PriMera Scientific Surgical Research and Practice (ISSN: 2836-0028)

Research Article

Volume 1 Issue 2

Impact of Epidemiological and Clinical Risk factors in the Pathogenesis of Coronary Heart Disease

Rajesh Kumar Galimudi, Saraswati Mudigonda, Srilatha Reddy Gantala and Surekha Rani Hanumanth*

February 12, 2023

Abstract

Coronary heart disease (CHD) is a multifactorial disease resulting due to accumulation of atheromatous plaques within the walls of the coronary arteries that supply the myocardium (the muscle of the heart) with oxygen and nutrients. The aim of the present study is to investigate association of epidemiological and clinical risk factors in the development of disease in CHD patients and their first degree relatives (FDRS) in comparison with controls. The aetiology of CHD is multifactorial. It is the result of interaction between genetic, lifestyle and environmental factors. Monitoring the epidemiology and clinical risk factors of CHD is an important component in the pathogenesis of CHD.

References

  1. Sawant A., et al. “Prevalence of Metabolic Syndrome in Urban India”. Hindawi Publishing Corporation, Cholesterol (2011).
  2. Tsung Tan S., et al. “Coronary heart disease in Indian Asians”. Global Cardiology Science and Practice 4 (2014): 1-11.
  3. Canto JG., et al. “Number of Coronary Heart Disease Risk Factors and Mortality in Patients with First Myocardial Infarction”. JAMA 306 (2011): 19.
  4. Zock PL and Katan MB. “Diet, LDL oxidation, and coronary artery disease”. Am J Clin Nutr 68 (1998): 759-60.
  5. Madamanchi NR, Vendrov A and Runge MS. “Oxidative Stress and Vascular Disease”. Arterioscler Thromb Vasc Biol 25 (2005): 29-38.
  6. Cavalca V., et al. “Oxidative stress and homocysteine in coronary artery disease”. Clin Chem 47 (2001): 887-92.
  7. Martin RB. “Reactive Oxygen Species and Death Oxidative DNA Damage in Atherosclerosis”. Circ Res 88 (2001): 648-650.
  8. Gavino VC., et al. “Effects of polyunsaturated fatty acids and antioxidants on lipid peroxidation in tissue cultures”. Journal of Lipid Research 22 (1981): 763-69.
  9. Lepoivre M., et al. “Alteration of ribonucleotide reductase activity following induction of nitrite generating pathway in adenocarcinoma cells”. J. Biolchemo 265 (1990): 14143-49.
  10. Singh NP., et al. “A simple technique for quantitation of low levels of DNA damage in individual cells”. Exp. Cell Res 175 (1988): 184-191.
  11. Re R., et al. “Antioxidant activity applying an improved ABTS radical cation decolourization assay”. Free Radic Biol Med 26 (1999): 1231-7.
  12. Ozcan Erel. “A new automated colorimetric method for measuring total oxidant status”. Clinical Biochemistry 38 (2005): 1103-1111.
  13. Beltrame JF, Dreyer R and Tavella R. Epidemiology of Coronary Artery Disease, Coronary Artery Disease - Current Concepts in Epidemiology, Pathophysiology, Diagnostics and Treatment, Dr. David Gaze (Ed.) (2012).
  14. Mikhail GW. “Coronary heart disease in women”. BMJ 3-331.7515 (2005): 467-468.
  15. Banks AD. “Women and heart disease: missed opportunities”. J Midwifery Women’s Health 53 (2008): 430-439.
  16. Eastwood JA and Doering LV. “Gender differences in coronary artery disease”. J Cardiovas Nurs 20 (2005): 340-351.
  17. Anand SA., et al. “Risk factors for Myocardial Infarction in Women and men: Insights from the Interheart study”. Europen Heart Journal 29.7 (2008): 932-940.
  18. Lusis AJ, Mar R and Pajukanta P. “Genetics of atherosclerosis”. Annu Rev Genomics Hum Genet 5 (2004): 189-218.
  19. Lerner DJ and Kannel WB. “Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population”. Am Heart J 111.2 (1986): 383-390.
  20. Mensah MJ. “Atlas of Heart Disease and Stroke”. World Health Organisation (WHO) (2004).
  21. Joshi P., et al. “Risk factors for early myocardial infarction in South Asians compared with individuals in other countries”. JAMA 297.3 (2007): 286-294.
  22. Das S and Tripathy BB. “Diabetes, Dyslipidaemia and Atherosclerotic Coronary Artery Disease”. Int. j. diab. dev. Countries 15 (1995): 91-95.
  23. Mohan V., et al. “Epidemiology of type 2 diabetes: Indian scenario”. Indian J Med Res 125 (2007): 217-230.
  24. Pop-Busui R, Mehta M and Pennathur S. “Chapter 11-Oxidative Stress and Cardiovascular Disease in Diabetes”. Studies in Diabetes Oxidative Stress in Applied Basic Research and Clinical Practice (2014): 189-235.
  25. Valdez R., et al. “Family History in Public Health Practice: A Genomic Tool for Disease Prevention and Health Promotion”. Annu. Rev. Public Health 31 (2010): 69-87.
  26. Flossmann E and Rothwell PM. “Family history of stroke in patients with transient ischemic attack in relation to hypertension and other intermediate phenotypes”. Stroke 36 (2005): 830-835.
  27. Svati HS., et al. “Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis”. PLoS Genet 5.1 (2009): e1000318.
  28. Singh SP, Sikri SG and Garg MK. “Body Mass Index and Obesity: Tailoring “cut-off” for an Asian Indian Male Population”. MJAFI 64 (2008): 350-353.
  29. Andre Cornier M., et al. “Assessing Adiposity a Scientific Statement from the American heart association”. Circulation 124 (2011): 1996-2019.
  30. Rosendorff C., et al. “Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease a Scientific Statement from the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention”. Circulation 115 (2007): 2761-2788.
  31. Gupta R. “Trends in hypertension epidemiology in India”. Journal of Human hypertension 18 (2004): 73-78.
  32. Das SK, Sanyal K and Basu A. “Study of urban community survey in India: Growing trend of high prevalence of hypertension in a developing country”. International Journal of Medical Sciences 2 (2005): 70-78.
  33. Ambrose JA and Barua RS. “The Pathophysiology of Cigarette Smoking and Cardiovascular Disease-An Update”. J Am CollCardiol 43 (2004): 1731-1737
  34. Gupta R. “Recent trends in coronary heart disease epidemiology in India”. Indian Heart J 60.2 (2008): B4-18.
  35. Campesi I., et al. “Regular cigarette smoking influences the transsulfuration pathway, endothelial function, and inflammation biomarkers in a sex-gender specific manner in healthy young humans”. Am J Transl Res 5.5 (2013): 497-509.
  36. Lou XY., et al. “A generalized combinatorial approach for detecting gene by gene and gene by environment interactions with application to nicotine dependence”. American Journal of Human Genetics 80 (2007): 1125-1137.
  37. FenZhu W., et al. “Triglyceride and Non-High-Density Lipoprotein Cholesterol as Predictors of Cardiovascular Disease Risk Factors in Chinese Han Children”. Indian Pediatrics 50 (2012): 394-398.
  38. Lloyd-Jones D., et al. “Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee”. Circulation 119 (2009): e21-181.
  39. Stapleton PA., et al. “Hypercholesterolemia and microvascular dysfunction: interventional strategies”. Journal of Inflammation 7 (2010): 54.
  40. Khaki-khatibi, Yaghoubi A and Rahbani NM. “Study of antioxidant enzymes, lipid peroxidation, lipid profile and immunologic factor in coronary artery disease in East Azarbijan”. Int J Med Biomed Res 1.2 (2012): 147-152.
  41. Arsenault BJ., et al. “Beyond Low-Density Lipoprotein Cholesterol Respective Contributions of Non-High-Density Lipoprotein Cholesterol Levels, Triglycerides, and the Total Cholesterol/High-Density Lipoprotein Cholesterol Ratio to Coronary Heart Disease Risk in Apparently Healthy Men and Women”. JACC 55 (2010): 1.
  42. Miller M., et al. “Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association”. Circulation 120.30 (2011): 2292-333.
  43. Goldberg IJ, Eckel RH and McPherson R. “Triglycerides and Heart Disease Still a Hypothesis?”. Arterioscler Thromb Vasc Biol 31 (2011): 1716-1725.
  44. Savel J., et al. “Very low levels of HDL cholesterol and atherosclerosis, a variable relationship-a review of LCAT deficiency”. Vascular Health and Risk Management 8 (2012): 357-361.
  45. Barter P., et al. “HDL cholesterol, very low levels of ldl cholesterol, and cardiovascular events”. N Engl J Med 357.13 (2007): 1301-1310.
  46. Cockerill GW and Reed S. “High-density lipoprotein: multipotent effects on cells of the vasculature”. Int Rev Cytol 188 (1999): 257-297.
  47. Saku K., et al. “Quantity and Function of High Density Lipoprotein as an Indicator of Coronary Atherosclerosis”. JACC 33.2 (1999): 436-43.
  48. Schamberger BM., et al. “Influence of LDL apheresis on LDL subtypes in patients with coronary heart disease and severe hyperlipoproteinemia”. J. Lipid Res 41 (2000): 727-733.
  49. Ghosh J., et al. “Oxidised LDL, HDL Cholesterol, LDL Cholesterol Levels in Patients of Coronary Artery Disease”. Indian Journal of Clinical Biochemistry 21.1 (2006): 181-184.
  50. Gawron-Skarbek A., et al. “Cardiovascular Risk Factors and Total Serum Antioxidant Capacity i n Healthy Men and in Men with Coronary Heart Disease”. BioMed Research International (2014).
  51. Goldberg IJ, Eckel RH and McPherson R. “Triglycerides and Heart Disease Still a Hypothesis?”. Arterioscler Thromb Vasc Biol 31 (2011): 1716-1725.
  52. Real JT., et al. “Importance of HDL cholesterol levels and the total/ HDL cholesterol ratio as a risk factor for coronary heart disease in molecularly defined heterozygous familial hypercholesterolaemia”. European Heart Journal 22 (2001): 465-471.
  53. Afanas’ev I. “ROS and RNS Signaling in Heart Disorders: Could Antioxidant Treatment Be Successful?”. Oxidative Medicine and Cellular Longevity (2011).
  54. Kaur K., et al. “Lipidperoxidation and the levels of antioxidant enzymes in coronary artery disease”. Indian Journal of Clinical Biochemistry 23.1 (2008): 33-37.
  55. Omer N., et al. “Nitric Oxide: Role in Human Biology”. International Journal of Pharmaceutical Sciences and Drug Research 4.2 (2012): 105-109.
  56. Cooke JP. “NO and angiogenesis”. Atheroscler Suppl 4 (2003): 53-60.
  57. Soydinc, S., et al. “The relationship between Oxidative stress, Nitricoxide, and Coronary artery disease”. Eur J Gen Med 4.2 (2007): 62-66.
  58. Cook S. “Coronary artery disease, nitric oxide and oxidative stress: the “Yin-Yang” effect - a Chinese concept for a worldwide pandemic”. Swiss Med Wkly 136 (2006): 103-113.
  59. Ozsavci D. “Oxidative DNA damage and repair system”. Adv Mol Med 3.2 (2007): 57-61.
  60. Wiseman H and Halliwell B. “Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer”. Biochem. J 313 (1996): 17-29.
  61. Botto N., et al. “Evidence for DNA damage in patients with coronary artery disease”. Mutat Res 493 (2001): 23-30.
  62. Zhang PY, Xu X and Li XC. “Cardiovascular diseases: oxidative damage and antioxidant protection”. European Review for Medical and Pharmacological Sciences 18 (2014): 3091-3096.
  63. Subash VK., et al. “The role of antioxidants and oxidative stress in cardio- vascular disease”. Ann Biol Res 1 (2010): 158-173.
  64. Surekha RH., et al. “Oxidative stress and total antioxidant status in myocardial infarction”. Singapore Med J 48.2 (2007): 137-42.
  65. Fazendas P, Joao IF and Llobet S. “Plasma total antioxidant status in young survivors of myocardial infarction”. Rev Port Card 19 (2000): 463-467.
  66. Aksoy S., et al. “Oxidative stress and severity of coronary artery disease in young smokers with acute myocardial infarction”. Cardiology Journal 19 (2012): 381-386.
  67. Ayd?n M., et al. “Relationship between total antioxidant capacity and the severity of coronary artery disease”. JCEI 3.1 (2012): 22-28.
  68. Edward TH., et al. “C-reactive protein Linking Inflammation to Cardiovascular Complications”. Circulation 104 (2001): 974-975.
  69. Koenig W., et al. “Increased Concentrations of C-Reactive Protein and IL-6 but not IL-18 Are Independently Associated with Incident Coronary Events in Middle-Aged Men and Women Results From the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002”. Arterioscler Thromb Vasc Biol 26 (2006): 2745-2751.
  70. Roger V., et al. “Heart disease and stroke statistics-2012 Update: A report from the American Heart Association”. Circulation 5125.22 (2011): e1002.
  71. Beckman JA., et al. “Diabetes and Atherosclerosis Epidemiology, Pathophysiology and Management”. JAMA 287.19 (2002): 2570-2581.
  72. Scheuner MT., et al. “Expanding the definition of a positive family history for early-onset coronary heart disease”. Genet Med 8.8 (2006): 491-501.
  73. Nissen SE., et al. “Effect of Rimonabant on Progression of Atherosclerosis in Patients eith Abdominal Obesity and Coronary Artery Disease the STRADIVARIUS Randomized Controlled Trial”. JAMA 299.13 (2008): 1547-1560.
  74. Baguet JP and Mallion J. “Hypertension and Coronary Heart Disease. European Society of Hypertension Scientific News letter”. Update on Hypertension management 6 (2005).
  75. Ignarro LJ, Balestrieri ML and Napoli C. “Nutrition, physical activity, and cardiovascular disease: An update”. Cardiovascular Research 73 (2007): 326-340.
  76. Law MR, Wald NJ and Rudnicka AR. “Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis”. Br. Med. J 326 (2003): 1423.
  77. Jousilahti P., et al. “Is the effect of smoking on the risk for coronary heart disease even stronger than was previously thought?”. J. Cardiovasc. Risk 6.5 (1999): 293-298.