PriMera Scientific Medicine and Public Health (ISSN: 2833-5627)

Case Report

Volume 2 Issue 5

Chronic Constipation and Its Curable Treatment with Senna Leaves in Wistar Rats

Trilok Kumar and BL Gupta*

April 17, 2023

DOI : 10.56831/PSMPH-02-059

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Abstract

Chronic constipation developed by loperamide in Wistar rats were subjected to experimentation and their treatments with senna leaves extracts. It was observed that there was an increase of body weight, swollen stomach and belly size. The stools were hard and less in amount in constipated rats which all they got normalized with sanay treatments.

In chronic constipation the glutathione peroxidase activity was observed to be decreased by 18% approximately in case of male and 16% approximately in case of female. The glutathione reductase activity also increased by 22% in male and 25% in female rats red blood cells. The catalase activity has shown an increase of 14% in males and 32% approximately in female rats red blood cells. The GOT activity increased by 54% in males and 48% in females. The GPT activity in red blood cells was observed to be increased by 36% approximately in case of male and 44% in female. The catalase activity was found to be increased by 14% in male and 32% in female rats red blood cells. All these enzymes activities normalized after sanay leaves extract treatments to chronic constipated rats.

The metabolites levels of GSH also decreased by 25% in both male and female rats and the GSSG levels increased by 77% in male and 66% in female. The sanay treatments to both male and female rats normalized the metabolites levels.

In chronic constipation the creatinine levels were observed to be increased by 8% approximately in case of male and 13% in case of female. This metabolits level was observed to be normalized after sanay leaves extracts treatments to chronic constipated rats.

It may be concluded that the female rats suffer the most biochemical dysfunction in comparison to male in chronic constipation.

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