PriMera Scientific Medicine and Public Health (ISSN: 2833-5627)

Review Article

Volume 5 Issue 2

Effect of Gongronema latifilium and Luffa aegyptiaca decoction on the blood glucose, lipids and liver enzymes of alloxan induced diabetic rats

Ngozi Mercy Nnam, Ngozi Helen Onyia and Ijioma John Okorie*

July 29, 2024

DOI : 10.56831/PSMPH-05-158

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Abstract

There is lack of information on the use of Gongronema latifilium and Luffa aegyptiaca leafy vegetables decoction in the management of diabetes. The study investigated the effect of G. latifilium and L. aegyptiaca leafy vegetable decoction on blood glucose level, lipid profile and liver enzymes of alloxan-induced diabetic wistar rats. Experimental design was adopted to randomly assign 30 rats of 5 treatment groups and 1 untreated group each. The leafy vegetables were purchased, picked separately and washed with deionized water. The vegetables were separately boiled for 10.3minutes in 3.5L and 4.5L of water, respectively. The decoctions were sieved out separately and stored in the refrigerator for further study. Alloxan was used to induce diabetes in the rats, while treatment lasted for 21days. Phytochemicals, acute toxicity test, blood glucose and liver function test were done using standard methods. Pair-sample t-test (p < 0.05) was used to determine the effect of the decoctions and percentage difference was calculated. There were 69.64% and 68.88% decreases in the blood glucose level of diabetic rats treated with 3mL/kg bodyweight of G. latifilium and L. aegyptiaca decoctions, respectively. There was significant increase (p < 0.05) in the HDL-C level of diabetic rats after treatment with 3mL/kg bodyweight of G. latifilium and L. aegyptiaca decoctions. Significant decrease (p < 0.05) was observed in the liver enzymes activity of the diabetic rats after treatment with 3mL/kg bodyweight of G. latifilium and L. aegyptiaca decoctions. The leafy vegetables decoction had potentials to reduce high blood glucose level, dyslipidemia and, for normal liver function.

Keywords: Gongronema latifilium; Luffa aegyptiaca; decoction; blood glucose; diabetic rats; liver enzymes; dyslipidemia

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