Review Article
Volume 9 Issue 3
Anton Lacko*, Egor Chernomorskii, Lukas Lacko, Matus Kolarcik, Jan Straka, Peter Valko, Pavol Pucat, Jozef Babecka, Katarina Hruskova and Antonin Hrubon
September 18, 2026
Abstract
Introduction: In the present turbulent era, security management extends across a broad spectrum of societal life, ranging from the everyday activities of citizens to scientific and technical endeavors in many disciplines. A critical element of every social system is healthcare. Modern technologies are being introduced into this field almost on a daily basis. For accurate disease diagnostics, contemporary healthcare requires high-quality imaging methods. One of the imaging modalities is the discipline of nuclear medicine. Radioactive substances administered into the patient’s body provide an accurate picture of the functional state of the internal environment. Both patients and healthcare personnel are exposed to invisible ionizing radiation, which, in doses exceeding established limits, becomes hazardous. Similar to other disciplines, nuclear medicine is continually advancing. The current standard is represented by SPECT technologies. SPECT CZT is an upgraded system in which analog detection technology has been replaced by semiconductors.
The high incidence of cardiovascular diseases, especially ischemic heart disease, requires early diagnosis and modern treatment.
Methodology: Using nuclear medicine methods, we try to detect these changes in time and thus prevent the occurrence of acute coronary events. In nuclear cardiology, instead of a large-area scintillation detector, a new type of cardio-gamma camera “Discovery CZT 530c” based on the principle of semiconductor detectors began to be used. The abbreviation CZT stands for semiconductor composition (Cadmium-Zinc-Tellur).
The set of respondents consisted of 6280 people examined in the years 2020-2025 by myocardial perfusion scintigraphy. There were 3140 nondiabetic patients and 3140 diabetic patients in the analysed group of the 6280 examined.
Results: In the analysed group of 3140 nondiabetic respondents, 75% had negative findings and 25% had positive findings in terms of the presence of ischemic heart disease. In the group 3140 of diabetic patients, there was a negative finding in 63% of respondents and a positive finding in 37% of the respondents in the sense of positive ischemic heart disease. Using myocardial perfusion scintigraphy in the diagnosis of functional changes, we confirmed a benefit in detecting early changes in coronary heart disease, including in the diagnosis of microvascular angina.
Conclusion: Nuclear medicine methods are of great benefit for the diagnosis of small vessel disease, diabetic cardiomyopathy and cardiac autonomic neuropathy in patients with diabetes mellitus. The new type of cardio gamma camera “Discovery CZT 530c” allows more accurate assessment of myocardial perfusion abnormalities and at the same time the reduction of the radiopharmaceutical dose reduces the patient's radiation load by 50%.
Keywords: Semiconductor Detectors for Ionizing Radiation; Cardiac CZT SPECT gamma camera 530c; SPECT/CT camera Star Guide; Coronary heart disease; Radionuclides
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