PriMera Scientific Surgical Research and Practice (ISSN: 2836-0028)

Review Article

Volume 7 Issue 3

Recent Advances in the Fabrication of Gelatin based Nanoparticles Using Desolvation Techniques and Their Pharmaceutical Applications

K Chandramohan, R Nepolean, S Sivasankari*, D Anbarasu and N Jayaram

March 02, 2026

DOI : 10.56831/PSSRP-07-247

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Abstract

Gelatin based nanoparticles (GNPs) produced using desolvents of gelatine have become a high interest as a biocompatible and versatile nanoparticle system for pharmaceutical and biological field. In this manuscript, an in depth analysis of the basic principles of desolvation is presented which includes solvent induced aggregation, polymer solvent thermodynamics, and gelatin type, molecular weight distribution, and critical process parameters. Classical two step desolvation and optimized one step processes are analyzed and compared to new invention scenarios of green, microfluidics assisted, ultrasonics, supercritical fluid and AI guided fabrication processing strategies, focusing on scalability, reproducibility and environmentally inspired strategies. Advances in cross linking methodologies that employ chemical, natural and physical stabilization approaches are reviewed in the light of stability, biodegradation, and drug release behaviour of nanoparticles. Characterization techniques are highlighted and the relevance of invitro and in vivo correlations for clinical translation is made. Finally, the wide ranging pharmaceutical potential of GNPs in drug, gene, and vaccine delivery, diagnostics, and regenerative medicine is outlined, making desolvation derived gelatin nanoparticles a promising platform for next generation precision nanomedicine.

Keywords: Gelatin Nanoparticle; Desolvation; Nanocarriers; Biomedical Applications

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