Antibiotic Resistance Phenotypes of Escherichia Coli Strains Isolated from Urinary Tract Infections in the Medical Biology Laboratory of Niamakoro FOMBA Hospital in Segou, Mali
Diarra L*, Guindo I, Kalambry AC, Coulibaly K, Thiero M, Koné A, Keita-Traore M and Ouedraogo AS
July 22, 2023
DOI : 10.56831/PSMPH-03-079
Introduction: In order to guide antibiotic therapy, most often probabilistic this study aimed to characterize the different phenotypes of antibiotic resistance of E. coli strains responsible for urinary tract infections. Materials and methods: This was a prospective cross-sectional study with descriptive purposes that took place from January to December 2020 at the medical biology laboratory of Niamakoro FOMBA Hospital in Ségou. Uriselect 4 Agar was used for urine culture followed by biochemical identification by API 20E gallery. The antibiogram was then performed by the disc method according to the 2019 recommendations of the antibiogram committee of the French Society of Microbiology. Results: During this study, 56 enterobacteriaceae were isolated and identified in urinary tract infections, including 43 strains of E. coli or 76.79%. Regarding resistance patterns, the ESBL phenotype was the most observed with 46.51% for the beta-lactam class. Aminoglycoside resistance affected 41.46% of strains resistant to all aminoglycosides tested. Quinolone resistance was identified with 88.10% of strains resistant to all quinolones. ESBL profiles were associated with resistance to aminoglycosides, fluoroquinolones and sulfamethoxazole + trimethoprim in 13.95% of cases. Conclusion: The present study on resistance phenotypes in E. coli isolates reports worrisome results for the main classes of antibiotics.
Keywords: Antibiotics; E. coli; urinary tract infection; resistance phenotypes
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