PriMera Scientific Surgical Research and Practice (ISSN: 2836-0028)

Research Article

Volume 5 Issue 5

Effect of Green Synthesized Silver Nanoparticles from Orange Peels on Growth Performance and Liver Function Parameters of Male Albino Rats

Arowora Kayode Adebisi, Moses Adondua Abah*, Ugwuoke Kenneth Chinekwu, Onyelucheya, Victoria, Micheal Abimbola Oladosu, Gbadeyan Femi Ayo, Ekele Jiata Ugwah, Okabeonye Sunday Agbo, Igwe Ejikeme Peter, Wisdom Oshireku Abiodun, Ugoagwu Kingsley Ugonna, Sunday Kaura, Ibraheem Kehinde Sherifat, Asare Bernard Kwame, Pelumi Adams David, Onyekachi Chimaobi George and Upahi Etudaye

April 28, 2025

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Abstract

It has been estimated that of all nanoparticles used in consumer products, silver nanoparticles currently have the highest degree of commercialization with a wide range of industrial and medical applications that may put human health at risk. The toxicity of nanoparticles is a subject of continued controversy and concerns about their adverse effects on human health and the environment are growing. This study investigated the effect of green synthesized silver nanoparticles from orange peels on growth performance and liver function parameters of male albino rats. Orange peel samples were collected from Federal University Wukari and air dried, ground and soaked in 80% ethanol solution for 24 hours. The orange peel extract was filtered. Silver nanoparticle was produced by boiling orange peel extract with 1mMsilver nitrate solution for 30 minutes. The green synthesized silver nanoparticles were orally administered at different doses (200, 400, 600ppm) to rats in group 2-4 for two weeks. The result of growth performance elicited highest feed efficiency in group 1(control) while the lowest value was found in group 3. Sera levels alanine transaminase (ALT)and aspartate transaminase (AST) were significantly higher in treatment groups (2-4), when compared with the control (group1). Sera level of ALP and GGT were slightly higher in the control group when compared with that of treatments. Higher sera levels of ALT and AST were observed which could be due to slight toxicity of AgNPs administered on the liver membranes of albino rat. Based on the findings of study, it was revealed that oral administration of silver nanoparticles between 200and 600ppm had varying effects on liver function parameters and growth performance of the experimental animals. However, higher sera levels of ALT and AST were observed which could be due to slight toxicity of AgNPs exerting its effect on liver membranes of the albino rats.

Keywords: Silver nanoparticles; Albino rats; Orange peel; Biochemical parameters; Growth performance

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