Review Article
Volume 8 Issue 2
Christina Rahm*
August 04, 2026
Abstract
Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) receptor agonists have transformed the clinical management of obesity, type 2 diabetes, and gastrointestinal disorders. Despite their strong therapeutic efficacy, their use is often limited by high cost, the requirement for injectable administration, gastrointestinal side effects, reduction in lean muscle mass, and challenges associated with long-term discontinuation. These limitations highlight the need for alternative or supportive approaches that can maintain metabolic benefits while minimizing adverse effects and improving patient adherence.
This white paper evaluates evidence-based natural ingredients as supportive or adjunctive strategies to GLP-1 and GLP-2 pharmacotherapies. Drawing from emerging pharmacological and nutraceutical research, the focus is placed on botanical compounds and bioactive nutrients that influence appetite regulation, glucose homeostasis, gut signaling, mitochondrial function, and skeletal muscle preservation. Particular attention is given to ingredient systems that may support safe titration of peptide therapies or serve as non-pharmaceutical alternatives for individuals who prefer not to utilize injectable agents.
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