PriMera Scientific Surgical Research and Practice (ISSN: 2836-0028)

Review Article

Volume 2 Issue 3

The Development of Lethal MH-PSS with the Secondary Development of an Intense Peripheral Vasoconstriction: A Review

Charles H Williams*

August 25, 2023

DOI : 10.56831/PSSRP-02-058


The pigs used in these experiments were raised from the initial five pigs reserved as breeding stock in January 1969 from stock at the Arlington Farm, UW. They were challenged with 3% Halothane in O2 and identified as MH susceptible whenever the rear legs became extended and appeared to be in rigor. The Halothane challenge was stopped and the animals spontaneously recovered and were raised for breeding stock. The two males and three females were raised in UW Swine Barn A under Leo’s supervision. Unfortunately, when they reached 225-240 lbs. in weight, they were hauled off to the UW slaughter house. Leo found them missing and called the slaughter house and recovered one male and two females that had not been slaughtered. We relocated the MH breeding stock to the UW Sheep Farm so there could not be any other possible confusion with other pigs in Swine Barn A. I moved the key MHS breeding animals to Sinclair Research Farm at MZZOU in 1973 when I relocated to MIZZOU for a new research position. Later in 1982, the entire stock of MHS susceptible breeding animals were moved to TTUHSC at El Paso, TX. They were housed on a pig farm near El Paso, TX.


  1. Williams CH, C Houchins and MD Shanklin. “Pigs susceptible to energy metabolism in the fulminant hyperthermia stress syndrome”. BMJ 16 (1975): 411-413.
  2. Charles H Williams. “Malignant hyperthermia: A runaway thermogenic futile cycle at the sodium channel level”. Advances in Bioscience and Biotechnology 5.3 (2014).
  3. Charles H Williams. “Malignant hyperthermia: Evaluation of “Organon” 9426 in Malignant Hyperthermia Susceptible Pigs”. Open Journal of Molecular and Integrative Physiology 5.2 (2015).
  4. Charles H Williams. “A Review of the Factors Affecting the Incidence of Malignant Hyperthermia in the Greater Kansas City Area”. Advances in Bioscience and Biotechnology 5.5 (2014).