but this is not speculation of what has happened in the far past, this is about what is happening now and why.
Lose your Spirit and you have lost everything … Lionel Richi (singer/song writer)
It is problematic that humans think they are nothing more than evolved mammalian primates (apes). Yes, those are the bodies we use, but we are spiritual beings having a human experience, not just naked apes that aspire to be spiritual. Spirit is not the enthusiasm you have for your local high school football team. It would behoove us all to try and understand what spirit is because there have been those trying to kill you for having one. There are juicy energies and powers connected with being human - a subject humans are almost completely unaware; however, there are those who know about these hidden features of the human experience and want those energies and powers for themselves. Without belaboring the point, tyranny can only be imposed if the population believes they are nothing more than their animal bodies limited to their five senses. Tyranny runs on fear and it is much harder to scare someone who is not completely tied to what their five senses tell them reality is all about. Tyranny cannot exist where there is freedom of speech so it is really easy to tell who the “bad” guys are…they censor and don’t want freedom of speech.
Where this Timeline starts
In a timeline that starts in 1933, although the darkness got its foothold long before that, a group of bankers hatched a plot to replace U.S. President Franklin Roosevelt with someone who was more in line with these entrenched institutions and the systemic ideologies that do not want democracies to exist. These dark ones were still drunk on their success from being able to create the Federal Reserve. There was no coup d’état because their point man, retired Marine Corps General Smedley Butler, betrayed them. So, the banking cabal shifted all their attention to Germany.
That same year the Public Health Service of the USA began its infamous Tuskegee Experiment on poor black males in Alabama. An experiment that lasted 40 years, and only ended in 1972 because of a leak to the press. Under the guise of receiving free health care, the victims were watched to see what the ravages of syphilis would do to them and their families. No Nuremberg trial held, no accountability - but if you are an American apparently, it’s okay to say you were just following orders if caught and it’s all mea culpa and asking for amnesty.
The lessons of the last century have not been completely understood, and now humanity is in that awkward place where there is a reckoning with these poorly understood experiences that have been swept under the rug. However, the rug is now gone and it would behoove the world to recognize the players of our immediate past for who they really were. For example, Adolf Hitler was probably the greatest teacher of hate the 20th century had ever seen. Intolerance was intense in the western world a century ago, and he filled the calling others had prepared for someone with this intention and influence. He had other options for his life, which he closed down early.
Bringing up Hitler or suggesting we are unduly influenced by energies we can’t perceive - many will just tune out, but that is merely a reflection of how indoctrinated we have all become. Indoctrinated by negative energies that have kept us trapped for millennia in deception, delusion, fear and wars, and part of that indoctrination was to convince us we were powerless to change any of this. Rather sad that the megalomanic leading this was again a German national, Klaus Schwab. One would have thought we were done with that part of our history.
In one sentence this is what WW II was about…Hitler, like Schwab, was merely a tool for large international corporations and banks that were funding him to implement a top-down feudal economy in Europe that would hopefully expand worldwide and reign for a 1000 years or as long as they had the slaves to feed into the system. Yet, their tool became too unstable, too unpredictable and too uncontrollable as he tried to take over the entire planet. The globalists were still able to use him as a pretext for the NATO/European Union (EU) paradigm to control Europe. Now, with both the inspiration for Hitler and much of his financial support coming from inside the USA, it was no surprise that Operation Paperclip brought so many Nazi scientists and technocrats to the USA after the kinetic war was completed (~30,000 Nazis). The American Nazis; although, they did not call themselves Nazis, brought their assets back while Hitler himself, a deletant compared to the fools who have made war against us today, was allowed to retire to South America [6].
The eugenicists in America (and to some extent England) were a great influence and inspiration to the Nazi regime and in fact it was a part of the defense used in the Nuremberg trials to justify the programs they implemented. But there were other influencers as well, and they may still be present today. The upper tier of Nazidom were deeply into the dark side of occult esoterica. The swastika itself was an ancient symbol of the universe so what the Nazi’s did was use that symbol rotating to the left or counter-clockwise - a symbol of a devolving universe, not an evolving universe shown when it rotates to the right [7].
This symbol drew in those worldwide who knew what it meant (rotating counter clockwise), which is why, for example, dead Tibetans were reported to have been found among the casualties in WW II… sorcerers perhaps enlisted to help with dark rituals. Rituals are really important to the puppets of darkness as it provides them with a sense of power. They are now flaunting some of their rituals in the open, just to name three - the weird closing Olympic ceremony in London 2012, which heralded a plague that would put many in hospital [8]. In late 2021, the rapper Travis Scott’s Astroworld performance was not only overtly satanic but murders (human sacrifices?) took place during the performance. In 2022, the overtly satanic advertisements of Balenciaga.
It would surprise many to find out just who these puppets of darkness have been and currently are. For example, Madeleine Albright, former Secretary of State, was celebrated when she passed in 2022, despite being a mass murderer. She publicly announced the sanctions that were imposed on Iraq that killed over half a million children were worth it. Research who has attended the ceremonies at Bohemian Grove (Northern California) where they worship the false deity Molech, and you may be surprised [9]. Then there is the Bilderberg/Davos group and their High Priests (that is literally what they call themselves) - a smarmier group of international corporate scum and villainy you will never find. The World Economic Forum (WEF) is just a front group for these power crazed psychopaths who draw into their circle those who are in synch with them (the Law of Attraction), and they may not all be human, which is almost a guarantee.
Consider the possibility that we are part of a universe replete with life and intelligences of all types and strips be they seen or unseen - trillions upon trillions of conscious beings to a greater or lesser degree. It is regrettable that humans are so unaware, and so misinformed about our participation in the cosmos and we are even less aware of non-humans in the affairs of our lives and our planet. Some seem to be divinely angelic; some are more like predatory parasites.
As questionable as the influence of these low vibrational “others” might be, they probably weren’t responsible for the descent of certain governments into satanic, murderous, pedophile networks used to control and manipulate those that entered the halls of power. Pedophilia is the sick glue that holds their system together. The dark ones know children, especially young children, are closer to Source and by defiling them, by being brutal and cruel one is showing God that you are a counterion - an angry counterion. Why would you want to show God you are an angry counterion? Seems counter-intuitive, but foolish humans believed the promises made to them about personal power and wealth, so for the weak minded… that apparently is all it takes, an unfortunately there are many with weak minds.
This is beyond mere corruption; world governments had been bled out from the inside by these global predators. In fact, international banks, working with Pfizer, successfully executed a planetary coup against the nation-state. Pfizer is the most criminally fined corporation in America that admitted in front of the EU that they never tested the COVID injection to see if it would stop transmission or infection. Of course now we know it doesn’t.
References
Medullary Thyroid Carcinoma is derived from parafollicular C-cells that normally secretes peptide hormones such as calcitonin, serotonin and vasoactive intestinal peptides and thus it is widely accepted as a neuroendocrine tumor. MTC usually has a good prognosis with a 10 years survival rate of approximately 95.6% in cases restricted to the thyroid gland, but reduces to 40% for those presenting with metastasis. Surgery is considered the primary and best modality of treatment in Medullary Thyroid Carcinoma. Here we present a case of a successful surgical management of a 38 year old female patient of sporadic, medullary thyroid carcinoma with sub sternal extension of the disease.
Keywords: MTC; Sporadic; Total Thyroidectomy; Sub-Sternal Extension
References
Introduction: Cranioplasty is a reconstructive procedure designed to repair skull defects or restore skull continuity following a previous operation or injury. Reconstruction with cranioplasty may be required after craniectomy to manage aesthetic disfigurement, increased intracranial pressure due to traumatic brain injury, ischemic stroke, or brain tumors.
Materials and Methods: This was a retrospective study carried out on 51 patients with cranial defects of different etiologies, sites and sizes who had cranioplasty in our hospital from January 2019 to December 2022.
Results: Fifty one patients included in the study, majority were in the age group of 21-30 years (37.3%). Mean age of the patients was 27.3 years. All patients had artificial material, polymethylmethacrylate (PMMA). The outcome of the procedure was good. The overall complication rate of 9.8% and reoperation rate of 3.8% were seen among our patients.
Conclusion: Cerebral protection and aesthetic contour of the cranium were achieved in all our patients. Cranioplasty is not without complications; however, good results are achievable in most of the patients.
Keywords: cranioplasty; craniectomy; trauma; brain
References
Background: The sagittal split osteotomy method for extraction of the mandibular third molars can be used in cases of deeply seated teeth, positioned in proximity to the mandibular canal, jeopardizing the integrity of the inferior alveolar nerve and the mandible itself. The classic sagittal split osteotomy approach, adopted from orthognathic surgery, may increase the risk of postoperative malocclusion and Temporomandibular joint dysfunction. For this reason, we would like to purpose a modified technique of sagittal split osteotomy that can be used for extractions.
Methods: This study presents a case of using a modified incomplete sagittal split osteotomy approach for the extraction of a deeply impacted right mandibular third molar in a 43-year-old man under general anesthesia.
Results: Only the superior border of the mandibular cortex was separated for approaching the impacted tooth while leaving the inferior cortex intact. After the surgery no inferior alveolar nerve sensory deficit was observed and the incomplete fracture was reduced back to the original anatomical position.
Conclusions: We suggest using the incomplete sagittal split osteotomy technique in deeply impacted third molars which pose a high risk when extracted. It allows for superior healing with perfect alignment of the segments.
Keywords: Sagittal split osteotomy; Third molars; Extraction; Wisdom teeth; Impacted
Understanding Biomedical Waste
Biomedical waste encompasses various materials generated during healthcare activities, including hospitals, clinics, laboratories, and research facilities. These waste materials can include sharps (needles, scalpels), pathological waste, pharmaceuticals, chemicals, and contaminated materials. It is essential to segregate and handle these wastes appropriately to minimize risks.
Hazards of Improper Biomedical Waste Management
When biomedical waste is improperly handled, it can lead to infections and diseases spreading among healthcare workers, waste handlers, and the general public. As a result, untreated biomedical waste can pollute water, soil, and air, posing long-term health hazards and environmental pollution.
Segregation and Collection
Effective waste management begins with proper segregation at the source. Healthcare facilities should implement color-coded containers for different types of waste to ensure correct segregation. This includes separate bins for sharps, infectious waste, pharmaceutical waste, and general non-hazardous waste. Trained staff should collect and transport these segregated wastes to designated storage areas.
Safe Handling and Storage
Biomedical waste should be handled with caution to minimize the risk of injuries and infections. Healthcare workers and waste handlers must utilize personal protective equipment (PPE) such as gloves, masks, and goggles while handling potentially hazardous waste. Secure and labelled storage areas with restricted access should be in place to prevent unauthorized handling and ensure proper containment.
Treatment and Disposal Methods
Biomedical waste requires appropriate treatment before final disposal to neutralize any potential hazards. Common treatment methods include incineration, autoclaving, microwaving, and chemical disinfection. The choice of treatment method depends on the type and volume of waste. After treatment, the waste can be safely disposed of in designated landfill sites or through authorized waste management services.
Training and Education
Proper biomedical waste management relies on the knowledge and commitment of healthcare professionals, waste handlers, and support staff. Regular training sessions and educational programs should be conducted to raise awareness about the importance of waste segregation, handling protocols, and safety measures. This helps ensure compliance with regulations and fosters a culture of responsible waste management.
Conclusion
Effective biomedical waste management is vital for protecting public health, minimizing environmental pollution, and ensuring the safety of healthcare workers and waste handlers. By implementing proper segregation, safe handling practices, and appropriate treatment and disposal methods, we can mitigate the risks associated with biomedical waste. It is a collective responsibility of healthcare institutions, government bodies, and individuals to prioritize and invest in comprehensive biomedical waste management systems, thereby creating a safer and healthier environment for all.
Biomedical waste, also known as healthcare or medical waste, poses significant risks to public health and the environment if not managed properly. With the rapid growth of the healthcare industry, it becomes crucial to implement effective biomedical waste management practices. In this article, we delve into the importance of proper biomedical waste management, its potential hazards, and strategies to ensure the safe handling, treatment, and disposal of biomedical waste.
The deep and long-term consequencies of the current wars all over the world, with physical and mental trauma on individual and social levels, require solidarity, support and help to all, including the health professionals. As an artist, an art therapist and a human, I dedicate this art collage to all of them all over the world, to express my admiration and gratefulness. Thank you, dear Medics!
The Hippocratic Oath is a covenant to treat and heal everybody and everywhere without any discrimination. Many doctors and other health professionals face big risks when dealing with dangerous illnesses, testing new treatments on themselves, working in war times where their life is in danger, helping people through earthquakes, inondations, forest fires, hurricanes... They are everyday heroes and we have to honour them. We are grateful for their dedication.
References
The objective of this Case Report was to determine that the use of an Autologous Dentinal Graft is so efficient that it shows comparable results and clinical performance similar to autologous bone, when used as a graft material in Immediate Post-Extraction Implants.
A Literature Review was carried out and various results were found from Meta-Analyses, Systematic Reviews, Clinical Trials (In Vitro and Animal), Randomized Controlled Studies, Prospective and Retrospective Studies to Case Reports.
The results reported in all studies conclude that the use of Autologous Particulate Dentine or Mineralized or Demineralized Dentine Matrix show clinical, histological performance similar to autologous bone and superior to Xenograft.
Autologous dentin is an effective option for bone augmentation around dental implants, with acceptable primary stability, marginal bone loss, and incidences of complications or failures.
Keywords: dentin; autologous; regeneration; implant; post-extraction
References
Respiratory viral infections are caused by a diverse group of viruses, including influenza A and B viruses, severe acute respiratory syndrome virus 2, respiratory syncytial virus, and human rhinovirus. Respiratory syncytial virus (RSV) is a common and highly contagious virus that affects the lower respiratory tract and can lead to severe illness in infants, young children, and older adults. After more than 60 years of research for developing an efficient vaccine against this single-stranded virus, the Center for Disease Control and Prevention (CDC) recently recommended two newly developed RSV vaccines, RSVPreF3OA (Arexvy) by GlaxoSmithKline (GSK) and RSVpreF (Abrysvo) by Pfizer. Both vaccines are approved to be administered as a single dose for ages 60 and older but Abrysvo is for those between 32 to 36 weeks of pregnancy to help protect their newborns. According to a CDC report, there are no substantial differences between these two vaccines and both were 80 to 90 percent effective in reducing RSV illness during the first season after vaccination. This article will discuss the epidemiological effects of RSV in the community, focusing on its prevalence, transmission, diagnostics, treatment, and prevention strategies.
Keywords: RSV; Vaccine; Infection; Immunity; Prevention
References
Introduction: When placing dental implants, there is some difficulty when rehabilitating some patients when they have low bone density. Therefore, one treatment option is bone regeneration surgery using an autologous dentin injector. And by using said injector, the aim is to promote osteogenesis, osteoinduction and osteoconduction.
Aim: To evaluate the vertical increase in a bone defect using the KometaBio system, by Cone beamTomography.
Method: Male patient presents with a vertical bone defect in the upper anterior sector for implant placement. The bone regeneration technique of choice was placement of an autologous dentin injector, with the KometaBio system to achieve vertical increase, which was evaluated after 6 months by means of Cone beam Tomography, to subsequently continue with assessment and implant planning.
Results: A vertical bone increase was found in the area of the dental organ 21, which was: 4.07 mm in the turbinate, 0.10 mm medially and 0.98 in the apical area.
Conclusion: The autogenous dentin injector appears to be able to promote bone formation through repeated osteoinduction and osteoconduction in vertical and horizontal bone defects, providing adequate bone density for future implant placement.
Keywords: Guided bone regeneration; Autologous dentin graft; Osseointegration
More scientific validation today indicates that most cancer patients have experienced some sort of trauma. Any kind of trauma, subtle or strong, average or accentuated, puts us on the path of fight and flight response. The body becomes reactive, and the body becomes a chemical factory, reacting. Such development of reaction is what we call cancer.
This has been backed by the tremendous work of a German doctor, Dr. Hamer. His belief was that when an unexpected, distressing event / trauma occurs, the biological program, called cancer is triggered.
Being sensitive to emotions and psychology, disappointments, depression, hurt, pain, suffering, resentments, and harbored hatred, all such emotional and psychological toxins and imbalances influence and impact our wellness.
The body's defense mechanism primarily goes out of hand, ungoverned, and instead of protection, it can kill, if not checked, well in time.
All kinds of such influences on us disturb our immunity, immunoglobulins, T-cells, our B-cell secretion, they disturb our digestion, process of absorption of nutrients, and elimination of toxins.
All this becomes a force multiplier effect and of course, then that develops into cysts, lumps, and knots which then keep growing, crowding the organ, and then of course begin to migrate and spread within the body.
Even while stressful life events are challenging to predict or prepare for, their potential connection to breast cancer development could give new perspectives into the disease's prevention and therapy.
Our bodies release the hormone cortisol when we are under stress. The stress hormone cortisol has been associated with an increased risk of breast cancer.
Additionally, stress can hinder our bodies' ability to combat cancerous cells. Neurotransmitters like norepinephrine are released when the body is under stress, which stimulates cancer cells.
Chronic stress exposure has been associated with adverse adjustments in the body's homeostasis. Telomere shortening caused by stress may affect cellular aging and have negative effects on health. This is how stress can cause cancer of the breast.
Controlling stress factors using a variety of self-learned coping mechanisms or seeking professional help to deal with unpleasant emotions early on should undoubtedly have a positive impact on women's health.
So drop your anxieties, dissolve your fears, let your insecurities get dwindled.
The emotional and psychological catharsis of screaming, crying, recreation, laughing, dancing, joy, reminiscing happiness, the joy of the past along with lots of rhythmic, calming, tranquilizing and regulated breaths, optimal movement and clean green nutrition, can certainly begin to heal and harmonize.
Among the medical fraternity, a famous scientist, Bruce Lipton, who has won many coveted awards, has mentioned in his popular book, The Biology of Belief, that “Your belief can change your Biology”.
Reportedly, many patients who suffered, benefitted by this understanding and simply by applying mental attitude, optimism, affirmations and faith. No wonder, Dr. Bruce Lipton has gained a lot of credibility.
Dr. Mickey Mehta says, your faith can change your physiology, breath can change your hormonology, meditation and prayers can change your emotion and psychology.
With optimism, faith and belief, begin to believe that you are whole, and healing and you will become whole and healed.
This faith elevates the mood and so turns the biochemistry, which in turn secretes happy hormones. Therefore, we can say, that Faith is happiness.
Your intentions, emotions, energy translates amavish (poison) to amruta (nectar).
Maintaining a general healthy pH balance in the body is fundamental for overall health. pH disturbances, defined as considerable deviations from the normal pH range, can have a variety of effects on the body's restoration and homeostasis. Mood conditions, emotional make up and your psychological ill effects can keep your body in the acidic zone and this can increase chances and be a cause of cancer.
This can lead to a disturbance in the circadian rhythm. The circadian rhythm is a natural, endogenous process that regulates the sleep-wake cycle and occurs approximately once every 24 hours. This internal clock is regulated by external cues like as light and darkness and is critical in regulating a variety of physiological functions such as hormone secretion, metabolism, and immunological function.
The circadian rhythm affects the release of hormones like cortisol, which regulates metabolism and the immune system. Circadian rhythm disruptions may have a direct impact on hormone balance, potentially influencing systems related to cancer development.
Maintaining a regular sleep-wake cycle, limiting light exposure at night, and adopting healthy sleep habits are all techniques that may assist sustain a healthy circadian rhythm.
The relationship between attitude, optimism, and food biochemistry involves the interaction of psychological and physiological components.
While the impact of attitude and optimism on food biochemistry is complex, there are a number of ways in which mental and emotional states can influence eating behaviour and, thus, the body's response to food.
Mind - body connection - The notion of the mind-body connection acknowledges the interaction of psychological and physiological variables.
Dr. Hamer has indicated achieving high success rates in last stage cancer patients with a form of mind - body healing.
Positive attitudes and optimism have been related to overall well-being, including enhanced mental health. A good attitude may influence healthy lifestyle choices, including eating choices, which can have a positive impact on biological processes.
Stress and cortisol level - Stress levels can be influenced by one's attitude and optimism. Chronic stress is linked to higher cortisol levels, a hormone involved in metabolism and energy management. Changes in eating patterns caused by stress may contribute to changes in blood sugar levels and metabolic processes.
Dopamine release - Dopamine is a neurotransmitter that has been linked to pleasure and reward. Dopamine release can be enhanced by positive experiences and attitudes. Food selection and eating, particularly delicious and fulfilling foods, can also cause dopamine release, altering the biochemistry of reward and satisfaction.
Emotional eating - Eating habits can be influenced by one's attitude and emotions. Some people may indulge in emotional eating, which is when they utilize food as a coping method for stress or bad feelings. Emotional eating can lead to the consumption of certain foods, which can have a variety of impacts on biochemistry, including changes in neurotransmitters and hormones.
Nutrient absorption - Chronic stress, for example, has been linked to alterations in gastrointestinal function and may impact nutrient absorption.
Inflammation and immune system - Reduced inflammation and improved immune function have been linked to positive attitude and optimism. Chronic inflammation has been linked to a variety of health problems, including metabolic abnormalities. Positive emotional states may help to balance the inflammatory response and improve overall immunological function.
Promoting longevity, immunity, and vitality can contribute to overall well-being and may play a role in prevention of cancer and other fatal diseases.
There have been a lot of studies conducted by the likes of Deepak Chopra, Baba Ramdev's Patanjali Research Foundation and findings of Sadhguru and Sri Sri Ravi Shankar Ji, Maharishi Mahesh Yogiji and other scientists of the world which includes Elizabeth Blackburn's findings on telomeres which state that good mood, faith and optimism are the causes of longevity, immunity and vitality.
Here are some broad principles that may contribute to longevity, immunity, and vitality, with a focus on cancer prevention:
Include Food For Gods - Healthy, wholesome and well balanced food supplies critical nutrients for energy, immunological function, and tissue repair.
This can be attained better with the use of plant-based foods. VEGETARIANISM is the ideal way to great health and well-being.
Consuming sattvik foods that are high in vital nutrients with a variety of seasonal and regional fruits and vegetables. These foods are high in antioxidants, vitamins, and minerals, which promote overall health and may protect against certain cancers.
It is important to be instinctive and eat only when hungry. Following the circadian rhythm and going by the cycle of eating is good for health.
The father of medicine, Hippocrates, has said, “Let thy food be thy medicine and thy medicine be thy food”.
Food can neutralize stress because food is an agent, a healing agent.
VEGETABLES cleanse you; FRUITS heal you; NUTS, SEEDS AND DRY FRUITS fortify you; and HERBS regulate you.
Arjun ni chaal, Giloy, Dashamula, Punarnava, Guggulu are the suggested and recommended herbs where a lot of research has been done for their curative properties. They have zero side effects if you take pure herbs and use them.
Adjuvants like cinnamon, nutmeg, cardamom, turmeric, black pepper, cloves and kadhas also have anti inflammatory and curative effect. They aid in repair, restoration, regeneration, revival and rejuvenation.
Weight management is important as being overweight or obese puts one at risk for a variety of malignancies. Adopting a nutritious sattvik dietary intake and engaging in regular physical activity can help with weight management.
Optimal movement therapy and postures in poetry on a regular basis with the right breathwork has been linked to a lower risk of several types of cancer.
Prioritising sleep routine and getting a good night’s sleep is ideal for balancing our unit rhythm. It determines the rhythm of our heart or it's better to say that the heartbeat determines that rhythm too.
So our unit rhythm when gets synchronised with the universal rhythm, the cosmic rhythm, our circadian rhythm remains harmonised and hormones behave well.
The most important factor for the same is rest. Rest, generally, we address it as sleep but sleep need not be restful. Sleep also is an art. It's a matter of a way of life, where you can literally breathe out, the moment the hour, the day, the days, the week, the weeks, the month, the months, the year, the years, the life and the lives lived till date. So breathing it all out and sleeping like a baby and waking up like a daisy is when maximum healing happens.
Sleep deprivation or poor sleep quality might have an impact on the immune system.
On the other hand, good sleep helps to restore other body clocks, like biological clocks, restoration, repair, rejuvenation.
Different brain neurons are activated by deep breathing, signaling the body to relax. Being stressed out and erratic, irregular breath, impacts breath management. Better breath management can neutralize stress.
Calming down, getting collected, slowing down, stopping, and stilling the mind with yoga, breath or meditation are other ways to signal body to relax.
Keeping in touch with a mental health professional for controlling stress and having a MD vaidya supervision would be beneficial as all this can aid in the creation of healthy coping strategies and a plan to lessen stress which helps in releasing endorphins, dopamine, serotonin, and oxytocin.
This life is an ocean that keeps moving, there will be high tides, there will be low tides, there will never be any steadiness. This unsteadiness causes stress.
The art of surfing this ocean is so important so that we can cope with the stress, meet the stress, re-create ourselves, and break the pattern of stress.
Being calm in the storm is an art, it's not easy, yet it can be achieved. So, we have to learn to be happy within and be fulfilled within.
Observe silence and meditation because these are the things that can bring back order. Make sure that we laugh with our friends and family, and make sure that we share a strong bond with our beloveds including parents and grandparents.
Dr Joe Dispenza has said that your mind can heal the body. The mismanagement of emotions and the hormones of stress is what begins to create their condition. That constant state of panic and stress is an imbalance that happens in our brains. It’s what causes our diseases.
If we learn how to change our thoughts, the mind can heal the body. It happens all the time — it’s called “spontaneous remission,” and even people with stage 4 cancer can be totally cured - Dr. Joe Dispenza.
When your mind and brain functions become coherent, they create an electromagnetic field for cleansing the environment, harmonising the environment and vitalizing the inner and outer environment.
Today, every leading hospital chain of the world, especially in the first world countries, have introduced lifestyle functional medicine, life coaching, integrating complementary medicine, because the findings of the last two decades and more says that all the pillars of lifestyle, which means nutrition, movement, breath, meditation, sleep, laughter, sports, outdoor environmental engagement and social engagements don’t just prevent but cure and heal all diseases.
Resistance to diseases certainly grows with recreation. So dance, music therapy, poetry, and singing are also extremely important to aid the healing process.
These are all healing quotients and they uplift, upregulate, and upscale our immunity to a big extent. So kindly restore, repair, revive, and rejuvenate using different therapies. Cancer neutralized… creativity Mickeymized!!
Our genes hold the gun, our environment can pull the trigger and activate the genes we've been carrying for decades, to live together.
There are trillions of bacteria, germs, and viruses in the environment that we breathe, and our ancestors have encountered many diseases including cancer, and breast cancer for females.
Cancer is a complex disease that is caused by a number of factors like collective trauma and the body finds expression in its defense mechanism. When not checked in time, and affected with factors like stress and lifestyle choices, can go awry.
References
Background: Outpatient surgical procedures have shown reduced costs, improved patient outcomes, and decreased postoperative complications. Interest in moving orthopedic and neurosurgical spine procedures to the outpatient setting has grown in recent years because of these factors. Studies investigating open posterior lumbar interbody fusions (PLIF) in the outpatient setting are sparse.
Methods: Patients who underwent an open PLIF with pedicle screw and rod construct from 2014 to 2018 were retrospectively reviewed. Outpatient procedures were defined by patient discharge being on the same day of procedure, without admittance to an inpatient ward. Pertinent demographic, clinical, radiographic, and surgical data were collected and analyzed.
Results: The current study included 36 outpatient PLIF cases with 94.4% of the study cohort undergoing a single level PLIF. The average Oswestry Disability Index Score improved by 20.4 points from preoperative measurements (p = 0.0002) and the Visual Analog Scale Score improved by 27.2 points (p = 0.0001). Postoperative fusion rate was 94.4%. One intraoperative complication occurred (2.78%), and four post-operative complications occurred (11.11%). There were no subsequent admissions throughout the postoperative follow up period; however, two of the 36 patients (5.56%) did require reoperation, both in an outpatient setting.
Conclusion: This study demonstrates that open posterior lumbar interbody fusions performed in an outpatient setting can be performed safely and effectively, with a significant reduction in VAS and ODI pain scores.
Keywords: Posterior lumbar interbody fusion; Outpatient lumbar fusion; Same-day discharge; Spinal fusion; Open surgery
References
Cytomegalovirus (CMV) is a DNA virus a member of the herpesvirus family, which includes herpes simplex virus types 1 and 2, varicella-zoster virus, and Epstein-Barr virus. These viruses share a characteristic ability to establish lifelong latency. After initial infection, which may cause few symptoms, CMV becomes latent, residing in cells without causing detectable damage or illness. CMV, is a common virus that infects people of all ages. Over half of adults have been infected with CMV by age 40. Most people infected with CMV are asymptomatic (90%).
References
Introduction: Guided surgery is a technique that has evolved too much in recent years for improvement in the area of implantology with the aim of reproducing what is planned in the planning software and reducing the risk of poor positioning by offering the patient less invasive treatments in the surgical and prosthetic area.
Objective: To evaluate surgical times and reduce postoperative discomfort after dental implant placement, comparing it with the freehand technique in partially edentulous posterior areas.
Material and Methods: we present an adult female patient with an edentulous zone in the upper and lower posterior area for the placement of dental implants. The technique used was guided surgery.
Results: It was observed that the three-dimensional position of the implants placed by means of guided surgery reduces and decreases iatrogenesis, which can injure some anatomical risk areas such as the inferior dental nerve. It also helped the patient to have an easy postoperative recovery; It also led to a good clinical result since it helps to reduce surgical times by 70%, the placement of the implant was as planned, the insertion of the implants was obtained in the appropriate three-dimensional position, anatomical structures that were at risk were not compromised and the patient's postoperative discomfort was improved.
Conclusion: Guided surgery by means of a 3D printed guide is a procedure that allows the application of a highly precise, safe, effective and fast technique, whose surgery becomes more accurate by virtually visualizing the placement of implants.
Keywords: Guided surgery; dental implant; cad-cam system; tomography; guided bone regeneration; surgical guides; guided surgery; 3D design
References
Background: The hand is an important part of the body that helps man express his thought and skills to the physical world. It is very essential to both function and cosmesis. Loss of this important body part can be devastating to the victim. We defined near total hand amputation as injury between the wrist and musculotendinous junction of extrinsic muscles of the hand transecting extensor and flexor compartment structures either passing through the wrist joint or transecting the two bones of the forearm leaving the hand attached to strip(s) of soft tissue. There are few reported cases of this type of injuries and most often completion amputation is done with loss of the hand. This study reports the outcome of near total hand amputation repair without revascularization in four patients seen and managed in Abubakar Tafawa Balewa University Teaching Hospital (ATBUTH) in 2020. This shows that with basic surgical equipment, hand salvage surgeries can be done with very good outcome. Methods: Consecutive Patients with near total hand amputation seen and managed in ATBUTH in 2020 were recruited for this case series report. Results: Four patients with such injury were seen and managed within four months in 2020. Three had their hands repaired with very good outcome while one had a completion amputation. Three out of the four had injury to their right hand, all four were right-handed males in their third decade of life and injuries commenced from ulnar borders. Majority had transection of virtually all structures except branches of major vessels. Conclusion: The study shows that a number of near hand amputation can be salvaged with basic equipment with significant functional and cosmetic outcome.
Keywords: Near amputation; hand; reconstruction; Without revascularization
Reference
Context: Burns has remained one of the severest forms of trauma a man suffers. All ages and sexes are affected however, different studies have shown predilection for certain age groups and sexes due to activities and environments such individuals are exposed to. These injuries are best managed in a dedicated burn centres or units. There is a paucity of data on such emanating centres in the North-eastern Nigeria. Materials and Methods: The study is a retrospective one looking at the pattern of burn injury among patients seen and treated in Abubakar Tafawa Balewa University Teaching Hospital, Bauchi (ATBUTH). Folders of burns patients seen and managed with major acute burns between January 2018 and December 2021 in the institution were collected and data was obtained using a proforma. Statistical package for social sciences version 25 was used to analyse the data and the result depicted in tables and charts. Result: A total of 77 patients were studied among which 68.8% were less or equal to 10 years of age, 64.9% were males, and scald was responsible for 57.1% of injury followed by flame (32.5%). Seventy-four point zero percent sustained superficial partial thickness injury and the most commonly affected body part is the back followed by the right upper limb seen in 57% and 50% of cases respectively. The majority, (72.1%), were managed with wound dressing only while 1.3% had skin grafting. A mortality rate of 9.1% was recorded. Trimodal peak was seen in the months of February/March, July and October. Conclusion: The paediatric age group was the most affected by scald burns which was largely due to domestic accidents. This shows that adults need to do more in order to protect these youngsters from the danger of burns.
Keywords: burns; epidemiology; aetiology; care; new burns unit
References
Objective: To determine the role of aggravating factors in the development of destructive pulmonary tuberculosis and to develop a model for predicting the probability of closure of decay cavities in patients with destructive forms of pulmonary tuberculosis.
A prospective study was conducted cohort study. Patients admitted to the hospital of the Grodno Regional Clinical Center “Phthisiology”, as well as to the Republican Tuberculosis Hospital “Novoelnya” were examined. Depending on the prevailing aggravating factor, patients are divided into 10 groups. In addition, 2 more groups of patients with XDR MBT were formed. The results obtained indicate a significant negative impact of aggravating factors on the formation of destructive processes in the lungs. Patients with TB accompanied by diabetes mellitus, ADS, CNRD, patients arriving from places of detention and with the presence of several factors simultaneously should be considered more significant for this factor.
The results obtained indicate that the frequency of formation of destructive forms of tuberculosis in MDR-TB depends on a number of aggravating factors. The most significant in this regard: diabetes mellitus, several factors at the same time, ADS, patients arriving from places of detention, CNRD. Factors such as contact and gastrointestinal morbidity do not have a significant impact on the formation of destruction in the lungs in MDR-TB.
In the presence of XDR-TB, the highest frequency of destructive forms is observed (over 70%), reaching 76.0% in patients with XDR-TB in combination with ADS.
In order to develop a mathematical model for predicting the probability of closure of decay cavities in patients with destructive forms of pulmonary tuberculosis, studies were carried out on 105 patients with pulmonary tuberculosis, who had different patterns of destruction of lung tissue.
As a result of the study, it was established that prognostically important signs of the likelihood of closure of decay cavities are: clinical form, number of cavities, dependence on alcohol, and timing of abacillation.
When Z ≥ -1.304, closure of the decay cavity is predicted within 6 months of chemotherapy. If Z< -1.304 - the decay cavity does not close within a given period, the risk of developing gross morphological, sometimes irreversible changes increases.
Keywords: destructive tuberculosis, risk factors for tuberculosis, multiple and extensive drug resistance of Mycobacterium tuberculosis, long-term results, prognosis
Reference
India has a severe health issue with undernutrition (U.N.), particularly among the underprivileged poor tribal population. The current cross-sectional study aims to evaluate the nutritional condition of 145 adult male Jene Kurubas in Karnataka and compare the two functional anthropometric indices of Chronic Energy Deficiency (C.E.D.). C.E.D. was assessed using the B.M.I. (body mass index) and the MUAC (mid-upper-arm circumference). According to the results of the current study, chronic energy deficiency was prevalent in 53.8% of cases, and undernutrition based on MUAC < 23.0 cm was present in 48.3% of cases. According to WHO recommendations, these prevalences fall into the highly high-prevalence category (≥ 40 percent), signifying a critical situation. The rate of C.E.D. was significantly higher (81.4%) among those with low MUAC(< 23.0 cm) than among those with a normal MUAC (≥ 23.0 cm) (18.6%).The findings of this study suggest that the Jene Kurubas tribal group was under significant dietary and nutritional stress. For surveys of the human population, particularly among indigenous people, i.e. tribes of developing countries like India, it may be more appropriate to employ mid-upper-arm circumference due to budget constraints or lack of resources and professional labour.
Keywords: Tribal; Jene Kuruba; Karnataka; Anthropometry; Nutritional Assessment; CED; MUAC
References
The term "theranostics" has transcended its status as a mere buzzword in the realm of nuclear medicine, thanks largely to the groundbreaking advancements in prostate-specific membrane antigen (PSMA)–targeted radioligands. These radioligands, which can be labeled with either positron- or γ-emitting isotopes for imaging or with β- or α-emitting isotopes for therapy, have revolutionized prostate cancer management over the past decade. Their success has not only led to the rapid adoption of PSMA-targeted imaging and therapy as a new clinical standard but also inspired exploration into other diseases. This development begs the question: What makes PSMA theranostics so successful, and how can these principles be applied to other areas in nuclear medicine?.
References
Many papers study cryonics, its feasibility and effectiveness as the only currently available method for preserving life beyond the declaration of clinical death. The estimated resuscitation times of each patient and how this affects the selection of the appropriate temperature for cryopreservation is introduced. The analysis of enzymatic reaction times proves that it is not necessary to cryopreserve at -196°C but at a higher temperatures, This is the main contribution of this work.
The scope of the analysis covers the use of which substances, cryoprotectants, as well as inhibitors, should be used as well as the enzyme reaction times that take place at different temperatures.
Not only the technical details are analyzed, but also the legal perspective. Cryopreserved subjects are considered "patients" and not lifeless bodies. It is explained why this is necessary and why it should be communicated at a social level through state policies, as well as the absolute necessity to apply an immediate legal and juridical modification that allows starting the procedures without delay before the metabolic arrest of the patient, and why the World Health Organization already guarantees this in its constitution.
The aim of this paper is to confirm the cryonics method as a current solution to pause biological time and give the patient a chance, which by right, to preserve his or her life.
Keywords: cryonics; cryopreservation; cryobiology; cryoprotective agents; intracellular ice formation
References
A child during their stay in the nursery should be equipped not only with adequate supply of physical forces. The nursery is a place where children are given a basis for their further comprehensive upbringing and are prepared for school education. During this time, a child obtains mental, physical, emotional and social maturity, as well as a certain degree of strength and resistance to stressful situations. Art and movement can help a child in this educational process. A special attention should be paid here to the theater forms that involve many elements of art. Theatre uses the word, sound, visual art and movement; it inspires and satisfies child’s intellectual, expressive, aesthetic, emotional and cultural needs as well as learns how to live, explains, clarifies and comments life. A very important role in the development of child’s personality is also played by fun and dance. In dance, one can reduce negative emotions, stress and tension of body and mind. Dance reduces anxiety, improves concentration, reduces psychophysical tension, relieves excess of energy and aggression, improves motor coordination and strength, improves self-esteem and changes the behavior profitably.
Keywords: movement; dance; rhythm; singing; a child; education; upbringing
References
Initial Coin Offerings (ICOs) have established themselves since 2017 as an attractive alternative for financing innovative companies. However, these new modes of financing from the world of blockchain technology have a very volatile return on investment (ROI) in the short term, and very ambivalent in the medium and long term: 90% of ICOs issued since 2017 have failed. This article attempts to shed some light on the question of the ROI of ICOs. The analysis of some databases of the most significant platforms for ICOs reveals that the highest ROIs reached on average 3100% at their peak and 30% on average over the period 2017-2022. The results of the analysis suggest that given the level of risk of ICOs, they do not represent a good financial asset over a long period; on the other hand, they would be a good lever for speculation and possibly a good financial strategy to boost the financial performance of a diversified portfolio.
Keywords: Initial coin offering; Return on investment; Blockchain; Financial regulation; financial risk
References
Tooth discoloration is a common problem and affects people of all ages. Apart from the conventional treatment modalities for the same, newer options are available today with better techniques and materials.
This case report describes the successful rehabilitation of dental fluorosis in a 25-year-old girl patient using laminate veneers. The patient presented with stained teeth and enamel irregularities, seeking for an aesthetic rehabilitation. This report discusses the treatment planning, clinical procedures, and outcomes achieved, emphasizing the role of laminate veneers in restoring the patient's smile and self-confidence.
Keywords: Dental fluorosis; Laminate veneers; Esthetic rehabilitation; Minimally invasive dentistry; Case report
.
Speaking about the causes of disturbances in the functioning of the self-regulatory system that is our body, the question arises: why does it get sick? Each doctor will give you hundreds of factors, not forgetting to mention heredity. But our forefathers lived up to 150 - 300 years. At the celebrations dedicated to the centenary of the Battle of Borodino in 1992, many such centenarians were present. Academician Bekhtereva N.P. She said that in our time there are many such people. She explained this phenomenon by the presence of program matrices in the brain, which fail over the years.
Not everyone today knows that the renewal of brain cells and their charging occurs from the muscles of the body that are tired during the day. But today human activity has decreased by 200 times. In such a situation, the principle no longer works: movement is life. In addition, human movements have become unnatural due to the use of shoes and deformities in the joints of the feet and spine, which are already diagnosed in 95% of the population of developed countries. Movement contains mechanisms for maintaining the vital functions of a self-regulating organism: cell metabolic processes. The movement of blood and lymph in the capillaries of the body is ensured by the musculoskeletal frame of the body, which, together with blood and lymph, makes up 83% of the body weight.
This was a contributing factor to the continuation of the calls that accompanied the Arab feminist struggle through multiple stages, to expand women’s and gender studies, as educational curricula and academic research multiplied in the region. The beginning was in Palestine through the Women’s Studies Program in 1994, then the program was transformed in 1988 into The institute grants a master’s degree in gender and development, and starting in 2014 it became the first institute to offer a bachelor’s-level program in women’s studies.
As a result of this first Arab experience; Several Arab universities have offered various programs offering diplomas and master's programs in women's and gender studies, and this reflects an optimistic idea about some Arab universities, and the extent of their interest in women's issues and developing them academically and scientifically.
Despite the importance of the scientific content provided by Arab academic institutions on women’s and gender studies, they continued to face challenges represented by the nature of the negative social and political environments, limited resources, inequality at the institutional or development and training levels, and security unrest in some countries.
In addition to the need for these studies to be further supported and developed on a quantitative and objective level, after the fragility of some established research centers led to the production of research dealing with women and gender, which would be accepted by governments and some influential and controlling parties in them, such as women’s rights in religion, or the influence of Enlightenment ideas on the role of women in the public sphere, or by focusing on the role of women in social protection programs, or refraining from teaching feminist movements locally and not paying attention to them as they deserve, and being content with teaching their models in the West or in the regions of Southeast Asia.
Developing Arab research centers concerned with gender studies after diagnosing the strengths and weaknesses and in a way that is consistent with women’s needs across multiple stages, especially in Arab countries that are witnessing political and social transformations, will help provide a solid scientific description of the reality and problems of Arab women, as well as provide scientific solutions, through research. Solid academic studies reflect the quality of research effort produced by both women and men.
It will also make Arab universities think tanks that provide scientific advice to decision-makers in the region to improve the situation of women in light of their priorities and needs, especially with regard to the conditions of women who are victims of armed conflicts, women (refugees and displaced women), marginalized women in the countryside and slums and non-urban areas, women who are victims of terrorism and extremism, as well as issues Related to the reality of women locally in light of the specificity of each Arab country, as well as the larger issue; The issue of cultural and societal reform and the rejection of discriminatory religious discourse.
Until the middle of the twentieth century, gender and women's studies in the Arab region faced great challenges represented by the nature of Arab societies based on discrimination and the liberation and independence movements that were the greatest concern at that stage.
Despite all this, feminist activists at the time made calls to institutionalize women's studies in Arab universities, during the Arab Women's Conference in Cairo in 1944, and demanded that a chair be allocated to the study of gender. Later, the founding of the journal Gender Society in 1986 helped to be Women's studies are strongly present in many universities and colleges around the world.
References
The aim of the present study was to examine the relationships between the Yo-Yo intermittent recovery test level 2 (YYIR2) and match-running performance across playing position in elite young soccer players. Participants were 142 players from 14 professional soccer academy under-14 teams. Twenty-six 11-a-side matches were analyzed using a Global Positioning System. Total distance, distance covered by sprinting (> 5.3 m∙s-1), distance covered at very high-intensity activity (VHIA, ≥ 4.5 m∙s-1), distance covered above maximal power (MaxP, > 55 W·kg-1) and metabolic power greater than or equal to 35 W·kg-1 (MP≥35), and acceleration (> 2 m∙s-2, NA>2) and deceleration (< 2 m∙s-2, ND<2) frequencies were computed. The YYIR2 test was conducted within three weeks of the matches. When all players were included, the YYIR2 distance was positively related to all match-running performance variables (r = 0.31-0.49, all P < 0.01). When the analysis was conducted on individual playing positions, the YYIR2 distance demonstrated: positive relationships with total distance in defenders and central midfielders (r = 0.42-0.63, all P < 0.05); positive relationships with sprinting, VHIA, MaxP and MP≥35 distance and NA>2 in all playing positions (r = 0.41-0.71, all P < 0.05); and positive relationships with ND<2 in central midfielders (r = 0.55, P = 0.005). The present results indicate that the YYIR2 is a valid test for the assessment of match-related physical fitness in elite young soccer players across playing position. However, the relationships between the YYIR2 and match-running performance variables are playing position-dependent except for match-running distance at high-speeds and high-metabolic powers and NA>2.
Keywords: Association football; endurance fitness; field test; match analysis; and young players
References
Welcome the present moment as if you had invited it. Pema Chodrom
Following the onslaught of CoVid-19, the United States was at a remarkable, watershed moment in the history of higher education. Educators have been required to transition their instructional practices to an entirely online, distance education format.
I’m bringing to your attention some ideas on Coaching. I hope they will be of value as you coach patients, learners, colleagues, friends, and family members during the uncertainty of the times.
References
This research finds critical issue of mental health problems among university students in Bangladesh. The introduction outlines the significance of the topic, emphasizing the growing concern surrounding the mental well-being of students. The research questions and hypotheses set the stage for exploring this pressing issue. The research objectives and methodology underscore the systematic approach taken in this study, which seeks to shed light on the scope and limitations of the research. The paper proceeds to examine why mental health is essential for university students and delves into the various mental health problems commonly encountered by this demographic, ranging from anxiety disorders to suicidal thoughts. Furthermore, it explores the severe consequences that mental health issues can impose on students, citing recent incidents of university students' suicides as compelling examples. The causes behind these tragic incidents are analyzed, both on the surface and through in-depth interviews with students struggling with depression and suicidal thoughts. A detailed case study on Saiyma Arabi's suicide provides a deep insight into the factors that can lead to such tragic outcomes. The findings, suggestions, and conclusions of this research contribute to a comprehensive understanding of the mental health challenges faced by university students in Bangladesh, calling for more proactive measures to support the well-being of this vulnerable population. This study offers valuable insights and recommendations for universities and policymakers to create a safer and more supportive environment for their students' mental health.
Keywords: Mental health; Anxiety Disorders; Attempt to suicide; Loneliness
References
A quantitative research approach with survey research design was adopted 100 women were selected urban area of Surat district by using non-probability convenient sampling technique formal permission was obtained from the authority before data collection. Structure knowledge questionnaire was used to collect the data from the participants.
In present study level of knowledge regarding breast cancer among women majority 61% of women have an average knowledge, 26% of women have a poor knowledge & 13% of women have a good knowledge.
Chi-square is use to find out the association between knowledge score with their selected socio-demographic variables. There is significant relation between knowledge score with their selected socio demographic variables (Religion, Education, Marital status, Family income).
Keywords: Assess; knowledge; breast cancer
Thus, it remains relaxed and enjoys a false cognitive peace. Therefore, there is no protection against the roaring current of thought except by taking refuge in the cognitive ruptures.
Hence, this hypothesis starts from a basic principle, which is that the moon witnesses a phased state of absence, darkness, and eclipse in its aspects, and it may extend to all its aspects during a period of its life, and just as the matter applies to modern administrative institutions, a leader may decide an organizational decision regarding an administrative issue, and that decision may be correct, but conclusively, we find that there is a dark side in that decision, so the next leader comes to remove that darkness, which may surround an aspect of communication or decision-making. Or attention to employees or incentives and rewards.
However, a rivalry may arise whose origin is undesirable organizational jealousy between the leaders who assume the leadership of the institution, based on the fact that each leader tries hard to prove his capabilities and the effectiveness of his capabilities, burning everything green and dry in order to obtain the loyalty of his employees, forgetting or ignoring the interest of the public institution under which he works and breathes in its achievements. Which may fade and the flame of its fire may be extinguished at the nearest crossroads.
The full moon hypothesis in leadership confirms that leadership based on the influence that enchants and attracts employees to work willingly with the leader and his ideas, constitutes the basis that guarantees the success and effectiveness of the administrative institution and its efficiency by keeping the leadership axes subject to criticism and doubt and a constant feeling of inadequacy and weakness, thus making the institution’s employees, especially those who are At the middle management level, they live in a state of brainstorming and constant thinking about solving emerging problems that the human will cannot restrain.
But good management, management, and work within the state of group dynamics may help in achieving the desired goals within a leadership characterized by the perfection of its axes, the quality of its performance, and the implementation of its tasks and duties to the fullest extent.
I go back to saying that the full moon hypothesis in leadership is suitable to be extended to the rest of the things through which we live, so that this hypothesis does not remain limited only to administrative institutions, but rather extends to include the individual, the family, and society as a whole, so as to ensure a state of creative interaction between its components.
Modern-day organizations live in a state of total or partial eclipse in the components of administrative leadership. Sometimes they witness darkness in the communication axis, and at other times they experience a state of partial eclipse in the decision-making axis and other administrative leadership axes.
Perhaps this may be due to the ideology from which the administrative institution bases its leadership, which may tend toward the constant at the expense of the variable and toward the prevailing at the expense of the renewable, in addition to an intense wave of insistence on consensus, a lack of belief in difference and diversity, and acceptance of ambiguity. Such a matter makes institutions live in a state of uncertainty. The ability to comprehend the complex reality around her and thus her inability to understand the intellectual structures without which it is impossible to understand the manifestations of reality.
References
Introduction: Nowadays, the use of orthodontics at any age, from adolescents to adults, has become a treatment of choice to correct malocclusions; Therefore, it is feasible to use it in the opening of spaces and their maintenance to later place a dental implant and thus replace a lost tooth.
However, it is not known the ideal moment during orthodontic treatment in which the specialist can place the dental implant, leaving it in osseointegration so that it can later be rehabilitated; and it is often placed after the treatment is finished; so it takes time for the patient to see results from the initial treatment that was intended; which is the replacement of the missing tooth.
Objective: Choose the time of implant placement during orthodontic treatment, seeking to shorten times and thus benefit the patient.
Method: A 20-year-old male patient is presented for evaluation for loss of space after an extraction of a lower first molar performed 2 years ago, he reported that it was extracted after a root canal treatment. Come in during your orthodontic treatment.
Result: The dental implant was placed during orthodontic treatment; shortening work times, for the benefit of the patient, since at the end of his orthodontic treatment he left with a rehabilitated implant.
Conclusion: The implant or implants necessary for the patient during orthodontic treatment can be placed and thus advance while they are osseointegrated, to later rehabilitate and finish both treatments at the same time; as long as you have the necessary spaces.
Keywords: orthodontics and implants; implants during orthodontics; osseointegration; tooth loss and spaces
Many pharmaceutical interventions do more than advertised. For example, one can’t wean cold-turkey off of SSRI’s even when substituting a serotonin analog, such as saffron, because SSRI’s do more than what they claim to do - they do far more than just inhibit serotonin reuptake. SSRIs such as Prozac, seem to hijack dopamine receptors to name one [3].
While the public is/was told mRNA is ephemeral in the body, a truth, what was not told was billions were being injected not with mRNA but modRNA, which is not ephemeral and it is no secret that it is programmed to make more than just the spike protein as per Pfizer’s own documentation:
“Self-amplifying mRNA (saRNA): saRNA is a platform that uses a much larger molecule because not only does it encode the antigen of interest, but four additional proteins. These extra proteins allow the cell to make more copies of the mRNA, resulting in more protein being expressed from a smaller dose” [4].
This bears repeating... these injections do not deliver natural mRNA but a modified version with extended stability which causes the cells of the body to produce unnatural proteins in addition to the spike protein but the true purpose of these proteins and what they are creating is unknown and on a practical level their presence is undisclosed. Be that as it may, the injection is clearly a gene-therapy and should have been labeled and regulated as such.
In the spring of 2020, the definition of vaccine was changed from something that would reduce infection and transmission to something that would reduce hospitalization, or the severity of the disease after receiving multiple injections - that violated the CDC’s own published rules on what a vaccine is supposed to be [5]. The public was lied to by saying it was a vaccine when it was an “experimental gene-therapy“ as per Moderna and BioNTech’s own filings - at least until April of 2020. They called it a vaccine so people would take it, because vaccines are the sacred cows of conventional medicine and everyone is preprogrammed to believe they are all “safe & effective,” because an authority figure told them it was and most in the First World have been carefully conditioned to concede our common sense or discernment to authority figures.
The manufacturers could legally lie about safety because in 2018 the legal definition of an adverse event was changed to being only something the medical literature or medical consensus had previously noted was an untoward sequelae of that injection. It would not have mattered if the injection gave every recipient myocarditis if that was not previously delineated - it would not be an adverse event.
While few are aware the injections are making multiple proteins this fact is clearly spelled out by Pfizer itself. Granted Pfizer has zero to no credibility for anything they write or say, but they seem to be very transparent about revealing the injection is making “these extra proteins.” They are admitting to four additional proteins; however, there may be many more unintended, and undisclosed proteins being made. Pfizer very much wanted to keep their clinical data sealed for 75 years, so they had a lot to hide.
What are these extra proteins and what are they doing in the human body and what could go wrong? How about death?
Note the words “self-amplifying,” because one might correctly assume that these other proteins are critical to self-amplification. Is there a connection between, for example, these never-seen-before massive clots found in so many deceased jab victims and these self-amplifying bio-nano machines?
War on humanity became fully operational but not recognized as such because there were no helmets, guns, bombs or bullets. Need proof? A systematic review of autopsy findings in deaths after Covid-19 injections revealed that 73.9% of those deaths were caused by or significantly contributed to by the Covid-19 injections [6].
Perusing the Moderna patent issued in April of 2023 (US patent number 11,622,972 B2) entitled: Lipid nanoparticle compositions and methods for formulating same, you can see that that these stealth nanoparticles are chock full of plastic polymers many of which are carcinogenic and toxic Phthalates. Phthalates are most often used as plasticizers that allow plastics to be more flexible, durable and long lasting. If the COVID injection were actually a vaccine these chemicals would be (and should have been) labeled as adjuvants or excipients, and subjected to safety evaluations.
Of course, safety gets side-stepped when no one even bothers to look or evaluate for same, and this is by design. It was already known many Phthalates are toxic endocrine disrupters, and should never have been allowed in these injections without adequate safety considerations, but ipso facto…safety is not a consideration in today’s captured regulator environment. Phthalate exposure alone is responsible for 100,000 deaths in America every year with a societal cost of almost $40 billion a year [7]. Why do you think testosterone levels have been crashing to use but one example?
Hydrogels
Complex organic polymers are called Hydrogels. Hydrogel-forming natural polymers include recognizable proteins such as fibrin and collagen. The Pfizer Lipid nanoparticles [8] are the constituents of hydrogels and again the question is what is being made by these constituents?
Remember the spike protein is a pathogen. So, it is of interest that the CoV-2 spike protein S1 alone induces fibrin(ogen) resistance to fibrinolysis. So, just the massive production of the spike protein alone by the cells of the human body could be causing these massive clots being seen today in those who have experienced post-injection thrombi that the body cannot destroy [9]. We have all heard the reassurances that mRNA does not affect DNA so not to worry your genome is safe, and indeed mRNA does not affect DNA, but modRNA has a direct effect on DNA [10].
At the very least injected breastfeeding mothers and organ donors who underwent the COVID-19 injection almost certainly transfer worrisome modRNA, adenoviral DNA, spike protein, and or anti-platelet factor-4 antibodies (vaccine induced thrombotic thrombocytopenia or VITT) to their close contacts [11].
VITT are these weird elongated clots pulled from the vaccinated dead. Platelets are activated in a novel and deadly manner to create an immune complex hydrogel. This is accomplished by platelet-activating anti-platelet factor 4 (PF4) antibodies. It is still a mystery as to what sets this off. No one is accusing the spike protein, but if not the spike protein could it be one of the many additional proteins the modRNA is instructing the cells to create? Or is it the undisclosed presence of Graphene oxide (GO) known to self-assemble?
Injecting modRNA, which does not seem to degrade in many - i.e. it is not ephemeral - could have serious repercussions on over-all mortality post injection, to say the least, by the pernicious disruption of the human genome. To believe, and this is about faith not science, that biopolymer particle (BP) vaccine technology is a benign intervention ready for prime time for a whole host of potential conditions is the height of arrogance and hubris in the face of the mounting death toll in the countries most heavily Injected.
Fear is the Mind Killer
Providing some additional background context, the Gain-of-Function work that created CoV2 was funded by the United States Government and approved by Anthony Fauci. The bagman was Peter Daszak of Eco-Health Alliance, who as of this writing is still getting millions in NIH grants. Yet, the apparent deliberate release of the CoV2 virus must have been big disappointment as it was hoped it would have killed billions and the injection, called a vaccine, was only meant to do clean-up. Since CoV2 didn’t perform as hoped the roll-out of the injection had to be moderated as not to draw too much attention to the death toll or those asking too many questions given there were too many still alive to ask those questions, so certain batches were not as problematic as others. Never evaluated to see if it would stop transmission or infection, because that was never the intention of the jab - the intention was democide. One need look no further than Canada to prove that point - those with vaccine injuries are being offered free euthanasia. Now, we all know the jab neither stopped transmission nor infection. The mass indiscriminate use of the modRNA vaccine was catastrophic but then wasn’t it meant to be?
It was also imperative any options for early treatment be extinguished lest that interfere with the injection roll-out, so hydroxychloroquine and ivermectin were demonized, while hospitals were being incentivized to literally murder COVID patients by intubation and the use of the ineffective and deadly drug Remdesivir. Unsupportable medical protocols were strictly enforced. Admitting a patient and labeling them a COVID patient was worth $11K to the hospital, $39K if they were intubated. Using Remdesivir and Versed as the only pharmaceutical protocol gave hospitals a 10 percent bonus on the total bill, so by using Remdesivir a typical $500K hospital bill would garner an extra $150K for the hospital. That is why all other treatments were forbidden.
Truly, this was probably the single greatest crime against humanity in the modern history of mankind. The world was told what they were going to do in 2015, but the world was asleep. At the end of February 2024, Russia submitted a 2,000-page report to the United Nations documenting the bio-security deep state and pharma manufactured the COVID event naming influential figures within the US political landscape who orchestrated the Covid-19 pandemic as part of a global domination strategy. Among those named as participants in this scheme are Hillary Clinton, Barack Obama, Joe Biden, and George Soros, implying their involvement in a conspiracy against humanity. This is really the overlooked big picture, there were a colluding set of conspirators both in industry and in the public sector that orchestrated the plandemic, and well planned it was. No one was allowed to question anything because it had been decided everyone would get the injection.
These individuals must be exposed lest they take matters into their own hands to hide their crimes in the chaos they are still very much capable of creating. For example, thousands of foreign military or para-military combatants were brought through the open boarder into the United States just waiting for the word to activate and pillage, rape and destroy United States citizens inside their own country. Then again, it could just be that new and improved infectious bio-weapon Bill Gates seems to be so anxious to unleash. The crime was not committed solely by Big Pharma, they were just the arms dealers - the crime is what allowed them to be arms dealers - this ongoing war on humanity itself - that is the crime. This is beyond the scope of this perspective but the elites want a return to feudalism with a vastly reduced planetary population -an 80 to 90 percent reduction. These individuals are detached from reality, but have never suffered the consequences.
The first patent [12] on CoV2 was back in 2002, but in 2019 Moderna filed four patents that had previously been rejected, “Because of concern for the reemergence or a deliberate release of the SARS coronavirus, vaccine development was initiated.” That is only something you say because you know what the plan is - no different than when Fauci announced in 2017 that Trump would face a surprise infectious disease outbreak...surprise? If anyone announced their local bank would experience a surprise robbery don’t you think that person would be a prime suspect?
In the fall of 2019, the WHO announced it would conduct a worldwide exercise to be ready for the release of a “rapidly spreading pandemic due to a lethal respiratory virus…which would impose additional preparedness requirements”. The “criminals” announced in advance what they were going to do and no one seemed to care but for literally a handful of individuals that were dismissed as conspiracy theorists. Did the lethal respiratory virus exercise also include distributing the virus to multiple locations around the world? Because it is clear this infection did not come from a wet-market in December of 2019. CoV2 circulating for months before that. Release implies intention and distribution; it does not imply an accident of happenstance. One could infer the WHO was actually involved in its release and the so-called exercise may have been far more than just an exercise.
Then came the diabolically dishonest cover-up. The distrust in government and public health edicts has grown exponentially as a result. More dangerous than CoV2 was the shutdown of free-speech, and of course self-righteous politicians and technocrats who knew nothing about the actual science were eager to censor, terminate, or delicense anyone who didn’t agree with the narrative they were pushing. The government used proxies to silence those asking inconvenient questions or had information that would expose the narrative. The FBI and DHS were meeting weekly with the high-tech platforms to make sure those platforms took down or suppressed information they disagreed with. Meanwhile, “I am the Science” Anthony Fauci’s emails from January 2020 showed he was well aware the NIH was funding Gain-of-Function research in Wuhan; nevertheless, the public was told the opposite (the least of his crimes). It is doubtful he will ever be prosecuted for anything, because in the United States there is now a two-tier system of justice where what is called lawfare is used to minimize anyone who threatens the elite’s plan for world dominance. If this is allowed to continue the judicial system in the United States will collapse and take the rest of the country with it.
Physicians could have stopped this tragedy but in the United States 85 percent of physicians work for institutions and those that knew better still feared more about their employment than doing the right thing. This is what happens when you have the corporate practice of medicine. So, modern conventional medicine went down a very dark path created 100 years ago by the Rockefeller Foundation. There was a pernicious turn from science to scientism, which is a non-evidence-based mix of scientific dogma and magical thinking that is meant to serve those in control or wanting to be in control.
Considering the rush is on to completely bypass informed consent and aerosolize this technology [13] it is critical to understand and expose the insanity of how this democide was carried out - an understanding that has yet to happen, so its instigators are still at it and are desperate for the next wave of infectious disease genocide they have up their sleeves if for no other purpose than to cover their tracks from their crimes related to COVID.
The public has been bombarded with distractions, from UFO’s, Drag Queen Story Time, George Floyd, January 6th, the drug and slave trade on the deliberately open southern border, DEI, men having babies, the climate change hoax, and unending wars in multiple locations. This was all orchestrated to invert reality so that the real crime would not be noticed - that a colluding set of misanthropes caused this all to happen. These conspirators knew the plandemic was coming and played their roles to make sure it took place. This information has been in the public domain now for over a decade, as per Peter Daszak’s 2015 presentation to the National Academy of Science:
“Daszak reiterated that, until an infectious disease crisis is very real, present, and at an emergency threshold, it is often largely ignored. To sustain the funding base beyond the crisis, he said, we need to increase public understanding of the need for MCMs (medical counter- measures) such as a pan-influenza or pan-coronavirus vaccine. A key driver is the media, and the economics follow the hype. We need to use that hype to our advantage to get to the real issues. Investors will respond if they see profit at the end of process, Daszak stated” [14].
But it goes back farther to 2005 when Ralph Baric gave the DARPA lecture: “Synthetic Coronaviruses. Biohacking: Biological Warfare Enabling Technologies. June 2005 Washington DC: DARPA/MITRE sponsored event”.
Why are we still debating where the virus came from?
Ralph Baric, the scientist who made the weaponized CoV2 virus, at the University of North Carolina, actually published the treatment for the bioweapon in 2010: Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture [15].
No surprise that the creator of the Gain-of-Function virus would have a countermeasure if for no other reason than his own protection. The public has been conditioned for years to accept fear-based narratives without questioning them and to surrender their own discernment for whatever the authority says is going on and what should be done. Combine that with the assault on our I.Q.’s with toxins, such as fluoridated water, pesticides, and a poor educational system to the point where we couldn’t see the information under our noses - the elites were fearless in their ability to pull off this great democide and will try again if they are not exposed.
References
The Trojan Horse
The nucleoside-modified messenger RNA (modRNA) is a synthetic messenger RNA Trojan Horse that has and will continue to cause untoward deaths and disability. This is not just about the spike protein, a known pathogen [1] Furthermore, it does not require a degree in immunology to appreciate that if you have the cells of the human body make foreign proteins - especially a pathogen - one’s immune system will attack those cells. The creation of this gene-altering injection was done with malicious intent. If you know the infectious agent is a virus that replicates and mutates rapidly, but you give a non-sterilizing intervention in the midst of an outbreak, are you not putting evolutionary pressure on the virus to side-step your intervention? Just another example that the injection was not intended to end the planned pandemic (plandemic) [2] but exacerbate the morbidity and mortality.
References
Introduction: Curcumin, is a natural polyphenol product found in turmeric, and it has primary anti-inflammatory and antioxidative properties. It modulates several molecules in the cell signal transduction pathway to exert the therapeutic benefits. It is widely used to treat multiple medical illnesses and has shown many health advantages. Bromelain, an enzyme obtained from pineapple is shown to promote tendon healing through anti-oxidant and immunosuppressive effects. This study is conducted to assess the effectiveness of Fortend, a drug consisting of MicroActive Curcumin, Epigallocatechin gallatoe Bromelina with Coenzyme Q10, Manganase and Selenium in treating Lateral Epicondylitis (LE).
Materials and Methods: This was a non-controlled, non-randomized retrospective observational clinical study. Records of all patients that were treated for LE in multiple centres between 1st April 2022 to 30th June 2023 with elbow disorders were assessed for eligibility. The inclusion criteria of the study are patients who have been diagnosed clinically to have LE through history, physical examinations and special tests and have been offered at least one course of Fortend. The exclusion criteria include patients with connective tissue disorders, previous history of surgery to the elbow, incomplete follow-up records and/ or without consent. One course of treatment consists of taking one tablet of Fortend per day for 20 days consecutively and a maximum 2 courses are offered based on clinical response. Patients were followed up at 1 month, 3 months and 6 months after initiating Fortend. The outcomes were assessed using Visual Analog Score (VAS) and Disabilities of the Arm, Shoulder, and Hand (DASH) score.
Results: A total of 260 patients that fulfilled the inclusion and exclusion criteria were selected for the study. VAS were 6.9±1.0 at first baseline, 5.6±0.8 at 1month (p=0.03), 3.8±0.6 at 3 months (p<0.001) and 1.7±0.7 at 6 months (p<0.001). DASH scores were 57.8±3.8 at baseline, 41.5±5.8 at 1 month (p<0.001), 26.5±4.6 at 3 months (p<0.001) and 14.6±3.2 at 6 months (p<0.001).
Discussion: Fortend has anti-inflammatory and anti-oxidative properties. It is being used widely in the world to treat many medical illnesses and can be used to treat tendinopathy. This study has shown that the use of Fortend in lateral epicondylitis yields promising results with fast recovery and minimal tolerable side effects. In addition, patients also can avoid any form of injections or surgery for lateral epicondylitis which has inconsistent results.
Conclusion: Fortend is a safe and effective adjunct to conservative treatment of lateral epicondylitis to relieve pain and improving function.
Keywords: Fortend; Tennis Elbow; Anti-inflammatory; Anti-oxidative; Pain
References
Rationale: Quality of life constitutes an indicator of well-being in patients with chronic diseases. Natural and Traditional Medicine has demonstrated effectiveness in increasing the quality of life in patients with chronic non-communicable conditions; However, there is no evidence of its results on the quality of life of patients with chronic kidney disease.
Objectives: Determine the application of Natural and Traditional Medicine through a comprehensive system of therapies in patients with chronic kidney disease with the aim of raising their quality of life.
Method: A descriptive cross-sectional observational study was carried out in a group of patients admitted to the Nephrology ward of the university hospital. Manuel Ascunce Domenech, to whom the comprehensive therapy called,: AMORE was applied, with the objective of determining their quality of life before and after it was applied. The variables were taken into account: Age, sex, APP, Quality of life and Adverse reactions.
Results: of the total number of patients treated, 18 were male, for 62%, of the total number of patients studied; their average age was 51 years. Quality of life at the beginning of treatment was evaluated as: Regular and at the end of treatment it was raised to Good.
Conclusions: At the end of the treatment, it was determined that the comprehensive therapy of Natural and Traditional Medicine, AMORE, positively influences the Quality of life of the admitted chronic kidney patient.
Keywords: exercises/METHOD; music therapy/METHOD; chronic kidney disease/DIAGNOSIS
The major industrialised countries have significantly contributed to global warming with unprecedented magnitude. It is worth noting that the major polluters are; China, India, and United States of America including Brazil. These countries have many industries which emit their affluence to the atmosphere, inform of ‘black carbon dioxide and methane gases’. This has led to global warming and climate change. Melting of junks of ice in North Pole and Alaska increased the volume of water in seas and oceans of the world thus causing unprecedented floods. Again, the widespread use of fossil fuel, and episodes of wild fire has significantly damaged the environment and contributed to global warming and climate change.
The world’s energy systems are still dominated by fossil fuels. However, it is imperative that countries scale down the use of fossil fuel usage to save the planet earth. Again, carbon dioxide usage should be taken out of the power sector by phasing out coal facilities. There is a dire need to increase the uptake of renewable energy around the world. Limit global warming to 1.50C and reduce greenhouse emissions. The said countries have promised to reduce fossil fuel and industrial pollution by 25 to 30 percent by 2030. It is easier to say but are we likely to witness tangible action?
Global actors need to institute actions to limit climate change, and avoid unacceptable risks to global health. Fund initiatives for climate change and implementation public health measures to reduce number of deaths from cancer, respiratory and cardiovascular diseases that are caused by air pollution, risks from extreme weather events, infectious disease, diminishing water supplies, and food insecurity. Public health specialists have a fundamental role in leading by example, primarily by: a) Raising awareness of the health effects of climate change and the potential health co-benefits of low carbon pathways. b) Contributing to the development and implementation of measures to limit climate change and protect people in workplaces, and communities; c) Working to minimize the environmental impacts on health systems, while improving health services.
There have been many global summits regarding climate change and global warming. Which started in 1992 in Rio de Janeiro in Brazil, then Montreal protocol, Kyoto protocol (Japan) and COP-21(Paris). The efforts advanced by world leaders in addressing the problem have been futile, hence, follow-up summits. Even the subsequent summit recommendations reached may not bear fruits but will likewise be mere rhetorics. The global dilemma shouldn’t be where it is if concerted and collective measure were implemented in a spirit of collective responsibility.
References
Premature cranial suture closure is a disease in which a skull suture fuses prematurely, leading to a skull deformity that affects the brain development and even endangers the patient’s life. Premature closure of different cranial sutures can lead to different cranial deformities. Sagittal sutures usually begin to close at about 18 months, and premature closure of sagittal sutures can lead to scaphoid or long head deformities. Traditional surgical treatment involves removing part of the skull after a craniotomy, to increase the cranial cavity space and avoid restricting the brain’s growth and development. However, the operation is traumatic, and the sagittal sinus, which is located below the sagittal suture, has a large amount of blood supply, and the risk of massive hemorrhage is very high. Therefore, through a simulation analysis of skull reconstructions in children, we designed a minimally invasive incision combined with a self-developed memory alloy traction arch, which avoided destroying the sagittal sinus. Using a binocular vision navigation system, the preoperative position of the traction arch and the intraoperative osteotomy line can be accurately navigated in the operative field, which greatly improves the operational accuracy while reducing the risk.
Keywords: Early closure of sagittal suture; memory alloy traction arch; visual navigation
References
Surgical instruments play a fundamental role in the success of surgical procedures. They have traditionally been manufactured from stainless steel due to its corrosion resistance and ease of sterilization. However, exposure to corrosive substances during cleaning and disinfection can affect their integrity over time.
This study investigates the corrosive effect of enzymatic, multi-enzymatic and sodium hypochlorite solutions on surgical grade stainless steel instruments. Samples were immersed in solutions under different concentrations and their breakdown potential was measured. Likewise, tests were carried out using normal ringer's serum as a medium, which is employed according to ISO 10993-15 standard, to evaluate the corrosion resistance of materials used for prostheses.
The results showed that the breakdown potential depends on the concentration of the solution and temperature. Enzymatic and multi-enzymatic solutions do not pose a significant risk if kept within recommended concentrations. However, normal ringer's serum induces corrosion from 8 hours of exposure.
This study provides relevant information for cleaning and maintaining surgical instruments in order to optimize their performance and safety.
Keywords: Surgical instruments; Stainless steel; Corrosion; Enzymatic; Hypochlorite
References
We live in a time of socio-cultural inequality, unemployment, poverty, moral degradation, conflict, lack of imagination and creativity. Is all this the consequence of an incorrect adjustment of the markets (economic crisis) or the end of a socio-cultural model incapable of responding to the problems of man as a person not as an object (anthropological crisis)?
This article attempts to respond to this question by discussing the role of economics as a science and a self-referential cultural model based on finance.
Keywords: Neoliberalism; Economics; Finance
So, why have I utilized a quote in relation to sex attributed to Marilyn Monroe? Simply, I thought it was an interesting lead in discussing the natural facets of sexual health; nonetheless, a topic which can be an uncomfortable conversation, for many.
From a clinical standpoint, sexual health is a crucial part of our physical, emotional, and mental well-being. The balance of hormones, the physical state of our bodies, and the clarity of our minds collectively support our sexual health. Though in contrast, it is important to be educated on how the impact of a poor diet, lack of exercise, sleep deprivation, stress, environmental factors, toxins, and hormonal imbalances can negatively impact our sexual health.
First, it is crucial to maintain a healthy lifestyle to support sexual function. Eating healthy foods and fueling your body with the nutrients it needs will improve your overall well-being. It is also important to exercise regularly. Aerobic exercises increase blood flow to the genitals, which can, in turn, increase libido for women and improve erectile function for men. Cardio exercise also helps reduce stress and anxiety, both of which are major libido killers.
According to the National Institutes of Health (NIH), obesity and inactivity have led to an increasing number of individuals with sexual dysfunctions (43% of women; 31% of men). Based on research, even insignificant amounts of exercise can drastically improve sexual functioning.
Second, stress can easily be a libido killer. Whether it be difficult family matters, work deadlines or bills, your body undergoes a series of changes when stressed. Commonly known as ‘fight or flight’ responses, stress can increase your heart and breathing rate, blood pressure, and decrease non-essential bodily functions, like your sex drive.
According to VeryWellMind.com, stress management techniques can include:
Other health related initiatives to focus on are to attain sleep, stay hydrated and obtain the appropriate vitamins, minerals, and varying nutrients. Personally, I like to walk outside to acquire sunlight for a natural source of Vitamin D. I make sure I incorporate foods rich in Vitamin C like strawberries, tomatoes, and red and green peppers. I also integrate Black Cumin Seed (to help reduce inflammation, promote immunity and energy metabolism); Turmeric (to support digestion, arthritis, and allergies); Broccoli (calcium source for strong bones, fiber, and healthy metabolism); Spirulina (to improve cholesterol and triglyceride levels, reduce blood pressure, and lower fasting blood sugar levels); and Cayenne Pepper into my diet.
I take a packet of ‘RESTORE’ daily, from The ROOT Brands®, to help with inflammation and assist my body’s immune system. I also detox daily, with ‘Clean Slate,’ to support the removal of toxins, heavy metals, and environmental pollutants. It is important to note, heavy metals can affect your circulation and blood flow, hormonal balance, fertility, and oxidative stress, which can also negatively affect your sexual function.
Clearing toxins from the body can help clear the mind, which plays a crucial role in also having, and/or sustaining a healthy sex life. For more information on those specific products, check out www.therootbrands.com/purelivingroot.
Regarding hormones, overall sexual motivation is influenced by testosterone, estrogen, progesterone, oxytocin, and vasopressin, among others. Although hormonal levels fluctuate regularly, long-term imbalances can lead to a myriad of symptoms and conditions, which can negatively affect your sexual health. Hormonal imbalances can also be a sign of an underlying health condition, or a side effect of certain medications. For this reason, people who experience recurring symptoms of hormonal imbalances should speak to their primary care physician, or OB/gyn, for hormone testing.
The bottom line is, we are responsible for managing the health of our body’s ability to function at optimal levels; whether physical, mental, emotional, psychological, or sexual. Therefore, we should work to sustain as much health and longevity as possible, to live the best life we can for ourselves, our families, and our partners.
As Marily Monroe once said, “Sex is a part of nature, and I go along with nature.” Though, according to Psychology Today, sexual behavior is not necessarily natural; sex within itself is considered a learned behavior. The act alone evolves as a result of whatever sex education a person has acquired. According to Diane Gleim, LMFT, CST, CST-S, “The sexual drive may be innate, but sexual information, sexual ethics and sexual behavior is learned.”
We only Know of one case in South Carolina in the recent time period, but the anesthesiolgist did not record sufficient data to clearly identify it as MH.
Malignant Hyperthermia is not a current problem in surgery or anesthesia if the medical staff is using Sevoflurane anesthesia and/or Organon 9426 (Rocuronium) to conduct the medical procedure. We evaluated Sevoflurane anesthesia in 10 highly MH susceptible pigs in 1984. Sevoflurane was on the market in 1992. The elapsed years have shown a decrease in MH cases to Zero during past years.
References
Ameloblastoma is the second most common odontogenic tumor after Odontomas. Ameloblastoma is a true neoplasm of odontogenic epithelial origin. Unicystic ameloblastoma, predominantly occur in the posterior part of the mandible usually in the second and third decades of life. Here describes a case report of unicystic ameloblastoma occurring in the left posterior mandible of 22year-old female. Radiograph showed a well-defined unilocular radiolucency lesion with involvement of mandibular left first molar to impacted second molar. It was initially diagnosed as a dentigerous cyst based on radiology and clinical finding and treated by enucleation and extraction of all involve teeth. Histopathological examination of the specimen showed unicystic ameloblastoma. After surgery, healing of the mandibular bone defect was uneventful, as shown by 1-3year follow-up of panoramic and CBCT radiograph respectively.
Keyword: Unicystic ameloblastoma; Marsupialization; Enucleation; Recurrence
References
Diabetic patients are at greater risk for several oral health complications, particularly periodontal disease. Periodontal disease has an impact on diabetes control. Good oral hygiene knowledge and practices are recommended to prevent and manage oral health problems.
Diabetic patients have limited knowledge about the risk of diabetes on their oral health, lack compliance with recommended oral hygiene behavior. Knowledge and oral hygiene practices levels are better among patients with controlled diabetes. It is therefore essential to educate patients about their increased risk for oral complications and motivate them for good oral hygiene practice, facilitate access to dental care, and advise them to have regular dental checkups.
Keywords: Oral hygiene; Diabetes Mellitus; Oral hygiene Knowledge; Attitude; Practices
References
Breast cancer is a pandemic non-communicable disease in the world. In early stage, most of the women are neglecting the disease but in advanced stage it is incurable as well as fatal. So, it is needed to increase information, education and communication system to prevent the disease. There is no evidence based treatment available to treat the fatal disease. Some evidence based herbal drugs like Echinacea purpurea, Allium sativum, Dacus carrota, Camellia sinensis, Panax ginseng, Cimicifuga recemosa, Linum usitatissimum can be used to treat the disease in early stage and prevent progression of the disease.
Reference
Background: Personal hygiene deficiency has been found to be a serious public health problem and people often affected are school children. These have been attributed to inadequate knowledge of personal hygiene and its practices. Personal hygiene is the science of healthy livings and embraces all those day to day activities that contribute to health and wellbeing of an individual. The diseases that arise due to deficiency of personal hygiene remain one of the major public health concerns, particularly in developing countries.
Objective: To assess the level of knowledge and practice about personal hygiene among secondary school children.
Methods: This was a Descriptive type of cross-sectional study. It was conducted from July 2023 to September 2023. Data were collected using self-administered structured questionnaire consisting of information about socio-demographic data and information about knowledge and practice about personal hygiene. The data were processed by computer and statistical analysis of data was carried out by using SPSS (Statistical Package for Social Science). A total of 115 participants participated in the study.
Result: Result showed that among 115 respondents’ majority were in class six and nine (28.7%). Most of the respondents were female (55.7%), 23.7% were 12 years old and all respondents were Muslim.97.4% knew about the relation between personal hygiene and health. Most of them 97.4% take bath every day and 100.0% brush their teeth every day. 78.3% respondents clean hair regularly and most of them 86.1% cut nails every week. Majority 75.7% respondents have the idea about use of clean clothing/undergarments/bed sheets. More than half 60.9% students do not forget to wash hand before having meal/ after defecation. Majority 85.2% respondents drink enough water daily (at least 1.5-2 liter) and most of them 99.1% have idea about the importance of pure drinking water. 93.9% respondents have regular habit of passing stool and urine. Majority 94.8% respondents have the knowledge to take enough vegetables, fruits, water regularly to avoid health problems and 77.4% knew that holding back urine can cause urinary tract infection and holding back of stool can cause constipation.
Conclusion: Personal hygiene is not an isolated behavior; instead it varies from person to person according to different factors. Intervention programs raising the awareness and importance of personal hygiene among school children through coordinated education measures by parents, teachers and media will be helpful to impart these early in life. Attention should be given for the monitoring and evaluating personal hygiene practices among children.
Keywords: Knowledge; practice; personal hygiene
.
Dental occlusion refers to closure which is assumed to be uneventful. But most closure is uneven because there are many facets on the teeth that may not coincide with one another so that a malocclusion develops. A disharmony can become harmonious by self adjustment which may be natural or the opposing jaws may never reach a harmonious state. It is up to the dentist to reach that decision however many do not look for disharmonies because there are few measuring systems to assess occlusal pathology. Often the pathology is an attempt by a patient to self adjust by grinding and gnashing their teeth. They never reach an occlusal harmony. That is the responsibility of the dental clinician but if the dentist does not see nor measure the disparities in the occlusal dynamic then the pathology remains and the oral health declines over time. Dentistry as a profession needs more education on the occlusion and better ways to assess the biting pathologies that exist in most people. An often used analogy is to a smooth running auto mobile where the wheels are properly balanced and aligned. First the teeth and then the jaws. It is worth a “look”.
Introduction
Over 1.9 million children of school age in the United States are tormented by a problem with side effects so serious that over 29% of them exit school before secondary school graduation (Ahmann et al., 2018). "Avery," a composite drawn by the specialist, is one of those understudies: Fifteen-year-old Avery, an eighth-grader at the nearby center school, is depicted as a brilliant, shrewd, disordered, hasty youngster. Kept down in kindergarten for adolescence and held in the 3rd grade to a great extent because of impulsivity, Avery is as yet attempting to defeat a standing of being wild.
Quickly flustered and having a limited ability to focus, Avery has a low disappointment resistance. His couple of companions are frequently furious with him. Different children could do without having him as a component of their helpful work-gatherings.
Each school year has been a battle for him scholastically with Avery scarcely passing, partially, because he neglects to record tasks or complete them or even to turn in tasks in the wake of completing them. Persistently baffled, frequently feeling that everybody is against him, Avery challenges his educators and invests energy consistently in the key's office for hollering out in class or for offering situationally improper remarks. Avery does not plan to disrupt the norms or to cause problems; it just consistently appears to happen to him. The drug he takes helps some yet he would rather not take it and doesn't believe that different children should be aware of it. He needs to go to secondary school one year from now, yet Avery doesn't know if he can hang on that long; furthermore, he is terrified of the change: "If I am scarcely making it in center school, how might I handle secondary school?" The reality of the situation is that Avery truly doesn't feel like he has a place or fits in at school or elsewhere.
"Avery" is a composite of understudies recognizable to this analyst. For youngsters like him, incorporating scores of thousands with ADHD, the impacts of dissatisfaction, discipline, dismissal, disappointment, and disarray over the years are combined and crushing. Research has shown that understudies determined to have ADHD are at an outrageous gamble for scholastic disappointment. The review demonstrates that understudies with ADHD are three to multiple times as possible as the normal understudy to drop out of school.
Scholastic and social disappointment for understudies with ADHD is unavoidable and total, making it extremely challenging to keep on remaining in school and register (Anastopoulos et al., 2018). Understudies with ADHD ordinarily experience difficulty with concentrating, and putting together, as well similarly as making sure to finish scholastic responsibilities. They experience difficulty with peer connections, are frequently youthful, and show a failure to sort out what to do in friendly circumstances or to alter their conduct given social criticism. Their associations with grown-ups are frequently stressed by their pugnacity and impulsivity. However, considering this large number of side effects/deterrents for scholarly achievement, an amazing 65% of the understudies with ADHD truly do figure out how to move on from secondary school and many alumni with good grades (Anastopoulos et al., 2021). The capacity to conquer weakening troubles brings up the issue: How do so many understudies with ADHD effectively complete their kindergarten through twelfth-grade insight notwithstanding the entanglements from ADHD, which frequently remember for going negative encounters at school?
While much consideration in momentum research has been dedicated to understudy dropouts in the general and minority populaces, incorporating quitters both with and without ADHD, there has been less spotlight on distinguishing those elements or conditions that urge ADHD in Students 6 understudies with ADHD to remain in school. Wolin and Wolin (1993) supported research on the effective elements in the existence of understudies, proposing specialists ought to examine people who have effectively conquered pessimistic obstructions. This is such a review. The capacity of specific understudies with ADHD to continue in school, particularly when the school climate is much of the time the most overpowering test these understudies have, seems perplexing (DuPaul et al., 2017).
The understudies' industriousness calls the inquiry: What variables urge understudies to remain in school and prevail despite the impediments introduced by the side effects of ADHD?
Problem Statement
Over 1.9 million young kids experience the ill effects of ADHD, the indications of which put them at a high gamble of exiting school. However, regardless of encountering rehashed and ongoing social dismissal and scholastic disappointment and disappointment, 1.2 million of these understudies will procure their secondary school recognition. Many of these understudies will likewise go on onto school or professional school, some proceeding with ADHD side effects and issues. A survey of the writing demonstrates that while the concentration in this space exists, insufficient is known or perceived in regards to the elements which add to scholastic accomplishment for youths and youthful grown-ups with ADHD, explicitly the impact of locus of control, adapting capacity, and grown-up help. An unmistakable comprehension of what upholds and spurs understudies with ADHD to succeed scholastically doesn't exist, nor is there an intensive comprehension of individual characteristics or of alleviating factors that cultivate the understudies' scholarly achievement (Dvorsky et al., 2017). This study looked for replies to questions in regards to medications which were seen by understudies with ADHD to be scholastically strong.
Literature Review
ADHD is an undeniably pervasive neurological condition that causes or fuels many learning, social, and enthusiastic issues for the two understudies and grown-ups. ADHD is assessed to influence 3-5% of all young youngsters, for certain examinations recommending an event pace of 10-20%.
Somewhere in the range of 1.59 and 2.1 million understudies in America have this issue, ordered to the American Psychiatric Association (Ewe, 2019). The center issues of ADHD-Impulsivity are hyperactivity, impulsivity, and absence of constancy. The center issues of ADHD-Inattention will be obliviousness and mental gradualness or drowsiness in performing perceptual-engine speed assignments. People may likewise have a combination of absentmindedness and impulsivity.
ADHD as a problem has center signs in consideration guidelines, action level regulation, and impulsivity. The key areas, which are attributes of the problem, are having extreme trouble with accomplishment in school, regardless of whether learning handicaps are available; introducing rebellion, hostility, and other solitary ways of behaving; and, dismissal by peers. Measurably, these key area highlights of ADHD place people with the problem at a basic gamble of exiting secondary school before graduation (Jansen et al., 2019). Measurements shift marginally for certain examinations showing that somewhere in the range of 35 and 40% of understudies with ADHD truly do leave school early and without a certificate. Battles looked by understudies tested by consideration deficiencies, if joined by hyperactivity, have been very much archived in late writing. This is especially obvious with what Aust (1994) alludes to as the "staggering social/passionate and instructive aftermaths of having ADHD."
Research demonstrates that one explanation ADHD kids are challenging to raise and instruct is because as little youngsters, they oftentimes display over the top (in recurrence and ADHD in Students 8 force) ways of behaving like hissy fits and tenacity. Guardians keep up with the fact that kids and young people with ADHD require significantly more observation and management than their non ADHD peers.
Youngsters with ADHD are accounted for to be m metal clumsy and to have a higher occurrence of issues, for example, inadvertent poisonings and genuine actual wounds because of their impulsivity (LaCount et al., 2018). More established kids with ADHD frequently foster attendant or existing together ways of behaving like hostility (verbal and physical), lying, insubordination, taking, delinquency, as well as expanded paces of wretchedness, uneasiness, a d lead or oppositional messes. An 8-year follow-up investigation of the scholarly results of kids analyzed as having ADHD confirmed that more than 29% had been held in somewhere around one grade, more than 39% had been suspended something like once, and more than 10% had been authoritatively ousted from school.
Learning is frequently fundamentally impacted by ADHD. 25% of youngsters determined to have ADHD have correspondence or learning handicaps. A little less than half of the understudies with ADHD show standards of conduct related to lead jumble and oppositional disobedient confusion. Different investigations show that as many kids with ADHD become older, their side effects frequently increase due, partially, to long periods of social, enthusiastic, and scholarly disappointment (Lefler et al., 2021). The appearance of youthfulness can bring new, unexpected issues. Puberty in America, even without a problem like ADHD, can be a troublesome time for both the juvenile and his/her loved ones. For most youths and their families, the young years are regularly a blend of fierce and quiet times. For youngsters tested by restraint problems, nonetheless, the violent piece of pre-adulthood, in combination with their hasty, disobedient characteristics and reduced by crap or social associations, can introduce snags that have never survived.
More than 49% of the understudies determined to have ADHD flop somewhere around one grade year in school and more than 29% of all understudies determined to have ADHD never complete secondary school. For those understudies with ADHD who in all actuality do remain in school, it is frequently challenging for them to keep up with fitting ways of behaving and to finish school tasks (Malmqvist, 2018). School is a battle for these understudies, and one of the most difficult scholastic battles for most understudies with ADHD is powerlessness or trouble with getting coordinated and remaining as such. Similarly, studies have shown that ADHD understudies naturally experience issues taking more time for their behavior, an ordinary characteristic Rotter (1966) considered an outer locus of control. Moreover, understudies with ADHD are regularly occupied and frequently proclaim remarks improperly, whether at home or in the study hall. As an outcome of these qualities, the understudies may over and over baffle or estrange instructors, peers, and guardians. These understudies, thus frequently feel that they are not upheld by educators at school.
Life at home with an ADHD relative is frequently distressing. For guardians, the subsequent strain of nurturing a kid with ADHD can bring about the conceivable reduced ability to parent suitably. This reduced limit can introduce another deterrent for the understudy and consequently present one extra region for the understudy where the backing is not accessible (McCoach et al., 2020). Steady with the family frameworks hypothesis, a family's effect on making or it is significant to support specific perspectives and ways of behaving. Guardians who are overpowered with nurturing a kid with ADHD can become focused on themselves. Unpleasant guardians are, thus, bound to deliver worried youngsters than non-stressed guardians.
This isn't to infer that everyday life is the reason for ADHD, as exploration demonstrates that ADHD is a neurological problem. Notwithstanding, in searching for factors that support scholarly accomplishment for understudies with ADHD, the examination proposes that there is a connection between a parent's capacity to adapt to pressure and the capacity of the youngster to adapt to pressure (Mochrie et al., 2020). How understudies return quickly from rehashed demoralization in the scholarly setting and how they remain focused to move on from secondary school is the focal point of this review, which inspected the understudies' scholastic progress in school from the perspective of the develops (locus of control, adapting abilities or capacities, and grown-up impacts). Information in regards to the effective variation of these understudies to distressing life conditions will add to the assemblage of information concerning deterrent intercessions for ADHD understudies as well as different understudies' incomparable high struggle classes.
Recommended Solutions
Intercession in the kindergarten or preschool years is a fundamental part of future scholastic achievement. The improvement of an interior locus of control and the development of one's adapting abilities ought to be started as soon as could be expected (Mohammad Hassani et al., 2018). Understudies endure pointlessly as a result of the absence of help by the school staff in a few regions, including how to assemble connections. In the early years, the ADHD understudy needs intercession as training for oneself about the confusion.
Such training can diminish social issues and forestall the fallout of decimating social marking which can happen. Immediate, centered mediation with the understudy with ADHD seems essential (Moore, et al., 2017).
Immediate, centered mediation seems essential as demonstrated by data from this review and others, ADHD understudies are frequently ignorant ADHD in Students 11 about the effect of their way of behaving on others and are commonly not deliberate in their activities, basically not in their initial years when intercessions can be best.
Past the need for schooling about the confusion, relational help on getting ready for the burdens that nurturing such a youngster makes is required. Guardians should be regularly reminded exactly how significant their job as a steady, predictable parent is: they need to know the crucial and basic nature of their inclusion (Pinho et al., 2019). Guardians need support about the positive future results as they battle with the consistent stress of kid raising. Guardians need
additional help from school guides in general training about ADHD and ADHD assets, as well as functional assistance with the association of the home and school plans whenever wanted.
Acknowledgement of the fundamental effect of having (and living with) somebody with ADHD is fundamental in laying out help and mediation plans.
The issue of drugs and their suitability ought to be a conversation right off the bat in the youngster's school profession. The viability of prescription is imperative. The quick and positive nature of the viability provided an opportunity to stop and ponder the potential hindrances of deferring drugs for kids with ADHD (Sacchetti et al., 2017). Prescription empowers understudies to tune in, learn, and make and keep companions. The capacity to find success in school and to associate with peers brought about an expansion in the confidence of the understudy. The deficiency of social help and individual confidence while guardians are choosing to permit drug treatment might take the kid a long time to recuperate.
Grown-ups who work with understudies, particularly key grown-ups, for example, instructors, should be intermittently helped to remember the effect of their mentality, words, and activities on the understudies. Educators and instructors who show concern and caring establish a lifetime positive connection. The individuals who do the contrary have a lifetime of adverse consequences. Educators who have had the accomplishment of empowering and creating in danger understudies, like those with ADHD, ought to be used by their school areas to share their educational procedures and study hall techniques with other school staff as a feature of a locale's ongoing proficient turn of events (Safer, 2018). Schools every day should be favorable to dynamic in the destruction of the badgering that happens at the school through prodding and verbal abuse. For understudies who don't have a sort of buffering home climate, the impacts of negative collaborations are possibly significantly really obliterating.
Grown-up experts who act negatively need mediation from their bosses. Such mediation could incorporate re-instruction, checking of execution, or thought of another call. Managers who permit experts to go on in places of power and impact youngsters ought to likewise be considered responsible for any inexcusable way of behaving (Scheithauer et al., 2017). Grown ups who are not equipped for non-emotionally diverting kids who are acting up or are oppositional ought not to be working with young people. The dependable pessimistic impacts of such a way of behaving concerning grown-ups who are paid to sustain and direct youngsters during the K-12 years is possibly disastrous.
Conclusion
The variables that help scholarly accomplishment for understudies are their characteristics of adapting and an interior locus of control, alongside an assurance to succeed which increments as they grow up (Weyandt, 2017). A few understudies encounter deficient companionship support all through their whole K-12 years. Understudies' schools do not show the ability to plan understudies for scholarly progress in their initial years. Understudies report being in homerooms with educators who deride, disparage, humiliate, alarm, push, and hammer them.
More data on ADHD is right now accessible to schools than was accessible when these ADHD in Students 13 understudies were in their rudimentary years. A review ought to be started to decide whether educators and school guides are presently better prepared to address the issues of understudies with the side effects of ADHD.
References
This study inspected factors that energized and upheld scholarly accomplishment for understudies determined to have ADHD. Understudies with ADHD are frequently not scholastically fruitful and don't move on from secondary school, due in an enormous measure to ADHD side effects of (I) hasty and careless ways of behaving, (ii) estrangement from soul mates including friends, and (iii) complication. The outcomes showed that all understudies in the review had been in danger of scholarly disappointment in light of their hastiness and social distance but completely were fruitful in secondary school. Understudies credited their school accomplishment to (I) their own creating inward locus of control, (ii) the development of adapting abilities and methodologies, (iii) predictable inclusion and backing by their folks which incorporated the whole family's capacity to acclimate to and oversee pressure, and (iv) the positive impact of no less than one caring instructor.
Introduction
Adenoid hypertrophy represents an enlargement of the adenoid tissue and can be a common condition in children. While this condition is more prevalent in children, it has been reported to regress with age. Due to age related adenoid deterioration, this condition can resolve on its own; however, it can lead to serious complications. The main symptom is obstruction of the nasopharynx, which can lead to mouth breathing, snoring, and sleep apnea. Adenoid hypertrophy can also cause recurrent upper respiratory infections, sinusitis, otitis media with effusion, and hearing loss. In some cases, adenoid hypertrophy can be severe enough to cause sleep disruption, which can lead to behavioral problems and learning difficulties. Adenoid hypertrophy is usually diagnosed by clinical examination or imaging, and the treatment is the surgical removal of the adenoid gland.
The complications that emanate from the blood supply to the adenoid are very low. However, in exceptional cases where there is an obstruction of the Eustachian tube, surgery may be considered to relieve the obstruction and improve hearing. The mainstay of treatment for adenoid hypertrophy is the surgical removal of the adenoid gland (adenoidectomy). Adenoidectomy can be performed using different techniques, including cold steel dissection, bipolar electrocautery, Coblation, or laser ablation. The choice of surgical technique is dependent on the surgeon's preference and experience.
Alternative remedies apart from surgical procedures have been explored and one such is the use of natural supplements. This is a significant finding because it shows that there are alternative treatments available for adenoid hypertrophy, without the need for surgery. The use of natural supplements is effective in reducing the size of the adenoid gland and alleviating the symptoms associated with adenoid hypertrophy. The deficiency of vitamins and minerals is a common cause of adenoid hypertrophy. As a preventative measure, it is important to ensure that the diet is rich in these nutrients. Supplementation with vitamins and minerals can also help to reduce the symptoms of adenoid hypertrophy.
Case Study (full)
Background: Preliminary results showed a 4-year-old male with Primary diagnosis of hypertrophy of the adenoid gland but also signs of eczema and always long-lasting colds accompanied a lot of mucus discharge that were occurring every month. Oftentimes, he was also constipated. Parents reported he was snoring at night and that they have planned an ENT procedure (adenoid removal) in 4 months.
Method: He was put on functional medicine gut healing protocol including elimination diet and inflammation reducing supplements, also using Proprietary blend 1 drops 1 drop B.I.D. He then slowly increased within 2 months to 3 drops B.I.D.
Results: In less than a month, his skin was without any signs of eczema, and his stool was normal. He had not caught a cold in 2 months.
Legend
Proprietary blend 1: silica, vitamin c, and trace minerals.
Proprietary blend 2: N-acetyl L tyrosine, anhydrous caffeine, L theanine, velvet bean seed, pine bark, curcumin, and vitamin d.
Proprietary blend 3: black seed oil, resveratrol, turmeric, raspberry ketone, apple cider vinegar, aloe Vera, and d-ribose
A minor one was reported after 2 months, but without any episodes of snoring. Snoring is completely resolved. He had an ENT exam in 2 months, checking his adenoid status. No adverse effects were reported.
Silica
Silica is a naturally occurring substance that is found in many foods and is also available in supplement form. It is necessary for the formation of collagen and helps to keep connective tissues, such as skin, bone, and tendons, healthy. Silica is also involved in the absorption of calcium and magnesium and helps to maintain healthy bones. Silica supplements are often used to treat osteoporosis, as they can help to strengthen bones. Silica is also sometimes used as a treatment for Alzheimer's disease and dementia, as it has been shown to improve cognitive function in some people. Silica can be toxic in large doses and should not be taken in supplement form if you are pregnant or breastfeeding.
Silica, in the form of silicon dioxide, is found in many foods. Foods high in silica include oats, barley, wheat, and rice. Silica is also found in leafy green vegetables, such as spinach and kale. Silica supplements are often made from horsetail extract, which is a plant rich in silica (EFSA Panel et al., 2018). Silica supplements are available in tablet, capsule, and powder form. As a food additive, silicon dioxide (E 551) is used as an anti-caking agent and flow regulator (EFSA Panel et al., 2018). It is found in salt, spices, dried soups, soup mixes, potato chips, corn chips, and other snack foods. Silicon dioxide is also found in some chewing gums and is used as a polishing agent in some toothpaste (EFSA Panel et al., 2018). Silicon dioxide is considered to be safe when used in food and cosmetics.
The deficiency of silica in the body can lead to several health problems, such as osteoporosis, Alzheimer's disease, and dementia. Silica supplements are often used to treat these conditions. Silica can also help to improve cognitive function in some people. Nanotechnology, an emerging field of cutting-edge technology utilizes physicochemical properties of nanomaterials as a means to control their size, surface area, and shape to generate different nanoscale-sized materials. According to Park et al. (2018), nanotechnology that uses silica decorated in silver inactivates the Influenza A virus (IFV-A). In a study done by Park et al. (2018), it was found that Ag30-SiO2 particles, which are silver nanoparticles decorated on silica, were able to reduce the infection that IFV-A caused on the cells.
Evidence of Silica/Silicon Dioxide for the Prevention or Treatment of Adenoid Hypertrophy
One study by Ivkovic et al. (2004), used a dietary supplement of zeolite to test the effect on immunodeficiency in 61 patients. The zeolite, TMAZ, was given at doses of 1.2 or 3.6 grams per day for 6-8 weeks. The study found that the group supplemented with 3.6 grams of TMAZ per day had increased CD4+ and CD19+ lymphocyte counts and decreased CD56+ cell count. The group supplemented with 1.2 grams of TMAZ per day had increased CD3+ cell count and reduced CD56+ lymphocyte count. There were no adverse effects to the treatment reported in either group. This study provides evidence that zeolite, specifically TMAZ, has immunomodulatory effects in humans and could potentially be used as a treatment for adenoid hypertrophy. According to Mastinu et al. (2019) zeolite is an antioxidant and anti-inflammatory agent. It is also a detoxifying agent. These properties could be beneficial in the treatment of adenoid hypertrophy. The exact mechanisms by which zeolite works are still unknown, but further research in this area is warranted. Based on the symptoms of adenoid hypertrophy, it is reasonable to expect that TMAZ would be effective in reducing enlarged adenoids. This is because TMAZ has anti-inflammatory and immune-modulating effects, which would be beneficial in reducing the symptoms of adenoid hypertrophy. Park et al. (2018) conducted a study, which found that Ag30-SiO2 particles, which are silver nanoparticles decorated on silica, were able to reduce the septicity on Madin-Darby Canine Kidney cells by IFV-A. Furthermore, the study found that the main antiviral action of Ag30-SiO2 elements emanates from interacting with viral constituents positioned at the membranes. Consequently, Ag30-SiO2 particles result in a nonspecific damage to different IFV-A constituents and form effective techniques to inactivate IFV-A. The antiviral property of nano silica has latency to be used to develop a new treatment for adenoid hypertrophy.
Vitamin C
Vitamin C is a water-soluble vitamin and needs to be taken in through diet or supplements, as the body cannot produce it. Vitamin C is found in many fruits and vegetables, including oranges, strawberries, kiwifruit, bell peppers, broccoli, and spinach. It is also found in some meats, such as liver and chicken. Vitamin C has many functions in the body and is essential for the growing and repairing tissues. It is also an antioxidant, meaning it helps protect cells from damage. Vitamin C is involved in the production of collagen, which is a protein that helps form connective tissue, such as skin, tendons, and ligaments. It is also necessary for the absorption of iron from food.
A lack of vitamin C can cause scurvy, which is an ailment characterized by fatigue, muscle weakness, joint pain, and bleeding gums. A vitamin C deficiency can also cause anemia, as it is necessary for the absorption of iron. In severe cases, a lack of vitamin C can lead to death. Taking too much vitamin C is not typically harmful, as the body will expel any excess in the urine. However, taking very enormous doses of vitamin C (excess of 2000 mg per day) can result in diarrhea, nausea, vomiting, and stomach aches (Gao et al. 2021).
Vitamin C aids the production of some neurotransmitters, such as noradrenaline and dopamine. It is also involved in the production of cortisol, a stress hormone. Vitamin C has several functions in the body, including aiding in the absorption of iron, boosting the immune system, and acting as an antioxidant. According to a 2021 study, high doses of vitamin C improved the oxygen support position and reduced the mortality rate in patients with Coronavirus disease 2019 (Gao et al. 2021). The study included 76 patients, 46 of whom were given high doses of vitamin C, and 30 who received standard therapy. The results showed that the high-dose vitamin C group had a lower risk of mortality than the standard therapy group (HR=0.14, 95% CI, 0.03- 0.72) (Gao et al. 2021). In addition, the high-dose vitamin C group had a better oxygen support status than the standard therapy group (63.9% vs 36.1%). The study also found that there were no safety actions linked with high-dose vitamin C remedy (Gao et al. 2021). Overall, Vitamin C is available in supplement form and can be taken orally. It is also found in many topical products, such as creams and serums.
Evidence of Vitamin C for the Prevention or Treatment of Adenoid Hypertrophy
Grebe et al. (2006) conducted a study on 10 healthy, untreated patients to test the hypothesis that endothelial dysfunction in OSA is related to oxidative stress. This research found that after an intravenous injection of 0.5 g of vitamin C, vasoreactivity improved in people with OSA to a level comparable to that tested in the control subjects. These results suggest that oxidative stress is liable for the endothelial malfunction in OSA and that antioxidant techniques, like vitamin C, must be exploited for the intervention of OSA-related cardiovascular infections. Vitamin C may thus have the potential as a preventative or treatment option for adenoid hypertrophy, which can obstruct the airway and lead to OSA. The study provides an evidence base for further research into the use of vitamin C for adenoid hypertrophy.
Asfora (1977) conducted a study to determine the influence of Vitamin C in treating common colds. The study found that when patients received 6.0 g of Vitamin C daily, the length of their colds was significantly reduced. The study also found that when the treatment began within 24 hours of the first symptoms, patients often did not develop the full cold. The findings suggest that Vitamin C can be used as a preventative or treatment option for adenoid hypertrophy. The study provides an evidence base for further research into the use of Vitamin C for adenoid hypertrophy.
Kim et al. (2015) sought to determine the effect of vitamin C in the production of epidermal ceramide in keratinocytes. The research found that vitamin C does stimulate the production of epidermal ceramide. Furthermore, the study found that vitamin C also increases the activity of S1P phosphatase, which is an enzyme responsible for the hydrolysis of sphingosine-1-phosphate (S1P). This finding suggests that vitamin C may improve overall epidermal barrier function. Drawing from the study, adenoid hypertrophy may be improved with vitamin C supplementation due to the stimulation of ceramide production. Ceramide production is important for the maintenance of epidermal barrier function, and thus, vitamin C may help to improve the symptoms associated with adenoid hypertrophy.
Trace Minerals
The role of trace minerals in human health is essential, as they are involved in many biochemical processes. More than 75 trace minerals are utilized in the proprietary blend, which is often found in foods such as meats, poultry, fish, and grains. However, the body does not store these minerals; therefore, a constant daily intake is necessary. Although the body requires trace minerals in small amounts, they play a vital role in many processes including being a key component for enzymes, supporting a multitude of biochemical reactions, and normal growth and development. The most important trace minerals are iron, zinc, chromium, copper, iodine, manganese, and selenium.
Iron embodies a vital constituent of several proteins and enzymes and is necessary to form red blood cells and lean muscular components. A lack of iron can lead to anemia, which is a condition characterized by fatigue, weakness, and pale skin. Chromium is involved in insulin function and glucose metabolism. A lack of chromium can lead to increased blood sugar levels. A lack of copper leads to anemia, osteoporosis, and joint pain.
Manganese is a key component of many enzymes and possesses antioxidant remunerations for a variety of metabolic purposes. It also supports bone development and wound healing. Selenium is a critical element of many selenoproteins, which contributes to reproduction, thyroid hormone uptake, DNA synthesis, and defense from oxidative harm and septicity. A lack of selenium can lead to goiter, hypothyroidism, and Hashimoto's disease. Iodine is a key constituent of the thyroid hormone. A deficit can have harmful implications on the development of the brain and can cause cognitive impairment and mental retardation in a child.
Evidence of Trace Minerals for the Prevention or Treatment of Adenoid Hypertrophy
The role of trace minerals in human health is essential, as they are involved in many biochemical processes. Selenium (Se), zinc (Zn), and copper (Cu) are trace minerals that have antioxidant properties and contribute to the immune system. Se, Zn, and Cu levels are decreased in patients with adenoid hypertrophy. The research aimed to estimate the Se, Zn, and Cu measurements in children with adenoid hypertrophy and to investigate the relationship between these trace elements and C reactive protein (CRP), white blood cells (WBCs), and adenoid size.
60 children participated in the study, 30 healthy children (Group 1) and 30 children with adenoid hypertrophy (Group 2). The Se, Zn, and Cu levels were measured in the plasma of all participants. The adenoid size was assessed by computed tomography (CT) in Group 2. The CRP and WBC levels were measured in both groups. The mean plasma Se, Zn, and Cu levels were considerably lower in Group 2 than in Group 1. There was a positive relationship between Se and Zn (r=0.276, p=0.033). The mean adenoid size was significantly larger in Group 2 than in Group 1 (p<0.001). The CRP and WBC levels were considerably higher in Group 2 than in Group 1 (p<0.001). This study shows that Se, Zn, and Cu levels are decreased in children with adenoid hypertrophy. The use of natural supplements containing these trace minerals may help to improve the antioxidant status and reduce inflammation in these children.
Chen et al. (2013) examined the relationship between Obstructive sleep apnea (OSA) and oxidative stress in 44 subjects. The subjects were between 3 and 12 years of age and had adenoid hypertrophy. The study found that OSA was associated with increased oxidative stress. The study also found that the use of natural supplements containing antioxidants, such as Se, Zn, and Cu, could help to reduce oxidative stress and improve OSA. The findings of the study show a higher plasma concentration of Se, Zn, and Cu in the OSA group than in the control group. The adenoid size was significantly correlated with the plasma concentration of Se, Zn, and Cu. The use of natural supplements containing these trace minerals may help to improve the antioxidant status and reduce inflammation in children with adenoid hypertrophy. Thus, the use of natural supplements containing Se, Zn, and Cu may help to reduce the symptoms of adenoid hypertrophy and improve the quality of life in these children.
In conclusion, silica, vitamin C, and trace minerals show promise as a proprietary blend for the treatment of adenoid hypertrophy in a 4-year old male. While more research is needed to confirm the efficacy of this blend, the current evidence suggests that it may be an effective treatment for adenoid hypertrophy. The case study shows that not only can this alternative treatment help reduce the size of the adenoid gland, but it can also help with other conditions such as eczema and constipation.
Reference
Adenoid hypertrophy is an obstructive condition of the adenoid, a patch of tissue behind the nose, characterized by difficulty breathing through the nose, post-nasal drip, chronic cough, snoring, excess nasal drainage, and/or sleep-disordered breathing. This condition has been reported to regress with age; however, it can lead to serious complications. Due to this, researchers have been seeking alternative medicinal therapeutics. In this paper, we will discuss the potential of silica, vitamin C, and trace minerals as a proprietary blend for treatment of adenoid hypertrophy in a 4-year-old male with primary diagnosis of hypertrophy of the adenoid gland, as well as signs of eczema.
General Causes of Asthma
Although it isn't apparent why some people become asthmatic and others do not, the mix of genetic and environmental variables is likely to be the cause of this. Asthma symptoms and signs may be triggered by encounters with numerous irritants and allergens (Ahmed & Turner, 2019). Airborne irritants include pollen, dust, spores, excrement, respiratory problems, cold air, harmful emissions, and irritants like cigarette smoke, emotional reactions, anxiety, sulfites, and p-phenylenediamine. When stomach acids flow into your esophagus, it's known as gastroesophageal reflux disease.
Signs and Symptoms
Children with asthma have a wide range of symptoms. Acute asthma episodes may occur just a few times a year; they may also arise exclusively at particular periods, such as while you're exercising. Children who have asthma often have symptoms such as difficulty of breath, wheezing while exhaling, difficulty sleeping, wheezing bouts, and coughing that are worsened by a respiratory disease, such as the cold or flu. All of these are indications and symptoms of Asthma (Beasley & Asthma, 2014). Increasing demand for a quick-relief inhaler is another clue that your asthma may be becoming worse. As assessed by the peak flow meter, asthma symptoms become more frequent and severe, increasing difficulty breathing. Those with exercise-induced asthma, for example, may have more severe symptoms when the air is chilly and dry. Asthma in the workplace is brought on by exposure to airborne irritants such as chemical vapors, gasses, or dust particles (Beasley et al., 2015). Pollen, mold spores, cockroach dung, or skin and dried saliva produced by dogs are common allergens that cause asthma attacks.
Case Study Presentation
This case study is about a young female patient of seven years with asthma who were taking Ventolin and Flixotide daily and saw her condition deteriorating. A chronic inflammatory illness, asthma affects children, adolescents, and adults. More than 20 million kids have been asthmatic in the United States alone. Asthma is caused by inflammation, irritation, and narrowing of the airways that transport air into and out of the lungs. Muscles around airways constrict, and mucus production inside airways rises beyond the ordinary. The respiratory and immunological systems fail to develop properly, resulting in this condition (Bush & Saglani, 2010). Breathing heavily, coughing, breathlessness, and chest tightening are symptoms. There is no treatment for asthma; however, medicines and lifestyle adjustments may help alleviate symptoms. Asthma may be diagnosed by medical history or a physical examination. Up to one third of kids with this condition get rid of it by reaching early adulthood, despite being more common in youngsters.
Risk Factors Associated with Asthma
Environmental allergens, viral infections, air pollution, cigarette smoke, and obesity are all risk factors for asthma. Asthma may be prevented by avoiding allergies, modifying one's diet, and increasing exposure to microbes. Once identified, a doctor will devise a treatment strategy to alleviate symptoms and reduce the risk of asthma attacks (Bush et al., 2017). Short-acting beta2-agonists (SABAs) inhaled into the lungs quickly relax the tight muscles surrounding the airways because there is no cure for this disease and reduce the body's inflammatory response by controlling medicines such as corticosteroids. Although this disease can be treated with medications, novel treatments are being investigated. Asthma treatment options that don't rely only on prescription.
Literature Review of the Case Study
Dyspnea, medication dependency, and a lack of social integration are just a few asthmatic children who face problems. Human health-related quality of life (HRQL) encompasses a wide range of subjective experiences linked to a person's physical and mental well-being and their capacity to cope with illness, disability, and impairment (Dharmage et al., 2019). When developing a questionnaire, the content validity is affected by the item selection method utilized. Although some published articles may imply differently, this knowledge is still insufficient when determining children's thoughts on HRQL via the focus group technique. Asthma-specific HRQL components were identified via in-depth focus group interviews with children in elementary school, which were used to gather data for this article. Individualized HRQL instruments for pediatric asthma will be developed using the components. Individualized devices are meant to identify and offer meaningful information for the specific needs of each person (Gans & Gavrilova, 2020). Asthma-specific HRQL tools are primarily used for research and cannot yet be used in therapeutic settings.
The airways and lungs of youngsters with asthma are easily inflamed when subjected to certain stimuli, such as cold or pollen or other breathing disorders. Adults who have asthma may find it challenging to participate in sports, schoolwork, and sleep. An asthma episode in a kid with uncontrolled asthma may be life-threatening (Guilbert et al., 2014). Even though asthma in children isn't different from asthma in adults, treating it may be particularly challenging. Emergency room visits, hospitalizations, and lost school days are linked to the disease. Unfortunately, there is no treatment for childhood asthma, and it may persist until adulthood. Your child's symptoms may be controlled, and lung damage can be avoided with proper therapy. You may see your child's chest and sides constricting as they try to breathe in the most severe instances (Feng et al., 2020). A rapid heartbeat, excessive perspiration, and tightness in the chest are all possible symptoms your kid is experiencing. It is best to seek immediate medical attention for any youngster who must stop mid-sentence in hopes of catching their breath and inhaling through the abdomen.
Diagnosis of the Case Study
Your kid may need the following tests to determine the health of the lungs (spirometry). Adult-specific tests are utilized to detect asthma in children. Spirometry evaluates how fast and how considerable air they can breathe out into a child's lungs. Lung examinations may be done during relaxation, after exercise, and while consuming asthma medication. Bronchoprovocation is another lung examination. A spirometry assessment shows how your lungs respond to various stimuli, including workouts or chilly air. Test for nitric oxide exhaled (Kuiper et al., 2005). The number of nitric oxides in an expelled breath sample from your kid may be measured by your doctor if the identification of asthma is questionable following lung function testing. Whether your kid has asthma, nitric oxide testing may help you evaluate if steroid therapy is the best course of action. However, the current asthma tests aren't reliable for children under five. Your pediatrician will use the information you and your kid offer concerning symptoms if your child is under eighteen. After months or even years of watching signs, a diagnosis may not be possible.
Discussion on the Case Study
Asthma control is now the primary aim of worldwide recommendations for asthma care. Inhaled steroids are an effective treatment for most asthma patients. However, some people are still unable to get their symptoms under control despite receiving proper asthma treatments. Nearly half of asthmatic children in the United States were uncontrolled in a multicenter study. A systematic assessment should be performed when treating children with uncontrolled Asthma (Maciag & Phipatanakul, 2020). This evaluation must involve first reconfirming the appropriateness of an asthma diagnosis and then assessing for any concomitant disorders that may impact one's ability to manage asthma. An asthma diagnosis might be tricky. Your kid's doctor will consider the frequency and severity of your child's symptoms and any prior medical conditions. Investigations to rule out other diseases and determine the most probable cause of the symptoms may be required for your kid. A variety of juvenile illnesses might generate similar symptoms to asthma. To make matters more complex, these ailments are often associated with asthma. Your kid's doctor will have to figure out whether your child is experiencing the result of asthma, something unrelated to asthma, or the combined effects of asthma and something else. Children with severe asthma may benefit from using Anti-IgE, a medication that works by lowering levels of the antibody IgE in the blood (Nakagome & Nagata, 2020). The efficacy of this chemical in treating asthma has been established in several published research. To open swollen airways, quick-relief medicines are available. In the event of an asthma attack, or if your kid's doctor advises it, quick-relief drugs may be administered to provide immediate, short-term relief of symptoms. Short-acting beta-agonists are examples of quick-relief medicines. An asthma attack may be quickly alleviated using these inhaled bronchodilators—both orally and intravenously (Pijnenburg & Fleming, 2020). People living with asthma may use these drugs to reduce the inflammation of their airways. Prednisone and methylprednisolone are two examples. Because of the potential for significant side effects, these medications are only prescribed for the short-term treatment of severe asthma symptoms.
Create an asthma action plan with your child's doctor. If your kid has severe asthma, this may be a vital element of their therapy. An asthma plan of action might be a valuable tool to assist you and your kid identify when long-term medication adjustments are necessary. Acquaint yourself with the warning symptoms of an asthma attack, and know what to do if one arises. A hand-held gadget may be used by youngsters who have sufficient coordination and knowledge to test their breathing ability (Pijnenburg et al., 2015). When peak flow measures exceed a certain threshold, having an asthma action plan in writing might help you and your kid recall what to do next. For example, the action plan may employ peak flow data and symptoms to identify your kid's asthma in various levels of severity. Each of the three zones corresponds to a different management level of symptoms. At first, you may not be able to pinpoint precisely what's bothering your kid. Signs should be closely monitored, and your doctor should coordinate medication adjustments.
Treatment of Asthma
A proprietary mix of one drop was prescribed, with two in the morning and two at night. After a few weeks, she began experiencing daytime mucus flow from her nose, and her parents noticed some mucus in her feces, despite their regular consistency. She started coughing up more mucus during the night after they upped her dosage from 2 to 3 drops twice a day. For a week or two, I went through these episodes. Parents were told to reduce their daughter's medication dosage, but at the same time, her condition improved. Her feces returned to normal, free of mucus, and she began sleeping better (Rabe et al., 2004). There was no longer any wheezing noted. During the following two months, she saw an improvement in her sleep and general function, and she no longer required Ventolin. Her pulmonologist also reduced her inhalation corticosteroid dosage to the bare minimum.
The intensity of your child's asthma dictates the first course of therapy. Controlling your child's asthma symptoms such that they are minimal or non-existent is the ultimate objective of asthma therapy. To achieve these goals, people with asthma must learn to manage their symptoms and treat an asthma attack while it is still in the process while minimizing the usage of quick-relief inhalers like albuterol and dealing with minimum or no adverse effects from the drugs they are taking. Asthma medications are tailored to each kid based on their age, symptoms, asthma triggers, and what works best to keep their condition in check (Ramratnam et al., 2017). Asthma symptoms in children under the age of 3 may warrant a wait-and-see attitude by the doctor. This is because the long period influences of asthma treatment on newborns and young children are not known. A newborn or toddler with severe wheezing may be given a medicine to test if it helps alleviate their symptoms.
Swelling in your child's airways is reduced with long-term, preventative treatments. For the most part, these drugs must be taken daily. The following are examples of long-term pain management medications: Fluticasone, budesonide, beclomethasone, and other inhaled corticosteroids are examples of this class. It may take a few days to a few weeks for these drugs to fully affect your youngster. The effects of long-term usage of these drugs on children's development are modest, although they have been reported. Controlling asthma in most circumstances is more beneficial than risking adverse effects. These include zileuton and other drugs taken orally (Schneider et al., 2017). For up to 24 hours, they may help alleviate symptoms of asthma. Inhalers that combine two or more medications. Corticosteroids and long-acting beta agonists are included in these drugs. Fluticasone and salmeterol, budesonide and formoterol, and fluticasone and vilanterol are a few of the medications in this class. Asthma episodes have been connected to long-acting beta-agonists in some instances. Therefore, LABA drugs should always be administered to a youngster with a corticosteroid inhaler. Only severe cases of asthma that have not responded adequately to previous treatments should be treated with these combo inhalers.
Preventive Measures against Severe and Uncontrolled Asthma
It's essential to limit your child's contact with asthma allergens as much as possible if she has the condition. They must identify the triggers that cause you to cough, gasp, and struggle for air. There is no treatment for asthma, but there are ways to keep it under control and avoid an attack. To begin, you must determine what causes the child's asthma symptoms to flare up since specific asthma triggers may start a chain reaction of symptoms. Allergens, air pollution, and chilly air are among them (Teach et al., 2015). For many weeks, keep a journal of your child's asthma symptoms. Describe how both physical and psychological factors impact their asthma. When they have an asthma episode, go back over your journal to identify what may have caused it. Molds and cockroaches, two major asthma causes, may not be readily apparent. Consult with an asthma expert to learn about allergy testing options. Avoid them at all costs.
To avoid an asthma attack while exercising in cold, humid, or dry air, children need to take precautions. Take your asthma medication as prescribed by your physician regularly by utilizing an asthma inhaler, including albuterol, before exercising. Allergens (items you're allergic to) should be avoided if you suffer from allergies or asthma. For a short time, exposure to allergens might cause your airways to become inflamed, rendering an asthma attack more probable (Toskala & Kennedy, 2015). Ensure that you are not exposed to smoke, including cigarettes, perfume or lamps, fires, or fireworks. Stay away from public areas that allow smoking, and don't smoke in your own house or automobile! Seek assistance if you want to stop smoking. Asthma is usually worsened by smoking.
The flu virus may worsen your asthma symptoms for days or weeks, so get vaccinated every year. Asthma increases your risk of flu-related hospitalization and comorbidities, such as pneumonia. Immunotherapy (allergy injections) may avert allergy symptoms and keep asthma from worsening if your doctor detects that you have allergies (Mutius & Smits, 2020). Allergy shots are injections of allergens into the skin that a doctor gives regularly.
Conclusion
This girl's case illustrates the need for a thorough differential diagnosis before determining that asthma is the root cause. Doctors should be alerted to the potential of additional airway obstructions if their patient's asthma is not responding to therapy. Because of this, we strongly advocate the idea of verifying a patient's diagnosis before attempting more costly treatments for uncontrolled asthma. Severe asthma might be challenging to control. Several medicines are now available to assist people with this illness, and experimental drugs are constantly being developed. Understanding the alternatives available and taking into account a patient's specific circumstances is essential to managing severe asthma. Both the disease pattern and individual choice must be taken into account. Bronchial thermoplasty was chosen as a treatment option for this patient because he indicated a strong preference not to add any other drugs to his current asthma regimen. For each patient, individualized therapy demands determining which of the current or forthcoming choices the most excellent fit.
References
Introduction
Your airways become swollen and restricted due to asthma, which is a disorder that causes your lungs to create more mucus. As an outcome, sneezing, wheezing as you breathe out, and breathlessness might transpire due to this disorder. Asthma might be a minor inconvenience for some individuals. Asthma attacks may be life-threatening for some people, so it's important to know what to look out for. This case study will present a case of chronic asthma in a seven year-old girl.
Results: His mom and dad, and coaches stated that he showed substantial progress in his ability to maintain attention and follow directions, as well as in his ability to complete particular school projects and remain focused during his basketball and soccer games. On days when he does not participate in sports, he will often take a proprietary mix of two capsules in the morning and a second capsule in the afternoon. He takes the Proprietary mix of two capsules without a meal and has seen a considerable improvement in his ability to concentrate as a result of the supplement.
There have been no known adverse effects.
Case Study No. 2
Patient's Gender: Male.
Twelve-year-old boy.
History: The mother states that after her son had the M.M.R. vaccination when he was one year old, he regressed and experienced a significant drop in appetite that lasted for nearly four years, as well as being hyperactive and preoccupied. In 2018, he was diagnosed with hyperactivity disorder (ADHD).
His treatment/method began at the age of twelve when he began using a Proprietary blend of 1, 5 drops B.I.D. He was diagnosed with ADHD.
Result: He claims that his "head feels clearer and less confused, that he has been trying to concentrate and focusing considerably better, that he sleeps better, and that it is easier to get out of bed in the morning" He claims that he is sleeping for longer periods of time and that he is feeling less hectic.
Follow-up is scheduled for six months.
Supporting literature
People with ADHD may struggle to pay attention and control impulsive actions (doing things without thinking about the implications) or being highly active, as shown in the two scenarios. ADHD is a chronic disorder that affects millions of children and often continues into maturity (Banaschewski et al., 2017). ADHD is characterized by a variety of long-term difficulties, such as difficulty focusing, hyperactivity, and impulsive behavior. ADHD may lead to low self-esteem, troubled relationships, and poor academic performance in children. As people get older, they may see a reduction in the symptoms. Some people fail to completely recover from their ADHD symptoms. Children, on the other hand, may learn to use successful strategies. ADHD symptoms often occur at an early age and become more noticeable whenever a child's environment changes, such as when they start school (Tong ET AL., 2020). The majority of cases are discovered between the ages of three and seven; however, they may also be discovered later in life. When ADHD is not detected as a child, it is often diagnosed in maturity. Even though the manifestations of ADHD usually improve with age, some people who were diagnosed with the illness as children continue to struggle (Tong ET AL., 2020). Additional challenges, including sleeping and anxiety problems, may be present in people with ADHD. In children, ADHD becomes the most frequently diagnosed psychiatric abnormality. It is more common in boys than in females.
Epidemiology
ADHD, as characterized by the D.S.M. standards, is among the most prevalent mental diseases in children and adolescents and has an epidemic incidence on a global scale of 5.3 percent. The implementation of the tighter ICD-10 research standards results in reduced prevalence estimations of 1-2%. As per the DSM-IV criteria, ADHD affects roughly 2.5 percent of the senior population. Among clinical populations (3-4: 1), Men have a higher incidence than women, according to epidemiological studies. An economically disadvantaged position is linked to ADHD, regardless of the fact that worldwide diagnosis rates have risen considerably in recent decades.
Rising diagnostic rates are therefore related to better diagnosis or an improvement in functional disability instead of an actual rise in incidence.
Increased motor excitement, lack of attention, and lack of impulse control are common characteristics of individuals with ADHD. The modern definition of ADHD, as described by the American Psychiatric Association's DSM-IV-TR (American Psychiatric Association 2000), is relatively recent. However, a review of historical literature indicates that youngsters exhibiting signs of attention deficit, restlessness, and recklessness have been recorded by a number of writers throughout the past 200 years (Tong ET AL., 2020). A continuing trend of inattention and hyperactivity-impulsivity that affects overall functioning or growth is characteristic of attention deficit hyperactivity disorder (ADHD). Individuals who have ADHD have a recurring tendency of the following side effects:
Inattention is defined as a person's failure to stay focused, maintain discipline, or stay on task, and it is not triggered by opposition or a lack of comprehension. Hyperactivity is characterized as a person who seems to walk around constantly, even if it is not desired, or who fidgets, bangs, or talks excessively. Adult hyperactivity might take the form of extreme restlessness or inappropriate talking.
Impulsivity is defined as a person's proclivity to act without thought or to battle with self control. Impulsivity can also be characterized as a need for immediate pleasure or an unwillingness to endure it. Somebody who is impulsive may cause problems for others or make key decisions without considering the long-term consequences.
Many healthy children are inattentive, restless, or impulsive at some time in their life (Rsov, 2019). Preschoolers are notorious for their short attention spans and inability to concentrate on a single activity for long periods of time. Even among older adolescents and teens, the number of interests influences focus and concentration. Hyperactivity works in a similar way. Youngsters are inherently lively, and they may keep going long after their guardians have worn out. Furthermore, many children are born with a greater degree of activity compared to others. Children must never be labeled as suffering from ADHD just because they are not like their classmates or siblings (Tong ET AL., 2020). Teenagers who have difficulties in the classroom but get along really perfectly when they are at home or even with their peers are most likely experiencing anything other than ADHD. This is similar for youngsters who become hyperactive or distracted at home yet still have no effect on their academics or friendships.
Symptoms
Symptom levels fluctuate throughout sectors of life and environmental stresses. In this regard, circumstances requiring focus, patience, and impulse management are frequently the earliest in which symptoms manifest (e.g., Classroom conduct, assignments, activities in the chair circle, etc.). However, substantial motor disturbance under four years is difficult to discern from normal activity. Furthermore, novelty, particular high incentive or reward anticipation, and powerful external behavioral controls might alleviate symptoms in specific instances (RÍsovÁ, 2019), but not permanently. The absence of symptoms within a constrained observational circumstance does not exclude the diagnosis. Inattentiveness increases in youngsters of elementary-age as outside pressures rise.
Inattentiveness, poor planning abilities, and impulsivity frequently linger throughout adolescence. Adults with ADHD may have more severe emotional disturbance symptoms, such as lower frustration endurance, impatience, and mood changes.
Longitudinal investigations have indicated a progressive decrease of main symptoms. G generally, roughly 5-15% of individuals meet the clinical definition for ADHD in maturity, despite 70% having chronic symptoms or impaired functioning (RÍsovÁ, 2019); however, results vary substantially between studies owing to methodological discrepancies and other factors. Comorbid illnesses may overshadow ADHD within the medical picture. Insufficiency in early infancy, parental psychopathology, intense core manifestations, and concomitant mental diseases (especially conduct problems and clinical depression) constitute risk variables for a poor course and longevity of ADHD (RÍsovÁ, 2019).
ADHD is linked to poor psychosocial functioning and perceived health-related standard of living. ADHD kids are four substantially less likely than their classmates to graduate from college and have a poorer socioeconomic level (Schug et al., 2015). Many of their engagements are tumultuous (10, 12). Their delinquency risk is increased by 2-3(Cortese, 2020). Their lifespan likelihood of suicide is fourfold greater compared to their peers; the degree of ADHD is significantly connected to the prevalence of suicidal behavior. The 50% rise in deaths among people with ADHD throughout all age categories is due to their accident-proneness, notably in motor vehicle accidents(Cortese, 2020).
It is natural for youngsters to have problems concentrating and acting at one point or another(C.D.C., 2020). Furthermore, individuals experiencing ADHD do not merely grow out of such habits. The symptoms remain, may be intense, and can create trouble in class, at home, or with colleagues.
Running head: ADHD 8 ix. Having problems connecting with others.
Clinically meaningful functional psychosocial disability has to be evident in several situations, such as at home, school, or job, in order to diagnose the illness (Sears & Zierold, 2017). Such fundamental indicators are dimensionally dispersed over a continuum within the overall population, with the higher end defining medically significant ADHD symptoms.
Approximately 75% of people experiencing ADHD also have another mental condition (Forns et al., 2014), while 60% have several comorbid mental illnesses, which might impact prognosis and demand particular treatment strategies (Banaschewski et al., 2017). Anxiety illnesses, tic abnormalities, and oppositional-defiant disorder (O.D.D.) begin earlier during child development.
The onset of depression and severe behavior problems usually occurs after the completion of elementary schooling and the start of puberty. In adolescence generally these disorders are connected with drug addiction and dependency, as well as the emergence of personality problems. ADHD affects around one in 4 kids, and more than 50 % of people with ADHD experience chronic depression (Lee et al., 2018). Comorbid disorders typically develop in successive phases with age, especially when comorbid disorders are distinct risk variables for subsequent mental illness progression. As a result, the age-dependent advancement of comorbidities frequently takes place in distinctive sequential stages, especially since comorbid abnormalities are specialized risk variables for the growth of additional mental disorders.
Pathophysiology
Genetics
ADHD runs in families. ADHD becomes five to 10 times more likely among first-degree families. According to twin research, 70-80% of phenotypic variation is hereditary (Tran & Miyake, 2017), sometimes in combination with environmental influences (epigenetic alterations of gene expression owing to particular environmental circumstances) (Banaschewski et al., 2017). The remaining variation is described by non-twin environmental variables. Shared environmental impacts are secondary. The etiology of ADHD has been linked to genes producing receptors and transporters for catecholaminergic and serotonergic neurotransmitter pathways. Common variations (variations with a prevalence greater than 5%) account for about 40% of genetic diversity (Banaschewski et al., 2017) but only slightly raises the risk.
The nicotinic and glutamatergic processes, as well as genes that affect brain growth and synaptogenesis, all play a role in ADHD etiology. There are also some genetic disorders linked to ADHD symptoms, such as fragile X syndrome, microdeletion 22q11 syndrome, tuberous sclerosis, and Williams-Beuren syndrome (Tran & Miyake, 2017).
Environmental risk variables
ADHD has been linked to many environmental variables in epidemiological research. Environmental toxins (organophosphates, P.C.B.s, lead) (Banaschewski et al., 2017), adverse psychosocial settings (severe poverty, maternal hostility), and dietary variables (maternal tension, smoking or drinking in pregnancy, reduced birth weight, preterm) are among the most important (Vrijheid et al., 2016). Many of these potential environmental risk variables have yet to be proved causal: The reported relationships could be attributable to confounding elements and selection influences. Moreover, ADHD may cause greater exposure to particular environmental elements. Multiple research has demonstrated that unfavorable mother-child relationships may generate (but not create) early childhood ADHD abnormalities and that maternal aggression adversely impacts symptoms later in life (Banaschewski et al., 2017). Contrary to popular belief, confounding variables do not account for the ADHD-related relationships with lower birth weights, preterm, and lead exposure (Vrijheid et al., 2016). Confounding elements appear to play a role in the relationships between ADHD and early exposure of the mother to stress and cigarettes. On the other hand, the causal significance of severe early childhood impoverishment has been demonstrated.
Neuropsychology
Research has demonstrated that various neuropsychological deficits in executive (inhibitory regulation, cognitive skills, planning abilities) and non-executive functions (stimulation and arousal modulation (Banaschewski et al., 2017), temporal processing, remembering, and reaction-time variation) in group comparisons. A sensitivity to postponed rewards, as well as impaired behavioral regulation and error encoding systems, influence motivational systems and learning procedures. Behavioral regulation and error processing systems are also decreased. Due to the small impact sizes, such abnormalities and their pattern are also shared with healthy control participants (Pellow et al., 2011). Only around 50% of ADHD sufferers have neuropsychological damage. It is still unclear if the related anomalies are causative or merely epi-phenomenal to the etiological pathways.
Anomalies in the structural and functioning of the brain
Gray matter is destroyed excessively, leading to a 3-5% loss in total brain volume. The development of the cortical regions, especially the prefrontal regions, is retarded. The gray matter is harmed more than the white matter. Prefrontal, basal ganglia, and cerebellar volume decreases correlate with the intensity of ADHD manifestations. Prefrontal development is slowed. The severity of these anomalies varies by brain area and client type. ADHD symptoms persisting into maturity correlates with such neuroanatomical defects. Within the prefrontal cortical regions the anterior cingulate gyrus, plus related parietal, striatal, as well as cerebellar regions, functional M.R.I. indicates hypoactive activity trends (Pellow et al., 2011).
Diagnostic evaluation
The diagnosis of ADHD involves a multi-step process. There is no singular examination to diagnose ADHD, and the symptoms of anxiety, depression, sleeplessness, and learning problems overlap with those of ADHD (Felt et al.,2014). A medical checkup, including ear and eyesight exams, is one stage in the process. When diagnosing ADHD, parents, teachers, and occasionally the kid is asked about their child's background.
One of the most important aspects of the diagnostic examination is the complete developmental and familial background (Pellow et al., 2011). Children and adolescents have their present medical manifestations and severity evaluated by their parents or even other people who connect with them. Observations from diverse sources should always be examined. In maturity, the individual becomes the major source of information, while data from relatives or other parties (e.g., school records) might be valuable (Pellow et al., 2011). Organized or semi structured conversations and checklists may help clinicians make clinical judgments, while disorder-specific questionnaires can help patients understand how teachers and families see them. Symptoms have to significantly hamper the client's productivity or social competence to be diagnosed (Li et al., 2020). The intensity of the main symptoms of ADHD/HKD is not only dependent on age or developmental stage. Questionnaires and checklists provide for easy, systematic, and consistent data gathering but might give deceptive results. If there are any differences in the patient's evaluation, extra information could be collected via the cellphone (e.g., from instructors or caretakers) or in person.
People filling out surveys are generally hesitant to offer unfavorable replies about children, or they might possess other emotional motives.
Psychological exams may be used to help answer particular differential-diagnostic queries. Considering the disorder's basic symptoms, 50% of all ADHD patients have appropriate cognition testing results (Li et al., 2020). One should eliminate diminished intellect by using a legitimate intelligence examination (e.g., WISC or CFT-20R for a preliminary analysis). Testing for thyroid illness, vision and hearing problems, organic sleep abnormalities, and drug-induced illnesses might aid in the examination of fundamental somatic illness or for the diagnostic process. ADHD is commonly misdiagnosed as a behavioral problem or melancholy. The basic symptoms of ADHD (poor attention, impulsivity, hyperactivity) should be distinguished from the dissocial and violent characteristics of conduct disorder (Monro et al., 2013). A loss of concentration and increased irritation might be attributed to a depressed mood disorder rather than a persistent expression of ADHD. Attachment disturbances, schizophrenia, and bipolar prodromes are many other uncommon clinical diagnoses.
Treatment
ADHD is usually treated as an outpatient. Whenever outpatient therapy fails because of poor cooperation, family finances, difficult drug modifications, or imminent school dismissal, partial or complete inpatient therapy might be required (Pellow et al., 2011). Other causes for inpatient therapy include difficult differential diagnoses or a heavy comorbidity load. There is no evidence that unsaturated fatty acid supplements have any impact on the basic manifestations of ADHD (32). No additional dietary measures are typically therapeutic.
The value of neurofeedback in a multimodal treatment approach is unknown. There aren't enough trials with high-quality learning regimens. These studies would definitely outperform other methods. Along with these therapies, medication (Muñoz et al., 2020) is an important part of treating ADHD (Muñoz et al., 2020). Several meta-analyses, such as the National Institute of Excellence's, have shown the effectiveness and tolerance of stimulant medication. A recent Cochrane study questioned the effectiveness of methylphenidate.
ADHD may be treated in numerous ways. However, evidence shows that multimodal treatment is optimal for many youngsters (Pellow et al., 2011). This entails combining different therapy modalities. Medication and counseling may help many ADHD symptoms. Therapists, physicians, educators, and parents must work closely together (Muñoz et al., 2020).
Medication. Stimulants remain the most often given ADHD treatments, despite concerns regarding overuse. They may reduce hyperactivity and enhance attention span. Inhibitors of impulsive behavior work on dopamine receptors within the brain. ADHD treatment may be pharmacological, nonpharmacological (Pellow et al., 2011), or both (Monro et al., 2013). These include stimulants (amphetamines and methylphenidate) and non-stimulants (atomoxetine, clonidine, and guanfacine extended-release). Stimulants are often considered first-line therapy. Following the discovery of an amphetamine molecule around 1937 and the F.D.A. authorization of methylphenidate around 1955, several research has been conducted regarding pharmacotherapy for ADHD.
Patient 1 began with 10 drops of Proprietary Mix 1 during the morning and evening hours. He began taking the Proprietary Blend 2 pills after three months. He began by taking one Proprietary mix 2 capsules each day, but after two weeks, he increased to two Proprietary blend 2 capsules in the morning and two in the afternoon. Inpatient 2, He waits 30 minutes before starting the exercises with them. At the age of twelve, he started utilizing a Proprietary mix of 1, 5 drops B.I.D. as a treatment/method. He was given an ADHD diagnosis.
Efficacy and Effectiveness
A meta-analysis10 of double-blind R.C.T.s demonstrated that ADHD medications outperformed placebo in reducing clinicians' ratings of lack of attention, restlessness, and impulsivity (KAREEM ET AL., 2019). The stimulating impact sizes were bigger compared to those observed in short-term R.C.T.s of psychiatric medicines in a number of different diseases. At the collective level, amphetamines outperformed methylphenidate, atomoxetine, and guanfacine. A greater reaction to amphetamines was shown in 28% of patients, whereas methylphenidate was seen in 16% of patients through crossover R.C.T.s (Muñoz et al., 2020). In case 1, the patient's mom and dad, and coaches stated that he showed substantial progress in his ability to maintain attention and follow directions, as well as in his ability to complete particular school projects and remain focused during his basketball and soccer games. On days when he does not participate in sports, he will often take a proprietary mix of two capsules in the morning and a second capsule in the afternoon. Inpatient 2, He claims that his "head feels clearer and less confused, that he has been trying to concentrate and focusing considerably better, that he sleeps better, and that it is easier to get out of bed in the morning"
He claims that he is sleeping for longer periods of time and that he is feeling less hectic.
References
Attention-deficit/hyperactivity disorder
Case Study No. 1
Patient's Gender: Male.
16-year-old is the appropriate age.
He has had attention deficit hyperactivity disorder (ADHD) since he was a child. He participates in sports and attends a premium school, but he has always had difficulty focusing on both school and sports.
Initially, he used 10 drops of the Proprietary mix 1 in the morning hours and at night, followed by 10 drops during the night. After three months, he began taking two capsules of the proprietary combination. The Proprietary mix 2 capsules were introduced to him in a one-a-day dose at the beginning, but after two weeks, he increased the dosage to two Proprietary blend 2 capsules during the morning hours and two in the afternoon. He gives them 30 minutes of his time before he begins the exercises.
Diagnosis
The diagnosis of this neuropathy necessitates a thorough medical examination to determine the different etiologies (Lehmann et al., 2020). Treating peripheral neuropathy is not always straightforward. Patients are referred for evaluation of peripheral neuropathy and have cervical myelopathy or bilateral lumbosacral radiculopathy (Siao & Kaku, 2019). Sometimes patients with multiple sclerosis come to be referred for evaluation of peripheral neuropathy since they present with numbness in the feet and gait imbalance (Siao & Kaku, 2019). One of the outstanding presentations of this neuropathy is symmetrical numbness of the feet with or without numbness of the hand (Siao & Kaku, 2019).
Clinical patterns
The first step in diagnosis is recognizing specific patterns that a patient with this neuropathy presents. These patterns are determined mainly by the signs and symptoms a patient with this disease portrays. Lehmann et al. (2020) proposed five clinical practices that could help doctors diagnose this neuropathy. The first pattern involves a slow progressive, distal symmetric, and primarily sensory neuropathy (Lehmann et al., 2020). This presentation is seen mainly in diabetes, chemotherapy, and alcoholic neuropathy patients. This patient needs limited evaluation when determining the diagnosis. The second pattern is slow and long-standing neuropathy, characterized by foot and muscle wasting (Lehmann et al., 2020). Patients with this neuropathy are limited, and diagnosis used to be focused on genetic testing (Lehmann et al., 2020). The third pattern is the onset of neuropathy with or without proximal involvement. Patients with this clinical presentation suggest that the neuropathy was acquired from an immune-mediated condition (Lehmann et al., 2020). Physicians here need to focus more on antibody testing. The fourth pattern involves rapid disease progression, neurological pain, multifocal symptoms, and autonomic dysfunction (Lehmann et al., 2020). This possible neuropathy with this presentation is amyloidosis, vasculitis, or paraneoplastic (Lehmann et al., 2020). Diagnosis of these three neuropathies required a patient to provide a detailed clinical history. The final pattern is sensory ataxic, which is related chiefly to sensory neuronopathy (Lehmann et al., 2020). Patients with this neuropathy present with a sense of vibration and proprioception (Lehmann et al., 2020).
Some patients with this neuropathy also portray some muscle strength. The diagnosis of this neuropathy involves the evaluation of mitochondrial and autoimmune disorders.
Clinical History
The diagnosis of this disease begins with a detailed history that includes family, occupation, and a list of medical uses (Siao & Kaku, 2019). Family history includes ethnic background, parent and sibling details such as the presence of possible inherited neuropathies, and consanguinity (Siao & Kaku, 2019). Social history consists of the residential area where the patient was currently residing, sexual history, alcohol and drug use, sexual orientation, and disease history (Siao & Kaku, 2019). The medical examination starts with a detailed history of symptoms, occupational and family history, and physical and neurological exam. Different patterns presented by this condition help build differential diagnoses based on how they present themselves. This presentation helps identify the etiology and helps the doctors know which treatment plan they will use to treat this neuropathy. After a detailed history has been recorded, the next vital step in evaluation is conducting a quantitative test.
Tandem Gait Testing
Tandem gait is one of the physicians' examinations (Margolesky & Singer, 2017). This test is widely used to screen patients with vestibular and neurological disorders (Cohen et al., 2017). Ordinary healthy people without neurological disorders; however, this performance decreases with time (Cohen et al., 2017). Individuals with neurological diseases cannot perform this test while their eyes are closed (Cohen et al., 2017). However, the test lacks a standard guide that could help researchers determine the sensitivity of abnormal tandem gait evaluation for peripheral neuropathies and neurodegenerative diseases (Margolesky & Singer, 2017).
Nerve Biopsy
Doctors perform another neurological test to determine if the patient has peripheral neuropathy: a nerve biopsy, M.R.I., and spinal tap. Nerve biopsy is one of the most recommended diagnoses for this neuropathy (Luigetti et al., 2019). Many neuropathies in the past produced peculiar lessons that were easily identified in the biopsy (Luigetti et al., 2019). Nerve biopsy helps diagnose dysimmune and vasculitic neuropathies (Luigetti et al., 2019). However, it is not effective in detecting inherited neuropathies. Genetic testing is highly recommended in diagnosing patients with peripheral neuropathies that result from inheritance (Lehmann et al., 2020). Current genetic testing includes NGS, which detects D.N.A. variants associated with peripheral neuropathy (Bacquet et al., 2022).
Neurological Examination
Evaluating the degree of nerve damage is essential in determining a particular clinical pattern (Lehmann et al., 2020). The doctor stimulates a nerve to assess if it will produce action potential (Rudin, 2019). The doctor will record the time from when a nerve stimulation occurred to when the action will be made and the magnitude produced (Rudin, 2019). These measures predict the extent to which this neuropathy has damaged the nerve. The two common neurological examinations are E.M.G. and N.C.S. An electromyogram (E.M.G.) is considered the standard for diagnosing this neuropathy (Jia et al., 2019). E.M.G. and N.C.S. confirm that the patient suffers from peripheral neuropathy, not other mimics like distal myopathy (Lehmann et al., 2020). They are also used to assess nerve damage's primary mechanism, such as demyelinating or axonal (Lehmann et al., 2020). These two tests are also used to determine which nerves are unaffected.
Peripheral Nerve Imaging
Ultrasound can be used to diagnose peripheral neuropathies. Ultrasound is used for patients suspected that they have an immune-mediated neuropathy. This neuropathy is primarily characterized by increased nerve cross-section, which can be imaged by an ultrasound (Lehmann et al., 2020). With nerve ultrasound, M.R.I. can view nerve segments that electromyography cannot access (Telleman et al., 2021). Nerve imaging helps to determine which nerves will be a target for biopsy examination (Lehmann et al., 2020).
Blood Tests
These laboratory tests are usually done to check if the patient has insufficient vitamins, toxic elements, or evidence of immune reaction. Blood tests are specific to the type of peripheral neuropathy; hence the doctor will first evaluate the clinical presentation of the neuropathy before ordering a blood test. Standard blood tests include folate and Vit. B12 levels, Hepatitis B and C, Lyme disease, HIV/AIDS, and antibody reaction tests (Lehmann et al., 2020).
Laboratory tests also include renal function, HbA1c, glucose level, liver function, and thyroid tests (Lehmann et al., 2020). Research has shown that deficiency of vitamin B12 can cause this neuropathy (Mallet et al., 2020). The shortage of this vitamin has also been linked with diabetes, one of the risk factors that elevate a person's risk of acquiring peripheral neuropathy (Mallet et al., 2020).
Case Study I
Patient: Male.
Age: 61-year-old.
History: A 61-year-old male, currently a union boilermaker and a steelworker since the late 70s, with pre-diabetes, hypertensive, peripheral neuropathic nerve pain, degenerative disc disease, and disc herniation. Experienced long-term exposure to environmental toxins including arsenic, lead, tungsten, antimony, thallium, cadmium, cesium, nickel, niobium, rubidium, titanium, and other heavy metals (working in a boilermaker, refinery, and steel mill). His symptoms included brain fog, sciatic pain, lumbar spine pain, and inability to sleep due to pain, and sitting and standing for long periods would cause pain and lower his quality of life. His medications consisted of Lotensin, Hydrochlorothiazide, Fenofibrate, and Vitamin D.
Treatment/Method: He started on ten drops of Proprietary blend 1 B.I.D.
Legend
Proprietary blend 1: silica, vitamin c, and trace minerals.
Proprietary blend 2: N-acetyl L- tyrosine, anhydrous caffeine, L-theanine, velvet bean seed, pine bark, curcumin, and vitamin d.
Proprietary blend 3: black seed oil, resveratrol, turmeric, raspberry ketone, apple cider vinegar, aloe Vera, and d-ribose
Results: After administering Proprietary blend 1, he noticed significant improvement in mental clarity, 90% improvement in neuropathic foot pain, and experienced improved quality of sleep.
Discussion
Patient Diagnosis
The patient suffers from a toxic neuropathy caused by exposure to harmful chemical substances like lead, arsenic, tungsten, antimony, thallium, cadmium, cesium, nickel niobium, rubidium, titanium, and other heavy metals.
Working in the boilermaker, refinery, and steel mill leads to chronic exposure to these toxic chemicals. Chronic and acute exposure results in nervous system disorders, immune system disorders, cancer, skin lesions, birth malformations, vascular damage, and kidney and G.I. dysfunction (Eskut & Koskderelioglu, 2021). Heavy metals result in neurotoxicity using oxidative stress, dysregulation of cell signaling, cell membrane disruption, and impairment of neurotransmission (Eskut & Koskderelioglu, 2021).
Heavy mental and Neurotoxicity
Lead toxicity is one of the significant causes of polyneuropathy characterized by wrist drops. The arsenic neurotoxic mechanism has not been proved, but researchers suggest it occurs through glutathione conjugation and oxidative methylation (Eskut & Koskderelioglu, 2021). Arsenic causes polyneuropathy, which does not cause multi organ involvement (Valappil & Mammen, 2019). Acute thallium poisoning results in seizures, mental disturbance, polyneuropathy, and memory impairment (Wang et al., 2021).
Prevention and Treatment for Peripheral Neuropathy
Different strategies have been proposed to prevent and treat peripheral neuropathies. There is no specific treatment for peripheral neuropathy as other underlying conditions in the body cause it. To manage it, treating the underlying conditions and their symptoms is the most used treatment plan to improve its symptoms. These underlying conditions are assumed to be the key triggers of peripheral neuropathy; hence keeping them under check improves the conditions and speeds recovery.
Nutritional Treatment of Peripheral Neuropathy
Nutrition regimens have shown evidence that they can treat peripheral neuropathy. There are proprietary nutritional blends used to treat and enhance symptoms of this condition: Silica, vitamin C, trace minerals, black seed oil, turmeric, L-tyrosine, anhydrous caffeine , and other nutrients. The patient was administered a proprietary blend composed of silica, vitamin c, and trace elements in this case study. Vitamin C Edobor's (2021) research on Wistar rats with diabetic peripheral neuropathy showed that administration of vitamin C reduces pain in them. Vitamin is a dietary supplement and an essential micronutrient vital for biological processes. Vitamin C has antioxidant activities that help overcome oxidative stress caused by reactive oxygen species (ROS) (Edobor, 2021). Most heavy metals damage the cell through oxidative stress. However, the administration of vitamin C helps cells counter oxidation stress through antioxidation. This treatment helps in managing pain in a patient with neuropathies. Pain is one of the significant symptoms of peripheral neuropathy that decreases the quality of life (Abdelrahman & Hackshaw, 2021). Evidence has shown that pharmacological treatment is ineffective in managing patients that result from peripheral neuropathy (Abdelrahman & Hackshaw, 2021). Huff et al.'s (2020) study shows that vitamin C is vital for myelinating Shawn cells in the (PNS) peripheral nervous system. This myelination results in the PNS nerves' saltatory conduction of electrical activities (Huff et al., 2020). Shawn cells also play a vital role in nerve regeneration after an injury. Huff et al. (2020) study used the mouse to illustrate how maternal vitamin C results in hypomyelination in the early development of infant mice. Vitamin C regulates periaxin and M.B.P. (Huff et al., 2020).
Zinc Supplements
Zinc is an essential micronutrient that has been used to treat a variety of sickle cell, neuropathic pain, muscle degeneration, and alcoholic liver disease (Abdelrahman & Hackshaw, 2021). Zinc deficiencies have been linked with immune suppression, apoptosis, and D.N.A. damage. The deficiency of trace elements like zinc also elevates the risk of an individual acquiring diabetes and diabetic conditions like diabetic neuropathy (Liu et al., 2014). The mechanism in which zinc is used to treat neuropathic pain since it plays a vital role in regulating oxidative stress. Zinc stimulates metallothionein synthesis by acting as a gene and expression protein (Liu et al., 2014). Mouse research has shown that zinc increases the mRNA transcript of proteins translated to produce metallothionein. Metallothionein is a powerful antioxidant that reduces oxidative stress that heavy metals have caused. When administered zinc supplements, rats with induced diabetic neuropathy showed reduced pain (Abdelrahman & Hackshaw, 2021). Metallothionein is also an anti-inflammatory agent which reduces neuropathy pain by reducing the pressure on the nerve endings (Abdelrahman & Hackshaw, 2021).
Vitamin B
This vitamin is one of the essential vitamins the body requires for biological processes. Vitamin B6, B1, B12, and B9 play a vital role in biological processes like immunity, R.N.A., D.N.A. synthesis, and metabolism (Abdelrahman & Hackshaw, 2021). Patients that have deficiencies in vitamin B12 have been shown to exhibit signs of lower and upper neuron dysfunction (Staff & Windebank, 2014). These patients also exhibit cognitive dysfunction (Staff & Windebank, 2014). Vitamin B6 has been shown to increase nerve conductance in rats with diabetic neuropathy (Abdelrahman & Hackshaw, 2021). Research has shown that vitamin B12 reduces neuropathy pain (Abdelrahman & Hackshaw, 2021).
Vitamin D
No research has provided a precise mechanism in which vitamin D reduces pain in neuropathies. Neuropathy pain has been treated with vitamin D in patients with type II diabetes (Abdelrahman & Hackshaw, 2021). One study proposes that vitamin D reduces pain in neuropathies by regulating cytokines (Abdelrahman & Hackshaw, 2021). Cytokines are a potent inflammatory mediator which results in acute or chronic inflammation. Inflammation increases the pain in neuropathies since it increases pressure on nerve endings. Vitamin D regulating cytokines will result in a reduction of inflammation.
Aluminosilicate
This regimen is used to treat or prevent neuropathies that result from toxic agents. Aluminosilicate is an adjuvant for zeolites which is a vital element due to its detoxification properties. Zeolite properties help the body detoxify harmful components like heavy metals consumed from the environment. Detoxification reduces pain in the peripheral nerve (Justia Patent, 2012). Silica reduces the pain in patients with neuropathies by removing heavy metals from cells. This removal results in a reduction of oxidative stress hence relieving the pain.
Conclusion
Peripheral neuropathies occur when there is damage to the nerves of the PNS. Damage to these nerves reduces dysfunction in motor and sensory functions. Individuals suffering from peripheral neuropathy tend to experience mild to severe symptoms, which continue to be severe as time goes by. Some of the symptoms of this condition include lack of coordination, paralysis, gradual numbness, and sharp pain. Several etiologies have been identified to be the cause of this neuropathy. These etiologies include diabetes, toxins, infections, autoimmune disease, and specific cancer. Individuals with these conditions tend to portray an elevated risk of acquiring peripheral neuropathy. Diagnosis of this neuropathy is not straightforward, and the doctor needs to follow standard protocols to determine if the neuropathy affects the patient. The doctor must conduct a detailed clinical history and perform quantitative tests to confirm and resolve the severity of the condition. Current treatment strategies focus on treating the etiology after the doctor. Antidepressants, anesthetics, and narcotics are some of the recommended pharmacological therapies for treating neuropathies. The medicines are also used to relieve the symptoms of peripheral neuropathy. Research has been increasing to find other more effective methods than pharmacological therapies. Nutritional supplements, including vitamins, herbal products, and trace elements, effectively manage pain in these neuropathies (Abdelrahman & Hackshaw, 2021). Extensive research on mouse models has illustrated their efficacy and mechanism in pain management. There is a significant need to translate these researches into a clinical setting to determine their efficiency in human beings and how they will help patients manage pain due to peripheral neuropathy.
References
Introduction
Peripheral neuropathy occurs when damage to the peripheral nervous system, which are the nerves located outside the spinal cord and brain. These nerves are responsible for carrying signals to the rest of the body, including the contraction of the body's muscles, urination, the blood vessels, the bones, the heart, digestion, sexual function, and the immune system. Symptoms can range from mild to severe and can develop over a long period of time. Signs of peripheral neuropathy include sharp or jabbing pain, gradual numbness, lack of coordination, extreme sensitivity to touch, muscle weakness, and in severe cases, paralysis. This neuropathy is brought on by several different conditions such as diabetes, tumors, infections, autoimmune diseases, inherited disorders, bone marrow disorders, certain cancers, and other diseases. People with a family history of neuropathy, alcohol misuse, diabetes, infections, kidney, liver, or thyroid disorders, and vitamin deficiencies are more likely to develop this neuropathy. Several studies have shown that obesity also elevates the risk of an individual developing this disease (Callaghan et al., 2018). This neuropathy is prevalent in old individuals, thus significantly reducing the quality of life (Callaghan et al., 2018).
Since their discovery, the targeted transport of substances into various organs, including the brain, has been accomplished with the help of nanoparticles. The primary pathophysiological alteration in most illnesses involving the brain has been identified as neurodegeneration (Armstrong & Okun, 2020). Despite modern science's constant attempts to provide a medicinal or surgical cure, the results have failed. Many older adults continue to experience clinical concerns related to Alzheimer's and dementia (Mathis et al., 2020). Despite its remarkable effectiveness, the blood-brain barrier (BBB) still poses a significant obstacle to the efficient therapy of many illnesses (Delamarre & Meissner, 2017). Alzheimer's disease is characterized by dementia common, a progressive disease characterized by mild memory loss, potentially leading to loss of communication ability. Parkinson's disorder affects the nervous system leading to stiffness with balance and coordination loss. Similarly, Amyotrophic sclerosis, a nervous system disease, affects the brain's nerve cells, thus causing loss of muscle control (Mathis et al., 2020). Even with the numerous triumphs achieved with surgeries and extremely evasive techniques, their clinical acceptance is constrained because of conflicting worries about their long-term benefits due to the possibility of damaging the blood-brain barrier.
Recently, millions of people have been affected by neurodegenerative diseases globally (Tambasco, Romoli & Calabresi, 2018). Researchers have shown that a mix of an individual's genetic makeup and environmental circumstances can contribute equally to increasing the risk for NDs, even if age is the most critical risk factor for developing all NDs (Bloem, Okun & Klein, 2021). The severity and timing of neurodegeneration also heavily depend on the local environment, despite the expression of specific genes responsible for NDs (Delamarre & Meissner, 2017). Recent research has shown that many other disorders may accompany a single neurodegenerative illness. Therefore, the severity of NDs depends purely on the nature and stage of the disease; in some cases, they may even be life-threatening (Mathis et al., 2020). These disorders thus impair numerous elements of human functioning and impede the capacity to accomplish simple and complex tasks since the brain regulates several bodily functions. While the majority of these conditions proceed without remission, some treatments aim to lessen symptoms, relieve any pain that may be present, and restore balance and mobility (Vázquez- Vélez & Zoghbi, 2021). This review comprehensively discusses the numerous NDs (Parkinson's disease, Amyotrophic lateral sclerosis, and Alzheimer's disease with the case study), their alternative treatments and the effectiveness of integrated approaches for management.
Parkinson’s disease
Introduction
Parkinson's disease (PD) is a common neurodegenerative disease characterized by postural instability, resting tremors, and rigidity (Jankovic, & Tan, 2020). The clinical symptoms and some of the therapeutic targets have been found to alter the progressivity of this disease. Typically, early symptomatic phases of PD are when treatment decisions are made to reduce disability resulting from the earliest motor signs and symptoms, avoiding motor problems later on, and, ideally, decreasing the disease's course (Bloem, Okun & Klein, 2021). Other stages of treatment have different goals, such as managing motor problems, preventing falls, treating dementia and psychosis, and finally, delaying the damage to self-sufficiency (Jankovic, & Tan, 2020). Moreover, the reflection of medicine changes is considered highly influential during the first 3-5 years to become linked to motor problems, which can include unpredictable on-off swings and dyskinesias, as well as a shortening of the antiparkinsonian effect's duration. Tysnes & Storstein, (2017) asserts that an increasing concern with the non-motor characteristics identified in Parkinson's disease, includes pain, sleep disorders, and neuropsychiatric symptomatology.
Nevertheless, non-pharmacological treatments for this condition may include psychosocial counselling, work-related therapy, speech, and physiotherapy (Bloem, Okun & Klein, 2021). Surgical therapies have also become crucial, mainly due to subthalamic nucleus stimulation. This white paper seeks to conduct a comprehensive review of Parkinson's disease and patient case studies presented with the disease and discuss the alternative to the treatments and the effectiveness of integrated approaches to treatment (Bloem, Okun & Klein, 2021).
History and Epidemiology
Parkinson, in 1817 described Parkinson's disease as a neurological syndrome, although his fragments of Parkinsonism were still in earlier descriptions. Also, the earliest reports of PD can be found in traditional Indian writings dating from 1000 BC and ancient Chinese sources. According to estimates based on healthcare utilization, incidences of Parkinson's disease range between 5 and 35 new PD cases yearly (Simon et al., 2020). Between the sixth and ninth decades of life, the incidence multiplies by 5 to 10 times (Tysnes & Storstein, 2017). Age is also seen to associate with the development of Parkinson's disease. Studies have shown that Parkinson's disease prevalently rose from less than 1% among men and women aged 45–54 to 6%, according to the meta-analysis of four North American groups (Tysnes & Storstein, 2017). In the next two decades, the prevalence of PD is predicted to more than double as the world's population ages. In addition to this rise, the societal and financial costs associated with PD will rise unless better cures, treatments, or preventative measures are found.
PD Risk Factors
Environmental factors
Although numerous research studies have identified the environmental factors contributing to PD, most findings have yet to be deemed conclusive. Water-borne risk factors and pesticide exposure impacts have received the majority of attention (Vázquez-Vélez & Zoghbi, 2021). The Geo-Parkinson study investigated such correlations among the five European nations and discovered a high proportion of pesticides containing manganese in patients' brains during a necropsy examination (Simon et al., 2020). Hence, it is hypothesized that even a little pesticide exposure can significantly raise the risk of developing PD (Simon et al., 2020). A meta- analysis of environmental risk factors for PD development shows that individuals living in rural areas and getting their water from wells are more likely to develop PD (Chen, Li & Liu, 2020). Therefore, the potentiality of developing PD is said to associate with exposure of pesticide.
Genetic Risk Factors
Genetic factors are also deemed major type of risk factors leading to PD development besides environmental exposures (Marinus et al., 2018). Despite PD accounting for a slight percentage of cases, it may also give a firm and precise understanding of the underlying mechanisms (Delamarre & Meissner, 2017). Since the disease is linked to several protein products, it has been established that different genes can influence how the disease manifests (Delamarre & Meissner, 2017). SYN gene mutations are thought to speed up the beginning of the disease in both people and animals. Moreover, findings shows that these mutations can cause dopaminergic neuronal degeneration, a reduction in motor function, and muscular atrophy (Delamarre & Meissner, 2017). However, research indicates that PTEN-induced kinase produces essential PINK1 protein which is majorly associated with causing containment in oxidative stress occurring in the mitochondria (Marinus et al., 2018). Moreover, PINK1 genes cause PD in the same way that SYN genes do. However, a critical genetic component has been applied since PINK1 gene is purported to cause PD (Chen, Li & Liu, 2020). Based on these findings, it has been established that mutations in the genes SYN independently cause the beginning of PD (Chen, Li & Liu, 2020).
Oxidative Stress
Oxidative stress refers to a phenomenon that causes the disparity in creation and accumulation of volatile oxygen species in tissues and cells (Delamarre & Meissner, 2017). Dopamine-producing neurons in the nigrostriatal system have been identified as the main cause of PD (Marinus et al., 2018). The role of unstable free radicles in the degeneration of nerve cells is among the triggers for PD that is gaining popularity (Chen, Li & Liu, 2020). Reactive oxidative species (ROS), often known as free radicals, are byproducts of chemical reactions that mainly occur in the mitochondria (Vázquez-Vélez & Zoghbi, 2021). The amount of ROS generated under some circumstances may surpass the capacity of the cleanup systems thus the inability to contain the disease (Vázquez-Vélez & Zoghbi, 2021). Typically, oxidative stress is the name given to this process and thus due this failure, the highly volatile oxidative types combine with other stable molecules (Delamarre & Meissner, 2017).
Pathophysiology
Parkinson's disease pathophysiology involves the demise of dopaminergic neurons because of the changes in biological actions within the brain concerning PD (Marinus et al., 2018). Several mechanisms have been developed in response to the death of neuronal cells in PD. Diverse hypothesized causes for neuronal death in PD are available some of which include; Lewy body aggregation, and blood-brain barrier disruption (Chen, Li & Liu, 2020). One of the main factors contributing to neuronal death in Parkinson's disease is protein oligomerization (Simon et al., 2020). Alpha-synuclein is more prevalent in the brain of PD patients and due to their insolubility, it clumps and form Lewy bodies within the neurons (Simon et al., 2020).
Moreover, heat-shock proteins help in refolding proteins that are prone to aggregations because of its favorable effect on Parkinson's disease (PD) when overexpressed (Delamarre & Meissner, 2017). These findings support this process. Reduced DNA repair appear to be closely related in ways that include alpha-synuclein (Tysnes & Storstein, 2017). Alpha-ability synucleins usually facilitate in the overall DNA repair process which is known as non-homologous end joining the double-stranded DNA breaks (Tysnes & Storstein, 2017). Simon et al., 2020) asserts that Lewy bodies, forms when alpha-synuclein aggregates in the cytoplasm, lower the nucleus levels of the protein, which in turn increases DNA double-strand breaks and raise programmed cell’s death within the neurons.
PINK1 and Parkin complex is thought to be the cause of mitochondrial malfunction in Parkinson's disease because it has been demonstrated that it promotes the autophagy of mitochondria (Vázquez-Vélez & Zoghbi, 2021). The protein can build up on the surface of damaged mitochondria in addition to being routinely carried inside the mitochondrion (Marinus et al., 2018). According to Marinus et al. (2018) these genes are assumed to be altered in Parkinson's disease, restraining the interruption of injured mitochondria, resulting to aberrant mitochondrial role and shape, and eventually cell death. However, the accumulation of mitochondrial DNA alterations has also been observed, signifying that this mechanism of neuronal death can be that susceptible with aging (Tysnes & Storstein, 2017).
Clinical Features and Diagnosis
The disease has distinctive neuropathological changes in the brain changes. Researchers have identified six neuropathological disease phases as PD stages (Tysnes & Storstein, 2017). Stage one and two of the disease according to Marinus et al. (2018). are usually the pre- symptomatic stages, in these stages the inclusion of bodies is restricted to the medulla oblongata and the olfactory anterior part of the nucleus. Substantia nigra and the forebrain nuclei are obstructed as the disease gets worsened within stages 3 and stage 4 (Vázquez-Vélez & Zoghbi, 2021). It is claimed that individuals usually begin to display clinical symptoms of the condition at this stage (Bloem, Okun & Klein, 2021). Individuals begins to show clinical signs of the illness at this point, and the process proceeds to last stage that is stages 5 stage 6 which is characterized by a wide range of clinical symptoms (Bloem, Okun & Klein, 2021). Although there may be problems in many other nervous system activities, motor disturbances typically characterize the clinical symptoms of PD (Vázquez-Vélez & Zoghbi, 2021). The dopaminergic medication may trigger or worsen some of the signs, symptoms thus can be divided into motor and non-motor symptoms (Delamarre & Meissner, 2017). A common sign can be bradykinesia, characterized by a delay at the beginning of intended actions and an advanced decrease in the speed and plenty of repetitive movements. These characteristics are prerequisites for PD diagnosis in addition to muscular rigidity and postural instability (Delamarre & Meissner, 2017).
The bradykinesia may cause an expressionless visage and reduced handwriting amplitudes (micrographia) (Bloem, Okun & Klein, 2021). A resting pill-rolling gentle of tremor of the hands is the most predominant limb tremor, affecting about 80% of people. (Tysnes & Storstein, 2017). The propensity of the thumb and index finger to come into touch and move in a rotary motion is known as "pill rolling." Typically, the tremor involves the legs, and other types of tremors which might occur (Vázquez-Vélez & Zoghbi, 2021). Bloem, Okun & Klein, (2021) estimates that more than half of the patients have speech abnormalities like quiet or rushed talking. Dystonia is another motor sign of PD, a continuous muscular contraction characteristically convoyed by atypical postures, motions, or both (Delamarre & Meissner, 2017). Most dystonic symptoms are connected to medicinal and surgical therapy, which may occasionally be a pre-diagnostic sign in PD. For non-motor symptoms, autonomic function disturbances and cognitive, sensory, and sleep disturbances have been commonly reported (Delamarre & Meissner, 2017).
Case Study
Choosing effective therapeutic interventions for every patient with their respective diseases for decades has become an issue due to fluctuating and advanced natural conditions and the required evaluation of numerous sources with the latent application to patient supervision (Tambasco, Romoli & Calabresi, 2018). However, this section provides a case study for a PD patient and further emphases on current available suggestion for the pharmacological treatment of PD motor symptoms. Therefore, to ascertain alternative treatment and integrated approaches toward PD management, we will look at the case scenario below.
A 63-year-old male having a 4-year history of Parkinson's disease had been referred to the movement disorders outpatient clinic due to deterioration of the condition. His medication consists of levodopa/benserazide 200mg/50mg. The patient started on two capsules of a proprietary blend.
No. 1, once in the morning and once at night, for three days. He then increased the dosage by one drop every three days and built up to 10 drops twice daily. No. 2, one capsule in the morning and afternoon for ten days. He then increased to two in the morning and one in the afternoon and added one sachet of proprietary blend. No.3 to his diet, one in the morning. He also started taking six drops twice daily of proprietary blend. However, after one-month, cardinal symptoms of Parkinson's disease would be, resting tremor and muscle stiffness signifying slight decrease. In addition, his quality of sleep improved, as well as his gait. His medications have not changed.
Treatment and Management of Parkinson's disease
Medication is known as the most popular therapy for PD. The intention is to remedy the dopamine insufficiency, which is the root of the symptoms (Tambasco, Romoli & Calabresi, 2018). Pharmaceutical therapy is typically initiated as symptoms interfere with daily activities or become incapacitating (Armstrong & Okun, 2020). Several treatments may be used basing on the patient's age, reactions, and symptoms towards a particular medication. However, finding the ideal medicine combination for each patient can frequently take some time (Armstrong & Okun, 2020).
The most efficient medication for treating PD is levodopa, a precursor to dopamine in the body (Delamarre & Meissner, 2017). Levodopa is mostly inactive; dopamine is formed when levodopa is decarboxylated, which has both medicinal and harmful consequences. The drug is quickly absorbed from the small bowel after oral administration thanks to the transport mechanism for aromatic amino acids (Armstrong & Okun, 2020). After an oral dose, concentrations of drug in the blood peak within 0.5 and 2 hours later. The pH of gastric juice, the pace of stomach emptying, and the amount of time the medication is visible to the digestive intestinal mucosa all affect how quickly and how much absorption takes place (Tambasco, Romoli & Calabresi, 2018). Typically, levodopa may be less readily absorbed if food amino acids compete for absorption sites in the small bowel; thus, taking this drug with meals delays absorption as well as lowers peak plasma concentrations (Bloem, Okun & Klein, 2021). The drug is primarily decarboxylated into dopamine in the brain's striatum, in the presynaptic joints of dopaminergic neurons. The dopamine generated is what gives the medication its therapeutic impact on PD (Armstrong & Okun, 2020). Levodopa drug is often administered in clinical practice along with a peripherally acting aromatic l-amino acid decarboxylase inhibitor with poor CNS penetration, such as carbidopa (Tambasco, Romoli & Calabresi, 2018). If it is taken alone, it will substantially decarboxylated by enzymes present in the intestinal mucosa, thus only a small amount of the drug will remain intact and probably only few penetrates to the brain by less than 1%. Dopamine concentrations in the bloodstream cause nausea by activating the chemoreceptive trigger zone in the brainstem (Vázquez-Vélez & Zoghbi, 2021). The amount of initiated levodopa remaining will not be metabolized thus they are available to pass the blood- brain barrier increases with peripheral decarboxylase inhibition, lowering the likelihood of gastrointestinal side effects (Bloem, Okun & Klein, 2021). Carbidopa 25 mg/levodopa 100 mg is the dosage of carbidopa with levodopa that is most frequently recommended as a result. With this formulation, dose regimens of three or more pills daily offer most people satisfactory decarboxylase inhibition (Tambasco, Romoli & Calabresi, 2018).
In the aforementioned case study, it is seen that the major symptoms the patient presented were resting tremor, rigidity (muscle stiffness), and Bradykinesia. However, as the literature and research findings mentioned, bradykinesia and rigidity are among the typical clinical features associated with Parkinson's disease (Delamarre & Meissner, 2017). Patient experienced a spontaneous loss of movement in the case of bradykinesia. The patient experienced rigidity because of resistance to movement due to an opposing muscle. However, rigidity as a symptom comes about when the opposing muscles' delicate balance is hampered in response to the signals originating from the brain (Armstrong & Okun, 2020). Typically, tremor, as a primary symptom associated with PD, takes the arrangement of a rhythmic movement of the forefinger and the thumb. It is also seen that the patient had not changed his medication and maintained his levodopa/benserazide 200mg/50mg dose (Armstrong & Okun, 2020). Since the drug relieved the symptoms one month after administration, it proves that levodopa is an effective drug that many patients with PD can use (Tambasco, Romoli & Calabresi, 2018).
Alternatives to PD Treatment and Management
The effectiveness of levodopa drugs does not limit the inclusion of other treatment models and approaches for the disease. Due to the continued vigorous research, researchers are finding more alternative treatments that can be used to cure PD through clinical trials and drug development other than the known ones (Simon et al., 2020). Recent research findings have highlighted drugs such as Bromocriptine, Ropinirole, and pramipexole as other drugs primarily for PD symptoms (Tambasco, Romoli & Calabresi, 2018). These integrated approaches are dimmed effective in action and less associated with adverse effects. Dopamine-Receptor Agonists, unlike levodopa, have effectively treated PD since they do not require enzymatic translation to active metabolites (Armstrong & Okun, 2020). Additionally, Dopamine-Receptor Agonists do not hinge on the functional capacities of the neurons and are thus considered a better alternative treatment for Parkinson's disease (Delamarre & Meissner, 2017). COMT inhibitors have been identified as a relatively recent class of medications for treating PD (Bloem, Okun & Klein, 2021). It is associated with the catabolism of Levodopa and dopamine. COMT produces the pharmacologically inactive substances 3-O-methyldopa (from levodopa) and 3-O-methoxy tyramine by transferring a methyl group from the donor S-adenosyl-l-methionine (from dopamine) (Bloem, Okun & Klein, 2021).
However, an AAD inhibitor, such as carbidopa, increases the quantity of levodopa, which is methylated by COMT, while decreasing dopamine production (Tambasco, Romoli & Calabresi, 2018). The main therapeutic effect of COMT inhibitors is to prevent the conversion of levodopa to 3-O-methyl-dopa in the peripheral nervous system, which prolongs the plasma half- life of levodopa and increases the proportion of each dose that reaches the central nervous system (Delamarre & Meissner, 2017). According to Tysnes & Storstein,( 2017), Selegiline, Rasagiline, and selective monoamine oxidase-B inhibitors are further PD treatment options. Selegiline is a selective MAO-B inhibitor that inhibits the enzyme irreversibly at low to moderate dosages (Tysnes & Storstein, 2017). Selegiline has been used for many years to treat the symptoms of Parkinson's disease. However, the ability of selegiline to suppress the striatal synthesis of dopamine is thought to be the basis of its effectiveness (Simon et al., 2020).
In people with early or mild PD, selegiline is typically well tolerated. Selegiline may exacerbate levodopa therapy's negative motor and cognitive consequences in patients with more severe PD or underlying cognitive impairment (Bloem, Okun & Klein, 2021). Amphetamine and methamphetamine are two of the selegiline metabolites which can have adverse side effects, including anxiety and insomnia. Rasagiline is a monoamine oxidase-B (MAO-B) inhibitor that also inhibits dopamine breakdown without producing unfavorable byproducts (Vázquez-Vélez & Zoghbi, 2021). Tablets containing rasagiline are recommended for treating PD symptoms and signs, both as initial therapy without the addition of treatment for moderate PD (Delamarre & Meissner, 2017). It may be helpful as a supplement for levodopa users with dose-related fluctuations and dyskinesias. Amantadine, an antiviral agent that is also used to treat influenza A, is a different therapy option that can be used. It also functions as an antiparkinsonian (Tambasco, Romoli & Calabresi, 2018). It is the first line antidyskinetic qualities have been linked to its effects on NMDA receptors, even though memantine, an NMDA receptor antagonist that is closely related, does not appear to have the same effect.
In addition to symptoms’ regulation of PD through clinical treatments, it would be advantageous to develop other therapies which, when combined, modify the process of degeneration that governs PD. Current research strategies are based on mechanical approaches such as energy metabolism, oxidative stress, environmental triggers, excitotoxicity, and detections related to the genetics of PD (Armstrong & Okun, 2020). The approaches also seek to address PD by assessing and ascertaining various risk factors associated with PD. For example, it would be more effective to manage PD when medical practitioners can seek to address ecological risk factors such as contact to toxic chemicals and pesticides (Tysnes & Storstein, 2017), Also, integrated approaches to address psychological factors such as stress through counseling are imperative to provide prevention against PD. More discoveries are coming up to offer a genetic solution if an individual has an inherited PD gene (Vázquez-Vélez & Zoghbi, 2021). Finally, observing a healthy and balanced diet is another measure that can be implemented to prevent physiological issues and cases of oxidative stress, which may accelerate the likelihood of developing PD (Bloem, Okun & Klein, 2021). Adopting these alternatives offers great betterment because they contain and manage them instead of treating them. Ideally, preventing a disease occurrence is termed more cost-effective than treatment (Armstrong & Okun, 2020). Also, since individuals will be prevented from developing the disease, there will be fewer reported cases of PD susceptibility for the future generation.
Amyotrophic Lateral Sclerosis
Introduction
Amyotrophic Lateral Sclerosis (ALS) refers to classic neurodegenerative condition which involves gradual degenerations of the motor neurons in the brain and spinal cord. Though it involves numerous levels of functional entities that alternate in different directions before convergence of the functional defining ALS disease development, tracing the evolving nature of ALS highlights critical measurement of individual variances which underpins this form of ailment (Masrori & Van Damme, 2020). ALS may begin as a single entity and develop into a complex disease. However, nothing is known about how these disparate elements ultimately function together to define the course of ALS (Masrori & Van Damme, 2020). Many theories have been put out; however, there hasn't been any agreement between the opposing philosophical camps.
History and Epidemiology
Most ALS cases are sporadic linked by cortical and spinal motor neuron degeneration (Longinetti & Fang, 2019). Baseball player Lou Gehrig was identified with ALS in 1939 by a French neurologist Jean-Martin Charcot originally described the condition in 1869. It resulted to a widespread awareness of the condition in the country (Masrori & Van Damme, 2020). It is sometimes referred to as Charcot disease after Jean-Martin Charcot, who first described it, and motor neuron disease (MND) since it was considered as one among the five diseases that often affect cells in the motor neurons (Mathis et al., 2020).
In the 1990s, about 1.5 and 2.7 documented ALS cases in Europe and North America. Current research has demonstrated that the disease frequency did not show any growth for the past ten years, as the prevalence rate is still remains at 2.7/100,000, and the prevalence of ALS was 0.32/100,000 of 2008 (Goutman et al., 2022). Whereas some research has demonstrated a balance in the ratio, many investigations have revealed an increase in the risk among the males to be higher than that of females (Goutman et al., 2022). Nonetheless, 64 years old accounts as the median age through which ALS begins, with a range of 50 to 65 years. Just 5% of the cases begin before the age of 30 (Mathis et al., 2020). The prevalence of this condition is particularly prominent in elderly individuals 80 years of age and older, and data suggests that the increase is due to variations in care.
ALS-associated risk factors
Exposure to environmental toxins, agriculture chemicals, dust/fibers/fumes, heavy metals, solvents, diet, and physical activity have been associated with developing ALS in patients according to the previous epidemiology (Obrador et al., 2020). Individuals prone to smoking are at higher risk for ALS through inflammation, oxidative stress, and neurotoxicity caused by the heavy metals present in the cigarette (Obrador et al., 2020). Similarly, people engaged in more physical activities are at risk for ALS than the general population. Genetic profiles promoting physical fitness hold a proportional correlation between ALS and physical activity (Mahoney et al., 2021). In other words, a genetic profile altered by exogenous factors which promote physical fitness increases an individual's susceptibility to ALS. However, the results from the beneficial vascular risk profile in patients and their relatives have been found to have supported this concept (Mathis et al., 2020). Researchers have conveyed an abridged frequency that corresponds to coronary heart disease which increases the risk to ALS due to physical fitness (Obrador et al., 2020). Additionally, age is another factor associated with ALS where the risk increases with age. Thus, the disease is common among people of age 40-60 years. However, as age progresses, it is observed that men are more slightly are risk of developing ALS than women (Andrew et al., 2021). In another research conducted, findings showed genetic factors as one of the common risk factors accelerating ALS (Andrew et al., 2021). Of the samples collected, it was observed that those presented with ALS symptoms had a medical history of inherited ALS.
Pathophysiology
The degeneration and the demise of upper and lower motor neurons, the reactive gliosis replacement of dead neurons accounts as the hallmarks of ALS (Lian et al., 2019). Spinal motor neurons have a regressive axonal damage characterized with secondary myelin pallor which greatly rise with aging (Dorst, Ludolph & Huebers, 2018). Although they affect the entire spinal cord, these alterations are more pronounced in the brainstem and upper spinal cord. The motor strip shows abnormal immunoreactivity to GFAP (Lian et al., 2019). The ALS motor cortex generally exhibits the astrocytic gliosis within the deeper levels at the gray matter and the parts of subcortical white matter (Dorst, Ludolph & Huebers, 2018). The lysosomal marker CD68 also demonstrated that microglia activation and active macrophages account for most of the glial reply at the spinal tracts.
ALS affects spinal motor neurons and the brainstem motor neurons. From the autopsy of ALS patients, it can be detected that the loss of motor neurons and atrophic motor neurons alters the general cell’s mechanism (Soriani & Desnuelle, 2017). As a result, the ventral roots are slimmed due to the loss of large myelinated fibers within the motor nerves hence denervating the atrophy of the affected muscles (Dorst, Ludolph & Huebers, 2018). ALS impacts both brainstem motor neurons and ventral horn spinal motor neurons. Motor neuron loss and atrophic motor neurons with a basophilic appearance are seen during autopsies of ALS patients, pointing to a programmed cell process (Lian et al., 2019). The motor neurons' ventral roots thinning and loss of their big myelinated fibers cause denervation atrophy with signs of re-innervation in the affected muscles. In addition to the normal clinical symptoms of the disease, ALS causes spongiform alterations in the neocortex accompanied by neuronal loss in the amygdale, hippocampus, and frontal (Soriani & Desnuelle, 2017). The non-motor ALS pathological findings include the demyelination of the posterior columns and the decreased myelinated sensory fibers density (Soriani & Desnuelle, 2017).
Clinical Features and Diagnosis
Manifestations of the phenotypical ALS are categorized into four typical groups: PMA with pure LMN involvement, and limb-onset ALS, and PLS with pure UMN involvement (Mathis et al., 2020). These categories are defined by amalgamation of limb motor neuron (LMN) and the upper motor neuron (UMN). However, the union between UMN and LMN impairment affects the brainstem and several spinal cord innervation sites thus accounting for the primary clinical hallmark of ALS (Obrador et al., 2020). In a study, Limb-onset ALS is seen as the main kind, 70% cases were reflected among patients where 25% had a bulbar onset, and the remaining 5% had respiratory involvement (Obrador et al., 2020). Patients with ALS suffer distal or proximal localized muscle weakness in both their upper and lower limbs (Dorst, Ludolph & Huebers, 2018). Asymmetrical initial symptoms that progress to generalized weakness and muscular atrophy are typical. Most patients experience spasticity, which impairs manual dexterity and walking, as well as bulbar and respiratory symptoms (Dorst, Ludolph & Huebers, 2018). Symptoms such as emotional lability with excessive yawning have been detected in many patients. Only 5% of individuals with respiratory impairment typically exhibit severe limb or bulbar symptoms (Soriani & Desnuelle, 2017). Some individuals, however, exhibit respiratory failure that corresponds to type 2. Type 2 respiratory failure is well known as the nocturnal hypoventilation, characterized by orthopnea, dyspnea, anorexia, disturbed sleep, morning headaches, poor attention, and prickliness in mood swings (Lian et al., 2019). In the early stages of limb-onset ALS, muscular atrophy is typically found in some parts of forearms, shoulders, hands, proximal thigh, and sometimes it may extend to the foot muscles down the lower limbs (Lian et al., 2019).
Treatment and management
Treatment for ALS can help to reverse the damage of the disease or prevent symptoms. However, the Food and Drug Administration has approved three medicines which can be used for treating this disease. Riluzole drug has been examined to reduce severe ALS, it is administered orally with an effectiveness of three to six months (Soriani & Desnuelle, 2017). Despite its effectiveness, Riluzole is associated with adverse effects such alterations in liver function, nausea, and dizziness. Edaravone is another drug of choice which is administered through the vein in the arm or as a pill orally (Obrador et al., 2020). These medicinal drugs are given daily for two weeks in a month according to research and that it helps in reducing ALS symptoms (Lian et al., 2019). Sodium phenylbutyrate and taurursodiol as recently approved medicine helps to restore or enhance the motor activities in ALS patients. In addition to the clinical treatment for ALS, other approaches for management have been deployed (Dorst, Ludolph & Huebers, 2018). For instance, inclusion of different therapies such as occupational, physical and psychological therapies all together are essential in lessening associated symptoms of ALS. Additionally, nutritional and social support can encompass as they are termed as effective preventive approaches.
Alzheimer’s disease
Introduction
Alzheimer's disease (AD) accounts to about 80% of cases of late-life cognitive dysfunction caused by degenerative condition of the brain. There is a widespread notion that dementia only occurs as a normal byproduct of aging (Weller & Budson, 2018). Dementia, however, affects the cognitive brain processes of perception, memory, thought, and language, severely limiting the capability to carry out daily functions (Burke et al., 2018). Even while dementia is not a definite result of aging, the risk of having it rises dramatically with age. Dementia and Alzheimer's disease are the primary causes of illness related to mortality in the old people, adding to the burden of non-communicable diseases worldwide (Weller & Budson, 2018).
History and Epidemiology
Neuronal cell death causes Alzheimer's, the dying cells sets on in the entorhinal cortex in the hippocampus (Juźwik et al., 2019). The disease was first identified in 1901 when German doctor Alois Alzheimer saw patient Auguste D. Oskar Fischer, a psychiatrist, and neuropathologist evaluated 12 instances of dementia simultaneously and gathered more clinical signs and symptoms and neuropathological evidence of the condition (Olivari et al., 2023). Later, in 1990, Levy and Frangione identified mutation as the root cause of amyloid protein buildup in the walls of the cerebral vessels in AD patients, which resulted in hemorrhages in the brain and early death (Juźwik et al., 2019). Since then, research on AD has advanced as scientists now look for the most efficient alternative and comprehensive treatment for the condition.
Epidemiological data on AD shows that the disease primarily affects older people. Alzheimer's illness usually affects old people due to their characteristic weak immune, globally the prevalence reported accounts to about 24 million (Eratne et al., 2018). It is therefore expected to rise heavily by the year 2050. It was estimated that 4.5 million Americans aging 65 and older were affected by clinical Alzheimer's disease in 2011 (Lane, Hardy & Schott, 2018). After the age of 65, the prevalence of Alzheimer's disease duos with five-year interval with less than 1% increase before age 65 and about 6% per year after age 85 (Hampel et al., 2018). The World Health Organization (WHO) estimates that there are presently 35.6 million individuals living with dementia worldwide, this figure is expected increase every 20 years to reach 115.4 million by 2050 (Liguori et al., 2019). Also, it is anticipated that over 5 million Americans had AD in 2013; by 2050, that number is expected to triple. Over $225 billion was spent on Alzheimer's patients in the United States in 2010 (Armstrong, 2019). According to the Centers for Disease Control and Prevention (CDC), AD is said to be the 6th leading disease that causes death. Even though much time, money, and effort are being put into understanding the pathophysiology and effective care for Alzheimer's and other forms of dementia, initial disease diagnosis is still a significant challenge (Caruso et al., 2019). Through delaying of AD and other forms of dementia within a year, it is expected that by 2050, less than nine million cases will be accounted for which suggestively reduces the disease's burden.
Risk factors
Alzheimer's disease is accompanied by various menace factors ranging from environmental, physiological, and genetic factors, which are suggested as common causes of AD and other dementias (Hampel et al., 2018). However, other risk factors include; diabetes and heart disease, can also accelerate prevalence and incidence of AD. Conversely, a recent cohort study has demonstrated that gout disease can potentially reduce the risk of developing the disease.
Genetic risk factors
Based on family history of dementia, intermittent mutations in genes impacts the amyloid within the brain. Apolipoprotein E are among the commonly identified genetic factors associated with AD (Caruso et al., 2019). Evidence shows that the risk of developing AD from a family history of dementia varies depending on the kind of familial link, the phase of the illness starts (Hampel et al., 2018). A person's chance of having AD rises by 10–30% if they have a first- degree relative who has dementia (Armstrong, 2019). Moreover, in the case of two or more persons are affected with the late-onset AD risk will be higher as compared to the overall population. The biggest genetic risk factor for late-onset AD is APOE (Lane, Hardy & Schott, 2018). Thus those persons carrying one or both e4 alleles is considered to have a 2- to 3-fold higher chance of acquiring Alzheimer's disease than non-carriers. Race, gender, and vascular risk factors alters the association's strength.
Physiological risk factor
Stress, age, gender, hypertension, and coronary disease are all physiological risk factors for AD. Researchers have discovered more about the association between stress and AD, which indicates that psychological stress is a major risk factor for AD (Weller & Budson, 2018). Age- related cognitive loss may be sped up by the persistent stress linked to elevated cortisol levels (Burke et al., 2018). In another study, it is evident that glucocorticoids are typically released in reaction to stress (Weller & Budson, 2018). Regarding age, research findings show that AD progresses with age, where the disease is primarily prevalent in older people (Caruso et al., 2019). However, several studies demonstrate gender, in addition to age, also has an imperative role as a risk factor for developing AD, suggesting that the prevalence of AD is more common among women than men (Eratne et al., 2018). However, inconsistencies have been observed in studies related to the incidence of AD between males and females, incidence of AD studies conducted in the United States shows no significant difference between men and women (Weller & Budson, 2018).
Environmental factors
Apart from genetic and psychological factors, current studies have sparked interest in investigating toxicity exposure to environment as the primary potential risk factors accounting for AD increase (Hampel et al., 2018). Smoke, pesticides, and air pollution are the examples of such potential factors within the environment. Exposure to air pollution and pesticides can accelerate the likelihood of developing coronary and heart-related health conditions, possibly increasing the risk of AD (Weller & Budson, 2018).
Pathophysiology
Alzheimer's disease is primarily build up by neurofibrillary tangles and the aberrant neurotic plague. Such plaques are usually spherical microscopic lesions having an extended axonal tail with an extracellular amyloid beta-peptide core (Lane, Hardy & Schott, 2018). Alpha, beta, and gamma-secretases work as proteases to cleave the beta-amyloid peptide from APP, amyloid precursor protein is a transmembrane protein that produces the beta-amyloid peptide (APP) (Caruso et al., 2019). Typically, alpha- or beta-secretase will cleave APP, and the resulting minute pieces are not harmful to neurons (Hampel et al., 2018). Rising in the beta- amyloid 42 leads to the aggregation amyloid which probably harms neurons. Amyloid buildup usually surrounds within the body parts including cerebral, meningeal, and gray matter arteries (Lane, Hardy & Schott, 2018). Multifocal gray matter deposits combine to produce plaques, which are milliary structures (Caruso et al., 2019). Hyper-phosphorylation of tau occurs since there is an aggregation of extracellular beta-amyloid causing the formation of tau aggregates, it is frequently seen in the cerebral cortex.
Clinical features and diagnosis
An asymptomatic period is experienced from the beginning of biochemical changes within the brain and the appearance of clinically related symptoms of AD (Juźwik et al., 2019). Research findings report memory impairment as a common hallmark of AD. The deterioration of other cognitive functions encompasses a memory decline (Weller & Budson, 2018). However, symptoms develop progressively with initial symptoms of AD include; executive dysfunction and visuospatial abnormalities, behavioral changes and language deficit are usually symptoms which appears in the later stages of the disease (Juźwik et al., 2019). Diagnostic and Statistical Manual (DSM) states that clinical assessment of AD has reflected the significant cognitive impairment within the cognitive areas like complex attention, memory, executive function, language, and perceptual-motor function (Armstrong, 2019).
Treatment and Management
There are now various pharmacologic therapies used to treat AD. For people with moderate to severe AD, melamine is one of the therapies which function as a non-competitive N- methyl-D-aspartate receptor antagonist (Weller & Budson, 2018). The second type involves giving patients with mild, severe AD inhibitors such as donepezil, galantamine, and rivastigmine to medicate them (Lane, Hardy & Schott, 2018). For people who choose alternative therapy, there are several possibilities besides these two programs. Examples include the nutritional supplement huperzine A, which has been shown to improve daily activities and memory (Hampel et al., 2018). Inhibitors and interventions for the main risk variables are used in the majority of standard AD treatments. BACE 1 successfully serves as an AD intervention by limiting the rate of A production. Researchers like Weller and Budson (2018) consider the use of unproven non-steroid anti-inflammatory medications and omega-3 fatty acids, such as fish oil, in the management of risk factors. According to Weller and Budson (2018), these supplements have been shown to have cardiovascular advantages over the past ten years, and two randomized control trials have shown that fish oil can help memory and thinking in MCI patients. The tiny sample size used in these investigations was their lone drawback.
Conclusion
PD is indeed a neurodegenerative movement disorder; its management is very challenging owing from the changing phenomenology leading to long duration (Vázquez-Vélez & Zoghbi, 2021). The case study shows that PD is a condition associated with older patients who may experience rigidity, tremor, and bradykinesia symptoms (Tysnes & Storstein, 2017). It has been demonstrated that as many other alternatives are essential in the treatment and management of PD, levodopa remains the most effective drug that can be used. The key root to the successful management of patients with PD is based on the available treatment evidence (Tysnes & Storstein, 2017). Amyotrophic Lateral Sclerosis (ALS) is a classic neurodegenerative condition where motor neurons in the brain and spinal cord gradually degenerate (Obrador et al., 2020). Though it involves numerous levels of functional entities that alternate in different directions before convergent functionally defining ALS disease development, the constantly evolving nature of ALS highlights a critical dimension of individual variances that underpin this ailment (Lane, Hardy & Schott, 2018). AD is one of the most prevalent types of dementia, mainly present in older people. According to the literature, the condition is designated as one among the neurodegenerative sicknesses that is progressive and incurable (Caruso et al., 2019). Its prevalence rises sharply from time to time with advancing age and the absence of effective treatments. An in-depth discussion has been given on AD's psychological, emotional, and biological elements, symptoms, and diagnosis (Caruso et al., 2019). It has been established that controlling risk factors and using inhibitors are the most prevalent therapies for the disease.
Introduction
Numerous diseases have been reported to have reduced human performance and functionality. Attention should be paid to neurodegenerative disorders as it usually oppresses patients' central and peripheral nervous systems, which weakens muscles. It dramatically affects the neurons which are produced by neural stem cells (Masrori & Van Damme, 2020). Neurons usually reduce with ageing. Neurons cannot live forever, but the progressive loss of neurons, their structure, or their activities, known as neurodegeneration, is a significant health concern and a vital component of the pathogenesis of many different brain illnesses (Hampel et al., 2018). Parkinson's disease and Alzheimer's account for the maximum prevalent neurodegenerative conditions. Although several medications are currently approved for treating neurodegenerative diseases, most address symptomatology (Mathis et al., 2020). The blood-brain barrier (BBB), which prevents over 99% of entirely "external chemicals" from entering the brain, is the leading cause of this death of pathogenesis-targeting therapeutics.
Natural Ingredients and supplement
According to Cohen et al. (2020), natural ingredients and dietary supplements are substances taken in the body to boost wellness and health to an individual. These dietary supplements form the blocks for body-building substances. Dietary supplements can be in the form of pills, tablets, liquid, or capsules. These products are added to the diet but are not considered food substitutes. Dietary supplements are widely available in a natural settings such as food stores, groceries, pharmacies, and online stores. Cohen argues that most dietary supplements are taken for health purposes to improve an individual's general body health and wellness. According to Jagim et al. (2019), the joint dietary supplement is minerals and vitamins such as vitamin C, botanical supplements such as plant products and herbs, and substances extracted from natural sources such as omega-three fatty acids. However, researchers indicated that makers of dietary supplements are not legally allowed to conclude that dietary supplements can cure, treat or diagnose people until proven medically accepted by a recognized physician. Nevertheless, makers of dietary supplements can say they contributed to health and wellness for individuals. In the United States, dietary supplements are no longer regulated in the same way as medicine and can be sold even without research on how it works on the human body.
Historically, they used natural ingredients and supplements as herbal medicine to prevent illness, relieve fever, cure infections, and heal wounds. Makers of dietary supplements can prepare substances used to treat constipation and ease pain through traditional formulas. According to the research, natural ingredients can have similar health impacts as conventional medicine, while some herbs and plants may have no impact on human health or may be harmful. For example, supplement such as beta-carotene and vitamin E does not lower the prevalence of heart diseases as claimed. Natural ingredients and supplements are critical in facilitating nourishment of a person's body and maintaining a healthy body. The supplement can be gotten by taking a variety of food sourced from natural sources. When the supplement is taken together with food, it can be absorbed easily in the bloodstream and directed to various body parts to initiate healing wellness. According to research, healthcare providers advises people to eat a variety of diet rich in minerals to keep their body strong and able to fight illness. For example, people are advised to take foods such as vegetables, fruits, lean meat, and fish since they constitute natural supplements that provide the body with the micronutrients required in the body. Nevertheless, there are various natural sources where dietary supplements can be extracted. Numerous sources are discussed below.
Water
A dietary supplement is a vital element to individual health. Water is taken to supplement the diet but cannot be taken as food alone. Water is a compound made up of hydrogen and oxygen. According to Ngunyen et al. (2021), water contains minerals and other carbon-based particles dissolved together. Water as a whole protects the tissues and body organs from drying. The dissolved substance may undergo a chemical reaction in the body to bring wellness and good health to humans. For example, nanoparticles such as graphene oxide, graphene, and carbon nanotubes dissolved in water can be used to adsorb steroid hormones to incorporate in membrane composites. Therefore, despite the fact that water is a purely natural compound, dissolved substances can be used to improve body wellness in the long run. Water is used as a dietary ingredient but does not heal illness. Nevertheless, water can intensify an illness if it contains impurities such as lead and other heavy metals. Ngunyen argues that nanoparticles can affect the adsorption by changing g the shape, structure, conformation, and geometry to influence the surface are of colloidal instability. Basically, all living organisms require water for survival. Water can be taken before or after the meal to supplement the diet. According to the survey conducted by Geological survey, our bodies comprise approximately 60% water. Therefore, water must be taken regularly to increase wellness. In the process of drinking water, our body has a special mechanism to extract minerals present in water to improve health and overall body wellness. For example, spring water is rich in magnesium, sodium, calcium, and other important minerals used to strengthen bones and teeth. For this reason, healthcare providers encourage people to drink water regularly to improve their health wellness. Nevertheless, studies have shown that natural ingredients such as water impact health and wellness. Discussed below are some of the impacts of taking water as a dietary supplement on overall health and wellness.
Water Protect Body Organs
Water acts as a quenching agent and protects body organs such as joints, spinal cord, and tissues. According to Luo et al. (2020), it protects body organs by producing selenium-doped quantum dots that effectively ameliorate spinal cord injury and recreates strong bones. Water components help maintain moisture within the body tissues to maintain body wellness. In addition, maintaining a hydrated body helps protect sensitive areas such as the brain, blood, and bones. Most body parts move freely during movement. Therefore, water acts as a lubricant between bones and a cushion between the joints. Thus, water is an important dietary supplement for maintaining health wellness.
Water Helps during Excretion of Waste
When food is taken into the body, it has broken down into small particles that can be absorbed in the body. Water dissolves important nutrients to be absorbed in the body. However, not all food particles are absorbed in the bloodstream. Therefore, water enables the body to excrete some of this waste, either inform of sweat or urea (Ahsan et al., 2018). Therefore, water helps maintain homeostasis for good and wellness in the body. Healthcare providers encourage people to drink more water as a dietary supplement to support body organs responsible for removing waste from the body. For example, kidneys require a lot of water to facilitate blood filtration. Blood impurities can endanger someone's life. Therefore, when water is taken as a supplement in the diet, it can help to maintain body wellness.
Water Aids in Digestion
When water is taken as a supplement, it plays a significant biological function. According to Jain et al. (2020), water helps break down food to allow nutrients to be absorbed in the bloodstream. Therefore, water is a crucial compound taken as a supplement in the human body. Typically, food is taken through the mouth inform of large chunks that cannot be taken directly into the bloodstream. Water helps soften and break down food particles into manageable sizes that can be absorbed in the small and large intestines. When water is combined with food, it forms a heavy porridge-like substance. When this solution passes through the colon and ilium, water is absorbed in the body, leaving a solid substance to be excreted in the form of stool. Therefore, water is a natural ingredient used to supplement diet to help maintain health and body wellness in the long run.
Turmeric
Turmeric is a natural flowering plant of the ginger family, used as a dietary supplement (Ayman et al., 2019). The plant contains active components such as curcumin, proven scientifically to possess health benefits. For instance, its components can improve heart health and prevent cancer and Alzheimer's. According to Bradford (2013), turmeric has been recognized by healthcare providers as a natural inflammatory and health-promoting product. Most people use turmeric to spice food to improve health stability. Turmeric contains a variety of compounds that can be used to serve a medicinal purpose. Curcumin is the primary anti- inflammatory health component found in turmeric. Evidence deduced that curcumin found in natural turmeric facilitates weight loss and reduces obesity-related diseases. Health statistics indicate increased obesity and overweight patients in healthcare centers (Grassi et al., 2019). However, when turmeric was discovered, obesity and overweight-related diseases have decreased spontaneously. Curcumin contains a chemical substance characterized by anti- inflammatory activity to burn excess fat and oil.
The recent scientific approach shows that curcumin directly interacts with the adipose tissues to minimize chronic inflammation incidence. Scientist indicates that curcumin prevents macrophage infiltration and suppress the nuclear factor that triggers inflammation. Curcumin reduces the inflammatory incidence by destroying pro-inflammatory adipokines growth. Therefore, turmeric is an essential dietary supplement with health benefits and can improve overall individual wellness.
On the other hand, turmeric can reduce Alzheimer's disease (AD). AD is a common neurodegenerative disorder among older adults (Tang, 2017). In the modern days, AD prevalence has been detected among the elderly community, demanding immediate action to save the community. AD prevalence can be reduced by developing efficient pharmacotherapies from natural ingredients. Healthcare providers have identified turmeric as a potential source for therapies to reduce the incidence. Tang argues that medicinal treatments for this condition target the symptoms associated with the condition rather than modifying the disease progress in the human body. However, research indicates that natural ingredients such as turmeric may contain compounds that can suppress AD conditions. Curcumin, a product extracted from turmeric, has demonstrated treating AD. Curcumin prevents the formation of amyloid and attenuates clearance of bind copper, lowers cholesterol in the blood, and modifies the microglial activities. Therefore, physicians will probably develop an effective natural therapy to cure AD using natural ingredients with continued research.
Consequently, turmeric can also be used to reduce cancer intensity. According to Unlu et al. (2016), curcumin, a product extracted from roots of a turmeric plant, was traditionally used by Chinese and Indians for medicinal purposes. Laboratory test indicates that curcumin has antioxidant, anti-inflammatory, and anti-cancer properties. However, there is no clear medical evidence that explains the findings. However, curcumin usage has been known for favorable results in reducing cancerous growth in the long run. Nevertheless, turmeric compounds also facilitate the treatment of cardiac fibrosis. Fibrotic genes are responsible for the immediate response to damage by cardiovascular diseases. Curcumin compound constitutes an extensive biological phenomenon that can stabilize heart conditions. The product helps to regulate blood pressure and heartbeat developed by cardiac fibrosis. According to Gorabi et al. (2020), healthcare providers have affirmed the role played by curcumin in the human body amid suppressing heart failure conditions. In general, turmeric is a natural ingredient with unlimited benefits for human health. According to Kocaadam et al. (2017), the turmeric plant is grown in Iran, Malaysia, India, and China held with great importance. Traditionally, people have been using turmeric to spice and for medicinal reasons. Thus, turmeric is a natural dietary ingredient that has numerous health advantages. Curcumin, a turmeric compound, is used as an antioxidant, anti-inflammatory, and anti-cancer and has no known side effects on human health.
Resveratrol
According to Galiniak et al. (2019), resveratrol can be considered a stilbenoid, a natural phenol, and phytoalexin that can be extracted from numerous plants under certain conditions plan is under attack by fungi or bacteria. Some familiar sources of resveratrol include; peanuts, mulberries, blueberries, and raspberries. Resveratrol can be found in grapes' skin and seeds and food sources such as peanuts, wine, and berries. Resveratrol is a natural supplement that impacts health and wellness in numerous ways. When resveratrol is taken in the body, it can treat cancer, reduce aging, act as an anti-inflammatory, and be used against glycation. In addition, resveratrol can treat and control diabetes and its complications.
Nevertheless, researchers have termed resveratrol a double-edged sword due to its health benefits. Resveratrol is compound that belongs to the polyphenol group made up of two phenol rings linked by Ethylene Bridge. Researchers have documented over 70 sources of this compound abundant in grapes, skins, and seeds. However, the compound can also be found in wine in discrete amounts. According to Salehi et al. (2018), resveratrol is used in cognitive performance and as a memory aid. Cognitive performance is the ability to acquire knowledge, reasoning, and manipulation of information. Therefore, resveratrol is used to improve thinking and make informed decisions. Resveratrol is a natural supplement that can help to improve reasoning and personal wellness in the long run.
In addition, resveratrol can also be used to impact older people's health conditions by treating Alzheimer's disease (AD). According to Sawda et al. (2017), the amyloid hypothesis suggests that continuous deposition of the central nervous system among the aging can result in AD. Therefore, resveratrol acts as a therapeutic agent for AD. According to the research, long- term use of resveratrol compounds can help to moderate mild AD. Therefore, resveratrol is an essential natural ingredient that can improve health and wellness. Nevertheless, research also indicates a direct relationship between resveratrol compound and ovarian hormone release. The release of progesterone, oxytocin, and progesterone are influenced by resveratrol. This is an important role this compound plays as it can be used to increase fertility rate and conception. Lastly, resveratrol can also be used to trigger cancer. Many people have become vulnerable to cancerous cells across all ages in the recent century. Evidence suggests that the style of living contributes to cancer and inflammatory growth. Healthcare providers have tried medicinal ways to treat cancerous cells, which may not respond appropriately. Therefore, physicians have recommended natural cancer treatment using the resveratrol compound found in grapes. Thus, natural ingredients and supplements can impact health and body wellness.
Raspberry Ketones
Raspberry ketones are a natural phenolic compound that forms the aroma compound of raspberries. According to Lim et al. (2021), numerous diseases are linked to oxidative stress that can be treated using the natural compound extracted from raspberries. Research indicates that raspberry ketone has numerous pharmacological functions. Essentially, raspberries are cheap natural compounds but can impact human health and improve individual wellness. Raspberry ketone compound is used to impact weight loss and cure obesity. Studies indicate that approximately 70% of the total population in the US are at weight and obesity compromise. The prevalence of weight-related diseases has heightened in the last few years due to changes in lifestyles. The majority of people spend the most time on a computer without undertaking any exercise. For this reason, healthcare providers have recommended people to develop a habit of taking raspberries as a supplement since they can impact health and stabilize body conditions.
In addition, raspberry ketone can be used to treat Alzheimer's disease. According to Huang et al. (2018), raspberry ketone is sometimes referred to as rheosmin, a compound that gives typical raspberries their distinct smell. Claims show that this compound has health benefits but is not scientifically tested and approved. Physicians advise older people to take more fruits that produce raspberry ketone compound or take an extracted compound directly into their body in the form of supplements. The compound indices increased acetylcholine level, which refreshes the brain tissues. Therefore, the compound is ideal in treating AD, which is associated with old age. Consequently, the raspberry ketone compound has been used as an over-counter weight loss supplement in the last few decades. According to Li et al. (2022), raspberry ketone has gained popularity in health due to positive responses to reduce weight loss and obesity treatment. Still, it lacks scientific support for its use for medicinal purposes. Therefore, we can deduce that natural ingredients and supplements can impact health and wellness.
Monk Fruit
Monk fruit is an herbaceous perineal vine grouped into gourd families. The fruit originated from southern China, where the locals used it as traditional therapy. Monk fruit sweeteners lower sugar intake while providing maximum enjoyment of food taken together. Monk fruit is a natural ingredient with numerous health benefits. Tey et al. (2017) argue that monk fruit can be used as a non-nutritive sweetener that controls body weight and manages glycemic. However, few studies demonstrate energy compensation derived from insulinemic and glycemic responses. Unlike other no-calorie sweeteners, monk fruit is an exclusive sweet with natural sugar that does not add cholesterol levels to the body. Therefore, monk fruit can be used intensively to manufacture beverages and soft drinks such as dairy products, candies, condiments, and desserts. In addition, monk fruit compound cab is used in baked goods due to its stability under high temperatures. Therefore, monk fruit may have myriad uses. Thus, the user can tailor the need to their specification. Nevertheless, monk fruit can also be used to trigger hormonal balance. The compound demonstrates effects when tested in the presence of glucose. The higher the monk fruit constituents, the higher the energy released. Therefore, we can conclude that natural ingredients taken as food supplements can improve individual wellness.
Monk fruit generally does not catch peoples' attention as it is not colorful as other fruits such as apples. However, in the modern days, people's attention is drawn close due to its health benefits. Monk fruit is ideal for patients with devoted foods with chemical sugar and the diabetes community. Research shows that monk fruit can boost food in the diet by adding natural sweetness. The makers of monk fruit sweeteners extract compounds from dried fruits to make natural sweeteners. The research shows that the extracted compound is approximately 150 times sweeter than the table sugar with no calories and does not raise sugar levels in the blood. Therefore, physicians recommend that people consume monk fruit sweeteners rather in large portions and take fewer table sugar-containing chemical substances.
Black Seed Oil
Black seed oil can be referred to as an herbal ingredient extracted from the Nigella Sativa plant initially found in western Asia and Eastern Europe. The compound is known for its powerful medicinal properties to treat a wide range of health conditions. According to kooti et al. (2016), black seed oil can be used in common treatments such as inflammatory conditions, asthma, rheumatoid arthritis, diabetes, and digestive diseases. The compound can also be consumed as a food supplement to improve wellness and health. Heath-wise, black seed oil helps reduce condition prevalence by eliminating the chemical compound in the body that causes diseases. The product demonstrates therapeutic properties due to thymoquinone that forms the primary bioactive compound vital in the oil. Extensive research has been conducted to understand elements that make up this compound and link it to pharmacological actions. The major explored parts include; anti-cancer, antidiabetic, antimicrobial, anti-inflammatory, bronchodilator, and other essential areas. Therefore, the present review shows a relationship between black seed oil and health.
Research shows natural compounds are far much better than artificial compounds used as remedies for various health conditions. This is because black seed oil is made up of natural compounds, while artificial medicine is made up of chemical compounds that can leave damage to the body. Research shows black seed oil is healthy for human consumption regardless of health conditions. Therefore, we can conclude that black seed oil can be used to maintain good health and wellness (Majdalawieh et al., 2015). In addition, recent research has proven a potential herb to treat Covid-19. Studies show that covid-19 is caused by acute respiratory syndrome coronavirus. The Nigella Sativa plant contains antiviral and antioxidant compounds that can treat coronavirus infection. In addition, black seed oil contains antihistaminic compounds that help the body maintain a good condition to fight against infectious diseases. Covid-19 has been recognized as a global pandemic as it can spread rapidly over a short period. Therefore, a natural control method is highly advisable to ensure that patients recover quickly without any bodily harm or leaving traces. Therefore, Nigella sativa is a natural ingredient that can control adverse conditions caused by immunomodulatory and antiviral diseases.
Apple Cider Vinegar
Apple cider vinegar is a vinegar extracted from fermented apple juice and is commonly used in salad dressing, food preservatives, and marinades. According to Gopal et al. (2019), apple cider vinegar has been validated scientifically fit for remedy. The research shows that there exists an unequivocal antimicrobial activity in apple cider vinegar which is used to treat myriad disease-related conditions. Therefore, apple cider vinegar can treat antimicrobial-related and inflammatory conditions. The global growth in antibiotic resistance has forced scientists to go for natural products as an alternative to control microbial conditions that can put human health in danger. Thus, apple cider vinegar is a natural ingredient but helps maintain good health.
According to Halima et al. (2018), the consequences of obesity can lead to a severe metabolic syndrome characterized by cardiovascular risk factors such as hypertension, glucose intolerance, and dyslipidemia. Research shows that a diet spiced with natural antioxidants such as apple cider vinegar is essential in reducing weight and controlling obesity-related conditions. When a study was conducted, apple cider vinegar showed a high correlation with obesity which shows the compound can trigger the condition. On the other hand, apple cider vinegar can control blood sugar levels. High lipid profiles and the associated glucose homeostasis can increase cardiovascular diseases. Therefore, adding apple cider vinegar as a supplement to the diet may help to improve wellness and health.
Aloe Vera
Aloe Vera is a tender plant species grouped in the genus Aloe. The plant has been used for medication for a couple of centuries. Researchers have extensively studied the therapeutic function found in this plant. There is numerous recognized therapy for the aloe Vera plant. They include; antibacterial, antiviral, hepatoprotective properties, immunoregulative function, and anti-cancer therapies. There are numerous traditional therapeutic uses for aloe Vera such as treating skin-affected burns, cuts, and insect bites, and used to enhance the digestive system due to impacts associated with anti-inflammatory and antimicrobial. Many researchers have been validating traditional usage for aloe Vera rather than expounding on its uses. Aloe Vera is a natural plant taken as an herbal to treat illness.
Aloe Vera species are distributed across Africa and Asia or any other tropical climate zone. Research deduced that Aloe Vera could treat skin affected by various conditions such as skin cancer and other microbial-related conditions. Ideally, Aloe Vera can effectively treat genital herpes, lichen planus, burn, inflammation, and wound healing. Nevertheless, Aloe Vera provides some promising outcomes when taken orally. However, the weakness is that dermatologists have not proven its effectiveness meticulously. In addition, Aloe Vera can be used as an antioxidant that increases nutritional value for food and increases shelf-life for food stored. Therefore, Aloe Vera can be used widely in cosmetic shops, pharmaceuticals, and the food industry to enhance wellness (Hęś et al., 2019). Antioxidant substance prevents substance oxidation that degenerates chemical compound that triggers food degradation. Aloe Vera has become one primary antioxidant compound necessary for food products. Lastly, Aloe Vera can be used to treat gastroesophageal reflux diseases. The plant product provides an effective treatment to maintain the required gut health. Aloe Vera is associated with numerous health benefits required to maintain wellness. They include; accelerating healing of the wound, lowering sugar levels, reducing constipation, helping in treating canker sores, and having antioxidant properties.
Restore
Restore is a substance designed to regulate body conditions to support and restore energy and gut microbiome. Importantly, restore contains all the natural antioxidants, antifungal, anti- inflammatory, and other essential health ingredients. Therefore, these ingredients help the body support microbiome and develop a robust immune system. Ideally, restore plays all the roles played by natural ingredients in one basket. Restore helps in the digestion of carbohydrates to provide the energy required in the body.
Conclusion
Natural ingredients and supplements are found in abundance in various natural settings. Therefore, makers of natural ingredients must have unique knowledge to extract the required natural ingredients from the right plan. Otherwise, one may be at risk of confusing the right plant to source these ingredients. Natural ingredients and supplements affect health and wellness by treating diseases, reducing the intensity of a condition, maintaining homeostasis, and controlling weight-related conditions.
References
Introduction
In the recent century, many people take natural ingredients as a dietary supplement. According to Rawson et al. (2018), it can be considered a substance taken in the body to improve the health or wellness of an individual. Dietary supplements may include; herbs, vitamins, and minerals. In Europe, children and adults take one or more natural ingredients to supplement their diet that contain minerals, amino acids, herbs, and other botanical constituents. Natural diet supplements may have numerous impacts on individual health depending on the condition and the nature in which they are taken in the body. Nevertheless, a portion of dietary supplements can help manage some health conditions and maintain overall health. However, herbal products can also pose unexpected health risks due to the presence of active substances that can have adverse effects on the body. For instance, taking herbal together with drug prescriptions can lead to a chemical reaction in the body that produces life-threatening compounds. Similarly, dietary supplement substances can undergo a chemical reaction when combined with other diet constituents to produce known or unknown compounds that can threaten human life. Therefore, the paper discusses how some natural ingredients and supplements can affect the health and wellness of a person.
Body
Early in history, adversaries started trying to harvest disease for reasons of war; however, they often went through challenges in making an effective disease as a tool of war. Naturally occurring diseases that kill people, plants, and animals are the beginning point for such chemical or biological weapons (Inglesby et al., 1999). These diseases were derived from fungi, toxins, and bacteria. Non-contagious and contagious diseases like anthrax and plaque can be turned into biological; weapons. During medieval times, military commanders tried to harm their enemies by contaminating their water supplier with carcasses of humans and animals that died from dangerous infectious diseases or, like early stated, throwing bodies over walls of enemy cities (Boscarino et al., 2003)). In current warfare, nations have used diseases sparingly. The most known case goes back to World War II when the imperial Japanese army unleashed cholera, plaque, and typhoid diseases on the China civilians, killing several thousand. To use biological compounds today, aircraft bombs, missiles, rudimentary delivery systems, and artilleries can be used (Cieslak, 2001). The delivery of aerosol chemical and biological compounds using ultra-fine particles that could be inhaled poses a significant risk of many causalities. Attacking the human population can also be done using deliberate food supply contamination because infections occur easily and quickly by ingesting. Abrasions and cuts on the skin's surface could also be a route for exposure to multiple infections of biological attacks.
The susceptibility of chemical and biological compounds to meteorological conditions like ultraviolent rays can quickly cause death. It complicates the ability to execute an effective chemical weapon attack (Al-Agamy, 2011). Compounds can be hardened against some meteorological complications, but shifting according to the direction of the wind can still blow the agent away from the target. Nevertheless, these weapons can be used strategically and tactically. Tactically, a command post can be attacked with a non-contagious biological disease to take an adversary down in military leadership. A strategic attack can target even a large metropolitan area with a contagious disease (Whitby & Rogers, 1997). Eventually, a pandemic could bring down so many people that the military can no longer be sustained since they are not getting enough supplies such as ammunition, food, and other necessities. Targeting civilians deliberately completely goes against the Geneva convention principle of war. However, the devastating impacts of biological warfare could be because of multiple reasons that find using biological and chemical weapons attractive (Warner et al., 2011). Others might include the ability to offset their enemy nuclear or conventional military power with biological weapons. The technicality and ease with which these weapons can be acquired compared to nuclear weapons makes it easy to create a biological weapon covertly. One of the research questions broaches this issue of the proliferation problem.
The possible integration of advanced technology in chemical and biological weapons interest and programs of sub-national actors in this warfare could create quantitative and qualitative proliferation quandaries (Szinicz, 2005). The rate of discovering the science in life for the last few years is astonishing, from the knowledge of altering genetic material artificially to the human genome and disease pathogenesis besides transferring it from one organism to another. Therefore, genetic engineering can be used to make diseases resistant to medical treatment and vaccines, making the effects even more contagious and lethal. With technological development, scientists cab also fabricates segments of disease materials to make biological weapons (Szinicz, 2005). Revolution in life science shows that there is no sign of abatement. Many quality-of-life and life-saving enhancing developments will emerge from laboratory science in years to come. Still, potential abuse of new equipment and technologies and knowledge about malevolent goals will always be present.
A drastic change from the traditional practices of acts of violence started to instigate sympathy for a party's political reason. In the past couple of years, two sequences in terrorist activities have realized a possibility that some people will turn into biological weapons as their best method of going to war (Szinicz, 2005). The initial trend is some groups' proven intention to cause the highest number of causalities with absurd methods of attacking. Secondly, it is the growth in incidents where a terrorist is planning to use biological attacks by obtaining biological agents, trying to reproduce and use them on civilians. Currently, attacks that show a clear indication of biological warfare are atypical. For instance, the 2001 anthrax attack is a good example (Szinicz, 2005). At some point, taking advantage of the developed technology, some groups might overcome the technical challenge to attack a significant number of civilians using biological weapons. At that point, the number of deaths and injuries from the attack could be significantly high.
Two main international accords were designed to contend with the risk of biological or chemical weapons at a nation-state level. The deliberate use of biological weapons was so vile that the international community burned its use in the Geneva convention, consequently outlawing using poisonous gas (Stokes & Banderet, 1997). The components of the proliferation regime are the "Biological and Toxin Weapons Convention (BWC)," which prohibited the production, development, and use of deadly weapons. In contrast to these laws, the Soviet Union ramped its biological and weapon programs and hid them inside commercial activities. They also engineered multiple diseases like plague, smallpox, and Marburg, diseases that nullified vaccines and treatments (Russell et al., 2003). Many of these activities and facilities are now engaged in peaceful studies with foreign experts, trying to establish commercial activities. Still, the country's refusal to allows people from outside into military institutions concerned that remnants of biological weapons have not been destroyed.
Moreover, United States intelligence has highlighted biological proliferation worries about Russia, Syria, and North Korea. However, Iraq is the only country confirmed to have had biological weapons programs ongoing in recent times (Ritchie & Owens, 2004). In the last few decades, the international community had conveyed a group of professionals to analyze what could have been done to monitor BCW. The dual-use method of biological gear and materials, besides the difficulty in distinguishing legal defence practices from illegal offensive, is amid the obstacles experienced (Ritchie & Owens, 2004). Talks about creating a legally binding monitoring process that had begun earlier, culminating in a draft agreement that the United States refused, stating that it was not enough to establish a treaty of compliance, which could compromise important defense prosperity and information.
The character of biological warfare is now going through a significant alteration. These changes are derived from society and science, very parallel developments. Biological security is shifting from weapons of mass demolition to a sphere of info conflict where targeted small- scale attacks might have a huge impact on the victims (Richards et al., 1999). Future biological wars might even use the same strategies to exact confusion and shock on their counterparts using a mere threat of casualties, increasing the previous disadvantage of biological and chemical warfare (Richards et al., 1999). Rapid advancements in science and biology may be widened to defend against these attacks. The element of surprise is important for during an attack using biological weapon, and fairly easy to achieve. The small amount of the toxic compound needed for an attack, will spray several miles to the target group making the weapon more difficult to detect while using aerosols. The uncertainty nature of manifesting symptoms can mask the beginning of an outbreak and enhance a possibility that they catch more people adversely not prepared.
In the current era, large-scale partisan battles will be affected by equipped scuffles but will include humanity at large. Encounters of psychological manipulation will intensify, while secluded conflict may be a reality (Reyna, 2004). Fear of a health predicament can be why a whole nation goes into chaos, opening up the country to external risks. For instance, an epidemic of contagious disease can compel people to live and work in a digital domain where they will be subtle to technical breakdowns and cyberattacks (Ramesh & Kumar, 2010). However small, it is clear that biological attacks will still reach their effects at a tactical equal by changing the aim for biological weapons ways from the combat military towards the whole community (Ramesh & Kumar, 2010). To bring an authentic physical consequence, an incomplete number of attacks may need a basis in the real action of a devastating landscape. Considering this, the achievement of future biological attacks in the risk zone conflict is dependent on stressing the significance that the toxic substance appears contagious, which will initiation doubts of enormous spread.
Because of the target method of operation, future biological warfare may surround most of the challenges that prevented biological weapons from getting to strategic impact from the past (Hedén, 1967). Large deployment and production of biological toxins may be useless. Placement on an enormous gage to get to a strategic advantage on the battleground required that weaponized compounds were ecologically friendly. They had to be paired with a transfer scheme that could yield a massive explosion (Koblentz, 2003). This element was a challenge to keep toxic weapons a secret besides demanding a considerable investment in infrastructure. In difference, since even minor eruptions can cause strategic impacts, future bioweapons production can be produced in academic or industrial molecular biology as long as these conveniences are open to international inspection.
Moreover, the armamentarium of biological weapons will widen its range of valuable biological compounds. Many definitive plans in biological combat have been limited to ordinary compounds such as pathogens, with the help of the “Soviet Union” near to its end. This has reduced the range of pathogens so that countermeasures could be well premeditated. This disadvantage is now being counterbalanced on a protection scale by the gradual expansions in biology and technology (Inglesby et al., 1999). Animal cells and infectious agents can now be built from as simple as a laboratory. Biological weapons in biotech are improving, and the determination of such operation could vary and include palpable developments of armaments. However, manipulation can be extensive and contain mutation primer that allows move from animals to people or a nucleus that codes nonlethal effects. It might even be possible to paradigm functions for overdue signs, allowing wide distribution from one person to another (Inglesby et al., 2002). Therefore, the victims will seek medical services in places where medical services are offered. Such prolonged attacks would cause a quarantine, and other efforts for coordinating responses to a crisis difficult.
Fundamental studies on food insecurity are subtle for surrogate and economic biological warfare. Conflict on shared resources in some nations is a commonplace. Food security, human health, and environment management are consciously threatened, globally and regionally, by simple water reserves (Marchant et al., 2011). Other constituents are within the model of a real-world view of food security and biotechnology, waterlogging, salinization, and over-cultivation (Mauroni, 2007). Deliberately contaminated herbicides, food, pesticides, and using arable land to produce food is another component of food insecurity. Moreover, emerging and new plant infections affect agriculture sustainability and food security, increasing malnutrition in a country rendering its people susceptible to human diseases. Deliberate release of pathogenic and harmful organisms that destroy an enemy's reserves and cash crops comprises an effective biological warfare weapon (Noy, 2004). Warfare involving herbicides and biological agents is anticrop warfare that results in famine, the decimation of agriculture- based economy, malnutrition, and food insecurity.
On large-scale attacks, self-protection may not be needed any longer. Using classic weapons, biological weapons have rested on conditions that must be prevented or treated for the enemy's military (Petro et al., 2003). Keeping the outbreak targeted and small may surround this issue. Moreover, compounds with high morbidity and high lethal content, and easily containable toxins can be advanced in the laboratory of a more benign to be more contagious (Bazarkina, 2019). Recent developments in biology may also ease the outbreak restraint. Though still argued as to its viability, this cannot be exempted from that increase in the accessibility of information on people gene disparity that could target precise individuals, ethnic grouped based on their genes. As an extra safety precaution, an attacker may fix for a large-scale vaccine in contrast to an attack by a pathogen (Harris & Paxman, 2002). The Covid pandemic has shown that a vaccine can be manufactured quickly. Ironically, if the enemy escapes attributing while giving a timeline vaccine for the affected, the attacker might be successful in creating great publicity on their side of the conflict.
Factors previously discussed all led to dissolving the tension made by biological war challenging to practice. However, one aspect that may retain its character as an obstacle contrary to organic attacks; is their morals when focused against civilians. This challenge may be heightened in current battles of the aspect (Franklin, 2018). Realistically, if a biological attack is bound to happen, it is vital to ensure that someone else gets the fault. Bringing mix- up about the initials of a prompted contagious occurrence could be the answer to planned accomplishment. The attribution and accountability can be problematic by changing the making of bioweapons from the state government to individually industry (Patel et al., 2019). The current global economy, where international tech firms are used as cover for the production of chemical and biological are increasingly getting connected with huge research organizations and nongovernmental institutions, provides a perfect condition to develop biological and chemical weapons under biomedical research (Patel et al., 2019). One may have to foresee that future antagonist will blend nonstate and state actors using biological and chemical weapons to their advantage.
A biological weapon is unique in its delayed effects and visibility. These two factors allow the military to cause confusion and inculcate fear among their victims besides escaping undetected (DiGiovanni, 1999). An attack using a biological weapon would cause fatal deaths or sickness in large numbers and create panic, anxiety, and uncertainty. Its objective is disruption of economic and social activities, impairment of military response, and breakdown of a government authority. Evident in the anthrax attacks in the aftermath of the World Trade Centre attacks, the occurrence of a few numbers' infections could create a substantial psychological impact until people feel vulnerable (DiGiovanni, 1999). Choosing biowarfare compounds is dependent on the technical, economic, and financial capacities of an organization or state. Ebola, smallpox and anthrax are the most used biological weapons because they have a devastating reputation for causing horrific sickness (DiGiovanni, 1999). Images of law enforcement personnel and doctors in full gears for protection alone could cause widespread public panic, anxiety, and distractions.
Today, attacks using biological weapons are possible. The public and the medical community should be familiar with control measures and epidemiology to increase the likelihood of a reasoned and calm response if an outbreak occurs (Ganesan et al., 2010). Moreover, the principle that enables clinicians to develop strategies against such attacks is essential as the health community system considers the issue a proliferation (Ganesan et al., 2010). Further knowledge through education emphasizes recognizing that vulnerability is both necessary and timely. Prevention rest on developing a firm hold on the global norm, rejecting the development of any biological weapons (Cooper, 2006). This implies that early prompt and detection treatment of signs is a secondary measure. The medical society plays a significant role in secondary measures by taking part in reporting and surveillance, thus providing information that biological warfare is being used. Consequently, continued studies to improve surveillance and research for enhanced effective response plans, therapeutic compounds, and diagnostic capabilities will strengthen prevention measures.
Conclusion
In conclusion, it is a warning; it is crucial to keep a civil and stable tactic when entering a different era of preparedness. Over vigilance amid most government agencies to biological and chemical warfare can be risky in itself, carrying vulnerability that a relative natural outbreak of pathogens can cause lockdowns, which prevent other elements of protection, risk attenuating the response, and proving financially costly once a risk arises. Discovery out with high and fast accuracy what instigated a set of diseases and suspicion before it becomes critical will be effective. Ramping intelligence in medicine tries to include the frontline method and tops molecular biology professionals with prominent significance. Finally, the role of tertiary prevention by reducing disability from diseases caused by biological weapons should not be forgotten. While BWC is ready to help affected nations, medical help must be prepared to go through sequelae should an unthinkable happens.
References
Introduction
Biological, chemical, and nuclear warfare are deeply embedded in the history of world conflicts. Since ancient times, the search for tactical warfighting and wartime advantages has been written. A chemical weapon can be traced back to the time of BC when the "Southern African San society" used snake poison for hunting antelopes. Among the first suspected uses of chemical compounds during the war was during the Romans and Persians war in 256 years. According to studies, the Persian military exposed their counterparts to poisonous chemical compounds, destroying them before facing them on the battlefield. It goes unnoticed that Persians used sulfurous gas in the tunnels to kill some Roman soldiers through asphyxiation. This backward method was among the first biological material used as an offensive weapon during the conflict. It was a century before the Geneva conventions outlawed using weaponized chemical weapons. The word can also mean typical images during the medieval warriors tossing dead animals over the city wall or even the government's undercover agents secretly releasing unknown microbes to the enemy territory. Of course, chemical weapons do not comprise such activities. However, the main components of a biological weapon are more mundane. For many years, organisms have gradually devised ways to kill each other. Any organism that produces toxins engages in the form of chemical or biological weapons. People who engage in chemical warfare use the chemical-producing creature's advantage. This chapter provides background information about biological weapons, developments that impact biological weapons proliferation threat, existing non-proliferation tools, and various chemicals non-proliferation policy actions.
How zeolite can completely get hydrolyzed
As revealed by studies, zeolite constantly undergoes complete hydrolysis, and this process encompasses many perspectives or steps (Hasegawa et al., 2010; Wheatley et al., 2014). The first and most notable condition is this procedure incorporates the assembly-disassembly-organization-reassembly technique. Compared to conventional ones, this approach has proved to produce new zeolite that is somewhat pure and reliable (Hasegawa et al., 2010; Wheatley et al., 2014). To effectively accomplish this perspective allow for the formation of the stated components, there is a need to begin the exercise by including materials with appropriate physical and chemical properties as failure to do so will deter the whole process. While researchers consider various properties to necessitate complete hydrolysis the leading ones are the existence of multiple conditions, including "double four rings" and preferentially accommodative materials (To et al., 2006; Mintova et al., 2013). Then reassemble and organization of zeolites rely on the prevailing conditions and the general expectation, especially as the final product. Material scientists and technicians have portrayed many reasons to ascertain whether the mentioned component can effectively get hydrolyzed. The most fundamental one is how it behaves insolvent and other liquids (Mintova et al., 2013; Shamzhy et al., 2014). Based on the provided information, the most commonly employed technique to necessitate hydrolysis is reassembling the layered species to lead to a relatively uniform reaction (To et al., 2006; Hasegawa et al., 2010). The associated components or materials efficiently undergo chemical transitions to form a specified condition with such an occurrence.
Still, regarding complete hydrolysis, zeolite usually undergoes controlled desilication, resulting in mesoporous components (Hasegawa et al., 2010; To et al., 2006). As revealed by academic scholars, this approach helps to strengthen the applicability of the stated chemical material. In most circumstances, the process allows for hydrolysis and other related incidences by lifting restrictions occasioned by various metrics and factors, particularly diffusion limitations (Wheatley et al., 2014; Mintova et al., 2013). Throughout various investigative studies, academic advocates mentioned how incorporating the above-stated conditions enhances the whole procedure as it modifies the ratio of Silicon and Aluminum (Hasegawa et al., 2010; Wheatley et al., 2014). The success of the entire process mainly relies on the number of alkaline solutions used, with the best outcome being experienced with optimum alkaline-based states. Based on this description and highlight, one can easily depict how zeolite can effectively get hydrolyzed when the required ratio of Silicon and Aluminum is integrated into the system (To et al., 2006; Hasegawa et al., 2010; Wheatley et al., 2014). Compared to other materials or elements, it is evident through constant exploration how including the Si and Al play an essential role in optimizing the process of neutralizing chemicals that otherwise produce zeolite and other chemical compounds.
Although the primary function of various elements such as micropore confinements and micro-solvation, there is a high chance that "siliceous zeolite chabazite" can be formed by integrating alkaline-based hydrolysis (Mintova et al., 2013; Wheatley et al., 2014). Throughout this process, there is always a need to incorporate Sodium Hydroxide to catalyze the formation of a given product effectively. Besides, complete hydrolysis of zeolite entirely depends on collective efforts that mainly involve reaction-related initiation. As depicted by academic professionals, this situation is occasioned by the formed Q3 defects and other occurrences (Wheatley et al., 2014; Shamzhy et al., 2014). Based on similar scholarly research, complete hydrolysis undergoes enhancement by solvating the Sodium ion cation with sufficient liquids, mainly water. Capturing the procedure or development involves including reliable hydration surroundings and natural treatments in zeolite pores (Hasegawa et al., 2010; To et al., 2006; Mintova et al., 2013). Through such a perspective, the hydrolyzed materials will exhibit the required physical and chemical properties as their hydrolysis, synthesis, and break-downs follow the correct procedure.
Steps that were taken to Hydrolyze zeolite
Based on available information, researchers have initiated many mechanisms used to hydrolyze, synthesize, and break-down zeolites into functional components (To et al., 2006; Mintova et al., 2013). High contents of various elements like Aluminum and Silicon in coal fly ash have forced scientists and technicians to study whether zeolites can be hydrolyzed from those materials. The process can be used as the first step towards obtaining high-quality components and enhancing their application, especially from a real-life situation (Mintova et al., 2013; Hasegawa et al., 2010). Although the technique got undertaken in the ancient period, its incorporation in the contemporary world will necessitate the production of suitable zeolites. To effectively heighten the whole process and necessitate upward trends, there is a need to commence the exercise by dissolving fly ash that includes making complex depolymerization- related reactions. As depicted by academic scholars, this occurrence is to release various elements, particularly Aluminum and Silicon that are presented in the form of solutions through what we call the dissolution process (To et al., 2006; Mintova et al., 2013). Regardless of smooth transition during hydrolysis, it is worth noting how the whole procedure is hampered with or depends on several metrics such as agitation conditions, alkaline concentrations, existing atmospheric pressure, and temperature. With this step, researchers insisted on a need to include optimum water content.
According to scholarly evidence, this situation is based on the condition that zeolites building blocks rely on hydration and cationic components (Mintova et al., 2013; Wheatley et al., 2014). One can quickly ascertain how water plays an essential role in determining the general whereabouts of hydrolyzed zeolites and related compounds. Such a liquid also helps to fill the voids created displayed by various devices throughout hydrolysis and synthetic reaction. At this stage, it is essential for those engaged in this practical work to increase the water content (Mintova et al., 2013). Doing the stated condition depresses critical growth and ensures the hydrolyzed components have the required physical and chemical characteristics (Mintova et al., 2013; Hasegawa et al., 2010). This situation occurs for many reasons, with the first and most prevalent being the efficiency of water in deterring growth and necessitating consistent chemical conditions. While the whole process directly contradicts diverse researchers, especially around hydrolysis, it is depicted through investigative studies how integrating enough water in the system heightens crystal growth rate occasioned by enhanced colloidal silica-based dissolution rates (To et al., 2006; Hasegawa et al., 2010). With the presence of this liquid or rather conditions at this stage, there are also increased water contents that, when effectively accommodated at the mentioned section, enhances various occurrences, including purity and yield of the eventual or final products (Hasegawa et al., 2010; Mintova et al., 2013). Compared to the previous hydrolysis and synthesis that led to the production of diverse materials and components, complete hydrolysis of Aluminum and Silicon to produce zeolites entirely depends on the prevailing water content. Its incorporation deters endless complications during the whole process.
Another notable practical metric during the above-stated stage is the time or duration of the whole process and reaction (To et al., 2006; Hasegawa et al., 2010). Based on the available information, this condition is an essential factor that directly determines the general transition of the provided materials into excellent and high-quality zeolites that can easily improve people's well-being (Wheatley et al., 2014; Mintova et al., 2013). Its incorporation is, in this regard, based on the fact that the intended products are always in a metastable section and hence can easily transition to various zeolites. This situation mainly occurs whenever there is a need to react against the associated changes or transformation. Studies have shown how the intended products will gradually form denser phases occasioned by constant reactions (To et al., 2006; Mintova et al., 2013). To enhance this section's general whereabouts, it is usually advisable for those engaged in experiments to rearrange sodalite cases in varied structural categories as failure to do so could necessitate a reversed reaction and will compromise with the production process. Based on the depictions by Ostwald and other academic scholars, the eventual groupings should get rearranged regularly to strengthen the formation of stable forms. In most circumstances, the eventual or the needed products are usually characterized by a relatively denser structure (Mintova et al., 2013; Hasegawa et al., 2010). Based on this description and highlight it is evident that the success of the whole process will depend on how well an individual will determine the most reliable or appropriate crystallization timeframe as doing so will generate metastable phases (Wheatley et al., 2014; Mintova et al., 2013).
The synthesis time is also followed by determining the best temperature for the reaction (To et al., 2006; Mintova et al., 2013). As revealed by studies, the stated metric is one of the leading physical parameters constantly investigated in the general hydrolysis of zeolites and related materials. Based on academic studies, this condition and highlight relies on its immense effect, especially on the eventual products and the process-related kinetics (Hasegawa et al., 2010; Wheatley et al., 2014). For example, based on available information, increased crystallization temperature heightens zeolites' growth and general progression occasioned by the high kinetic energies that directly strengthen the vibration of particles. This explanation and allegation instantly reveal the interconnection between time and temperature, especially in a chemical and physical reaction (To et al., 2006; Wheatley et al., 2014). With such a perspective, one can easily depict how during the process, an increased temperature increases what we call crystallization time and vice versa. Such a depiction and description can easily get explained using the law of kinetics how the procedure can lead to various occurrences, including increased crystal growth and nucleation. This incidence will enhance how coal fly ash gets converted into zeolite components with given optimum conditions that include reliable time and temperature (Mintova et al., 2013; Wheatley et al., 2014). As revealed by other academic professionals, temperature plays a vital role in the crystallization stage by initiating Ostwald ripening perspectives and allowing for proper and timely synthesis (To et al., 2006; Mintova et al., 2013). Throughout the process, it is evidence that an increase in temperature necessitates the production of higher Silicon components than Aluminum ones, and the reverse is valid for a temperature decrease.
In addition to considering temperature and time, the next step that should get followed to present a hydrolyzed zeolite entirely is the agitation that encompasses mixing (Wheatley et al., 2014; To et al., 2006). As depicted by academic advocates, this procedure increases the homogeneity of the mixture, especially in process-based metrics. Incorporating such a condition also necessitates uniformity that eventually guarantees quality and reliable experiments or productions (Hasegawa et al., 2010; Mintova et al., 2013). This development should occur in agitated vessels to allow for proper and consistent operation as this heightens mixing and hence efficiency and effectiveness. In most cases, studies have shown how presenting or somewhat using unmixed systems results in unpredictable results, including the production of highly concentrated products (To et al., 2006; Hasegawa et al., 2010). In addition to this description and highlight, the general information has revealed how using unmixed products like Aluminum, Sodium Hydroxide, and Silicon leads to the presentation of products that cannot be easily separated in the vessels thereby compromising the whole process (Geboers et al., 2011). Based on the provided information, such conditions may also necessitate the formation of various zeolite phases that could otherwise be of low quality. Throughout the crystallization procedure, the efficiency of the eventual zeolite products will entirely depend on many factors, with the first and most prevalent one being how mixing will enhance the transportation of nutrients to the ever-growing crystals that get always situated on the surface (Mintova et al., 2013; Wheatley et al., 2014). However, it is worth noting that there is a need to effectively study the system and make reliable decisions as mechanical agitation may have devastating consequences on specified attributes such as particle size-related distribution, crystal sizes, and precursor gels (Hasegawa et al., 2010; Shamzhy et al., 2014; Wheatley et al., 2014). With such a condition, relying on the most relevant selection will necessitate mixing and synthesizing materials to form hydrolyzed zeolites.
Besides the above steps and exhibitions, other procedures can get followed to entirely or somewhat produce a hydrolyzed zeolite (Hasegawa et al., 2010; Wheatley et al., 2014). While previously academic scholars relied on polyhedral condensation procedure, depolymerization, and complex polymerization to present the best outcome, individuals in the contemporary world have shifted towards other modernized and most flexible techniques that strengthen production as well as lead to efficient and reliable products (To et al., 2006; Hasegawa et al., 2010). Within these metrics, the respective personality advocated for the following three leading steps to form hydrolyzed zeolites: dissolution of Aluminum and Silicon, condensation procedure, and building block-related connections or linkages (Geboers et al., 2011; Wouters et al., 2001). Although it is regarded by scientists and technical personnel that proper and reliable hydrolysis could follow diverse methods and produce a similar outcome or depictions, the three stated procedures are perceived by many as the most efficient and effective in dealing with the prevailing situation (Hasegawa et al., 2010; Mintova et al., 2013). Besides this depiction and condition, before initiating the process and necessitate effective execution, the exercise needs to be conducted by ascertaining the anticipated findings and whether the targeted mechanisms can lead to recommendable depiction. The first and most prevalent step of this process allows forming a precursor gel. Such a formation is usually characterized by various incidences, particularly feedstock precursors-related depolymerization. Regardless of many outcomes, this condition helps develop what is referred to as Silicon polymers (To et al., 2006; Wheatley et al., 2014). At this phase, the eventual products contain monomeric species accompanied by TO4 or tetrahedra. The following phase encompasses complex procedures that directly differ with "zeolite to zeolite" conditions.
Based on explorative investigations, this situation arises due to constant formation of monomeric species through regular depolymerization and polymerization developments that mainly rely on semi-regular structures (To et al., 2006; Wheatley et al., 2014). To effectively necessitate the process and lead to the production of appropriate materials or compounds, one must continue by joining "hydrated cat-ionic" devices together as doing so plays an essential role in balancing structure's charge-based deficiency (Hasegawa et al., 2010; Wheatley et al., 2014). These conditions, if effectively accommodated, form simplified SBU and aluminosilicates through crystallization. Contrary to the expectation, the resulting compounds always contain "6- membered and 4-membered rings" that strengthens the whole process (Wheatley et al., 2014). This mechanism is followed by forming semi-structured materials, especially in the precursor gels, where its success depends on how well the stated membered components could join. Once nuclei of various elements like zeolites have effectively been produced, immense crystallizations could happen instantly. This explanation and highlight directly deduce the importance of combining different mechanisms and building blocks to form high-quality zeolites that can easily withstand various environmental conditions like high pressure and temperature (To et al., 2006; Hasegawa et al., 2010). Like another chemical and physical process, forming hydrolyzed zeolites through relevant processes depend on specific parameters or metrics, including temperature, pressure, water content, and agitation.
References
Introduction
Zeolites are mineral components that contain micro-porous aluminosilicate and commercially used as catalysts and adsorbents (To et al., 2006). These materials have many characteristics, including being porous. This feature enables them to accommodate many cations, including Magnesium, Calcium, Potassium, and Sodium ions with positive charges. Unlike others, the respective positively charged ions can comfortably exchange ions, especially while in solution form. Natural forms of this material occur worldwide and arise whenever there is a reaction between the ash and volcanic rocks (Hasegawa et al., 2010). However, this process mainly depends on specified components, particularly alkaline groundwater. While mineral zeolites exist in many perspectives and states, the most prevalent ones are stilbite, phillipsite, natrolite, and heulandites. The general production and synthesis of zeolites enable them to have vast roles and applications (Mintova et al., 2013; Shamzhy et al., 2014). For example, its essential feature has allowed it to be used in water filtering and softening mechanisms. The mentioned material traps the otherwise water hardening elements such as magnesium and calcium ions. In such a scenario, the manufactured or eventual water is always rich in sodium but lacks hardening ions (Hasegawa et al., 2010; To et al., 2006). This essay will depict whether the stated element can completely be hydrolyzed and the steps that should be followed to accomplish such a chemical process.
Measuring QoL is important from a clinical and regulatory perspective. Physicians may be interested in knowing the impact their care has on patients. They could use measures of QoL to monitor and follow their patients over time, or before and after a specific intervention, such as surgery.
Item measurement theory - how to measure the unmeasurable?
The components of the quality of life cannot be observed directly. The value of the quality of life can be measured indirectly by asking a series of questions, which are asked to the patient in a different form. Responses are converted to numerical scores which are then combined to obtain "scale scores" or combined to obtain domain scores or other statistically calculated summary scores.
The European urological guideline strongly recommends monitoring the treatment effects of BPH patients using validated questionnaires. The answers received as feedback have a role in the direction in which the further treatment of the patient will take place.
The International Prostate Symptom Score (IPSS) questionnaire is the most used to determine the severity of lower urinary tract symptoms associated with BPH. The first seven questions refer to these symptoms, and the final sum categorizes patients with mild, moderate, and severe LUTS, so further treatment takes place in that direction. The eighth question refers to the quality of life associated with living with those symptoms and is important to ask because it reflects the patient's subjective perception of the symptoms associated with the disease. Often, due to this subjectivity, patients who have mild or moderate LUTS have an extreme impairment of the quality of life and vice versa. Thus, this parameter strongly suggests to us how to direct the therapeutic approach to the patient.
The Benign Prostatic Hyperplasia Impact Index (BII) questionnaire measures the magnitude of change in an individual's BPH-LUTS impact over time. The BII is easy to understand, capturing the clinically relevant impacts of BPH related to urinary problems. It has 4 questions, is easy to understand and validated.
The Overactive Bladder Questionnaire (OAB) - short form (SF) has a total of 19 questions in 2 domains: 6 related to distressing symptoms and 13 related to health quality. Calculated separately, a higher score on the symptom scale indicates greater symptom severity and a higher score on the QoL scale indicates better QoL, so they are inversely related to each other.
The long form of the Male Incontinence Questionnaire has 23 questions on LUTS and related QoL. The short form of 11 questions covers 2 domains: the first one related to micturition - 5 questions and 6 questions related to incontinence. The advantage is in Separate consideration of frequency, nocturia and impact on daily life.
The SF-36 is a generic or general questionnaire in over 10000 items in a PubMed search. It consists of two dimensions - physical and mental. There is no exact balance between the two components’ different approaches in the interpretation of the total result. its validity may be questioned due to the biased amount of data.
The goals in assessing QoL in BPH patients
The latest studies more comprehensively analyze the role of BPH in characterizing the quality of life, but also in relation to the cost-benefit of therapeutic options. For this purpose, combined questionnaires are used, general ones relating to health, disease-specific and general ones analyzing the economic moment.
The QUALIPROST study is of relatively recent date and is a prospective, longitudinal, multicenter, open-label study conducted in outpatient urology clinics to evaluate change in quality of life (QoL) and symptoms in patients with lower urinary tract symptoms/benign prostatic hyperplasia. (LUTS/BPH) in current clinical practice by use of IPSS and BII questionnaires. Improvements in QoL and symptoms were equivalent to the medical treatments most widely used in real-life practice for the treatment of patients with moderate or severe LUTS.
Due to the aging population, the prevalence of BPH is expected to increase dramatically. There is an emerging need to develop and implement effective interventions to improve the QoL and psychological well-being of patients with BPH. A holistic approach in the management of BPH in each individual patient is needed for these goals.
This analytical approach provides additional evidence for current therapeutic options for the management of LUTS/BPH and should help further inform decision-making regarding treatment strategies in this patient population.
Benign prostatic hyperplasia (BPH) is a condition that results in lower urinary tract symptoms (LUTS) leading to significant deterioration in patients' quality of life (QoL). BPH affects QoL by inducing psychological stress in patients due to anxiety and worsening their social function. The more severe the symptoms of BPH, the lower the QoL becomes. However, the QoL of BPH patients whose symptoms worsen due to aging has been shown to be significantly reduced. In the last few years, there has been an increasing trend of analyzing the effect of BPH symptoms on QoL and the most widely used therapeutic strategies.
The definition of quality of life was given by the WHO in 1947, but the first 5 papers with an analysis of these keywords in the Medline database appeared until 1973. From 1974, the number of professional papers that give an overview of the quality of life of patients began to grow exponentially, so that in the last decade there has been almost no professional communication that does not address this issue as a conclusion.
References
Quantitative electroencephalogram (qEEG) helps a) characterize normal versus disease, developmental and neurocognitive states as well as b) in diagnosis and prognosis enabling a clinician to determine via statistics if a client/subject is, i) within a reference normal population, ii) how best to customize treatment based on the client’s/subject’s qEEG results and iii) if a client/subject is responding positively to treatment. However constructing of qEEG normative databases for use in both research and clinical settings has proved challenging over the last 61 years due to methodological issues such as, i) determining who makes up the “normal” study population and ii) lack of standardized procedures when acquiring, measuring, analyzing, and interpreting resting state or active task EEG data. This review focuses on a) the many challenges/milestones the field had to overcome, b) standards to be followed when constructing and validating a normative databases c) commonly used peer-reviewed normative databases, and d) an illustrated step-by-step guide to qEEG normative database validation and comparison.
References
Modern techniques demonstrate positive esthetic outcomes for replacing a tooth in the esthetic zone by an immediate implant placement and provisionalization (IIPP). This case report presents a clinical case who underwent orthodontic treatment with retained deciduous canine and missing permanent canine. It was planned for extraction of retained deciduous tooth with an immediate implant placement and provosionalization using the extracted tooth.
Keywords: Implant; Provisionalisation; Natural Teeth; Pontic
References
Septo - Optic Dysplasia (SOD) also known as De Morsier Syndrome, is a rare medical condition, the diagnosis of which is made when there are two or more characteristics of the classic triad. The triad consists of optic nerve hypoplasia, pituitary hormone abnormalities, and midline brain defects. We present the case of a 15-year-old boy with a history of seizures and optic nerve disease that was diagnosed with septo-optic dysplasia with characteristic imaging findings.
References
The technical culture bonded inseparably with economics as we know it leaves the door wide open to ancestral greed and limitless hunger for profit realizable only through material goods. In this way it creates the system we feel prisoners of today, which is the source of the risk of an asocial society.
References
Chapter 1: General Guidelines
Most Important Duty
The first and foremost duty of the treating doctor is to save the life of a patient and give necessary urgent treatment. Police should be informed as early as possible but the patient should not be allowed to suffer. For this he must not wait for the arrival of police.
References
The Overwhelming Evidence of Covid as Mass Occult Event? Children Are 4,423% MORE Likely to Die If Injected with These Serums.
By K. Paul Stoller, MD American College of Pediatricians
Since the Globalist bankers and the oligarch families that control them failed to impose feudal socialism on Europe with WW II, they have been scheming ever since to have the will of their pedophile death-cult accomplish what they could not almost a century ago.
References
Cancer treatment is a difficult task. Mental and bodily exhaustion are possible outcomes of the practice. Alternative therapy options for cancer may be enhanced via integrative cancer care. Combining traditional medicine with complementary and alternative medicine, nutritional medicine, and lifestyle interventions to cure and prevent disease and optimize health is an integrated approach to treating illnesses like lung cancer. The case study has also explored some challenges patients face in this lung cancer treatment journey. The patient, after being diagnosed with Stage IV non-small cell lung cancer NSCLC adenocarcinoma, undergoes a set of combination of carboplatin-pemetrexed-pembrolizumab chemotherapy, which exposes her to a significant number of side effects like extreme weakness, elevated inflammatory markers, and nausea. Throughout this paper, we will discuss the integrative approaches to treating patients with lung cancer and the side effects of traditional treatment in lung cancer.
References
Managing Fibromyalgia, anxiety, and depression can be extremely challenging. Fibromyalgia manifests as widespread muscle and joint pain, fatigue, and sleep disturbances. It often coexists with anxiety and depression, exacerbating the syndemic and significantly impacting quality of life. This literature review looks at integrative methods for treating these many illnesses, highlighting the need for a more complete approach beyond regular treatments. To make treatments work, we need to understand how fibromyalgia, anxiety, and depression are all connected. Traditional therapies have helped people deal with their problems. Still, they have boundaries, and people want care focused on them, which has made people interested in integrative methods. Integrative medicine, which looks at the mind, body, and spirit, might help treat these problematic conditions.
References
Fibromyalgia is a complex condition that can be challenging to diagnose and treat. In addition to the symptoms you mentioned, some people with Fibromyalgia may also experience depression, anxiety, and other mood disorders. Currently, Fibromyalgia cannot be cured, however, various treatments can be found that focus on managing the symptoms and improving quality of life. These may include medications, physical therapy, cognitive behavioral therapy, and lifestyle changes such as exercise, stress management, and good sleep habits. Developing individualized treatment initiative that addresses the specific goals and needs of people with Fibromyalgia, they should work closely with their healthcare provider.
References
Presentation of the case
A 56 years old female patient has a history of systemic lupus erythematosus (S.L.E.) and COPD. Symptoms began around prior and gradually improved as she continued to get medications. She has been experiencing Coughing, sputum production, palpitations, chest pain, and wheezing. She describes new-onset and shortness of breathe, labored breathing at rest, mild weariness, feeling chilly and depressed. There are no documented allergies to foods, medications, or the environment.
Her medication includes Hizentra 15 grams, Benlysta 200mg weekly, prednisone 15mg, Amitiza 60x2, Cymbalta 60x2, Topiramate 50 x 2 and 100x2 Fosamax 70 mg week, Botos 200 Units (S.L.E. migraines) Singular 10, Allegra 180, Wellbutrin 300, and Pilocarpine 5x4 and took most medicines of them was taken every week.
Past medical history is significant in developing coronary artery disease, COPD, hypertension, hypothyroidism, myocardial infarction, hyperlipidemia, diabetes mellitus, peripheral vascular disease, and cigarette use. A history of heart catheterization, appendectomy, stent nephrectomy, implantation, hysterectomy, or is noteworthy.
References
Breast cancer remains a significant global health issue, prompting the need for further exploration of alternatives to conventional treatments. Through the years, this has led to the formulation and investigation of protocols using natural ingredients as potential remedies for holistic control of breast cancer. An integrated protocol with a case study of a 58-year-old woman diagnosed with breast carcinoma will be discussed to ascertain this approach. The case study details the patient's discovery of a lump, followed by a detailed analysis using more precise breast imaging methods. The examination identified a hypoechoic and dense tumor in her right breast. The subsequent core biopsy confirmed the diagnosis of carcinoma lobular mammae, emphasizing the necessity for an effective and personalized therapeutic approach.
References
According to Zhu et al. (2021), Medicine and Health encloses the study of the prevention, care, and tendering of diseases as well as the examination of physical and mental well-being. Medicines can help control things like high blood pressure or high cholesterol. These drugs cannot cure the hidden problems, but they can help prevent some of its body damaging effects overtime among important medicines are immunization. A lot of medicines are swallowed, either as pills or a liquid. Once the medicine is swallowed, the digestive juice in the stomach breaks it down, and the medicine can progress into the bloodstream. Blood then carries it to other parts of your body where the medicines work best.
References
Today, with all the pollution in our environment and so many of us working in toxic environments, we need to take extra steps to cleanse and protect our bodies. These green supplements can help by addressing the science behind certain greens and how they assist with detoxification and aging, among other things. Many of us are not even familiar with the many different greens we can take to support our immune system, our digestive system and how they help cleanse the body. The following article is meant to explain a few of the many green supplements you can find on the market today. Just like conventional medicine, not every green supplement is going to work for everybody. What works for one person may not work for another. It's best to simply experiment and see what works best for you and your particular needs. As a rule of thumb, always consult with your primary care physician before adding any new supplement or herb to your daily regimen if you have any known health problems or are currently taking any medications.
References
Currently, due to increased industrialization, chemicals of all types and heavy metals continue polluting water, air, and soil, causing food contamination and hurting the general body health and wellbeing of people. Persistent organic pollutants and heavy metals from the most cause of environmental pollutants are delivered through the food that people eat. The continued chronic exposure to accumulated pollutants is linked to the development of non-communicable diseases that include diabetes, obesity, chronic respiratory disease, cardiovascular diseases, and cancer (Mehrandish, Rahimian, & Shahriary, 2019). Research also shows that toxic trace element accumulation within the body causes metabolic disorders that induce obesity or overweight and increased energy intake among victims of diabetes and obesity. Additionally, the diets that obese people take the lead to trace nutrient imbalance. To manage obesity, such people are encouraged to have a sufficient intake of minerals and vitamins. One of the popular means of promoting toxin removal and reduced weight includes the use of a detox dieting strategy. The process helps with improved life quality and enhanced health. Some contradictory research shows controversial outcomes, with some studies showing no scientific evidence for detox diets and health benefits (Stocker et al., 2017). Besides, others consider such diets as harmful to the body. However, the study of food-based nutrients shows their potential ability in modulating metabolic pathways that detoxification processes have. It is evident that nutrients and food extracts regulate toxins' eventual excretion and transduction. The detoxification diets include calorie-restricted foods that involve beverages, single fruits, and vegetables. Beverages include vinegar, tea, saltwater, lemon juice, and other drinks having micronutrients.
References
Colon cancer, which is also referred to as colorectal cancer, is an invasive and fatal disease that commences in the cells that line the colon or the rectum. This third most prevalent cancer among men and women has seen an increase in incidences and now constitutes a public health challenge. The American Cancer Society projected about 153,020 new cases in the U.S. alone and 52,550 mortalities in 2023 (American Cancer Society, 2023). Increases in incidence point out the need to develop new effective strategies that will help to improve treatment efficiency, leading to a better quality of patients' lives.
The case study's data was collected using a standard form, and three broad groupings were identified: naturalistic studies, comparative cohort studies, and randomized controlled studies. Additional information was recorded about the sample's socio-demographic features, the study's inclusion criteria, the key outcomes used, and the environment. Female Age: 62, developed adrenal fatigue and blood sugar issues, and was diagnosed with chronic fatigue in 2013. She had trouble with mental focus, anxiety, and high blood pressure.
After the initial outbreak of ME/CFS in Los Angeles in 1934, the condition has experienced a number of modifications in terms of nomenclature and case definition, including being dubbed 'benign ME', 'chronic Epstein-Barr virus syndrome', and 'postviral fatigue syndrome'. The CDC published the ME/CFS criteria in 2003, which encompassed both ME and CFS clinical symptoms. The ICD system exemplifies the complexities of such confusing terms. The World Health Organization categorized ME as a neurological illness in 1969, but the ICD-10 (2016) and ICD-11 (2019) categorized ME and CFS as distinct illnesses, with tiredness (MG22) being excluded. As a result, ME/CFS is poorly defined. The term "myalgia Nervosa" was coined by Dr. S. Freud to suggest a psychiatric etiology, while the original term "neurasthenia" denoted an organic neurological ailment. Until recently, the cause of ME/CFS was a contentious issue. In 2015, the IOM proposed a new name, SEID, and related criteria, which eschewed the stigma associated with "fatigue". The study's sample size ranged from 15 to 498 people, and it used a range of classifications. Only three of the 2075 patients tracked with organic exclusion in the 19 trials died, and one of them was caused by an unconnected physical disease. The authors conclude that ME/CFS is difficult to comprehend and treat for both patients and health care providers, and question the prevalent socio-cultural narratives surrounding academics' and physicians' views on ME/CFS and their victim-blaming tendencies.
Richman and Jason discovered that the medical establishment still credits mental and psychological reasons for ME/CFS, while patients with ME/CFS generally ascribe their condition to a still unknown biological etiology. Further qualitative research is needed to understand marginalization experiences. The literature review has highlighted the causes of Chronic Fatigue Syndrome, which is a long-term condition that affects a variety of bodily systems. It can affect people of any age group, and symptoms may appear gradually over months or years.
This research analysis aims to present a case study analysis on the topic of chronic fatigue syndrome, which is a long-term condition that affects a variety of bodily systems. It can affect people of any age group and can appear gradually over months or years. Chronic tiredness is a poorly understood condition characterized by physical and mental exhaustion exacerbated by physical and mental activity that occurs 50% of the time or more and lasts at least six months. The prognosis is unclear, but the lay literature indicates a lifelong path with only sporadic recovery. In 2016, four databases were searched for peer-reviewed papers that provided follow-up data following an initial diagnosis of chronic fatigue syndrome. Papers that employed a combination of goal symptoms were the key excursion criterion.
Herbal supplements are essential naturally made health remediation dietary components. The American FDA has authorized the use of natural herbal supplements by individuals willing to have a healthy body. Vitamin B6 is a natural food supplement that improves the wellness and health of individuals. Vitamin B6 is found in potatoes and bananas and is essential for building the human body. Natural food supplements are essential in ensuring increased healthy well-being of individuals consuming them. These supplements are sometimes contaminated, but they still have importance in preventing diseases.
6 Natural supplements are essential in improving individuals' health and wellness. However, there is a need to be concerned about some of the contaminated products' incidences in making these natural supplements, especially the herbal ones. Microalgae are another essential natural product that improves the healthy supplementation of individuals. It is responsible for curing chronic and acute diseases and also contains high protein content that meets the dietary requirement of any population. Natural supplements are essential in treating multiple diseases, including inflammation and pain reduction. Moreover, natural supplements reduce tissue damage, and therefore, ensure that humans have strong bodies and live healthily.
A 36-year-old female who suffered from Covid infection was treated with a proprietary blend that improved her breathing, her coughing decreased, and her headache disappeared. Turmeric and nigella sativa seeds are natural extracts that help humans to stay healthy and prevent themselves from diseases. Natural supplements are vital for adults at any age to ensure that their bodies are healthy and well. Medical personnel have recommended the consumption of natural supplements to patients and other people willing to have strong body immunity. Multivitamins from natural products are essential in ensuring healthy living and wellness for people. Fruit intake helps improve health and wellness of individuals, and the presence of vital vitamins obtained from fruits helps strengthen the human body and increase wellness. Fish oil supplements improve the health of the human body by regulating inflammation, improving blood flow, and promoting muscle and joint health. Moreover, fish oil supplements improve the human body's immune system, thus ensuring a healthy body and overall wellness.
References
Intervention of various viable technologies to improve the food & nutritional status of the population proved the following facts: Promotion of malt-based small-scale food provides an opportunity for rural women to develop entrepreneurship and employment. It also provides food and nutritional security through additional income. Several technologies like value addition to fish & prawn products, artificial pearl culture, and processing of salted fish were developed under the National Agricultural Technological Project which helped the self-help group women of Andhra Pradesh, Karnataka, Kerala, and Tamil Nadu to improve their economic status. Received two patents for fabricating I) a Low-Cost Ice Cream Freezer (to prepare ice cream with small quantity of milk in rural area) and II) Fresh Fish Vending and Display Table (which helped the fisherwomen to reduce their drudgery and also preserve fresh fish for a longer time without getting spoiled) The technology was licensed twice. Food Product development can be taken as an income-generating activity in the rural areas by the illiterate women which can be included in supplementary feeding programs mainly to improve the nutritional status of the children. The horse gram which is commonly used for cattle feed can be diversified for human consumption with less investment. Mothers as well as Anganwadi workers preferred amylase - rich supplementary foods as these supplementary foods better as compared to earlier supplied food i.e., ready-to-eat food. Introducing red palm oil is beneficial to overcome vitamin A deficiency. The supplementary income of women has a positive impact on the nutritional status of the family.