PriMera Scientific Medicine and Public Health (ISSN: 2833-5627)

Review Article

Volume 5 Issue 5

Reviewing African Antitussive Plants: Traditional Uses, Phytochemistry, and Pharmacology

Bertin Mikolo* and Pavel Ossiala

October 30, 2024

Abstract

This review explores the therapeutic potential of African antitussive plants by examining their traditional uses, phytochemical properties, and pharmacological evidence. It highlights the historical and cultural significance of these plants in African medicine and provides an overview of the key phytochemicals associated with their antitussive effects. The review also evaluates scientific studies that support the efficacy of these plants, including in vitro, in vivo, and clinical research. Additionally, it addresses challenges in standardizing and conserving these valuable resources while discussing opportunities for integrating traditional knowledge with modern healthcare practices. This comprehensive analysis aims to advance the understanding of African antitussive plants and their potential contributions to global health.

Keywords: Antitussive plants; African traditional medicine; Phytochemicals; Pharmacological evidence; Ethnopharmacology

References

  1. Abdelkhalek ST., et al. “Classification of Phytochemicals in Plants with Herbal Value”. In S. C. Izah, M. C. Ogwu, & M. Akram (Éds.), Herbal Medicine Phytochemistry: Applications and Trends. Springer International Publishing (2023): 1‑39.
  2. Aboriginal AI of and Studies TSI. “Guidelines for ethical research in Indigenous studies”. Australian Indigenous Law Reporter 8.1 (2003): 85‑94.
  3. Adejayan AA., et al. “Evaluation of the anti-asthmatic and antitussive potentials of methanol leaf extract of Napoleona vogelii in rodents”. Biomedicine & Pharmacotherapy 109 (2019): 120‑126.
  4. Adeleye OA., et al. “Ethnomedicinal herbs in African traditional medicine with potential activity for the prevention, treatment, and management of coronavirus disease 2019”. Future Journal of Pharmaceutical Sciences 7.1 (2021): 72.
  5. Adesina SK, Johnny II and Olayiwola G. “Plants in respiratory disorders I-anti-asthmatics, a review”. British Journal of Pharmaceutical Research 16.2 (2017a): 1‑22.
  6. Adesina SK, Johnny II and Olayiwola G. “Plants in respiratory disorders II antitussives”. Br. J. Pharm. Res 16.3 (2017b): 1‑21.
  7. Ahmad Khan MS and Ahmad I. “Herbal Medicine”. In New Look to Phytomedicine. Elsevier (2019): 3‑13.
  8. Akerele O, Heywood V and Synge H. (Éds.). “Conservation of Medicinal Plants”. Cambridge University Press (1991).
  9. Akunne (formerly Okoye) T., et al. “Safe African Medicinal Plants for Clinical Studies”. In Toxicological Survey of African Medicinal Plants (2014): 535‑555.
  10. Almusaed A and Almssad A. “Housing”. BoD – Books on Demand (2018).
  11. An M., et al. “Anti-asthma and antitussive effects of a fermented extract of a mixture of Ramulus mori, Anthriscus sylvestris, and Salvia plebeian”. Food Science and Biotechnology 30.9 (2021): 1257‑1268.
  12. Balogun O., et al. “Innovations in drug delivery systems: A review of the pharmacist’s role in enhancing efficacy and patient compliance”. World Journal of Advanced Research and Reviews 20 (2023): 1268‑1282.
  13. Bansal G, Kaur I and Kaur J. “Herbal health products quality through stability studies: A global regulatory concern”. Applied Clinical Research, Clinical Trials and Regulatory Affairs 4.1 (2017): 26‑35.
  14. Barik CS., et al. “A review on therapeutic potential of polyherbal formulations”. International Journal of Pharmaceutical Sciences and Drug Research (2015): 211‑228.
  15. Bhakta T., et al. “Studies on Antitussive Activity of Cassia fistula (Leguminosae) Leaf Extract”. Pharmaceutical Biology 36.2 (1998): 140‑143.
  16. Biharee A., et al. “A Comprehensive Study on Natural Products and their Bioactive Constituents to Cure Respiratory Diseases”. The Natural Products Journal 14.2 (2024): 32‑70.
  17. Breman E., et al. “Plant diversity conservation challenges and prospects—The perspective of botanic gardens and the Millennium Seed Bank”. Plants 10.11 (2021): 2371.
  18. Builders P. “Herbal Medicine”. BoD – Books on Demand (2019).
  19. Balogun O., et al. “Innovations in drug delivery systems: A review of the pharmacist’s role in enhancing efficacy and patient compliance”. World Journal of Advanced Research and Reviews 20 (2023): 1268‑1282.
  20. Jacob D., et al. “Indigenous Knowledge and Phytochemistry: Deciphering the Healing Power of Herbal Medicine”. In Herbal Medicine Phytochemistry: Applications and Trends (2023): 1‑53.
  21. Kassahun T., et al. “Ethnobotany, traditional use, phytochemistry and pharmacology of Cymbopogon citratus: Review article”. International Journal of Herbal Medicine 8.4 (2020): 80‑87.
  22. Chaachouay N and Zidane L. “Plant-Derived Natural Products: A Source for Drug Discovery and Development”. Drugs and Drug Candidates 3.1 (2024): 184‑207.
  23. Chaitanya MVNL., et al. “Traditional African Medicine”. In Natural Medicinal Plants. IntechOpen (2021).
  24. Chirwa DM. “Access to medicines and health care in sub-Saharan Africa: A historical perspective”. Md. J. Int’l L 31 (2016): 21.
  25. Enegide C and Charles CO. “Ocimum Species: Ethnomedicinal Uses, Phytochemistry and Pharmacological Importance”. International Journal of Current Research in Physiology and Pharmacology (IJCRPP) (2021): 1‑12.
  26. Fayiah M., et al. “Value of Herbal Medicine to Sustainable Development”. In S. C. Izah, M. C. Ogwu, & M. Akram (Éds.), Herbal Medicine Phytochemistry. Springer International Publishing (2024): 1429‑1456.
  27. Fischer NH, Isman MB and Stafford HA. “Modern Phytochemical Methods”. Springer Science & Business Media (2012).
  28. Franova S, Nosalova G and Mokry J. “Phytotherapy of cough”. Advances in phytomedicine 2 (2006): 111‑131.
  29. Harborne AJ. “Phytochemical methods a guide to modern techniques of plant analysis”. Springer science & business media (1998).
  30. Heinrich M., et al. “Ethnopharmacological field studies: A critical assessment of their conceptual basis and methods”. Journal of ethnopharmacology 124.1 (2009): 1‑17.
  31. Hubert BJ., et al. “Anti-inflammatory activities of fruit and leaves extract of lannea microcarpa england K. Kraus (anacardiaceae)”. Int J Pharm Pharm Sci 7 (2015): 177‑182.
  32. Imosemi I. “A review of the medicinal values, pharmacological actions, morphological effects and toxicity of Ocimum gratissimum linn”. European journal of pharmaceutical and medical research 7 (2020): 29‑40.
  33. Iwu MM. “Handbook of African Medicinal Plants, Second Edition”. CRC Press (1993).
  34. Jacob D., et al. “Indigenous Knowledge and Phytochemistry: Deciphering the Healing Power of Herbal Medicine”. In Herbal Medicine Phytochemistry: Applications and Trends (2023): 1‑53.
  35. Jamshidi-Kia F, Lorigooini Z and Amini-Khoei H. “Medicinal plants: Past history and future perspective”. Journal of herbmed pharmacology 7.1 (2017): 1‑7.
  36. Janzen JM and Green EC. “Medicine in Africa”. Encyclopedia of History of Science, Technology, and Medicine in Non-Western Cultures (2008): 1‑17.
  37. Kadam ST and Pawar AD. “Conservation of medicinal plants: A review”. Int. Ayurvedic Med. J 8 (2020): 3890‑3895.
  38. Kaggwa B., et al. “Safety and Efficacy of Medicinal Plants Used to Manufacture Herbal Products with Regulatory Approval in Uganda: A Cross-Sectional Study”. Evidence-Based Complementary and Alternative Medicine (2022): 1‑21.
  39. Karal A and Çelik H. “Drugs and Natural Products Used in COPD”. International Journal of Innovative Research and Reviews 6.1 (2022).
  40. Kassahun T., et al. “Ethnobotany, traditional use, phytochemistry and pharmacology of Cymbopogon citratus: Review article”. International Journal of Herbal Medicine 8.4 (2020): 80‑87.
  41. Keter LK., et al. “Validation of safety and efficacy of antitussive herbal formulations”. African Journal of Pharmacology and Therapeutics 2.1 (2013).
  42. Koffuor GA., et al. “Anti-tussive, muco-suppressant and expectorant properties, and the safety profile of a hydro-ethanolic extract of Scoparia dulcis”. Int J Basic Clin Pharmacol 3.3 (2014): 447‑453.
  43. Kumar B and Bhat R. “Cassia fistula: A Comprehensive Analysis of its Phytochemical Constituents and Pharmacological Activities” 11.6 (2024): 688‑693.
  44. Kunle OF, Egharevba HO and Ahmadu PO. “Standardization of herbal medicines-A review”. International journal of biodiversity and conservation 4.3 (2012): 101‑112.
  45. Lawal IO., et al. “Ethnobotanical survey of plants used for treating cough associated with respiratory conditions in ede south local government area of Osun State, Nigeria”. Plants 9.5 (2020): 647.
  46. Malú Q., et al. “Ethnomedicinal, chemical, and biological aspects of Lannea Species—A Review”. Plants 13.5 (2024): 690.
  47. Maroyi A. “Lannea microcarpa: A review of its medicinal uses, phytochemistry and pharmacological properties”. Journal of Pharmacy and Nutrition Sciences 8.4 (2018): 168‑177.
  48. Martin GJ. “Ethnobotany: A methods manual”. Routledge (2010).
  49. McFarlane C. “South Africa: the rise of traditional medicine”. Insight on Africa 7.1 (2015): 60‑70.
  50. Meher A. “Antitussive evaluation of formulated polyherbal cough syrup”. Journal of Drug Delivery and Therapeutics 2.5 (2012).
  51. Mokgobi MG. “Views on traditional healing: Implications for integration of traditional healing and Western medicine in South Africa”. [PhD Thesis, University of South (2012).
  52. Mollica A., et al. “A study on chemical characterization and biological abilities of Alstonia boonei extracts obtained by different techniques”. Antioxidants 11.11 (2022): 2171.
  53. Mule Geetanjli T., et al. “Formulation and In-vitro Evaluation of Poly-herbal Cough Syrup” 2.6 (2023): 127‑132.
  54. N’Guessan K, Assi-Kaudjhis C and Kouassi KH. “Ethnobotanical study of antitussive plants used in traditional medicine by Abbey et Krobou populations, in the south of Côte d’Ivoire”. International Journal of Advances in Pharmacy Biology and Chemistry 4.2 (2015): 513‑522.
  55. Nishimoto Y., et al. “Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro”. Journal of Pharmacological Sciences 113.1 (2010): 76‑83.
  56. Nosalova G., et al. “Herbal polysaccharides and cough reflex”. Respiratory Physiology & Neurobiology 187.1 (2013): 47‑51.
  57. Ogidi OI and Emaikwu NG. “Utilization Methods and Practices of Herbal Medicine in Africa”. In Herbal Medicine Phytochemistry: Applications and Trends (2024): 1367‑1393.
  58. Onwuegbuzie AJ. “Seven steps to a comprehensive literature review: A multimodal and cultural approach” (2016).
  59. Organization WH. “WHO guidelines on good manufacturing practices (GMP) for herbal medicines”. World Health Organization (2007).
  60. Ozioma E-OJ and Chinwe OAN. “Herbal medicines in African traditional medicine”. Herbal medicine 10 (2019): 191‑214.
  61. Ozolua R and DI U. “Evaluation of the Anti-asthmatic and Antitussive Effects of Aqueous Leaf Extract of Ocimum gratissimum in Rodents”. Medicinal & Aromatic Plants 05 (2016).
  62. Paul A., et al. “Pharmaceutical application of bio-actives from alstonia genus: current findings and future directions”. In advanced structured materials (2021): 463‑533.
  63. Pérez-Padilla R., et al. “Respiratory health effects of indoor air pollution”. The International Journal of Tuberculosis and Lung Disease 14.9 (2010): 1079‑1086.
  64. Pourova J., et al. “Proposed mechanisms of action of herbal drugs and their biologically active constituents in the treatment of coughs: An overview”. PeerJ 11 (2023): e16096.
  65. Raja W., et al. “In vivo antitussive activity of a pectic arabinogalactan isolated from Solanum virginianum L. in Guinea pigs”. Journal of ethnopharmacology 156 (2014): 41‑46.
  66. Reichman JH. “Intellectual property in the twenty-first century: will the developing countries lead or follow?”. Houston law review/University of Houston 46.4 (2009): 1115‑1185.
  67. Rimmer M. “Indigenous Intellectual Property: A Handbook of Contemporary Research”. Edward Elgar Publishing (2015).
  68. Rozas LW and Klein WC. “The Value and Purpose of the Traditional Qualitative Literature Review”. Journal of Evidence-Based Social Work 7.5 (2010): 387‑399.
  69. Saraswathy GR., et al. “Antitussive medicinal herbs-an update review”. International Journal of Pharmaceutical Sciences and Drug Research (2014): 12‑19.
  70. Shah V, Shah V and Santani DD. “Asthma and plants used for asthma-An overview”. Research journal of pharmacology and pharmacodynamics 4.5 (2012): 328‑338.
  71. Shang J-H., et al. “Pharmacological evaluation of Alstonia scholaris: Anti-tussive, anti-asthmatic and expectorant activitie”s. Journal of ethnopharmacology 129.3 (2010): 293‑298.
  72. Sharma A, Bhardwaj G and Cannoo D. “Overview of Phytochemistry and Pharmacology of Adhatoda vasica” (2018).
  73. Sharma A, Kumar A and Jaitak V. “Pharmacological and chemical potential of Cassia fistula L-a critical review”. Journal of Herbal Medicine 26 (2021): 100407.
  74. Shoaib A. “A systematic ethnobotanical review of Adhatoda vasica (L.), Nees”. Cellular and Molecular Biology 67.4 (2021): 248‑263.
  75. Stewart MK., et al. “Participatory development and implementation of a community research workshop: Experiences from a community-based participatory research partnership”. Progress in community health partnerships: research, education, and action 3.2 (2009): 165‑178.
  76. Sultana S., et al. “Cough suppressant herbal drugs: A review”. Int. J. Pharm. Sci. Invent 5.5 (2016): 15‑28.
  77. Šutovská M., et al. “Antitussive activity of polysaccharides isolated from the Malian medicinal plants”. International journal of biological macromolecules 44.3 (2009): 236‑239.
  78. Šutovská M., et al. “Possible mechanisms of dose-dependent cough suppressive effect of Althaea officinalis rhamnogalacturonan in guinea pigs test system”. International Journal of Biological Macromolecules 45.1 (2009): 27‑32.
  79. Tan OJ., et al. “Improving oral bioavailability of medicinal herbal compounds through lipid-based formulations – A Scoping Review”. Phytomedicine 90 (2021): 153651.
  80. Velavan S. “Phytochemical techniques-a review”. World Journal of Science and Research 1.2 (2015): 80‑91.
  81. WHO. 1: WHO guidelines on good herbal processing practices for herbal medicines. WHO Technical Report Series (2018).
  82. Wang H., et al. “Advancing herbal medicine: Enhancing product quality and safety through robust quality control practices”. Frontiers in Pharmacology 14 (2023): 1265178.
  83. Wankhar W., et al. “Phytochemicals screening and antimicrobial efficacy of Scoparia dulcis Linn (Scrophulariaceae) against clinical isolates”. Journal of Pharmacognosy and Phytochemistry 3.6 (2015): 17‑21.
  84. Wireko I and Béland D. “The challenge of healthcare accessibility in sub-Saharan Africa: The role of ideas and culture”. European J. of International Management 7.2 (2013): 171.
  85. Ziment I. “Herbal antitussives”. Pulmonary Pharmacology & Therapeutics 15.3 (2002): 327‑333.