PriMera Scientific Surgical Research and Practice (ISSN: 2836-0028)

Case Study

Volume 2 Issue 4

Severe Jaundice, due to Vanishing Bile Duct Syndrome in Hodgkin's Lymphoma, Fully Reversible after Chemotherapy

Pramod Kumar Singh*, Rajit Rattan, Ritesh Kumar and Budhi Singh Yadav

September 26, 2023

DOI : 10.56831/PSSRP-02-062


Liver involvement in Hodgkin's lymphoma is common and is caused by hepatic infiltration, biliary obstruction by lymphoma, hepatitis, sepsis or complications of chemotherapeutic treatment. Jaundice caused by the vanishing bile duct syndrome related to Hodgkin's lymphoma is very rare. The mechanism is poorly understood but a paraneoplastic effect seems most likely as liver biopsy and imaging study the absence of lymphoma cells in liver. We describe a 13-year-old man with vanishing bile duct syndrome and Hodgkin's lymphoma who was treated successfully with chemotherapy. The markedly elevated serum Bilirubin levels completely normalized. Our case demonstrates that although dosing of chemotherapy in this situation can be very difficult, a good clinical outcome is possible, which makes the attempt at curative treatment worthwhile.

Keywords: Hodgkin’s lymphoma; jaundice; vanishing bile duct


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