Abstract
Alzheimer’s disease is a growing global public health concern, affecting millions of individuals worldwide and imposing substantial emotional, social, and economic burdens on patients, caregivers, and healthcare systems. As population aging continues to accelerate, the prevalence of Alzheimer’s disease is expected to rise, underscoring the increasing importance of strategies aimed at preserving cognitive function and delaying disease onset. Evidence suggests that Alzheimer’s disease is multifactorial in nature, with contributions from genetic predisposition, lifestyle choices, and environmental exposures. Importantly, many of these factors are modifiable, providing a critical opportunity for early intervention. Integrative and holistic approaches including targeted nutrition, regular physical activity, cognitive and mind-body therapies, sleep optimization, and selected herbal or natural supplements have demonstrated potential in supporting neuroplasticity, reducing oxidative stress, and enhancing overall brain resilience. Nutritional patterns such as the Mediterranean and MIND diets, combined with routine aerobic and resistance exercise, ongoing mental stimulation, meditation, and adequate sleep, may play a meaningful role in maintaining cognitive health. Additionally, certain natural compounds may offer complementary neuroprotective benefits. While limitations in study design and variability in evidence quality warrant cautious interpretation, holistic interventions can serve as valuable adjuncts to conventional medical care. Personalized, lifestyle-based strategies hold promise for reducing Alzheimer’s disease risk, supporting cognitive well-being, and improving quality of life for both patients and caregivers, while also contributing to broader public health efforts aimed at mitigating the growing burden of neurodegenerative disease.
References
- Abbaoui Z., et al. “Alzheimer’s disease: In silico study of rosemary diterpenes activities”. Current Research in Toxicology 6 (2024): 100159.
- Ahmad S., et al. “Natural remedies for Alzheimer’s disease: A systematic review of randomized controlled trials”. Metabolic Brain Disease 38 (2023): 17-44.
- Bayo Jimenez MT., et al. “Natural Products in Alzheimer’s Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms”. International Journal of Molecular Sciences 26.21 (2025): 10631-10631.
- Bhat BA., et al. “Natural Therapeutics in Aid of Treating Alzheimer’s Disease: A Green Gateway Toward Ending Quest for Treating Neurological Disorders”. Frontiers in Neuroscience 16 (2022).
- Chen L., et al. “Natural Products and Exercise Synergy: Unraveling Molecular Mechanisms to Enhance Brain Function in Alzheimer’s Disease”. Phytotherapy Research 39.8 (2025): 3800-3812.
- Hoang LN, Lee H and Lee SJ. “Improving cognitive impairment through chronic consumption of natural compounds/extracts: a systematic review and meta-analysis of randomized controlled trials”. Frontiers in Aging Neuroscience 16 (2025).
- Liu X., et al. “The long-term neuroprotective effect of MIND and Mediterranean diet on patients with Alzheimer’s disease”. Scientific Reports 15.1 (2025).
- Martínez-López S., et al. “A systematic review of lifestyle-based interventions for managing Alzheimer’s disease: Insights from randomized controlled trials”. Journal of Alzheimer’s Disease 102.4 (2024): 943-966.
- Nguyen SA, Oughli HA and Lavretsky H. “Use of Complementary and Integrative Medicine for Alzheimer’s Disease and Cognitive Decline”. Journal of Alzheimer S Disease 97.2 (2023): 523-540.
- Ornish D., et al. “Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial”. Alzheimer’s Research & Therapy 16.1 (2024): 122.
- Reza-Zaldívar EE and Jacobo-Velázquez DA. “Comprehensive Review of Nutraceuticals against Cognitive Decline Associated with Alzheimer’s Disease”. ACS Omega 8.39 (2023): 35499-35522.
- Sri RS., et al. “Integrative approaches in Alzheimer’s disease: evaluating the potential of traditional, complementary, and integrative medicine (TCIM)”. Frontiers in Pharmacology 16 (2025).
- Szabo-Reed AN and Key MN. “A Narrative Review Evaluating Diet and Exercise as Complementary Medicine for the Management of Alzheimer’s Disease”. Nutrients 17.11 (2025): 1804.
- Thawabteh AM., et al. “Promising Natural Remedies for Alzheimer’s Disease Therapy”. Molecules 30.4 (2025).
- Wang S., et al. “Non-pharmacological treatment of Alzheimer’s disease: an update”. Frontiers in Aging Neuroscience 17 (2025).
- Xu Lou I, Ali K and Chen Q. “Effect of nutrition in Alzheimer’s disease: A systematic review”. Frontiers in Neuroscience 17 (2023).