PriMera Scientific Medicine and Public Health (ISSN: 2833-5627)

Review Article

Volume 4 Issue 2

A Review on Coacgulation Activity of Ageratum Conyzoid Plant

Manvi Karayat*, Arun Kumar Pal, Gagan Chawla, Anjali Tolia and Jaydev Mandal

January 27, 2024


Ageratum conyzoides (billygoat-weed, chickweed, goatweed, whiteweed, mentrasto) is native to Tropical America, particularly Brazil, but has become an invasive weed in many other parts of the world. It is a 0.5-1 m tall herb with ovate leaves 2-6 cm long and white to mauve flowers. The dichloromethane extract of Ageratum conyzoides aerial parts. (Aster-aceae), a plant widely used in folk medicine for a variety of diseases including sleeping sickness, was recently discovered to have strong activity (IC50 = 0.78 g/mL) against bloodstream forms of Trypanosoma brucei rhodesiense.

This study set out to assess the haemostatic potential of an aqueous extract of Ageratum conyzoides leaves in order to support or refute the plant's traditional use as a hemostatic agent. According to the ability of the extract to reduce bleeding time in experimental animals, Ageratum conyzoides leaf aqueous extract seems to have hemostatic properties. Although the extract prevented whole blood coagulation, it did cause blood material precipitation. Because of their ability to (a) cause vasoconstriction, (b) precipitate proteins at bleeding sites, and (c) promote the natural process of blood coagulation, various substances can be used to control local bleeding. The extract's ability to stop bleeding may be due to a confluence of two mechanisms. According to the findings of the current experiments, these mechanisms include the precipitation of blood constituents (as evidenced by the heavy precipitation), forming a bung to plug the blood vessel cut.

Keywords: Ageratum conyzoides; Haemostatic effect; Blood coagulation


  1. Sukmawan YP and Suhendy H. Hemostatic effect of ethanolic extract of Ageratum conyzoides l to strains of mice male swiss webster induced with combination of aspirin, clopidogrel, and enoxaparin 10 (2017).
  2. Boudaaa H., et al. Effect of essential oils from leaves of Ageratum conyzoides, Lantana camara and Chromolaena odorata on the mortality of Sitophilus zeamais (Coleoptera, Curculionidae) (2000).
  3. Bautista Roela Feliz M., et al. Development of a TAPE-Agar Liquid Gel Bandage 841 (2020).
  4. Gholmy H and El Sherwet. Performance and testing of adhesive bandage tape 14 (2019).
  5. Catherine Hannan. What are liquid stitches (2020).
  6. H Kristianto. Water Conservation Science and Engineering. Springe (2017).
  7. MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team (2022).
  8. Yufei Ma., et al. Liquid Bandage Harvests Robust Adhesive, Hemostatic, and Antibacterial Performances as a First-Aid Tissue Adhesive (2020).
  9. Mathuram M, Meera R and Vijayaraghavan G. “Application of Locally Sourced Plants as Natural Coagulants For Dye Removal from Wastewater: A Review”. J. Mater. Environ. Sci 9 (2018).
  10. Andrew Gonzalez (2019).
  11. Bautista Roela Feliz M., et al. Development of a TAPE-Agar Liquid Gel Bandage 841 (2020): 20-25.
  12. Rachel Petkewich. What's that stuff? Liquid Bandages.