Manvi Karayat*, Arun Kumar Pal, Gagan Chawla, Anjali Tolia and Jaydev Mandal
January 27, 2024
Ageratum conyzoides (billygoat-weed, chickweed, goatweed, whiteweed, mentrasto) is native to Tropical America, particularly Brazil, but has become an invasive weed in many other parts of the world. It is a 0.5-1 m tall herb with ovate leaves 2-6 cm long and white to mauve flowers. The dichloromethane extract of Ageratum conyzoides aerial parts. (Aster-aceae), a plant widely used in folk medicine for a variety of diseases including sleeping sickness, was recently discovered to have strong activity (IC50 = 0.78 g/mL) against bloodstream forms of Trypanosoma brucei rhodesiense.
This study set out to assess the haemostatic potential of an aqueous extract of Ageratum conyzoides leaves in order to support or refute the plant's traditional use as a hemostatic agent. According to the ability of the extract to reduce bleeding time in experimental animals, Ageratum conyzoides leaf aqueous extract seems to have hemostatic properties. Although the extract prevented whole blood coagulation, it did cause blood material precipitation. Because of their ability to (a) cause vasoconstriction, (b) precipitate proteins at bleeding sites, and (c) promote the natural process of blood coagulation, various substances can be used to control local bleeding. The extract's ability to stop bleeding may be due to a confluence of two mechanisms. According to the findings of the current experiments, these mechanisms include the precipitation of blood constituents (as evidenced by the heavy precipitation), forming a bung to plug the blood vessel cut.
Keywords: Ageratum conyzoides; Haemostatic effect; Blood coagulation