Abstract
Background: Chronic kidney disease is a growing global health issue, leading to high morbidity and mortality rates. Hemodialysis patients are particularly vulnerable to complications such as iron deficiency, anemia, and lipid profile abnormalities.
Objectives: This study aims to determine the prevalence of iron deficiency, anemia, and dyslipidemias and to explore the relationship between these conditions.
Material and Methods: We conducted an observational, descriptive, cross-sectional, prospective, and monocentric study at the Organ and Tissue Transplantation Department of Frantz Fanon Hospital in Blida, Algeria, from March to May 2024. Ferritin, hemoglobin, mean corpuscular volume, and a complete lipid profile were assessed for each patient.
Results: Sixty hemodialysis patients aged 18 and older were included in this study. The results indicate that 30% of patients suffer from iron deficiency, while 81.7% have anemia. Regarding the lipid profile, 65% of participants have dyslipidemia, with hypertriglyceridemia (35.9%) and hyper-LDL-cholesterol (23.1%) being the most common. Spearman correlation analyses show a significant inverse relationship between ferritin levels and total cholesterol concentrations (R = -0.417, p<0.05), triglycerides (R = -0.365, p <0.05), and LDL-cholesterol (R = -0.48, p <0.05). However, no significant correlation was found between ferritin and HDL-cholesterol (R = 0.234, p>0.05).
Conclusions: These results highlight the need for integrated and personalized clinical management for hemodialysis patients. Appropriate nutritional interventions and regular monitoring are crucial to optimizing clinical outcomes and improving the quality of life for these patients.
Keywords: Chronic kidney disease; iron deficiency; anemia; dyslipidemia; correlation
References
- Hasan YK., et al. “The prevalence of dyslipidemia in patients on hemodialysis: a cross-sectional study from Syria”. Ann Med Surg 85.8 (2023): 3838-44.
- Filipska A., et al. “Chronic kidney disease and dialysis therapy: incidence and prevalence in the world”. Pharmacia 68.2 (2021): 463-70.
- Kushwaha R, Vardhan PS and Kushwaha PP. “Chronic kidney disease interplay with comorbidities and carbohydrate metabolism: a review”. Life 14.1 (2023): 13.
- Cohen E., et al. “Physiology, development, and disease modeling in the Drosophila excretory system”. Genetics 214.2 (2020): 235-64.
- Pretto CR., et al. “Quality of life of chronic kidney patients on hemodialysis and related factors”. Rev Lat Am Enfermagem 28 (2020): e3327.
- Portolés J., et al. “Unresolved aspects in the management of renal anemia, a Delphi consensus of the Anemia Group of the S.E.N”. Nefrol (Engl Ed) 43.5 (2023): 517-30.
- Kumthekar GV., et al. “Reverse epidemiology for lipid disorders in hemodialysis-dependent patients: Role of dilutional hypolipidemia”. Indian J Nephrol 32.2 (2022): 104-9.
- Bishaw F., et al. “Prevalence of anemia and its predictors among patients with chronic kidney disease admitted to a teaching hospital in Ethiopia: A hospital-based cross-sectional study”. Medicine (Baltimore) 102.6 (2023): e31797.
- Kattah AG and Garovic VD. “Understanding sex differences in progression and prognosis of chronic kidney disease”. Ann Transl Med 8.14 (2020): 897.
- Siligato R., et al. “Maternal and fetal outcomes of pregnancy in nephrotic syndrome due to primary glomerulonephritis”. Front Med (Lausanne) 7 (2020): 563094.
- Giandalia A., et al. “Gender differences in diabetic kidney disease: Focus on hormonal, genetic and clinical factors”. Int J Mol Sci 22.11 (2021): 5808.
- Coyne E., et al. “Young adults with chronic kidney disease: An exploration of their relationships and support networks”. J Ren Care 45.1 (2019): 20-8.
- Trivedi A and Kumar S. “Chronic kidney disease of unknown origin: Think beyond common etiologies”. Cureus 15.5 (2023): e38939.
- Garrido D., et al. “Description of iron deficiency in patients with end-stage chronic kidney disease on hemodialysis, Quito”. Revista Colombiana de Nefrología 6.2 (2019): 95-102.
- Hain D., et al. “Iron-deficiency anemia in CKD: A narrative review for the kidney care team”. Kidney Med 5.8 (2023): 100677.
- Shih H-M, Wu C-J and Lin S-L. “Physiology and pathophysiology of renal erythropoietin-producing cells”. J Formos Med Assoc 117.11 (2018): 955-63.
- Kędzierska-Kapuza K., et al. “Demand for water-soluble vitamins in a group of patients with CKD versus interventions and supplementation-A systematic review”. Nutrients 15.4 (2023).
- Choukroun G., et al. “Prevalence of iron deficiency in patients with non-dialysis chronic kidney disease: the CARENFER national, multicentre, observational study”. Nephrol Ther 18.3 (2022):195-201.
- Amjad AWAIS., et al. “Prevalence of iron deficiency anemia in hemodialysis patients at NIKD”. Pak J Med Health Sci 15.6 (2021): 1192-4.
- Wojtaszek E, Glogowski T and Malyszko J. “Iron and chronic kidney disease: still a challenge”. Front Med (Lausanne) 7 (2020): 565135.
- Gutiérrez OM. “Treatment of iron deficiency anemia in CKD and end-stage kidney disease”. Kidney Int Rep 6.9 (2021): 2261-9.
- Akidağı Z. Which Blood Group is More Anemic: Five Years of Retrospective Experience (2023).
- Suh SH and Kim SW. “Dyslipidemia in patients with chronic kidney disease: An updated overview”. Diabetes Metab J 47.5 (2023): 612-29.
- Bulbul MC., et al. “Disorders of lipid metabolism in chronic kidney disease”. Blood Purif 46.2 (2018): 144-52.
- Wyszyńska J., et al. “Association and risk factors for hypertension and dyslipidemia in young adults from Poland”. Int J Environ Res Public Health 20.2 (2023):982.
- Kochan Z., et al. “Dietary lipids and dyslipidemia in chronic kidney disease”. Nutrients 13.9 (2021): 3138.
- Patel MJ and Priya N. “Association between iron indices and dyslipidemia among patients with iron deficiency anemia: A cross-sectional study”. J Clin Diagn Res 18.3 (2024).
- Gharib MAA, Abd Elalal NS and Elhassaneen YAE. “A study of the correlation between dyslipidemia and iron deficiency anemia in Egyptian adult subjects”. Alexandria Sci Exchange J 43.1 (2022): 53-63.