PriMera Scientific Medicine and Public Health (ISSN: 2833-5627)

Review Article

Volume 2 Issue 3

Sanay Leaves Treatment in Constipation Rats Restores Defence System in Red Blood Cells

Trilok Kumar and BL Gupta*

March 01, 2023

DOI : 10.56831/PSMPH-02-046

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Abstract

     The defensive enzymes like glutathione preoxidase, glutathione reductase and catalase along with the defensive metabolites like reduced glutathione and oxidised glutathione were measured in red blood cells of acute constipated rats also along with sanay treated constipated rats. It was observed a decrease in GPx activity in both sexes of rats i.e., males and females. The GR activity in constipated rats was shown to be increased by more than GPx activity. The catalase activity has been observed to be increased insignificantly in acute condition. However, the GSH levels were found to be decreased in acute constipated rats but GSSG levels enhanced in acute condition. The sanay leaves treatment to acute condition rats restored the changed enzymes activities and metabolites levels.

     The liver function test carried out by the two enzymes namely GOT & GPT which increased in constipated rats. It shows that the enhanced GOT & GPT activities caused dysfunction of liver and invite kinds of liver diseases. The creatinine levels in red blood cells showed insignificant changes in both acute constipated rats and its treated condition with sanay leaves. It may be concluded that sanay treatment restores the low defense system found in constipated rats as well as the liver function which is slightly changed during constipation.

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