Research Article
Volume 2 Issue 1
Quirino Piacevoli*, Radmila Karan and Antonio Mascia
December 23, 2022
DOI : 10.56831/PSMPH-01-031
Abstract
The number of different biomarkers used in patients admitted in ICU for SIRS, sepsis and septic shock is extremely high, but no single one has high specificity and sensitivity so it has been suggested that combinations of several biomarkers may be more effective than single biomarkers. The aim of this study was to investigate the use of Presepsin, a soluble fragment of the cluster of differentiation marker protein 14 (CD14), involved in pathogen recognition by innate immunity. In selected ICU patients and cardiac surgery patients we tried to investigate the diagnostic and prognostic value of Presepsin (PSP) compared to Procalcitonin (PCT), C-reactive Protein (CRP), White blood cells (WBC) and IL6. The assay for biomarkers were performed on whole venous or arterial blood, on days 1, 2, 4, and 7 from admission of patients eligible for the study. The diagnostic accuracy of the biomarkers studied was evaluated using the areas under the curve (AUCs). The accuracy of all biomarkers decreases with time until they are no longer useful. The use of Presepsin (PSP) to early detect the presence of infection could improve patient survival and outcome in distinguishing sepsis from SIRS in intensive care unit.
Keywords: Sepsis; Septic Shock; Biomarker; Presepsin; Procalcitonin; C-reactive Protein; Interleukin-6