PriMera Scientific Surgical Research and Practice (ISSN: 2836-0028)

Review Article

Volume 4 Issue 4

Pathogenesis and Management Modalities of Typhoid Perforation: A Review of Literature

Kefas John Bwala*, Ballah AM, Kirfi AM, Ogunleye OO, Adamu A, Baffah AM, Essien OB, Abdul MM, Dauda MM and Duke R

October 03, 2024

DOI : 10.56831/PSSRP-04-140

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Abstract

Typhoid fever has been a recognized infectious disease for centuries, with historical accounts of outbreaks dating back to ancient times. However, it was not until the late 19th and early 20th centuries that the association between typhoid fever and intestinal perforation was fully elucidated. Pioneer works by Widal, Wilson, and Ganière provided early insights into the pathogenesis of typhoid intestinal perforation. Transmission is through feco-oral route. Virulence and dose of the organism as well as the host resistance play pivotal role in the pathogenesis. Adequate resuscitation, prompt surgical intervention, with repair of the damaged bowel as well as copious peritoneal lavage are key to favourable outcome.

Keywords: pathogenesis; management; typhoid perforation

References

  1. Osifo OD and Ogiemwonyi SO. “Typhoid ileal perforation in children in Benin city”. Afr J Paediatr Surg 7.2 (2010): 96-100.
  2. Ukwenya AY, Ahmed A and Garba ES. “Progress in management of typhoid perforation”. Annals of African Medicine 10.4 (2011): 259-65.
  3. Grema BA., et al. “Typhoid ileal perforation in a semi-urban tertiary health institution in north-eastern Nigeria”. South African Family Practice 60.5 (2018): 168-73.
  4. Akinyemi KO., et al. “Typhoid Fever: Tracking the Trend in Nigeria”. The American Journal of Tropical Medicine and Hygiene 99.3_Suppl (2018):41-7.
  5. Muhammed RS., et al. “Phenotypic characterization of Salmonella typhi isolated from febrile and diarrhea patients in Bauchi, Nigeria”. GSC Biological and Pharmaceutical Sciences 4.3 (2018).
  6. Usang UE., et al. “Typhoid perforation in children: an unrelenting plague in developing countries”. J Infect Dev Ctries 11.10 (2017): 747-52.
  7. Uba AF., et al. “Typhoid intestinal perforation in children: a continuing scourge in a developing country”. Pediatr Surg Int 23.1 (2007): 33-9.
  8. Bhutta ZA. “Typhoid Fever: Current Concepts”. Infectious Diseases in Clinical Practice 14.5 (2006): 266.
  9. Bhutta ZA and Threlfall J. “Addressing the Global Disease Burden of Typhoid Fever”. JAMA 302.8 (2009): 898-9.
  10. Crump JA and Mintz ED. “Global Trends in Typhoid and Paratyphoid Fever”. CLIN INFECT DIS 50.2 (2010): 241-6.
  11. Ekenze SO and Ikefuna AN. “Typhoid intestinal perforation under 5 years of age”. Ann of Tropical Paediatr 28.1 (2008): 53-8.
  12. Torborg A., et al. “Outcomes after surgery for children in Africa (ASOS-Paeds): a 14-day prospective observational cohort study”. The Lancet 403.10435 (2024): 1482-1492.
  13. Ajao OG. “Typhoid perforation: factors affecting mortality and morbidity”. Int Surg 67.4 (1982): 317-9.
  14. Adrien Hodonou M. “Prognostic Factors of Non-Traumatic Small Bowel Perforation Peritonitis: A Multicenter Study in North Benin”. JS 6.1 (2018): 29.
  15. Edino ST., et al. “Prognostic Factors in Typhoid heal Perforation: A Prospective Study of 53 Cases”. Journal of the National Medical Association 99.9 (2007): 1042-5.
  16. Birkhold M., et al. “Morbidity and Mortality of Typhoid Intestinal Perforation Among Children in Sub-Saharan Africa 1995-2019: A Scoping Review”. World J Surg 44.9 (2020): 2892-902.
  17. Birkhold M., et al. “Characterization of Typhoid Intestinal Perforation in Africa: Results From the Severe Typhoid Fever Surveillance in Africa Program”. Open Forum Infectious Diseases 10.Supplement_1 (2023): S67-73.
  18. L Lefrançois and N Lycke. “Isolation of Mouse Small Intestinal Intraepithelial Lymphocytes, Peyer’s Patch, and Lamina Propria Cells”. Current Protocols in Immunology, Chapter 3 (2001): Unit 3.19.
  19. Ameh E., et al. “Role of damage control enterostomy in management of children with peritonitis from acute intestinal disease”. Afr J Paediatr Surg 10.4 (2013): 315-9.
  20. Wu J., et al. “Surgical Outcomes in Adults with Acute Small Bowel Perforation and Risk Factors for Mortality: A Single-Center Retrospective Cohort Study”. In Review (2021).