PriMera Scientific Surgical Research and Practice (ISSN: 2836-0028)

Case Report

Volume 8 Issue 4

Factor XII Deficiency: Two Cases about A Rare Coagulation Disorder in a Pediatric Hematology-Oncology Department

Essrifi Khadija*, S Bouramdane, K Mkaddem, H Eddou and S Benmiloud

October 09, 2026

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Abstract

Factor XII (FXII) deficiency is a rare autosomal recessive inheritad disorder that causes a significant prolongation of activated partial thromboplastin time (aPTT), imitating a coagulation disorder. The distinctive feature of FXII deficit is the absence of clinical bleeding complications and the tendency to thromboembolic events. Our work concerns two patients with factor XII deficiency. At the time of diagnosis, the patients were aged between 10 months and 2 years with no significant medical history. Neither patient presented with hemorrhagic syndrome, with an extended APTT being discovered incidentally during pre-operative testing.

Keywords: factor XII deficiency; inheritad desease; coagulation; thromboembolic events

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