PriMera Scientific Medicine and Public Health (ISSN: 2833-5627)

Review Article

Volume 3 Issue 2

Understanding Impulsivity through P300 among Clinical Population: A Systematic Review

Debjani Kar*, Nishant Goyal and Sreemoyee Tarafder

July 04, 2023

DOI : 10.56831/PSMPH-03-078


Impulsivity has been conceptualized as a predictive factor among various problem behaviours of people who are clinically diagnosed with psychiatric disorders. In recent decades, there has been an attempt to understand impulsivity in terms of brain activities. The trait impulsivity is measured through P3a and P3b amplitudes to understand how they might change in pathological populations. Altered P300 is a biomarker for psychotic disorders, neurotic disorders, and various disorders related to addiction. Overall, P300 can be associated with impulsivity and inhibitory control. However, in different psychiatric disorders, the nature of changes in P300 indicated different types of underlying processing in decision-making and response inhibition.

Keywords: Impulsivity; P300; Psychopathology; Addiction; Psychosis


  1. Barratt E. “Impulsiveness and aggression”. Chicago: University of Chicago (1994): 61-79.
  2. Bauer LO. “Neural Responses to Signals for Behavior Change: Greater Within-Person Variability is Associated with Risk Factors for Substance Dependence”. Alcoholism, clinical and experimental research 44.9 (2020): 1783-1790.
  3. Brennan GM and Baskin-Sommers AR. “Brain-behavior relationships in externalizing: P3 amplitude reduction reflects deficient inhibitory control”. Behavioral brain research 337 (2018): 70-79.
  4. Carlson SR and Thái S. “ERPs on a continuous performance task and self-reported psychopathic traits: P3 and CNV augmentation are associated with Fearless Dominance”. Biological psychology 85.2 (2010): 318-330.
  5. Chamberlain SR and Sahakian BJ. “The neuropsychiatry of impulsivity”. Current Opinion in Psychiatry 20.3 (2007): 255-261.
  6. Chen AC., et al. “Reduced frontal lobe activity in subjects with high impulsivity and alcoholism”. Alcoholism, clinical and experimental research 31.1 (2007): 156-165.
  7. Chudasama Y. “Animal models of prefrontal-executive function”. Behavioral Neuroscience 125.3 (2011): 327-343.
  8. Dayan-Riva A, Berger A and Anholt GE. “Early cognitive processes in OCD: An ERP study”. Journal of affective disorders 246 (2019): 429-436.
  9. Dimoska A and Johnstone SJ. “Neural mechanisms underlying trait impulsivity in non-clinical adults: stop-signal performance and event-related potentials”. Progress in neuro-psychopharmacology & biological psychiatry 31.2 (2007): 443-454.
  10. Dong G, Zhou H and Zhao X. “Impulse inhibition in people with Internet addiction disorder: electrophysiological evidence from a Go/NoGo study”. Neuroscience letters 485.2 (2010): 138-142.
  11. Drislane LE, Vaidyanathan U and Patrick CJ. “Reduced cortical call to arms differentiates psychopathy from antisocial personality disorder”. Psychological medicine 43.4 (2013): 825-835.
  12. Duven EC., et al. “Altered reward processing in pathological computer gamers—ERP results from a semi-natural gaming design”. Brain and behavior 5.1 (2015): 13-23.
  13. Fein G and Cardenas VA. “P3b amplitude is not reduced in abstinent alcoholics with a current MDD”. Alcohol (Fayetteville, N.Y.) 63 (2017): 33-42.
  14. Hoptman MJ., et al. “Sensory and cross-network contributions to response inhibition in patients with schizophrenia. NeuroImage”. Clinical 18 (2018): 31-39.
  15. Ibanez A., et al. “The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)”. PloS one 7.5 (2012): e37306.
  16. Kam JW, Dominelli R and Carlson SR. “Differential relationships between sub-traits of BIS-11 impulsivity and executive processes: an ERP study”. International journal of psychophysiology: official journal of the International Organization of Psychophysiology 85.2 (2012): 174-187.
  17. Kamarajan C., et al. “Theta oscillations during the processing of monetary loss and gain: a perspective on gender and impulsivity”. Brain research 1235 (2008): 45-62.
  18. Kim JS., et al. “Auditory evoked potential could reflect emotional sensitivity and impulsivity”. Scientific reports 6 (2016): 37683.
  19. Kim M., et al. “Neurophysiological correlates of altered response inhibition in internet gaming disorder and obsessive-compulsive disorder: Perspectives from impulsivity and compulsivity”. Scientific reports 7 (2017): 41742.
  20. Kim YY and Jung YS. “Reduced frontal activity during response inhibition in individuals with psychopathic traits: an sLORETA study”. Biological psychology 97 (2014): 49-59.
  21. Koelsch S. “P3a and mismatch negativity in individuals with moderate Intermittent Explosive Disorder”. Neuroscience letters 460.1 (2009): 21-26.
  22. Krakowski MI., et al. “Disturbances in Response Inhibition and Emotional Processing as Potential Pathways to Violence in Schizophrenia: A High-Density Event-Related Potential Study”. Schizophrenia bulletin 42.4 (2016): 963-974.
  23. Kreusch F., et al. “Alcohol abuse and ERP components in Go/No-go tasks using alcohol-related stimuli: impact of alcohol avoidance”. International journal of psychophysiology: official journal of the International Organization of Psychophysiology 94.1 (2014): 92-99.
  24. Lole L, Gonsalvez CJ and Barry RJ. “Reward and punishment hyposensitivity in problem gamblers: A study of event-related potentials using a principal components analysis”. Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology 126.7 (2015): 1295-1309.
  25. Merlotti E., et al. “Impulsiveness in patients with bulimia nervosa: electrophysiological evidence of reduced inhibitory control”. Neuropsychobiology 68.2 (2013): 116-123.
  26. Morie KP., et al. “Intact inhibitory control processes in abstinent drug abusers (II): a high-density electrical mapping study in former cocaine and heroin addicts”. Neuropharmacology 82 (2014): 151-160.
  27. Munro GE., et al. “Response inhibition in psychopathy: the frontal N2 and P3”. Neuroscience letters 418.2 (2007): 149-153.
  28. Oberg SA, Christie GJ and Tata MS. “Problem gamblers exhibit reward hypersensitivity in medial frontal cortex during gambling”. Neuropsychologia 49.13 (2011): 3768-3775.
  29. Park M., et al. “Differential neurophysiological correlates of information processing in Internet gaming disorder and alcohol use disorder measured by event-related potentials”. Scientific reports 7.1 (2017): 9062.
  30. Park M., et al. “Sustained dysfunctional information processing in patients with Internet gaming disorder: 6-month follow-up ERP study”. Medicine 96.36 (2017): e7995.
  31. Ribordy Lambert F., et al. “Acute alcohol intoxication and expectations reshape the spatiotemporal functional architecture of executive control”. NeuroImage 215 (2020): 116811.
  32. Rosburg T., et al. “Inhibition and attentional control in pedophilic child sexual offenders - An event-related potential study”. Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology 129.9 (2018): 990-1998.
  33. Sandy. P300. NeuRA Library (2020).
  34. Schmüser L., et al. “Data-driven analysis of simultaneous EEG/fMRI reveals neurophysiological phenotypes of impulse control”. Human brain mapping 37.9 (2016): 3114-3136.
  35. Schuermann B., et al. “Impaired decision making and feedback evaluation in borderline personality disorder”. Psychological medicine 41.9 (2011): 1917-1927.
  36. Sehrig S., et al. “Decision- and feedback-related brain potentials reveal risk processing mechanisms in patients with alcohol use disorder”. Psychophysiology 56.12 (2019): e13450.
  37. Steele VR., et al. “Brain potentials measured during a Go/NoGo task predict completion of substance abuse treatment”. Biological psychiatry 76.1 (2014): 75-83.
  38. Sumich A., et al. “Neurophysiological correlates of excitement in schizophrenia”. Progress in neuro-psychopharmacology & biological psychiatry 46 (2013): 132-138.
  39. The impulsive client: Theory, research, and treatment (1993).
  40. Venables NC., et al. “Factors of psychopathy and electrocortical response to emotional pictures: Further evidence for a two-process theory”. Journal of abnormal psychology 124.2 (2015): 319-328.
  41. Verona E, Sprague J and Sadeh N. “Inhibitory control and negative emotional processing in psychopathy and antisocial personality disorder”. Journal of abnormal psychology 121.2 (2012): 498-510.
  42. Watson TD, Sweeney JF and Louis H. “Neurocognitive, psychological and behavioral correlates of binge drinking and use of alcohol with caffeinated beverages in college-aged adults”. The American journal of drug and alcohol abuse 40.1 (2014): 58-66.
  43. Wei S., et al. “Enhanced neural responses to monetary rewards in methamphetamine use disordered individuals compared to healthy controls”. Physiology & behavior 195 (2018): 118-127.
  44. Yau YH., et al. “Blunted feedback processing during risk-taking in adolescents with features of problematic Internet use”. Addictive behaviors 45 (2015): 156-163.