Peripheral neuropathy is a broad and clinically diverse group of disorders affecting the peripheral nervous system. Patients may experience pain, numbness, tingling, weakness, impaired balance, and progressive difficulties with daily activities. Diabetes is one of the most common causes, but peripheral neuropathy may also result from inherited disorders, nutritional deficiencies, infections, autoimmune conditions, medications, toxins, and metabolic abnormalities. This diversity makes effective treatment a continuing challenge.