PriMera Scientific Surgical Research and Practice (ISSN: 2836-0028)

Guest Editorial

Volume 3 Issue 1

The Potential Hidden Burden of Primary Cytomegalovirus Infection During Pregnancy: How to Mitigate Burden & The Challenges for Screening and Prevention

Abdelaziz Farouk Aldeeb*

December 12, 2023


Cytomegalovirus (CMV) is a DNA virus a member of the herpesvirus family, which includes herpes simplex virus types 1 and 2, varicella-zoster virus, and Epstein-Barr virus. These viruses share a characteristic ability to establish lifelong latency. After initial infection, which may cause few symptoms, CMV becomes latent, residing in cells without causing detectable damage or illness. CMV, is a common virus that infects people of all ages. Over half of adults have been infected with CMV by age 40. Most people infected with CMV are asymptomatic (90%).


  1. American Academy of Pediatrics. Cytomegalovirus Infection. In: Kimberlin DW, Brady MT, Jackson MA, Long SS, eds. Red Book®: 2015 Report of The Committee on Infectious Diseases. American Academy of Pediatrics (2015): 317-322.
  2. Cannon MJ., et al. “Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection”. Rev Med Virol 20.4 (2010): 202-213.
  3. Chung W., et al. “Middle Ear Effusion in Children with Congenital Cytomegalovirus Infection”. The Pediatric Infectious Disease Journal 39.4 (2020): 273-276.
  4. Chatzakis C., et al. “Timing of primary maternal cytomegalovirus infection and rates of vertical transmission and fetal consequences”. Am J Obstet Gynecol 223 (2020): 870-83.
  5. Enders G., et al. “Intrauterine transmission and clinical outcome of 248 pregnancies with primary cytomegalovirus infection in relation to gestational age”. J Clin Virol 52.3 (2011): 244-246.
  6. Grosse SD., et al. “Newborn screening for congenital cytomegalovirus: Options for hospital-based and public health programs”. J Clin Virol 46.4 (2009): S32-36.
  7. Kimberlin DW., et al. “Valganciclovir for symptomatic congenital cytomegalovirus disease”. N Engl J Med 372.10 (2015): 933-943.
  8. Krause PR., et al. “Priorities for CMV vaccine development”. Vaccine 32.1 (2013): 4-10.
  9. Kurath S., et al. “Transmission of cytomegalovirus via breast milk to the prematurely born infant: a systematic review”. Clin Microbiol Infect 16.8 (2010): 1172-1178.
  10. Lanzieri TM., et al. “Hearing Loss in Children with Asymptomatic Congenital Cytomegalovirus Infection external icon”. Pediatrics 139.3 (2017).
  11. Lanzieri TM., et al. “Long-term outcomes of children with symptomatic congenital cytomegalovirus disease”. J Perinatol 37.7 (2017): 875-880.
  12. Lanzieri TM., et al. “Influence of parity and sexual history on cytomegalovirus seroprevalence among women aged 20-49 years in the USA”. Int J Gynaecol Obstet (2016).
  13. Lopez AS., et al. “Intelligence and Academic Achievement with Asymptomatic Congenital Cytomegalovirus Infection”. Pediatrics 140.5 (2017).
  14. Manicklal S., et al. “The “silent” global burden of congenital cytomegalovirus”. Clin Microbiol Rev 26 (2013): 86-102.
  15. Oduwo E and Edwards SJL. “A systematic review of factors affecting children’s right to health in cluster randomized trials in Kenya”. Trials 15 (2014): 287.
  16. Practice bulletin no. 151: Cytomegalovirus, parvovirus B19, varicella zoster, and toxoplasmosis in pregnancy. External. Obstetrics & Gynecology 125.6 (2015): 1510-1525.
  17. Revello MG., et al. “Prevention of Primary Cytomegalovirus Infection in Pregnancy”. External EBioMedicine 2.9 (2015): 1205-1210.
  18. Ross DS and Fowler KB. “Cytomegalovirus: A Major Cause of Hearing Loss in Children External”. The ASHA Leader 13.6 (2008): 14-17.
  19. Satterfield-Nash A, Umrigar A and Lanzieri T. “Etiology of Prelingual Hearing Loss in the Universal Newborn Hearing Screening Era: A Scoping Review”. Otolaryngol Head Neck Surg (2020).
  20. Schmink, S., et al. “Effect of Breastfeeding and Additional Household Children on Cytomegalovirus Seroprevalence among U.S. Children 1 to 5 Years of Age”. Clin Vaccine Immunol 24.11 (2017).
  21. Ssentongo P., et al. “Congenital cytomegalovirus infection burden and epidemiologic risk factors in countries with universal screening: a systematic review and meta-analysis”. JAMA Netw Open 4 (2021): e2120736.
  22. Wang S., et al. “Cohort study on maternal cytomegalovirus seroprevalence and prevalence and clinical manifestations of congenital infection in China”. Medicine (Baltimore) 96.5 (2017): e6007.
  23. Wang C., et al. “Cytomegalovirus IgM Seroprevalence among Women of Reproductive Age in the United States”. PLoS ONE 11.3 (2016): e0151996.